M L Bots

..Because the overall effect of tibolone on cardiovascular risk was unknown, the OPAL study was designed...

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..We set out to assess the differences in HRQOL of hemodialysis patients between dialysis centers and explore which modifiable center characteristics could explain possible differences...

..The relation of FGF23 with other renal and non-renal cardiovascular risk factors is not well established...

..Yet, short-term mortality is not significantly higher in diabetic patients. Risks appear to be equally elevated in men and women...

..By linkage of registers, recurrent events and double counts can be excluded...

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..Age and gender are important predictors of mortality in hospitalized HF patients. However, studies assessing short- and long-term risk of death stratified by age and gender are scarce...

..It is not known how general practitioners in the Netherlands care for these women after delivery with respect to cardiovascular risk factor management...

..To determine if recommended treatment targets, as specified in clinical practice guidelines for the management of cardiovascular disease, reduces the risk of renal complications in high risk patient populations...

..Therefore, our objective was to determine risk of death after first hospital admission for atherosclerotic disease located at different sites...

..We aimed to investigate the effect of the CETP inhibitor, torcetrapib, on carotid atherosclerosis progression in patients with mixed dyslipidaemia...

..The Perindopril-Function of the Endothelium in Coronary artery disease Trial (PERFECT) evaluated whether long-term administration of perindopril improves endothelial dysfunction...

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..These markers may provide earlier indications of efficacy in trials involving fewer participants. One approach gaining interest in recent years is the measurement of atherosclerotic progression, a major underlying cause of CVD...

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..Automated edge detection is thought to be superior to manual edge detection in quantification of the far wall common carotid intima-media thickness (CIMT), yet published evidence making a direct comparison is not available...

..We studied the relationship between cardiovascular risk factors and echolucency of the carotid intima-media in low-risk individuals...

..Insights in absolute mortality risks following admission for PAD in the lower extremities can be useful to improve awareness as they are easy to interpret...

..01; 1.41), but not for AIx (4.60% (95% CI 1.34; 7.85)). In summary, low-grade inflammation seems to be independently related to increase of aortic artery stiffness over and above traditional risk factors and atherosclerosis...

..We studied these aspects in the Measuring Effects on intima media Thickness: an Evaluation Of Rosuvastatin (METEOR) study, a randomized placebo-controlled trial amongst 984 low-risk subjects...

..06 (95% CI -0.01; 0.13)). The results of this study do not support the presence of an independent relationship between circulating tHcy levels and large artery stiffness and thickness...

..To investigate the prevalence and determinants of unrecognised myocardial infarction (UMI). Design, setting,..

..Here we evaluate whether strict implementation of guidelines aimed at multiple targets with the aid of nurse practitioners (NP) improves management in patients with CKD...

..Background: We recently showed that AMi patients can be followed longitudinally within dutch national medical registrations in a valid way. This makes it possible to provide nationwide incidence estimates of first AMi in the Netherlands...

..02% risk/SD birth length; 95% CI: -0.04, 0.0001). These results suggest that small birth size is associated with an increased risk score for coronary artery disease in young adulthood...

..Tibolone did not alter fmd. The clinical significance of this improvement in fmd for cardiovascular disease risk needs to be established...

..Information on incidence of stroke is important for developing and maintaining public health strategies in primary and secondary prevention. Nationwide data on the incidence of stroke are scarce and absent for the Netherlands...

..These findings support the view that AIx may be used as a marker for early vascular damage and cardiovascular disease risk...

..However, studies show conflicting results and are limited to elderly subjects. To study this issue further, we evaluated the relation of arterial stiffness to subclinical atherosclerosis in 524 healthy young adults, aged 27-30 years...

..CONCLUSION: Adolescent BMI predicts cardiovascular risk, as estimated by common CIMT in young adulthood. Individuals who experience the largest increase in BMI and those who remain overweight over time have the thickest common CIMT...

..Changes appear to be more pronounced in postmenopausal women compared to perimenopausal women...

..We compared different ultrasound protocols in a post-hoc analysis in the 'Osteoporosis Prevention and Arterial effects of tiboLone' (OPAL) study, a 3-year randomized controlled trial among healthy postmenopausal women...

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..CONCLUSIONS: In a population-based cohort of men aged 40-80 years the relation of alcohol consumption level with AIx was U-shaped, further expanding the evidence for vascular protective effects of moderate alcohol intake...

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..CONCLUSION: The incidence of sudden cardiac death is markedly increased on Monday, similar for men and women, and for subjects below and above 65 years of age...

..A short questionnaire with one or two questions is recommended for example the one from the Boxmeer-study. These data may be used to adjust (age-specific) prevalence rates comparing ED prevalence in the open population across studies...

..To identify plaque characteristics of carotid artery radiation-induced stenosis...

..CONCLUSIONS: Our study provides the first nationwide incidence estimates of first AMI in the Netherlands. From 1995 to 2000, the risk of AMI declined considerably...

..Yet, studies into differences between men and women in survival after a stroke yielded inconsistent results. We investigated whether gender was associated with all-cause mortality after hospital admission for stroke...

..02 [95% CI: 0.89; 1.16]). CONCLUSIONS: This study shows that in patients with manifest arterial disease, increasing hemoglobin levels are associated with reduced severity of atherosclerosis...

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..In this study, we assess whether NIRS and perioperative TCD are related to the onset CHS following CEA...

..This knowledge enhances the understanding of atherosclerosis development and CVD risk and is needed to improve the available primary prevention programs...

..There seems to be ample room for improvement in implementing the guidelines. Probably, patient tailored interventions and a multisiciplinary and multimodality approach can support this improvement...

..Our results may point to the relevance of naturally occurring rhythmic fluctuations in human physiology, and socially determined rhythms in human behaviour as underlying mechanism...

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..Data on the effect of vitamin K intake on coronary heart disease (CHD) risk, however, are scarce. To examine the relationship between dietary vitamins K(1) and K(2) intake, and its subtypes, and the incidence of CHD...

..To estimate the influence of information on the coronary arteries obtained from routine thoraco-abdominal CT angiography (CTA) on pre-operative clinical management in abdominal aortic aneurysm (AAA) patients...

..We aimed to (1) compare the value of NIRS related to existing cerebral monitoring techniques in prediction of perioperative cerebral ischaemia and (2) compare the relation between NIRS and the occurrence of CHS...

..For this purpose 1000 subjects with chronic hypertension will undergo cardiac MR imaging. In addition, this study allows the extrapolation of animal experimental genetic research into the human situation. (Neth Heart J 2007;15:295-8.)...

..In particular, ischemic heart disease mortality is 2% lower. Although the risk of death from uterine or ovarian cancer is increased by 5%, the net effect of a later menopause is an increased lifespan...

..Hyperphosphatemia is an independent risk factor for all-cause and cardiovascular mortality in hemodialysis (HD) patients. Phosphate control often is unsuccessful using conventional dialysis therapies...

..These observations may be relevant for explaining the effect of HRT on cardiovascular risk in healthy postmenopausal women...

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..Management of hypertension is too often not risk-based despite recommendations in guidelines on prevention of cardiovascular diseases available since 2000...

..Coronary heart disease (CHD) mortality has steadily declined since the early 1970s in the Netherlands. However, in some Western countries the rate of decline in younger groups may be starting to plateau or even rise...

..We therefore investigated the role of this polymorphism on the occurrence of acute myocardial infarction (AMI) and CHD in a population of healthy Dutch women...

..At present it seems that the published evidence to quantitatively support the use of a CIMT measurement to help in risk stratification on top of a risk function is limited...

..Yet, no published report has dealt with this issue in detail...

..CONCLUSION: In young men, PWV and CIMT are better measures of CHD risk than AIx. In women, AIx, PWV and CIMT estimate CHD risk equally well...

..CONCLUSION: Our findings strengthen the notion that elevated BP at adolescence and a relative increase in BP from adolescence to adulthood unfavorably affect cardiovascular risk, as indicated by increased CIMT...

..Aggressive lipid lowering by administration of atorvastatin, resulting in substantial improvement of the lipid profile, did not reverse endothelial dysfunction...

..To determine the diagnostic value for predicting cerebral hyperperfusion syndrome (CHS) by adding a transcranial Doppler (TCD) measurement in the early postoperative phase after carotid endarterectomy (CEA)...

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..To investigate whether an important football match increases stress to such an extent that it triggers acute myocardial infarction and stroke...

..It is insufficiently known if routine blood pressure (BP) measurement by school doctors has added predictive value for later hypertension and cardiovascular risk...

..CONCLUSIONS: In this prospective follow-up study of postmenopausal women, SBP and MAP seemed to be strongest related with CVD-related death; however the CI of the HR overlapped...

..This cohort study investigated the relationship between reproductive factors and coronary artery calcification in elderly women and whether this relationship could be explained by metabolic disturbances...

..The purpose of this study was to investigate the relationship between PPA and cardiovascular risk factors and cardiovascular risk in a population-based sample of 40- to 80-year old men...

..CONCLUSION: Lower birth weight indicates a higher risk for metabolic syndrome in young adults, particularly through higher serum triglycerides and higher systolic blood pressure...

..The aim of this study was to investigate the role of RRF, expressed as GFR, in phosphate and anemia management in chronic HD patients...

..Several determinants have been identified which affect BP control. In the current analysis we evaluated differences in achieved BP and achievement of the BP goal between hospitals and explored possible explanations...

..CONCLUSION: Systolic blood pressure was the best predictor for cardiovascular disease, whereas the role of diastolic pressure appeared to be limited...

..99, 95% CI 0.56-1.73). Our findings suggest that aspirin use may increase the risk of stroke in elderly subjects free from vascular disease...

..Arterial stiffness is a risk factor for stroke and myocardial infarction. We investigated whether carotid arterial stiffness is related to other localizations of manifest arterial disease...

..This does not mean that moderate alcohol consumption may not be recommended for the prevention of heart attacks in the relevant segments of the population...

..41, 95% confidence interval = 0.22-0.76, P for trend over tertiles = 0.004). CONCLUSION: The results of this study suggest a protective effect of dietary lignan intake on blood pressure and hypertension, even at low levels...

..The OPAL study results are expected to complement other studies on atherosclerosis progression in healthy postmenopausal women...

..This may be due to different effects of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone, MK), but few studies included both...

..Recently, a new model based on the SCORE system has been proposed. We compared both risk models with regard to their ability to predict cardiovascular mortality in the Netherlands...

..We set out to estimate the incremental prognostic utility of inflammation and atherosclerosis markers in the prediction of all-cause and CV mortality in elderly men...

..To determine maternal and perinatal morbidity and mortality after uterine rupture in the Netherlands...

..We estimated the prevalence of clinically relevant ECG abnormalities and the number needed to screen (NNS) with a routine ECG to prevent the occurrence of one death in the next 10 years conditional on adequate treatment and follow-up...

..Participants were randomized to torcetrapib or placebo on top of optimal atorvastatin therapy...

..MASTERPLAN is a multicentre study which evaluates the effect of a multifactorial intervention in prevalent CKD patients on cardiovascular (CV) events and progression of kidney failure...

..We conclude that low levels of adiponectin are associated with adverse changes in morphology and function of central arteries over time independently of other cardiovascular risk factors in postmenopausal non-diabetic women...

..In addition, we investigated which proportion received optimal medical treatment or underwent diagnostic workup of the kidneys prior to CEA...

..Moreover, in only 1 patient were all risk factors within the limits as defined in various guidelines, which underscores the relevance of our initiative...

..A suitable marker for atherosclerosis, however, should meet several criteria before it can be validly used...

..Hence, B-mode ultrasonography is being used increasingly to elucidate the efficacy of new therapies, enabling the benefits of treatment to be established more rapidly and with fewer patients compared with clinical outcome trials...

..CONCLUSIONS: The improvement in endothelial function in postmenopausal women treated with CEE+MPA appears to be partially mediated by change in Lp(a), and apparently not by changes in other lipids...

..Animal studies suggest that dietary cis-9,trans-11 (c9,t11) conjugated linoleic acid (CLA) may inhibit or regress the development of atherosclerosis. The effect of CLA on atherosclerosis has not been assessed in humans...

..To develop a prediction model for the occurrence of hypertension in pregnancy using clinical variables obtained routinely at the antenatal booking visit prior to 16 weeks gestation...

..The goal of this work was to assess whether high dietary glycemic load and glycemic index are associated with an increased risk of cardiovascular disease (CVD)...

..These findings suggest that the presence of insulin resistance in Type 1 diabetes or "double diabetes" plays a key role in determining daily insulin need...

..04 to 2.37). After adjusting for age, the relation did not change (OR: 1.64; 95% CI: 1.07 to 2.53). We concluded that high blood pressure during pregnancy is associated with an increased risk of coronary calcification later in life...

..Information on the incidence and causes of sudden (cardiac) death in the young (1-40 years) is essential for the development of these preventive strategies...

..To determine the incidence, indication, association with caesarean section (CS) and outcome of emergency peripartum hysterectomy (EPH) in The Netherlands...