M L Bots

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint The effect of tibolone and continuous combined conjugated equine oestrogens plus medroxyprogesterone acetate on progression of carotid intima-media thickness: the Osteoporosis Prevention and Arterial effects of tiboLone (OPAL) study
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, HP Str 6 131 University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Eur Heart J 27:746-55. 2006
  2. ncbi request reprint Thromboxane prostaglandin receptor antagonist and carotid atherosclerosis progression in patients with cerebrovascular disease of ischemic origin: a randomized controlled trial
    Michiel L Bots
    From the Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands M L B Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom I F, S M L Department of Pharmacology and INSERM U970, Hopital Europeen Georges Pompidou, Paris, France S L Department of Neurology and Stroke Center, Hôpital Bichat and INSERM U698, Paris, France P J T and Department of Neurology, UMM, University of Heidelberg, Mannheim, Germany M G H
    Stroke 45:2348-53. 2014
  3. pmc The M235T polymorphism in the AGT gene and CHD risk: evidence of a Hardy-Weinberg equilibrium violation and publication bias in a meta-analysis
    Mohammad Hadi Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 3:e2533. 2008
  4. pmc Short- and long-term mortality after acute myocardial infarction: comparison of patients with and without diabetes mellitus
    H L Koek
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HPN Str 06 131, P O Box 85 060, 3508, AB, Utrecht, The Netherlands
    Eur J Epidemiol 22:883-8. 2007
  5. pmc Should we still focus that much on cardiovascular mortality in end stage renal disease patients? The CONvective TRAnsport STudy
    Claire H den Hoedt
    Department of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands
    PLoS ONE 8:e61155. 2013
  6. pmc Neighbourhood socioeconomic inequalities in incidence of acute myocardial infarction: a cohort study quantifying age- and gender-specific differences in relative and absolute terms
    Carla Koopman
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht STR 6, 131, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    BMC Public Health 12:617. 2012
  7. pmc Identification of effective screening strategies for cardiovascular disease prevention in a developing country: using cardiovascular risk-estimation and risk-reduction tools for policy recommendations
    Sharmini Selvarajah
    Clinical Research Centre, Ministry of Health Malaysia, Kuala Lumpur, Malaysia
    BMC Cardiovasc Disord 13:10. 2013
  8. doi request reprint Lessons from the past and promises for the future for carotid intima-media thickness
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Coll Cardiol 60:1599-604. 2012
  9. pmc Differences in quality of life of hemodialysis patients between dialysis centers
    Albert H A Mazairac
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    Qual Life Res 21:299-307. 2012
  10. pmc Fibroblast growth factor 23 is associated with proteinuria and smoking in chronic kidney disease: an analysis of the MASTERPLAN cohort
    Marc G Vervloet
    Department of Nephrology and ICaR VU, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Nephrol 13:20. 2012

Detail Information

Publications176 found, 100 shown here

  1. ncbi request reprint The effect of tibolone and continuous combined conjugated equine oestrogens plus medroxyprogesterone acetate on progression of carotid intima-media thickness: the Osteoporosis Prevention and Arterial effects of tiboLone (OPAL) study
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, HP Str 6 131 University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Eur Heart J 27:746-55. 2006
    ..Because the overall effect of tibolone on cardiovascular risk was unknown, the OPAL study was designed...
  2. ncbi request reprint Thromboxane prostaglandin receptor antagonist and carotid atherosclerosis progression in patients with cerebrovascular disease of ischemic origin: a randomized controlled trial
    Michiel L Bots
    From the Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands M L B Robertson Centre for Biostatistics, University of Glasgow, Glasgow, United Kingdom I F, S M L Department of Pharmacology and INSERM U970, Hopital Europeen Georges Pompidou, Paris, France S L Department of Neurology and Stroke Center, Hôpital Bichat and INSERM U698, Paris, France P J T and Department of Neurology, UMM, University of Heidelberg, Mannheim, Germany M G H
    Stroke 45:2348-53. 2014
    ..We assessed whether Terutroban, a thromboxane prostaglandin receptor antagonist, affects the progression of atherosclerosis, as measured by common carotid intima-media thickness and carotid plaques...
  3. pmc The M235T polymorphism in the AGT gene and CHD risk: evidence of a Hardy-Weinberg equilibrium violation and publication bias in a meta-analysis
    Mohammad Hadi Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 3:e2533. 2008
    ..The M235T polymorphism in the AGT gene has been related to an increased risk of hypertension. This finding may also suggest an increased risk of coronary heart disease (CHD)...
  4. pmc Short- and long-term mortality after acute myocardial infarction: comparison of patients with and without diabetes mellitus
    H L Koek
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HPN Str 06 131, P O Box 85 060, 3508, AB, Utrecht, The Netherlands
    Eur J Epidemiol 22:883-8. 2007
    ..Yet, short-term mortality is not significantly higher in diabetic patients. Risks appear to be equally elevated in men and women...
  5. pmc Should we still focus that much on cardiovascular mortality in end stage renal disease patients? The CONvective TRAnsport STudy
    Claire H den Hoedt
    Department of Internal Medicine, Maasstad Hospital, Rotterdam, The Netherlands
    PLoS ONE 8:e61155. 2013
    ..In addition, we compared patients who died from the three most common death causes. Finally, we aimed to study factors related to dialysis withdrawal...
  6. pmc Neighbourhood socioeconomic inequalities in incidence of acute myocardial infarction: a cohort study quantifying age- and gender-specific differences in relative and absolute terms
    Carla Koopman
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht STR 6, 131, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    BMC Public Health 12:617. 2012
    ..Our objective was to examine socioeconomic inequalities in the incidence of AMI considering both relative and absolute measures of risk differences, with a particular focus on age and gender...
  7. pmc Identification of effective screening strategies for cardiovascular disease prevention in a developing country: using cardiovascular risk-estimation and risk-reduction tools for policy recommendations
    Sharmini Selvarajah
    Clinical Research Centre, Ministry of Health Malaysia, Kuala Lumpur, Malaysia
    BMC Cardiovasc Disord 13:10. 2013
    ..This study assessed whether the current national policy recommendation of universal screening was optimal, by comparing the effectiveness and impact of various cardiovascular screening strategies...
  8. doi request reprint Lessons from the past and promises for the future for carotid intima-media thickness
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Coll Cardiol 60:1599-604. 2012
    ....
  9. pmc Differences in quality of life of hemodialysis patients between dialysis centers
    Albert H A Mazairac
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    Qual Life Res 21:299-307. 2012
    ..We set out to assess the differences in HRQOL of hemodialysis patients between dialysis centers and explore which modifiable center characteristics could explain possible differences...
  10. pmc Fibroblast growth factor 23 is associated with proteinuria and smoking in chronic kidney disease: an analysis of the MASTERPLAN cohort
    Marc G Vervloet
    Department of Nephrology and ICaR VU, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Nephrol 13:20. 2012
    ..The relation of FGF23 with other renal and non-renal cardiovascular risk factors is not well established...
  11. pmc Acute myocardial infarction incidence and hospital mortality: routinely collected national data versus linkage of national registers
    Huberdina L Koek
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, HPN Str 06 131, PO Box 85 060, 3508 AB Utrecht, The Netherlands
    Eur J Epidemiol 22:755-62. 2007
    ..By linkage of registers, recurrent events and double counts can be excluded...
  12. pmc Inter-scan reproducibility of coronary calcium measurement using Multi Detector-Row Computed Tomography (MDCT)
    Siamak Sabour
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Str 6 131, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur J Epidemiol 22:235-43. 2007
    ....
  13. pmc Age- and gender-specific risk of death after first hospitalization for heart failure
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Public Health 10:637. 2010
    ..Age and gender are important predictors of mortality in hospitalized HF patients. However, studies assessing short- and long-term risk of death stratified by age and gender are scarce...
  14. pmc Cardiovascular risk factor assessment after pre-eclampsia in primary care
    Marie Elise Nijdam
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Fam Pract 10:77. 2009
    ..It is not known how general practitioners in the Netherlands care for these women after delivery with respect to cardiovascular risk factor management...
  15. pmc Cardiovascular risk factor treatment targets and renal complications in high risk vascular patients: a cohort study
    Sharmini Selvarajah
    Clinical Research Centre, Kuala Lumpur Hospital, Kuala Lumpur, Malaysia
    BMC Cardiovasc Disord 11:40. 2011
    ..To determine if recommended treatment targets, as specified in clinical practice guidelines for the management of cardiovascular disease, reduces the risk of renal complications in high risk patient populations...
  16. pmc The dynamics of mortality in follow-up time after an acute myocardial infarction, lower extremity arterial disease and ischemic stroke
    Ilonca Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Cardiovasc Disord 10:57. 2010
    ..Therefore, our objective was to determine risk of death after first hospital admission for atherosclerotic disease located at different sites...
  17. doi request reprint Intensive lipid lowering may reduce progression of carotid atherosclerosis within 12 months of treatment: the METEOR study
    M L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Intern Med 265:698-707. 2009
    ....
  18. ncbi request reprint Carotid intima-media thickness and coronary atherosclerosis: weak or strong relations?
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands, and Hopital Broussais Assistance Publique Hopitaux de Paris Faculte de Medecine Rene Descartes, France
    Eur Heart J 28:398-406. 2007
    ....
  19. ncbi request reprint Torcetrapib and carotid intima-media thickness in mixed dyslipidaemia (RADIANCE 2 study): a randomised, double-blind trial
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, Netherlands
    Lancet 370:153-60. 2007
    ..We aimed to investigate the effect of the CETP inhibitor, torcetrapib, on carotid atherosclerosis progression in patients with mixed dyslipidaemia...
  20. pmc ACE inhibition and endothelial function: main findings of PERFECT, a sub-study of the EUROPA trial
    M L Bots
    Julius Center for Health Sciences and Primary Care, HP Str 6 131, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Cardiovasc Drugs Ther 21:269-79. 2007
    ..The Perindopril-Function of the Endothelium in Coronary artery disease Trial (PERFECT) evaluated whether long-term administration of perindopril improves endothelial dysfunction...
  21. ncbi request reprint Carotid intima-media thickness as a surrogate marker for cardiovascular disease in intervention studies
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Med Res Opin 22:2181-90. 2006
    ..These markers may provide earlier indications of efficacy in trials involving fewer participants. One approach gaining interest in recent years is the measurement of atherosclerotic progression, a major underlying cause of CVD...
  22. ncbi request reprint Coagulation and fibrinolysis markers and risk of dementia. The Dutch Vascular Factors in Dementia Study
    M L Bots
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:216-22. 1998
    ..Additional stratified analyses indicated that an increased TAT level was the primary factor related to dementia. The present study provides evidence that predominantly increased thrombin generation is associated with dementia...
  23. pmc Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i19-24. 2002
    ..This paper investigated the association of total and HDL cholesterol level to fatal and non-fatal, and haemorrhagic and ischaemic stroke in four European cohorts participating in EUROSTROKE...
  24. ncbi request reprint Is carotid intima-media thickness useful in cardiovascular disease risk assessment? The Rotterdam Study
    A I del Sol
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 32:1532-8. 2001
    ..We determined the contribution of common carotid intima-media thickness (IMT) in the prediction of future coronary heart disease and cerebrovascular disease when added to established risk factors...
  25. doi request reprint Near-infrared spectroscopy to indicate selective shunt use during carotid endarterectomy
    C W A Pennekamp
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 46:397-403. 2013
    ....
  26. pmc Role of residual renal function in phosphate control and anemia management in chronic hemodialysis patients
    E Lars Penne
    Department of Nephrology, Room F03 223, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Clin J Am Soc Nephrol 6:281-9. 2011
    ..The aim of this study was to investigate the role of RRF, expressed as GFR, in phosphate and anemia management in chronic HD patients...
  27. pmc Gamma-glutamyltransferase and risk of stroke: the EUROSTROKE project
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i25-9. 2002
    ....
  28. pmc Level of fibrinogen and risk of fatal and non-fatal stroke. EUROSTROKE: a collaborative study among research centres in Europe
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i14-8. 2002
    ..This study investigated the association between fibrinogen and fatal, non-fatal, haemorrhagic and ischaemic stroke in three European cohorts participating in EUROSTROKE...
  29. doi request reprint Manual or semi-automated edge detection of the maximal far wall common carotid intima-media thickness: a direct comparison
    S A E Peters
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Intern Med 271:247-56. 2012
    ..Automated edge detection is thought to be superior to manual edge detection in quantification of the far wall common carotid intima-media thickness (CIMT), yet published evidence making a direct comparison is not available...
  30. ncbi request reprint Cross-sectionally assessed carotid intima-media thickness relates to long-term risk of stroke, coronary heart disease and death as estimated by available risk functions
    M L Bots
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Intern Med 245:269-76. 1999
    ....
  31. ncbi request reprint Increased age, high body mass index and low HDL-C levels are related to an echolucent carotid intima-media: the METEOR study
    S A E Peters
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Intern Med 272:257-66. 2012
    ..We studied the relationship between cardiovascular risk factors and echolucency of the carotid intima-media in low-risk individuals...
  32. pmc Long-term survival after initial hospital admission for peripheral arterial disease in the lower extremities
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Cardiovasc Disord 9:43. 2009
    ..Insights in absolute mortality risks following admission for PAD in the lower extremities can be useful to improve awareness as they are easy to interpret...
  33. ncbi request reprint C-reactive protein and aortic stiffness and wave reflection in middle-aged and elderly men from the community
    H R Nakhai-Pour
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Hum Hypertens 21:949-55. 2007
    ..01; 1.41), but not for AIx (4.60% (95% CI 1.34; 7.85)). In summary, low-grade inflammation seems to be independently related to increase of aortic artery stiffness over and above traditional risk factors and atherosclerosis...
  34. ncbi request reprint C-reactive protein lowering with rosuvastatin in the METEOR study
    S A E Peters
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Intern Med 268:155-61. 2010
    ..We studied these aspects in the Measuring Effects on intima media Thickness: an Evaluation Of Rosuvastatin (METEOR) study, a randomized placebo-controlled trial amongst 984 low-risk subjects...
  35. ncbi request reprint Response to activated protein C in subjects with and without dementia. The Dutch Vascular Factors in Dementia Study
    M L Bots
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:209-15. 1998
    ..82-5.63), respectively. No association was found for APC response. We showed a nonsignificant twofold increased risk of dementia among subjects with factor V Leiden. The association appeared to be stronger for vascular dementia...
  36. ncbi request reprint Change in body mass index from adolescence to young adulthood and increased carotid intima-media thickness at 28 years of age: the Atherosclerosis Risk in Young Adults study
    A Oren
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Obes Relat Metab Disord 27:1383-90. 2003
    ..Although data on tracking of body mass index (BMI) are available, little is known about the impact of weight change over time on the development of vascular damage...
  37. ncbi request reprint Circulating homocysteine and large arterial stiffness and thickness in a population-based sample of middle-aged and elderly men
    H R Nakhai-Pour
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Hum Hypertens 21:942-8. 2007
    ..06 (95% CI -0.01; 0.13)). The results of this study do not support the presence of an independent relationship between circulating tHcy levels and large artery stiffness and thickness...
  38. ncbi request reprint Unrecognised myocardial infarction in subjects at high vascular risk: prevalence and determinants
    M F L Meijs
    Department of Cardiology, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
    Heart 95:728-32. 2009
    ..To investigate the prevalence and determinants of unrecognised myocardial infarction (UMI)...
  39. ncbi request reprint Nurse practitioners improve quality of care in chronic kidney disease: two-year results of a randomised study
    A D van Zuilen
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neth J Med 69:517-26. 2011
    ..Here we evaluate whether strict implementation of guidelines aimed at multiple targets with the aid of nurse practitioners (NP) improves management in patients with CKD...
  40. ncbi request reprint Incidence of first acute myocardial infarction in the Netherlands
    H L Koek
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neth J Med 65:434-41. 2007
    ..Background: We recently showed that AMi patients can be followed longitudinally within dutch national medical registrations in a valid way. This makes it possible to provide nationwide incidence estimates of first AMi in the Netherlands...
  41. ncbi request reprint Birth size and coronary heart disease risk score in young adulthood. The Atherosclerosis Risk in Young Adults (ARYA) study
    L E Vos
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Eur J Epidemiol 21:33-8. 2006
    ..02% risk/SD birth length; 95% CI: -0.04, 0.0001). These results suggest that small birth size is associated with an increased risk score for coronary artery disease in young adulthood...
  42. ncbi request reprint Ultrasound protocols to measure carotid intima-media thickness: a post-hoc analysis of the OPAL study
    S Dogan
    Julius Center for Health Sciences and Primary Care www juliuscenter nl, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Med Res Opin 25:109-22. 2009
    ..We compared different ultrasound protocols in a post-hoc analysis in the 'Osteoporosis Prevention and Arterial effects of tiboLone' (OPAL) study, a 3-year randomized controlled trial among healthy postmenopausal women...
  43. pmc Left ventricular hypertrophy and risk of fatal and non-fatal stroke. EUROSTROKE: a collaborative study among research centres in Europe
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i8-13. 2002
    ..This study investigated the association between electrocardiographically assessed left ventricular hypertrophy (LVH) and fatal, non-fatal, haemorrhagic and ischaemic stroke in four European cohorts participating in EUROSTROKE...
  44. ncbi request reprint Alcohol and arterial wave reflections in middle aged and elderly men
    M J C A van Trijp
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Clin Invest 35:615-21. 2005
    ..The relation of alcohol consumption level with AIx has not been widely investigated, which prompted this study of the relation of alcohol consumption with AIx in a population-based cohort of men aged 40-80 years...
  45. ncbi request reprint Effect of hormone replacement therapy on lipids in perimenopausal and early postmenopausal women
    M E Ossewaarde
    Julius Center for Patient Oriented Research, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Maturitas 39:209-16. 2001
    ..Changes appear to be more pronounced in postmenopausal women compared to perimenopausal women...
  46. ncbi request reprint Soluble intercellular adhesion molecule 1 and flow-mediated dilatation are related to the estimated risk of coronary heart disease independently from each other
    D R Witte
    Julius Center for Health Sciences and Primary Care, D 01 335, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Atherosclerosis 170:147-53. 2003
    ..The comparative value of the two measures in relation to cardiovascular risk is unknown...
  47. doi request reprint Incompleteness of the circle of Willis is related to EEG-based shunting during carotid endarterectomy
    C W A Pennekamp
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 46:631-7. 2013
    ..We set out to develop a rule to predict the likelihood for shunting during CEA based on preoperative assessment of collateral cerebral circulation and patient characteristics...
  48. ncbi request reprint Hormone replacement therapy and endothelial function. Results of a randomized controlled trial in healthy postmenopausal women
    M J de Kleijn
    Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, HP D01.335, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Atherosclerosis 159:357-65. 2001
    ..Tibolone did not alter fmd. The clinical significance of this improvement in fmd for cardiovascular disease risk needs to be established...
  49. ncbi request reprint Nationwide incidence of first stroke and TIA in the Netherlands
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Neurol 15:1315-23. 2008
    ..Information on incidence of stroke is important for developing and maintaining public health strategies in primary and secondary prevention. Nationwide data on the incidence of stroke are scarce and absent for the Netherlands...
  50. ncbi request reprint Impact of various questionnaires on the prevalence of erectile dysfunction. The ENIGMA-study
    B J de Boer
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Impot Res 16:214-9. 2004
    ..A short questionnaire with one or two questions is recommended for example the one from the Boxmeer-study. These data may be used to adjust (age-specific) prevalence rates comparing ED prevalence in the open population across studies...
  51. ncbi request reprint A meta-analysis of excess cardiac mortality on Monday
    D R Witte
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Epidemiol 20:401-6. 2005
    ..Available evidence suggests a peak in the incidence of cardiovascular events on Mondays compared to other days of the week. The exact magnitude of the excess risk and the role of age and gender, however, remain unclear...
  52. doi request reprint Near-infrared spectroscopy can predict the onset of cerebral hyperperfusion syndrome after carotid endarterectomy
    C W A Pennekamp
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 34:314-21. 2012
    ..In this study, we assess whether NIRS and perioperative TCD are related to the onset CHS following CEA...
  53. ncbi request reprint Determinants of augmentation index in young men: the ARYA study
    M J C A van Trijp
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Clin Invest 34:825-30. 2004
    ..In contrast, data in the young are scarce. However, as AIx might be used to evaluate cardiovascular disease risk already at an early age, we aimed to study determinants of AIx in a population of healthy young men...
  54. ncbi request reprint Aortic stiffness and carotid intima-media thickness: two independent markers of subclinical vascular damage in young adults?
    A Oren
    University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Clin Invest 33:949-54. 2003
    ..However, studies show conflicting results and are limited to elderly subjects. To study this issue further, we evaluated the relation of arterial stiffness to subclinical atherosclerosis in 524 healthy young adults, aged 27-30 years...
  55. ncbi request reprint Activation products of the haemostatic system in coronary, cerebrovascular and peripheral arterial disease
    J G van der Bom
    Julius Center for Patient Oriented Research, University Medical Center, Utrecht, The Netherlands
    Thromb Haemost 85:234-9. 2001
    ....
  56. doi request reprint Radiation-induced carotid stenotic lesions have a more stable phenotype than de novo atherosclerotic plaques
    M Fokkema
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 43:643-8. 2012
    ..To identify plaque characteristics of carotid artery radiation-induced stenosis...
  57. ncbi request reprint The Atherosclerosis Risk in Young Adults (ARYA) study: rationale and design
    A Oren
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Eur J Epidemiol 18:715-27. 2003
    ..The Atherosclerosis Risk in Young Adults (ARYA) study was specifically designed to address this issue...
  58. ncbi request reprint Gender differences in mortality after hospital admission for stroke
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 28:564-71. 2009
    ..Yet, studies into differences between men and women in survival after a stroke yielded inconsistent results. We investigated whether gender was associated with all-cause mortality after hospital admission for stroke...
  59. ncbi request reprint The value of near-infrared spectroscopy measured cerebral oximetry during carotid endarterectomy in perioperative stroke prevention. A review
    C W A Pennekamp
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 38:539-45. 2009
    ..We aimed to (1) compare the value of NIRS related to existing cerebral monitoring techniques in prediction of perioperative cerebral ischaemia and (2) compare the relation between NIRS and the occurrence of CHS...
  60. ncbi request reprint Apolipoprotein E and carotid artery atherosclerosis: the Rotterdam study
    A J Slooter
    Department of Epidemiology, Erasmus Medical Center, Rotterdam, Netherlands
    Stroke 32:1947-52. 2001
    ..It is yet unclear whether the apolipoprotein E polymorphism (APOE) is related to atherosclerosis in the carotid arteries. The aim of the present study was to investigate the role of APOE in carotid artery atherosclerosis...
  61. ncbi request reprint Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly: the Rotterdam study
    M Hollander
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, and Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, The Netherlands
    Circulation 105:2872-7. 2002
    ..1 to 4.9]). A >10-fold increased risk of lacunar infarction was found in subjects with severe plaques (RR 10.8 [95% CI, 1.7 to 69.7]). No clear difference in risk estimates was seen between ipsilateral and contralateral infarction...
  62. ncbi request reprint A high menaquinone intake reduces the incidence of coronary heart disease
    G C M Gast
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Nutr Metab Cardiovasc Dis 19:504-10. 2009
    ..Data on the effect of vitamin K intake on coronary heart disease (CHD) risk, however, are scarce. To examine the relationship between dietary vitamins K(1) and K(2) intake, and its subtypes, and the incidence of CHD...
  63. ncbi request reprint Cardiovascular determinants of carotid artery disease. The Rotterdam Elderly Study
    M L Bots
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Hypertension 19:717-20. 1992
    ..Our data suggest that hypertension, smoking, and reduced serum high density lipoprotein cholesterol levels, combined with unfavorable increases in hemostatic factors, may be related to carotid artery disease in the elderly...
  64. ncbi request reprint Short-term effects of online hemodiafiltration on phosphate control: a result from the randomized controlled Convective Transport Study (CONTRAST)
    E Lars Penne
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Kidney Dis 55:77-87. 2010
    ..Hyperphosphatemia is an independent risk factor for all-cause and cardiovascular mortality in hemodialysis (HD) patients. Phosphate control often is unsuccessful using conventional dialysis therapies...
  65. pmc Decline in incidence of hospitalisation for acute myocardial infarction in the Netherlands from 1995 to 2000
    H L Koek
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    Heart 92:162-5. 2006
    ..To study the change in incidence of hospitalisation for a first acute myocardial infarction (AMI) in the Netherlands from 1995 to 2000...
  66. ncbi request reprint Menopausal status and distensibility of the common carotid artery
    I C Westendorp
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 19:713-7. 1999
    ..5 microm [SE 9.5] versus 397.3 microm [SE 9.6]). These results suggest that the distensibility of the common carotid artery is negatively affected by natural menopause in presumed healthy women...
  67. ncbi request reprint Is chronic fatigue syndrome a connective tissue disorder? A cross-sectional study in adolescents
    E M van de Putte
    Department of Pediatric, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, Netherlands
    Pediatrics 115:e415-22. 2005
    ....
  68. pmc Incidence, risk, and case fatality of first ever stroke in the elderly population. The Rotterdam Study
    M Hollander
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 74:317-21. 2003
    ..To estimate the incidence, survival, and lifetime risk of stroke in the elderly population...
  69. ncbi request reprint Excess cardiac mortality on Monday: the importance of gender, age and hospitalisation
    D R Witte
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Epidemiol 20:395-9. 2005
    ..The underlying mechanism may be summarised as naturally occurring rhythmic fluctuations in human physiology, and socially determined rhythms in human behaviour. Change in these rhythms may lead to attenuation of the peak on Mondays...
  70. ncbi request reprint Hemoglobin and atherosclerosis in patients with manifest arterial disease. The SMART-study
    J M Dijk
    Julius Center for Health Sciences and Primary Care, University, Medical Center Utrecht UMCU, Utrecht, The Netherlands
    Atherosclerosis 188:444-9. 2006
    ..Similar remodeling mechanisms of the vessel wall that may result in atherosclerosis are likely to be present. We studied whether hemoglobin levels are related to different vascular indicators of atherosclerosis...
  71. doi request reprint Multi Detector-Row Computed Tomography (MDCT) had excellent reproducibility of coronary calcium measurements
    S Sabour
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Clin Epidemiol 61:572-9. 2008
    ....
  72. ncbi request reprint Simultaneous aortic and coronary assessment in abdominal aortic aneurysm patients by thoraco-abdominal 64-detector-row CT angiography: estimate of the impact on preoperative management: a pilot study
    R P J Budde
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 40:196-201. 2010
    ..To estimate the influence of information on the coronary arteries obtained from routine thoraco-abdominal CT angiography (CTA) on pre-operative clinical management in abdominal aortic aneurysm (AAA) patients...
  73. pmc Rationale and design of the SMART Heart study: A prediction model for left ventricular hypertrophy in hypertension
    M F L Meijs
    Departments of Cardiology and Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neth Heart J 15:295-8. 2007
    ..For this purpose 1000 subjects with chronic hypertension will undergo cardiac MR imaging. In addition, this study allows the extrapolation of animal experimental genetic research into the human situation. (Neth Heart J 2007;15:295-8.)...
  74. ncbi request reprint Awareness of hypertension: will it bring about a healthy lifestyle?
    T Scheltens
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Hum Hypertens 24:561-7. 2010
    ..There seems to be ample room for improvement in implementing the guidelines. Probably, patient tailored interventions and a multisiciplinary and multimodality approach can support this improvement...
  75. ncbi request reprint Age at menopause, cause-specific mortality and total life expectancy
    Marlies E Ossewaarde
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Epidemiology 16:556-62. 2005
    ..The net effect on mortality is unclear. We determined the association of age at menopause with longevity and with the balance between cardiovascular and cancer mortality...
  76. ncbi request reprint Treatment with hormone replacement therapy lowers remnant lipoprotein particles in healthy postmenopausal women: results from a randomized trial
    M E Ossewaarde
    Julius Center for Health Sciences and Primary Care, Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Clin Invest 33:376-82. 2003
    ..We determined whether 3 months' treatment of postmenopausal women with Tibolone or conjugated oestrogens combined with medroxyprogesterone acetate (CEE + MPA) affects RLP-cholesterol (RLP-C)...
  77. ncbi request reprint Awareness, treatment and control of hypertension: the 'rule of halves' in an era of risk-based treatment of hypertension
    T Scheltens
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Hum Hypertens 21:99-106. 2007
    ..Management of hypertension is too often not risk-based despite recommendations in guidelines on prevention of cardiovascular diseases available since 2000...
  78. ncbi request reprint T64A polymorphism in beta3-adrenergic receptor gene (ADRB3) and coronary heart disease: a case-cohort study and meta-analysis
    M H Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Intern Med 263:79-89. 2008
    ..We therefore investigated the role of this polymorphism on the occurrence of acute myocardial infarction (AMI) and CHD in a population of healthy Dutch women...
  79. doi request reprint Coronary heart disease mortality trends in the Netherlands 1972-2007
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht STR 6 131, GA Utrecht, The Netherlands
    Heart 97:569-73. 2011
    ..Coronary heart disease (CHD) mortality has steadily declined since the early 1970s in the Netherlands. However, in some Western countries the rate of decline in younger groups may be starting to plateau or even rise...
  80. ncbi request reprint Regional differences in incidence of sudden cardiac death in the young
    A Hendrix
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neth J Med 68:274-9. 2010
    ....
  81. ncbi request reprint Aggressive lipid lowering does not improve endothelial function in type 2 diabetes: the Diabetes Atorvastatin Lipid Intervention (DALI) Study: a randomized, double-blind, placebo-controlled trial
    Francine V van Venrooij
    Julius Center for General Practice and Patient Oriented Research and Department of Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 25:1211-6. 2002
    ..Type 2 diabetic patients show a characteristic dyslipidemia. Aggressive lipid lowering might be an effective method to improve endothelial function in these patients...
  82. ncbi request reprint Adolescent blood pressure and blood pressure tracking into young adulthood are related to subclinical atherosclerosis: the Atherosclerosis Risk in Young Adults (ARYA) study
    Lydia E Vos
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hypertens 16:549-55. 2003
    ..Our aim was to study the relationships of adolescent BP and tracking of BP into young adulthood with subclinical atherosclerosis, as assessed by carotid intima-media thickness (CIMT), at the age of 28 years...
  83. ncbi request reprint Noninvasive arterial measurements of vascular damage in healthy young adults: relation to coronary heart disease risk
    Marijke J C A van Trijp
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Dept of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
    Ann Epidemiol 16:71-7. 2006
    ..Our aim was to study whether AIx is related to coronary heart disease (CHD) risk and to compare the strength of the relations of AIx, PWV, and CIMT with cardiovascular risk in healthy young adults...
  84. doi request reprint Carotid intima-media thickness measurement in cardiovascular screening programmes
    Yvonne Plantinga
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 16:639-44. 2009
    ..At present it seems that the published evidence to quantitatively support the use of a CIMT measurement to help in risk stratification on top of a risk function is limited...
  85. ncbi request reprint Common carotid intima-media thickness and risk of acute myocardial infarction: the role of lumen diameter
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, Univeristy Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 36:762-7. 2005
    ..Yet, no published report has dealt with this issue in detail...
  86. doi request reprint Common carotid intima-media thickness does not add to Framingham risk score in individuals with diabetes mellitus: the USE-IMT initiative
    H M Den Ruijter
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Diabetologia 56:1494-502. 2013
    ..The aim of this work was to investigate whether measurement of the mean common carotid intima-media thickness (CIMT) improves cardiovascular risk prediction in individuals with diabetes...
  87. doi request reprint Prediction of cerebral hyperperfusion after carotid endarterectomy with transcranial Doppler
    C W A Pennekamp
    Department of Vascular Surgery G04 129, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 43:371-6. 2012
    ..To determine the diagnostic value for predicting cerebral hyperperfusion syndrome (CHS) by adding a transcranial Doppler (TCD) measurement in the early postoperative phase after carotid endarterectomy (CEA)...
  88. pmc Cardiovascular mortality in Dutch men during 1996 European football championship: longitudinal population study
    D R Witte
    Julius Centre for General Practice and Patient Oriented Research, University Medical Centre Utrecht, Huispostnummer D01 335, 3584 CX Utrecht, Netherlands
    BMJ 321:1552-4. 2000
    ..To investigate whether an important football match increases stress to such an extent that it triggers acute myocardial infarction and stroke...
  89. doi request reprint Low plasma HDL-c, a vascular risk factor in high risk patients independent of LDL-c
    G R Hajer
    Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Clin Invest 39:680-8. 2009
    ....
  90. ncbi request reprint Does a routinely measured blood pressure in young adolescence accurately predict hypertension and total cardiovascular risk in young adulthood?
    Lydia E Vos
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    J Hypertens 21:2027-34. 2003
    ..It is insufficiently known if routine blood pressure (BP) measurement by school doctors has added predictive value for later hypertension and cardiovascular risk...
  91. ncbi request reprint Reproductive factors, metabolic factors, and coronary artery calcification in older women
    Femke Atsma
    Department of Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 15:899-904. 2008
    ..This cohort study investigated the relationship between reproductive factors and coronary artery calcification in elderly women and whether this relationship could be explained by metabolic disturbances...
  92. ncbi request reprint Lower birth weight predicts metabolic syndrome in young adults: the Atherosclerosis Risk in Young Adults (ARYA)-study
    Made K Ramadhani
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Atherosclerosis 184:21-7. 2006
    ..To study the relationship between intrauterine growth and the metabolic syndrome, particularly fasting serum lipids in young adulthood...
  93. doi request reprint Pulse pressure amplification and risk of cardiovascular disease
    Marie Elise Nijdam
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hypertens 21:388-92. 2008
    ..The purpose of this study was to investigate the relationship between PPA and cardiovascular risk factors and cardiovascular risk in a population-based sample of 40- to 80-year old men...
  94. ncbi request reprint Average blood pressure and cardiovascular disease-related mortality in middle-aged women
    Marijke J C A van Trijp
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hypertens 18:197-201. 2005
    ....
  95. doi request reprint Atherosclerosis and physical functioning in older men, a longitudinal study
    M E M den Ouden
    Julius Center for Health Sciences and Primary Care, Str 6 131, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Nutr Health Aging 17:97-104. 2013
    ..The objective was to investigate the association between non-invasive atherosclerosis measures and physical functioning in older men...
  96. ncbi request reprint Hospital specific factors affect quality of blood pressure treatment in chronic kidney disease
    A D van Zuilen
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neth J Med 69:229-36. 2011
    ..Several determinants have been identified which affect BP control. In the current analysis we evaluated differences in achieved BP and achievement of the BP goal between hospitals and explored possible explanations...
  97. ncbi request reprint Increased arterial stiffness is independently related to cerebrovascular disease and aneurysms of the abdominal aorta: the Second Manifestations of Arterial Disease (SMART) Study
    J M Dijk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnummer Str 6 131, PO Box 85060, 3508 BA Utrecht, The Netherlands
    Stroke 35:1642-6. 2004
    ..Arterial stiffness is a risk factor for stroke and myocardial infarction. We investigated whether carotid arterial stiffness is related to other localizations of manifest arterial disease...
  98. ncbi request reprint [Prediction of cardiovascular disease on the basis of blood pressure measurements more reliable with systolic than with diastolic measurement]
    M J van Trijp
    Universitair Medisch Centrum Utrecht, Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde, Heidelberglaan 100, 3584 CX Utrecht
    Ned Tijdschr Geneeskd 147:1456-9. 2003
    ....
  99. ncbi request reprint Aspirin use and risk of stroke in the elderly: the Rotterdam Study
    Z Voko
    Department of Epidemiology and Biostatistics, University Medical Center Utrecht, The Netherlands
    Neuroepidemiology 20:40-4. 2001
    ..99, 95% CI 0.56-1.73). Our findings suggest that aspirin use may increase the risk of stroke in elderly subjects free from vascular disease...
  100. ncbi request reprint [Moderate alcohol consumption may be recommended for the prevention of heart attacks]
    J W J Beulens
    Universitair Medisch Centrum Utrecht, Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 151:2716. 2007
    ..This does not mean that moderate alcohol consumption may not be recommended for the prevention of heart attacks in the relevant segments of the population...
  101. doi request reprint The potential yield of ECG screening of hypertensive patients: the Utrecht Health Project
    Tjarda Scheltens
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Hypertens 28:1527-33. 2010
    ..We estimated the prevalence of clinically relevant ECG abnormalities and the number needed to screen (NNS) with a routine ECG to prevent the occurrence of one death in the next 10 years conditional on adequate treatment and follow-up...