M L Bots

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. pmc Gamma-glutamyltransferase and risk of stroke: the EUROSTROKE project
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i25-9. 2002
  2. ncbi request reprint PERindopril-Function of the Endothelium in Coronary Artery Disease Trial: the PERFECT study--sub study of EUROPA: rationale and design
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, HP D01 335, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Cardiovasc Drugs Ther 16:227-36. 2002
  3. pmc The EUROSTROKE cohorts: a short description and data analytical approach
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i2-7. 2002
  4. pmc Left ventricular hypertrophy and risk of fatal and non-fatal stroke. EUROSTROKE: a collaborative study among research centres in Europe
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i8-13. 2002
  5. pmc Level of fibrinogen and risk of fatal and non-fatal stroke. EUROSTROKE: a collaborative study among research centres in Europe
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i14-8. 2002
  6. pmc Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i19-24. 2002
  7. ncbi request reprint Intima media thickness as a surrogate marker for generalised atherosclerosis
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Cardiovasc Drugs Ther 16:341-51. 2002
  8. ncbi request reprint Carotid intima-media thickness, arterial stiffness and risk of cardiovascular disease: current evidence
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University of Medical Center Utrecht, The Netherlands
    J Hypertens 20:2317-25. 2002
  9. ncbi request reprint [Cardiovascular risk factors. II. Signs of vascular damage: practical implications]
    M L Bots
    Universitair Medisch Centrum, Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde, Postbus 80 035, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 146:1174-8. 2002
  10. ncbi request reprint Carotid intima-media thickness measurements in intervention studies: design options, progression rates, and sample size considerations: a point of view
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Stroke 34:2985-94. 2003

Collaborators

Detail Information

Publications151 found, 100 shown here

  1. pmc Gamma-glutamyltransferase and risk of stroke: the EUROSTROKE project
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i25-9. 2002
    ....
  2. ncbi request reprint PERindopril-Function of the Endothelium in Coronary Artery Disease Trial: the PERFECT study--sub study of EUROPA: rationale and design
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, HP D01 335, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Cardiovasc Drugs Ther 16:227-36. 2002
    ..The PERFECT study was designed to verify the above mentioned pathophysiological concepts...
  3. pmc The EUROSTROKE cohorts: a short description and data analytical approach
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i2-7. 2002
    ....
  4. pmc Left ventricular hypertrophy and risk of fatal and non-fatal stroke. EUROSTROKE: a collaborative study among research centres in Europe
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i8-13. 2002
    ..This study investigated the association between electrocardiographically assessed left ventricular hypertrophy (LVH) and fatal, non-fatal, haemorrhagic and ischaemic stroke in four European cohorts participating in EUROSTROKE...
  5. pmc Level of fibrinogen and risk of fatal and non-fatal stroke. EUROSTROKE: a collaborative study among research centres in Europe
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i14-8. 2002
    ..This study investigated the association between fibrinogen and fatal, non-fatal, haemorrhagic and ischaemic stroke in three European cohorts participating in EUROSTROKE...
  6. pmc Total and HDL cholesterol and risk of stroke. EUROSTROKE: a collaborative study among research centres in Europe
    M L Bots
    Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Epidemiol Community Health 56:i19-24. 2002
    ..This paper investigated the association of total and HDL cholesterol level to fatal and non-fatal, and haemorrhagic and ischaemic stroke in four European cohorts participating in EUROSTROKE...
  7. ncbi request reprint Intima media thickness as a surrogate marker for generalised atherosclerosis
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Cardiovasc Drugs Ther 16:341-51. 2002
    ..Hence, B-mode ultrasonography is being used increasingly to elucidate the efficacy of new therapies, enabling the benefits of treatment to be established more rapidly and with fewer patients compared with clinical outcome trials...
  8. ncbi request reprint Carotid intima-media thickness, arterial stiffness and risk of cardiovascular disease: current evidence
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University of Medical Center Utrecht, The Netherlands
    J Hypertens 20:2317-25. 2002
    ..We aimed at providing an overview of epidemiological data on carotid intima-media thickness (CIMT) and arterial stiffness measurements and their relation to risk of cardiovascular disease...
  9. ncbi request reprint [Cardiovascular risk factors. II. Signs of vascular damage: practical implications]
    M L Bots
    Universitair Medisch Centrum, Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde, Postbus 80 035, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 146:1174-8. 2002
    ....
  10. ncbi request reprint Carotid intima-media thickness measurements in intervention studies: design options, progression rates, and sample size considerations: a point of view
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Stroke 34:2985-94. 2003
    ..We discuss the various options and provide a pooled estimate of CIMT progression. In addition, we quantify the effect of these choices on the sample size for a RCT...
  11. ncbi request reprint The Osteoporosis Prevention and Arterial effects of tiboLone (OPAL) study: design and baseline characteristics
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Control Clin Trials 24:752-75. 2003
    ..The OPAL study results are expected to complement other studies on atherosclerosis progression in healthy postmenopausal women...
  12. ncbi request reprint Cross-sectionally assessed carotid intima-media thickness relates to long-term risk of stroke, coronary heart disease and death as estimated by available risk functions
    M L Bots
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    J Intern Med 245:269-76. 1999
    ....
  13. ncbi request reprint Common carotid intima-media thickness and risk of acute myocardial infarction: the role of lumen diameter
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, Univeristy Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 36:762-7. 2005
    ..Yet, no published report has dealt with this issue in detail...
  14. ncbi request reprint Coagulation and fibrinolysis markers and risk of dementia. The Dutch Vascular Factors in Dementia Study
    M L Bots
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:216-22. 1998
    ..Additional stratified analyses indicated that an increased TAT level was the primary factor related to dementia. The present study provides evidence that predominantly increased thrombin generation is associated with dementia...
  15. ncbi request reprint Response to activated protein C in subjects with and without dementia. The Dutch Vascular Factors in Dementia Study
    M L Bots
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:209-15. 1998
    ..82-5.63), respectively. No association was found for APC response. We showed a nonsignificant twofold increased risk of dementia among subjects with factor V Leiden. The association appeared to be stronger for vascular dementia...
  16. ncbi request reprint Assessment of flow-mediated vasodilatation (FMD) of the brachial artery: effects of technical aspects of the FMD measurement on the FMD response
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, HP Str 6 131 University Medical Center, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Eur Heart J 26:363-8. 2005
    ..However, the absolute values obtained using this approach vary considerably across studies. We studied whether technical aspects of the methodology can explain the wide variety in absolute values across studies...
  17. ncbi request reprint Activation products of the haemostatic system in coronary, cerebrovascular and peripheral arterial disease
    J G van der Bom
    Julius Center for Patient Oriented Research, University Medical Center, Utrecht, The Netherlands
    Thromb Haemost 85:234-9. 2001
    ....
  18. doi request reprint Near-infrared spectroscopy to indicate selective shunt use during carotid endarterectomy
    C W A Pennekamp
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 46:397-403. 2013
    ....
  19. ncbi request reprint Is carotid intima-media thickness useful in cardiovascular disease risk assessment? The Rotterdam Study
    A I del Sol
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 32:1532-8. 2001
    ..We determined the contribution of common carotid intima-media thickness (IMT) in the prediction of future coronary heart disease and cerebrovascular disease when added to established risk factors...
  20. doi request reprint Manual or semi-automated edge detection of the maximal far wall common carotid intima-media thickness: a direct comparison
    S A E Peters
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Intern Med 271:247-56. 2012
    ..Automated edge detection is thought to be superior to manual edge detection in quantification of the far wall common carotid intima-media thickness (CIMT), yet published evidence making a direct comparison is not available...
  21. pmc Long-term survival after initial hospital admission for peripheral arterial disease in the lower extremities
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Cardiovasc Disord 9:43. 2009
    ..Insights in absolute mortality risks following admission for PAD in the lower extremities can be useful to improve awareness as they are easy to interpret...
  22. ncbi request reprint Increased age, high body mass index and low HDL-C levels are related to an echolucent carotid intima-media: the METEOR study
    S A E Peters
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Intern Med 272:257-66. 2012
    ..We studied the relationship between cardiovascular risk factors and echolucency of the carotid intima-media in low-risk individuals...
  23. ncbi request reprint C-reactive protein lowering with rosuvastatin in the METEOR study
    S A E Peters
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Intern Med 268:155-61. 2010
    ..We studied these aspects in the Measuring Effects on intima media Thickness: an Evaluation Of Rosuvastatin (METEOR) study, a randomized placebo-controlled trial amongst 984 low-risk subjects...
  24. ncbi request reprint C-reactive protein and aortic stiffness and wave reflection in middle-aged and elderly men from the community
    H R Nakhai-Pour
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Hum Hypertens 21:949-55. 2007
    ..01; 1.41), but not for AIx (4.60% (95% CI 1.34; 7.85)). In summary, low-grade inflammation seems to be independently related to increase of aortic artery stiffness over and above traditional risk factors and atherosclerosis...
  25. ncbi request reprint Circulating homocysteine and large arterial stiffness and thickness in a population-based sample of middle-aged and elderly men
    H R Nakhai-Pour
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Hum Hypertens 21:942-8. 2007
    ..06 (95% CI -0.01; 0.13)). The results of this study do not support the presence of an independent relationship between circulating tHcy levels and large artery stiffness and thickness...
  26. ncbi request reprint Change in body mass index from adolescence to young adulthood and increased carotid intima-media thickness at 28 years of age: the Atherosclerosis Risk in Young Adults study
    A Oren
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Obes Relat Metab Disord 27:1383-90. 2003
    ..Although data on tracking of body mass index (BMI) are available, little is known about the impact of weight change over time on the development of vascular damage...
  27. ncbi request reprint Unrecognised myocardial infarction in subjects at high vascular risk: prevalence and determinants
    M F L Meijs
    Department of Cardiology, University Medical Center Utrecht, Utrecht 3584 CX, The Netherlands
    Heart 95:728-32. 2009
    ..To investigate the prevalence and determinants of unrecognised myocardial infarction (UMI)...
  28. ncbi request reprint Nurse practitioners improve quality of care in chronic kidney disease: two-year results of a randomised study
    A D van Zuilen
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neth J Med 69:517-26. 2011
    ..Here we evaluate whether strict implementation of guidelines aimed at multiple targets with the aid of nurse practitioners (NP) improves management in patients with CKD...
  29. ncbi request reprint Birth size and coronary heart disease risk score in young adulthood. The Atherosclerosis Risk in Young Adults (ARYA) study
    L E Vos
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Eur J Epidemiol 21:33-8. 2006
    ..02% risk/SD birth length; 95% CI: -0.04, 0.0001). These results suggest that small birth size is associated with an increased risk score for coronary artery disease in young adulthood...
  30. ncbi request reprint Soluble intercellular adhesion molecule 1 and flow-mediated dilatation are related to the estimated risk of coronary heart disease independently from each other
    D R Witte
    Julius Center for Health Sciences and Primary Care, D 01 335, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Atherosclerosis 170:147-53. 2003
    ..The comparative value of the two measures in relation to cardiovascular risk is unknown...
  31. pmc Short- and long-term mortality after acute myocardial infarction: comparison of patients with and without diabetes mellitus
    H L Koek
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HPN Str 06 131, P O Box 85 060, 3508, AB, Utrecht, The Netherlands
    Eur J Epidemiol 22:883-8. 2007
    ..Yet, short-term mortality is not significantly higher in diabetic patients. Risks appear to be equally elevated in men and women...
  32. doi request reprint Incompleteness of the circle of Willis is related to EEG-based shunting during carotid endarterectomy
    C W A Pennekamp
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 46:631-7. 2013
    ..We set out to develop a rule to predict the likelihood for shunting during CEA based on preoperative assessment of collateral cerebral circulation and patient characteristics...
  33. ncbi request reprint Effect of hormone replacement therapy on lipids in perimenopausal and early postmenopausal women
    M E Ossewaarde
    Julius Center for Patient Oriented Research, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Maturitas 39:209-16. 2001
    ..Changes appear to be more pronounced in postmenopausal women compared to perimenopausal women...
  34. ncbi request reprint Aortic stiffness and carotid intima-media thickness: two independent markers of subclinical vascular damage in young adults?
    A Oren
    University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Clin Invest 33:949-54. 2003
    ..However, studies show conflicting results and are limited to elderly subjects. To study this issue further, we evaluated the relation of arterial stiffness to subclinical atherosclerosis in 524 healthy young adults, aged 27-30 years...
  35. ncbi request reprint Nationwide incidence of first stroke and TIA in the Netherlands
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Neurol 15:1315-23. 2008
    ..Information on incidence of stroke is important for developing and maintaining public health strategies in primary and secondary prevention. Nationwide data on the incidence of stroke are scarce and absent for the Netherlands...
  36. ncbi request reprint Ultrasound protocols to measure carotid intima-media thickness: a post-hoc analysis of the OPAL study
    S Dogan
    Julius Center for Health Sciences and Primary Care www juliuscenter nl, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Med Res Opin 25:109-22. 2009
    ..We compared different ultrasound protocols in a post-hoc analysis in the 'Osteoporosis Prevention and Arterial effects of tiboLone' (OPAL) study, a 3-year randomized controlled trial among healthy postmenopausal women...
  37. ncbi request reprint Hormone replacement therapy and endothelial function. Results of a randomized controlled trial in healthy postmenopausal women
    M J de Kleijn
    Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, HP D01.335, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Atherosclerosis 159:357-65. 2001
    ..Tibolone did not alter fmd. The clinical significance of this improvement in fmd for cardiovascular disease risk needs to be established...
  38. ncbi request reprint Determinants of augmentation index in young men: the ARYA study
    M J C A van Trijp
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Clin Invest 34:825-30. 2004
    ..In contrast, data in the young are scarce. However, as AIx might be used to evaluate cardiovascular disease risk already at an early age, we aimed to study determinants of AIx in a population of healthy young men...
  39. doi request reprint Near-infrared spectroscopy can predict the onset of cerebral hyperperfusion syndrome after carotid endarterectomy
    C W A Pennekamp
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 34:314-21. 2012
    ..In this study, we assess whether NIRS and perioperative TCD are related to the onset CHS following CEA...
  40. ncbi request reprint Impact of various questionnaires on the prevalence of erectile dysfunction. The ENIGMA-study
    B J de Boer
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Impot Res 16:214-9. 2004
    ..A short questionnaire with one or two questions is recommended for example the one from the Boxmeer-study. These data may be used to adjust (age-specific) prevalence rates comparing ED prevalence in the open population across studies...
  41. ncbi request reprint Hemoglobin and atherosclerosis in patients with manifest arterial disease. The SMART-study
    J M Dijk
    Julius Center for Health Sciences and Primary Care, University, Medical Center Utrecht UMCU, Utrecht, The Netherlands
    Atherosclerosis 188:444-9. 2006
    ..Similar remodeling mechanisms of the vessel wall that may result in atherosclerosis are likely to be present. We studied whether hemoglobin levels are related to different vascular indicators of atherosclerosis...
  42. ncbi request reprint The Atherosclerosis Risk in Young Adults (ARYA) study: rationale and design
    A Oren
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Eur J Epidemiol 18:715-27. 2003
    ..The Atherosclerosis Risk in Young Adults (ARYA) study was specifically designed to address this issue...
  43. ncbi request reprint Alcohol and arterial wave reflections in middle aged and elderly men
    M J C A van Trijp
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Clin Invest 35:615-21. 2005
    ..The relation of alcohol consumption level with AIx has not been widely investigated, which prompted this study of the relation of alcohol consumption with AIx in a population-based cohort of men aged 40-80 years...
  44. ncbi request reprint A meta-analysis of excess cardiac mortality on Monday
    D R Witte
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Epidemiol 20:401-6. 2005
    ..Available evidence suggests a peak in the incidence of cardiovascular events on Mondays compared to other days of the week. The exact magnitude of the excess risk and the role of age and gender, however, remain unclear...
  45. ncbi request reprint Incidence of first acute myocardial infarction in the Netherlands
    H L Koek
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neth J Med 65:434-41. 2007
    ..Background: We recently showed that AMi patients can be followed longitudinally within dutch national medical registrations in a valid way. This makes it possible to provide nationwide incidence estimates of first AMi in the Netherlands...
  46. doi request reprint Radiation-induced carotid stenotic lesions have a more stable phenotype than de novo atherosclerotic plaques
    M Fokkema
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 43:643-8. 2012
    ..To identify plaque characteristics of carotid artery radiation-induced stenosis...
  47. ncbi request reprint A high menaquinone intake reduces the incidence of coronary heart disease
    G C M Gast
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Nutr Metab Cardiovasc Dis 19:504-10. 2009
    ..Data on the effect of vitamin K intake on coronary heart disease (CHD) risk, however, are scarce. To examine the relationship between dietary vitamins K(1) and K(2) intake, and its subtypes, and the incidence of CHD...
  48. ncbi request reprint Carotid plaques increase the risk of stroke and subtypes of cerebral infarction in asymptomatic elderly: the Rotterdam study
    M Hollander
    Department of Epidemiology and Biostatistics, Erasmus Medical Center Rotterdam, and Julius Center for General Practice and Patient Oriented Research, University Medical Center Utrecht, The Netherlands
    Circulation 105:2872-7. 2002
    ..1 to 4.9]). A >10-fold increased risk of lacunar infarction was found in subjects with severe plaques (RR 10.8 [95% CI, 1.7 to 69.7]). No clear difference in risk estimates was seen between ipsilateral and contralateral infarction...
  49. ncbi request reprint Menopausal status and distensibility of the common carotid artery
    I C Westendorp
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Arterioscler Thromb Vasc Biol 19:713-7. 1999
    ..5 microm [SE 9.5] versus 397.3 microm [SE 9.6]). These results suggest that the distensibility of the common carotid artery is negatively affected by natural menopause in presumed healthy women...
  50. ncbi request reprint Is chronic fatigue syndrome a connective tissue disorder? A cross-sectional study in adolescents
    E M van de Putte
    Department of Pediatric, Wilhelmina Children s Hospital, University Medical Center Utrecht, Utrecht, Netherlands
    Pediatrics 115:e415-22. 2005
    ....
  51. ncbi request reprint Excess cardiac mortality on Monday: the importance of gender, age and hospitalisation
    D R Witte
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Epidemiol 20:395-9. 2005
    ..The underlying mechanism may be summarised as naturally occurring rhythmic fluctuations in human physiology, and socially determined rhythms in human behaviour. Change in these rhythms may lead to attenuation of the peak on Mondays...
  52. ncbi request reprint Cardiovascular determinants of carotid artery disease. The Rotterdam Elderly Study
    M L Bots
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Hypertension 19:717-20. 1992
    ..Our data suggest that hypertension, smoking, and reduced serum high density lipoprotein cholesterol levels, combined with unfavorable increases in hemostatic factors, may be related to carotid artery disease in the elderly...
  53. ncbi request reprint The value of near-infrared spectroscopy measured cerebral oximetry during carotid endarterectomy in perioperative stroke prevention. A review
    C W A Pennekamp
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 38:539-45. 2009
    ..We aimed to (1) compare the value of NIRS related to existing cerebral monitoring techniques in prediction of perioperative cerebral ischaemia and (2) compare the relation between NIRS and the occurrence of CHS...
  54. ncbi request reprint Gender differences in mortality after hospital admission for stroke
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 28:564-71. 2009
    ..Yet, studies into differences between men and women in survival after a stroke yielded inconsistent results. We investigated whether gender was associated with all-cause mortality after hospital admission for stroke...
  55. doi request reprint Multi Detector-Row Computed Tomography (MDCT) had excellent reproducibility of coronary calcium measurements
    S Sabour
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Clin Epidemiol 61:572-9. 2008
    ....
  56. ncbi request reprint Noninvasive arterial measurements of vascular damage in healthy young adults: relation to coronary heart disease risk
    Marijke J C A van Trijp
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Dept of Internal Medicine, St Antonius Hospital, Nieuwegein, The Netherlands
    Ann Epidemiol 16:71-7. 2006
    ..Our aim was to study whether AIx is related to coronary heart disease (CHD) risk and to compare the strength of the relations of AIx, PWV, and CIMT with cardiovascular risk in healthy young adults...
  57. ncbi request reprint Incidence of acute myocardial infarction in first and second generation minority groups: does the second generation converge towards the majority population?
    A A M van Oeffelen
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, Netherlands Electronic address
    Int J Cardiol 168:5422-9. 2013
    ..We assessed whether AMI incidence differences between minority groups living in the Netherlands and the Dutch majority population exist, and whether the incidence converges towards the majority population over generations...
  58. pmc ACE inhibition and endothelial function: main findings of PERFECT, a sub-study of the EUROPA trial
    M L Bots
    Julius Center for Health Sciences and Primary Care, HP Str 6 131, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Cardiovasc Drugs Ther 21:269-79. 2007
    ..The Perindopril-Function of the Endothelium in Coronary artery disease Trial (PERFECT) evaluated whether long-term administration of perindopril improves endothelial dysfunction...
  59. pmc Rationale and design of the SMART Heart study: A prediction model for left ventricular hypertrophy in hypertension
    M F L Meijs
    Departments of Cardiology and Radiology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neth Heart J 15:295-8. 2007
    ..For this purpose 1000 subjects with chronic hypertension will undergo cardiac MR imaging. In addition, this study allows the extrapolation of animal experimental genetic research into the human situation. (Neth Heart J 2007;15:295-8.)...
  60. ncbi request reprint Simultaneous aortic and coronary assessment in abdominal aortic aneurysm patients by thoraco-abdominal 64-detector-row CT angiography: estimate of the impact on preoperative management: a pilot study
    R P J Budde
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 40:196-201. 2010
    ..To estimate the influence of information on the coronary arteries obtained from routine thoraco-abdominal CT angiography (CTA) on pre-operative clinical management in abdominal aortic aneurysm (AAA) patients...
  61. pmc Incidence, risk, and case fatality of first ever stroke in the elderly population. The Rotterdam Study
    M Hollander
    Department of Epidemiology and Biostatistics, Erasmus Medical Centre, Rotterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 74:317-21. 2003
    ..To estimate the incidence, survival, and lifetime risk of stroke in the elderly population...
  62. ncbi request reprint Regional cerebral blood flow and cerebrovascular risk factors in the elderly population
    J J Claus
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Neurobiol Aging 19:57-64. 1998
    ..Reduced contractility of the vascular muscle wall with increasing age resulting from atherosclerosis may be the underlying mechanism...
  63. ncbi request reprint Awareness, treatment and control of hypertension: the 'rule of halves' in an era of risk-based treatment of hypertension
    T Scheltens
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Hum Hypertens 21:99-106. 2007
    ..Management of hypertension is too often not risk-based despite recommendations in guidelines on prevention of cardiovascular diseases available since 2000...
  64. ncbi request reprint Awareness of hypertension: will it bring about a healthy lifestyle?
    T Scheltens
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Hum Hypertens 24:561-7. 2010
    ..There seems to be ample room for improvement in implementing the guidelines. Probably, patient tailored interventions and a multisiciplinary and multimodality approach can support this improvement...
  65. ncbi request reprint Regional differences in incidence of sudden cardiac death in the young
    A Hendrix
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neth J Med 68:274-9. 2010
    ....
  66. ncbi request reprint Carotid intima-media thickness at different sites: relation to incident myocardial infarction; The Rotterdam Study
    A Iglesias del Sol
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Eur Heart J 23:934-40. 2002
    ....
  67. ncbi request reprint T64A polymorphism in beta3-adrenergic receptor gene (ADRB3) and coronary heart disease: a case-cohort study and meta-analysis
    M H Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Intern Med 263:79-89. 2008
    ..We therefore investigated the role of this polymorphism on the occurrence of acute myocardial infarction (AMI) and CHD in a population of healthy Dutch women...
  68. doi request reprint Coronary heart disease mortality trends in the Netherlands 1972-2007
    I Vaartjes
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht STR 6 131, GA Utrecht, The Netherlands
    Heart 97:569-73. 2011
    ..Coronary heart disease (CHD) mortality has steadily declined since the early 1970s in the Netherlands. However, in some Western countries the rate of decline in younger groups may be starting to plateau or even rise...
  69. ncbi request reprint [Prediction of cardiovascular disease on the basis of blood pressure measurements more reliable with systolic than with diastolic measurement]
    M J van Trijp
    Universitair Medisch Centrum Utrecht, Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde, Heidelberglaan 100, 3584 CX Utrecht
    Ned Tijdschr Geneeskd 147:1456-9. 2003
    ....
  70. ncbi request reprint Risk factors for vascular disease and dementia
    M M Breteler
    Department of Epidemiology and Biostatistics, Erasmus University Medical School, Rotterdam, The Netherlands
    Haemostasis 28:167-73. 1998
    ....
  71. ncbi request reprint Dietary phytoestrogens and plasma lipids in Dutch postmenopausal women; a cross-sectional study
    Sanne Kreijkamp-Kaspers
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, PO Box 85500 Room D 01 335 Utrecht, GA3508 The Netherlands
    Atherosclerosis 178:95-100. 2005
    ..Little is known about the effects of intake within the range of western diets on these endpoints. Design: We conducted a population-based cross-sectional study in 301 women aged 60-75 years...
  72. ncbi request reprint Is the association between flow-mediated dilation and cardiovascular risk limited to low-risk populations?
    Daniel R Witte
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heiderberglaan 100, 3584 CX Utrecht, The Netherlands
    J Am Coll Cardiol 45:1987-93. 2005
    ..The aim of this research was to study whether the relation between endothelial function measured by flow-mediated dilation (FMD) of the brachial artery and cardiovascular risk factors is affected by the baseline cardiovascular risk...
  73. doi request reprint Carotid intima-media thickness measurement in cardiovascular screening programmes
    Yvonne Plantinga
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 16:639-44. 2009
    ..At present it seems that the published evidence to quantitatively support the use of a CIMT measurement to help in risk stratification on top of a risk function is limited...
  74. ncbi request reprint Adolescent blood pressure and blood pressure tracking into young adulthood are related to subclinical atherosclerosis: the Atherosclerosis Risk in Young Adults (ARYA) study
    Lydia E Vos
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Hypertens 16:549-55. 2003
    ..Our aim was to study the relationships of adolescent BP and tracking of BP into young adulthood with subclinical atherosclerosis, as assessed by carotid intima-media thickness (CIMT), at the age of 28 years...
  75. ncbi request reprint Arterial stiffness in postmenopausal women: determinants of pulse wave velocity
    Corinne E I Lebrun
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht and Department of Internal Medicine, Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands
    J Hypertens 20:2165-72. 2002
    ..Increased PWV marks an increased risk of stroke, coronary heart disease, and death within 10-12 years...
  76. pmc Cardiovascular mortality in Dutch men during 1996 European football championship: longitudinal population study
    D R Witte
    Julius Centre for General Practice and Patient Oriented Research, University Medical Centre Utrecht, Huispostnummer D01 335, 3584 CX Utrecht, Netherlands
    BMJ 321:1552-4. 2000
    ..To investigate whether an important football match increases stress to such an extent that it triggers acute myocardial infarction and stroke...
  77. ncbi request reprint Increased arterial stiffness is independently related to cerebrovascular disease and aneurysms of the abdominal aorta: the Second Manifestations of Arterial Disease (SMART) Study
    J M Dijk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnummer Str 6 131, PO Box 85060, 3508 BA Utrecht, The Netherlands
    Stroke 35:1642-6. 2004
    ..Arterial stiffness is a risk factor for stroke and myocardial infarction. We investigated whether carotid arterial stiffness is related to other localizations of manifest arterial disease...
  78. ncbi request reprint [Trends in cardiovascular morbidity and mortality in the Netherlands, 1980-2000]
    H L Koek
    Universitair Medisch Centrum Utrecht, Julius Centrum voor Gezondheidswetenschappen en Eerstelijnsgeneeskunde, Postbus 85 060, Huispostnummer Str 6 118, 3508 AB Utrecht
    Ned Tijdschr Geneeskd 148:27-32. 2004
    ..To describe and interpret trends in cardiovascular morbidity and mortality among the Dutch population from 1980 to 2000, in particular the decline in hospital admissions for cardiovascular disease during the second half of the 1990s...
  79. ncbi request reprint [Cardiovascular risk factors. I. Review of possible causes of heart and vascular diseases]
    J G van der Bom
    Universitair Medisch Centrum, Julius Centrum voor Gezondheidswetenschappen en Eerstelijns Geneeskunde, Postbus 80 035, 3508 GA, Utrecht
    Ned Tijdschr Geneeskd 146:1169-74. 2002
    ....
  80. ncbi request reprint Statin treatment and progression of atherosclerotic plaque burden
    Diederick E Grobbee
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Drugs 63:893-911. 2003
    ....
  81. ncbi request reprint Aggressive lipid lowering does not improve endothelial function in type 2 diabetes: the Diabetes Atorvastatin Lipid Intervention (DALI) Study: a randomized, double-blind, placebo-controlled trial
    Francine V van Venrooij
    Julius Center for General Practice and Patient Oriented Research and Department of Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 25:1211-6. 2002
    ..Type 2 diabetic patients show a characteristic dyslipidemia. Aggressive lipid lowering might be an effective method to improve endothelial function in these patients...
  82. ncbi request reprint Carotid intima-media thickness as a surrogate marker for cardiovascular disease in intervention studies
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Curr Med Res Opin 22:2181-90. 2006
    ..These markers may provide earlier indications of efficacy in trials involving fewer participants. One approach gaining interest in recent years is the measurement of atherosclerotic progression, a major underlying cause of CVD...
  83. ncbi request reprint Low levels of adiponectin predict worsening of arterial morphology and function
    Stefan Störk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 194:e147-53. 2007
    ..We conclude that low levels of adiponectin are associated with adverse changes in morphology and function of central arteries over time independently of other cardiovascular risk factors in postmenopausal non-diabetic women...
  84. doi request reprint High dietary menaquinone intake is associated with reduced coronary calcification
    Joline W J Beulens
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 203:489-93. 2009
    ..This may be due to different effects of vitamin K(1) (phylloquinone) and vitamin K(2) (menaquinone, MK), but few studies included both...
  85. pmc Peroxisome proliferator-activated receptor gamma-2 P12A polymorphism and risk of acute myocardial infarction, coronary heart disease and ischemic stroke: a case-cohort study and meta-analyses
    Mohammad Hadi Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, Str 6 131, 3584 CX, Utrecht, The Netherlands
    Vasc Health Risk Manag 4:427-36. 2008
    ..Yet, the risk relation has not been confirmed, and data on ischemic stroke (IS) is scarce. We therefore investigated the role of this polymorphism on occurrence of AMI, coronary heart disease (CHD) and IS...
  86. ncbi request reprint Dietary phytoestrogens and vascular function in postmenopausal women: a cross-sectional study
    Sanne Kreijkamp-Kaspers
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Hypertens 22:1381-8. 2004
    ..To investigate the effects of low levels of intake of phytoestrogens in Western habitual diet on vascular function...
  87. ncbi request reprint Carotid artery plaque burden, stiffness, and mortality risk in elderly men: a prospective, population-based cohort study
    Stefan Störk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 110:344-8. 2004
    ..Carotid artery morphology (plaque burden) and function (stiffness indexes) as predictors of all-cause and cardiovascular mortality were prospectively evaluated in elderly men...
  88. ncbi request reprint The effect of tibolone and continuous combined conjugated equine oestrogens plus medroxyprogesterone acetate on progression of carotid intima-media thickness: the Osteoporosis Prevention and Arterial effects of tiboLone (OPAL) study
    Michiel L Bots
    Julius Center for Health Sciences and Primary Care, HP Str 6 131 University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Eur Heart J 27:746-55. 2006
    ..Because the overall effect of tibolone on cardiovascular risk was unknown, the OPAL study was designed...
  89. ncbi request reprint Higher usual dietary intake of phytoestrogens is associated with lower aortic stiffness in postmenopausal women
    Yvonne T van der Schouw
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 22:1316-22. 2002
    ..Phytoestrogens have been postulated to protect against cardiovascular diseases, but few studies have focused on the effect of Western dietary phytoestrogen intake...
  90. ncbi request reprint The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1
    Johanna G van der Bom
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht Van Creveldkliniek, The Netherlands
    Blood 101:1841-4. 2003
    ..Additionally, these findings show that homozygosity for the 4G allele is associated with increased PAI-1 levels during the morning only...
  91. ncbi request reprint Measurement of flow-mediated dilatation of the brachial artery is affected by local elastic vessel wall properties in high-risk patients
    Daniel R Witte
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Str 6 131, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Atherosclerosis 182:323-30. 2005
    ..To assess whether the validity of endothelial function measurement by flow-mediated dilatation (FMD) is affected by local brachial artery stiffness (distensibility coefficient; DC) and arterial wall thickness (intima-media thickness, IMT)...
  92. ncbi request reprint Reproductive factors, metabolic factors, and coronary artery calcification in older women
    Femke Atsma
    Department of Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Menopause 15:899-904. 2008
    ..This cohort study investigated the relationship between reproductive factors and coronary artery calcification in elderly women and whether this relationship could be explained by metabolic disturbances...
  93. ncbi request reprint Carotid stiffness indicates risk of ischemic stroke and TIA in patients with internal carotid artery stenosis: the SMART study
    Joke M Dijk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnummer Str 6 131, Postbus 85060, 3508 BA Utrecht, The Netherlands
    Stroke 35:2258-62. 2004
    ..We cross-sectionally investigated whether carotid stiffness is associated with previous ischemic stroke or transient ischemic attack (TIA) in patients with a carotid artery stenosis of at least 50%...
  94. ncbi request reprint Atherosclerotic disease regression with statins: studies using vascular markers
    Diederick E Grobbee
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, HP D01 335, P O Box 85500, Utrecht 3508 GA, The Netherlands
    Int J Cardiol 96:447-59. 2004
    ..Hence, imaging studies support early intervention with statins in coronary heart disease patients, irrespective of lipid level...
  95. ncbi request reprint Cardiovascular risk factors and increased carotid intima-media thickness in healthy young adults: the Atherosclerosis Risk in Young Adults (ARYA) Study
    Anath Oren
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Arch Intern Med 163:1787-92. 2003
    ..We evaluated the relationship between conventional risk factors and increased carotid intima-media thickness (CIMT) in 750 healthy young adults, aged 27 to 30 years...
  96. ncbi request reprint Birth weight and carotid intima-media thickness: new perspectives from the atherosclerosis risk in young adults (ARYA) study
    Anath Oren
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Epidemiol 14:8-16. 2004
    ..The authors investigated whether low birth weight leads to an increased risk of subclinical atherosclerosis in a population-based sample of 750 Dutch men and women, aged 27 to 30 years...
  97. ncbi request reprint Peri-coronary epicardial adipose tissue is related to cardiovascular risk factors and coronary artery calcification in post-menopausal women
    Alexander M de Vos
    Department of Cardiology, University Medical Centre Utrecht, Heidelberglaan 100, 3584CX Utrecht, The Netherlands
    Eur Heart J 29:777-83. 2008
    ..To determine whether peri-coronary epicardial adipose tissue (EAT) is associated with vascular risk factors and coronary atherosclerosis...
  98. ncbi request reprint Non-invasively measured structural and functional arterial characteristics and coronary heart disease risk in middle aged and elderly men
    Marijke J C A van Trijp
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Atherosclerosis 187:110-5. 2006
    ..Therefore, our aim was to relate AIx to CV risk and to compare the magnitude of relations of PWV, CIMT and AIx to CV risk...
  99. ncbi request reprint Alcohol consumption in relation to aortic stiffness and aortic wave reflections: a cross-sectional study in healthy postmenopausal women
    Aafje Sierksma
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 24:342-8. 2004
    ..Moderate alcohol consumption has been postulated to be cardioprotective. Such an effect might be reflected in large-artery properties, such as arterial stiffness and wave reflections...
  100. doi request reprint Alpha-adducin Gly460Trp variant increases the risk of stroke in hypertensive Dutch women
    Mohammad Hadi Zafarmand
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Heidelberglaan 100, Str 6 131, 3584 CX Utrecht, Utrecht, The Netherlands
    Hypertension 51:1665-70. 2008
    ..This risk is particularly elevated in the presence of systolic hypertension...
  101. ncbi request reprint Adolescent blood pressure does not predict aortic stiffness in healthy young adults. The Atherosclerosis Risk in Young Adults (ARYA) study
    Anath Oren
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Hypertens 21:321-6. 2003
    ..Increased arterial stiffness has been shown to be a good predictor of cardiovascular morbidity and mortality and to be associated with an adverse cardiovascular risk profile...