Fokko J Bosker

Summary

Affiliation: University Hospital Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Future antidepressants: what is in the pipeline and what is missing?
    Fokko J Bosker
    Department of Psychiatry, University and University Hospital of Groningen, Hanzeplein 1, PO Box 30 001, Groningen, 9700 RB, The Netherlands
    CNS Drugs 18:705-32. 2004
  2. ncbi request reprint Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies
    Thomas I F H Cremers
    Brains on Line, Antonius Deusinglaan 1, Groningen, The Netherlands
    Neuropsychopharmacology 32:1550-7. 2007
  3. ncbi request reprint Effect of increased serotonin levels on [18F]MPPF binding in rat brain: fenfluramine vs the combination of citalopram and ketanserin
    Joanna I Udo de Haes
    Department of Biological Psychiatry, University Medical Center Groningen, Groningen, The Netherlands
    Neuropsychopharmacology 30:1624-31. 2005
  4. ncbi request reprint Analysis of 5-HT(2A) receptor binding with [(11)C]MDL 100907 in rats: optimization of kinetic modeling
    Anniek K D Visser
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Mol Imaging Biol 15:730-8. 2013
  5. doi request reprint Locally increased P-glycoprotein function in major depression: a PET study with [11C]verapamil as a probe for P-glycoprotein function in the blood-brain barrier
    Onno L de Klerk
    Department of Psychiatry, University Medical Center Groningen UMCG, Groningen, The Netherlands
    Int J Neuropsychopharmacol 12:895-904. 2009
  6. ncbi request reprint Regional increase in P-glycoprotein function in the blood-brain barrier of patients with chronic schizophrenia: a PET study with [(11)C]verapamil as a probe for P-glycoprotein function
    Onno L de Klerk
    Department of Psychiatry, University Medical Center Groningen UMCG, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Psychiatry Res 183:151-6. 2010
  7. doi request reprint Oxazepam and temazepam attenuate paroxetine-induced elevation of serotonin levels in guinea-pig hippocampus
    Thomas I F H Cremers
    Department of Biomonitoring and Sensoring, University of Groningen Institute of Pharmacy, Groningen, The Netherlands
    Int J Neuropsychopharmacol 13:807-11. 2010
  8. ncbi request reprint The effect of chronic selective serotonin reuptake inhibitor treatment on serotonin 1B receptor sensitivity and HPA axis activity
    Minke E Jongsma
    Department of Psychiatry, University Medical Centre Groningen, Groningen, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 29:738-44. 2005
  9. pmc An animal model of emotional blunting in schizophrenia
    Charmaine Y Pietersen
    Graduate School of Behavioral and Cognitive Neuroscience, Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 2:e1360. 2007
  10. pmc Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications
    Anniek K D Visser
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 38:576-91. 2011

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Future antidepressants: what is in the pipeline and what is missing?
    Fokko J Bosker
    Department of Psychiatry, University and University Hospital of Groningen, Hanzeplein 1, PO Box 30 001, Groningen, 9700 RB, The Netherlands
    CNS Drugs 18:705-32. 2004
    ..Animal models that take this concept into consideration and identify mechanisms for acceleration of recovery from the effects of stress need to be developed...
  2. ncbi request reprint Augmentation of SSRI effects on serotonin by 5-HT2C antagonists: mechanistic studies
    Thomas I F H Cremers
    Brains on Line, Antonius Deusinglaan 1, Groningen, The Netherlands
    Neuropsychopharmacology 32:1550-7. 2007
    ..It was determined that the involvement of glutamate, norepinephrine, and dopamine in the augmentation did not seem likely, whereas evidence implicated a role for the GABA-ergic system in the augmentation...
  3. ncbi request reprint Effect of increased serotonin levels on [18F]MPPF binding in rat brain: fenfluramine vs the combination of citalopram and ketanserin
    Joanna I Udo de Haes
    Department of Biological Psychiatry, University Medical Center Groningen, Groningen, The Netherlands
    Neuropsychopharmacology 30:1624-31. 2005
    ..These results may imply that the majority of 5-HT1A receptors is in the low-affinity state, in vivo...
  4. ncbi request reprint Analysis of 5-HT(2A) receptor binding with [(11)C]MDL 100907 in rats: optimization of kinetic modeling
    Anniek K D Visser
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Mol Imaging Biol 15:730-8. 2013
    ..Preclinical positron emission tomography studies are important to follow disease progression and develop new pharmacological agents. We investigated whether kinetic modeling of 5-HT2A tracer [(11)C]MDL 100907 is possible in rats...
  5. doi request reprint Locally increased P-glycoprotein function in major depression: a PET study with [11C]verapamil as a probe for P-glycoprotein function in the blood-brain barrier
    Onno L de Klerk
    Department of Psychiatry, University Medical Center Groningen UMCG, Groningen, The Netherlands
    Int J Neuropsychopharmacol 12:895-904. 2009
    ..The decreased [11C]verapamil uptake correlates with an increased function of the P-gp protein and may be related to chronic use of psychotropic drugs. Our results may explain why treatment-resistant depression can develop...
  6. ncbi request reprint Regional increase in P-glycoprotein function in the blood-brain barrier of patients with chronic schizophrenia: a PET study with [(11)C]verapamil as a probe for P-glycoprotein function
    Onno L de Klerk
    Department of Psychiatry, University Medical Center Groningen UMCG, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Psychiatry Res 183:151-6. 2010
    ..The decrease of [(11)C]verapamil uptake correlates with an increased activity of the P-gp pump. Increased P-gp activity may be a factor in drug resistance in schizophrenia, induced by the use of antipsychotic agents...
  7. doi request reprint Oxazepam and temazepam attenuate paroxetine-induced elevation of serotonin levels in guinea-pig hippocampus
    Thomas I F H Cremers
    Department of Biomonitoring and Sensoring, University of Groningen Institute of Pharmacy, Groningen, The Netherlands
    Int J Neuropsychopharmacol 13:807-11. 2010
    ..It was concluded that benzodiazepines attenuate the ability of SSRIs to elevate hippocampal 5-HT levels. Thus, co-administration of benzodiazepines might affect the therapeutic efficacy of SSRI treatment...
  8. ncbi request reprint The effect of chronic selective serotonin reuptake inhibitor treatment on serotonin 1B receptor sensitivity and HPA axis activity
    Minke E Jongsma
    Department of Psychiatry, University Medical Centre Groningen, Groningen, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 29:738-44. 2005
    ..In addition, plasma levels of the catecholamines adrenaline and noradrenaline and the HPA axis hormones ACTH and corticosterone were all decreased after chronic treatment...
  9. pmc An animal model of emotional blunting in schizophrenia
    Charmaine Y Pietersen
    Graduate School of Behavioral and Cognitive Neuroscience, Department of Psychiatry, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 2:e1360. 2007
    ..A conceptual model reconciling our findings in terms of neurochemistry and behavior is postulated and discussed...
  10. pmc Measuring serotonin synthesis: from conventional methods to PET tracers and their (pre)clinical implications
    Anniek K D Visser
    Department of Nuclear Medicine and Molecular Imaging, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Nucl Med Mol Imaging 38:576-91. 2011
    ..In conclusion, PET with radiolabelled substrates for the serotonergic pathway is the only direct way to detect changes of serotonin synthesis in the living brain...
  11. ncbi request reprint Chronic stress and antidepressant treatment have opposite effects on P-glycoprotein at the blood-brain barrier: an experimental PET study in rats
    Onno L de Klerk
    Department of Psychiatry, University Medical Center Groningen UMCG, Groningen, The Netherlands
    J Psychopharmacol 24:1237-42. 2010
    ..Our data suggest that P-glycoprotein function at the blood-brain barrier is inhibited by chronic stress and increased by chronic administration of venlafaxine...
  12. ncbi request reprint 5-HT(1A) receptor imaging in the human brain: effect of tryptophan depletion and infusion on [(18)F]MPPF binding
    Joanna I Udo de Haes
    Department of Biological Psychiatry, University Hospital Groningen, 9700 RB Groningen, The Netherlands
    Synapse 46:108-15. 2002
    ..Therefore, in pathological conditions, where such large increases in 5-HT levels are not expected, [(18)F]MPPF seems a useful ligand to measure 5-HT(1A) receptor distribution without the interference of endogenous 5-HT...
  13. ncbi request reprint Effect of 5-HT1A receptor-mediated serotonin augmentation on Fos immunoreactivity in rat brain
    Minke E Jongsma
    Department of Biological Psychiatry, University Hospital Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Eur J Pharmacol 455:109-15. 2002
    ..The results, illustrating the synergistic consequence of the combined drug treatments, are discussed in terms of activity of the limbic-hypothalamic-pituitary-adrenocortical system...
  14. ncbi request reprint The role of p-glycoprotein in psychiatric disorders: a reliable guard of the brain?
    Onno L de Klerk
    Department of Psychiatry, University Medical Center Groningen UMCG, The Netherlands
    Cent Nerv Syst Agents Med Chem 11:197-209. 2011
    ....
  15. ncbi request reprint Ketamine administration disturbs behavioural and distributed neural correlates of fear conditioning in the rat
    Charmaine Y Pietersen
    Graduate School of Behavioural and Cognitive Neuroscience, Department of Psychiatry, University Medical Centre Groningen, University of Groningen, Groningen 9713GZ, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 30:1209-18. 2006
    ..The combination of ketamine and fear conditioning may therefore provide a useful model of abnormal fear processing, as observed in certain psychiatric conditions...
  16. ncbi request reprint Inactivation of 5-HT(2C) receptors potentiates consequences of serotonin reuptake blockade
    Thomas I F H Cremers
    Department of Medicinal Chemistry, Pharmacy, University of Groningen, Groningen, The Netherlands
    Neuropsychopharmacology 29:1782-9. 2004
    ..These findings reveal an unanticipated pharmacological action of 5-HT(2C) receptors that warrants consideration in the development of novel strategies for the treatment of depression...
  17. ncbi request reprint PET imaging of beta-adrenoceptors in human brain: a realistic goal or a mirage?
    Aren van Waarde
    PET Center, Groningen University Hospital, P O Box 30001, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Curr Pharm Des 10:1519-36. 2004
    ..BBB opening is not feasible in healthy subjects, but the prodrug approach may be successful and deserves to be explored...