Marco P M Boks

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Current status and future prospects for epigenetic psychopharmacology
    Marco P Boks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    Epigenetics 7:20-8. 2012
  2. ncbi The structure of psychosis revisited: the role of mood symptoms
    Marco P M Boks
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    Schizophr Res 93:178-85. 2007
  3. doi Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup
    Marco P M Boks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:707-11. 2008
  4. ncbi Investigating gene environment interaction in complex diseases: increasing power by selective sampling for environmental exposure
    M P M Boks
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Centre Utrecht, Utrecht, The Netherlands
    Int J Epidemiol 36:1363-9. 2007
  5. ncbi Psychiatric morbidity and X-chromosomal origin in a Klinefelter sample
    Marco P M Boks
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Utrecht, The Netherlands
    Schizophr Res 93:399-402. 2007
  6. ncbi Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia
    M P M Boks
    Department of Psychiatry, B01 206, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Eur Neuropsychopharmacol 17:567-72. 2007
  7. pmc "Forward genetics" as a method to maximize power and cost-efficiency in studies of human complex traits
    M P M Boks
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    Behav Genet 40:564-71. 2010
  8. doi Familial clustering of schizophrenia, bipolar disorder, and major depressive disorder
    Maartje F Aukes
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Genet Med 14:338-41. 2012
  9. ncbi The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val¹⁵⁸Met polymorphism
    Christiaan H Vinkers
    Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht UMCU, Utrecht, The Netherlands Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands Electronic address
    Schizophr Res 150:303-11. 2013
  10. doi BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects
    Jurjen J Luykx
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht UMCU, Utrecht, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 43:185-7. 2013

Detail Information

Publications43

  1. pmc Current status and future prospects for epigenetic psychopharmacology
    Marco P Boks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    Epigenetics 7:20-8. 2012
    ..After discussion of the most relevant epigenetic mechanisms we present the evidence for epigenetic effects for the most relevant classes of drugs...
  2. ncbi The structure of psychosis revisited: the role of mood symptoms
    Marco P M Boks
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    Schizophr Res 93:178-85. 2007
    ..The distinction of subgroups of psychosis patients, in particular those with major mood symptoms could facilitate the unravelling of the genetics of psychotic disorders...
  3. doi Do mood symptoms subdivide the schizophrenia phenotype? Association of the GMP6A gene with a depression subgroup
    Marco P M Boks
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Am J Med Genet B Neuropsychiatr Genet 147:707-11. 2008
    ..Overall, these finding suggests that investigating subgroups of schizophrenia based symptoms profile and particularly mood symptoms can facilitate genetic studies of schizophrenia...
  4. ncbi Investigating gene environment interaction in complex diseases: increasing power by selective sampling for environmental exposure
    M P M Boks
    The Rudolf Magnus Institute of Neuroscience, Department of Psychiatry University Medical Centre Utrecht, Utrecht, The Netherlands
    Int J Epidemiol 36:1363-9. 2007
    ..However, gene environmental interactions (GEIs) are not easily studied, since high numbers of subjects are required to detect GEI...
  5. ncbi Psychiatric morbidity and X-chromosomal origin in a Klinefelter sample
    Marco P M Boks
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, Utrecht, The Netherlands
    Schizophr Res 93:399-402. 2007
    ..Nevertheless, these findings provide further support for the role of the X-chromosome in the susceptibility to psychiatric disorders in general and psychotic disorders in particular...
  6. ncbi Reviewing the role of the genes G72 and DAAO in glutamate neurotransmission in schizophrenia
    M P M Boks
    Department of Psychiatry, B01 206, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Eur Neuropsychopharmacol 17:567-72. 2007
    ..The involvement of this gene is therefore indirect support for the glutamate dysfunction hypothesis in schizophrenia...
  7. pmc "Forward genetics" as a method to maximize power and cost-efficiency in studies of human complex traits
    M P M Boks
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Centre Utrecht, Utrecht, The Netherlands
    Behav Genet 40:564-71. 2010
    ..This approach is particularly apt for implementing in epidemiological studies for which DNA is already available but the phenotyping costs are high...
  8. doi Familial clustering of schizophrenia, bipolar disorder, and major depressive disorder
    Maartje F Aukes
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Genet Med 14:338-41. 2012
    ..To investigate familial clustering of schizophrenia, bipolar disorder, and major depressive disorder...
  9. ncbi The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val¹⁵⁸Met polymorphism
    Christiaan H Vinkers
    Department of Psychiatry, Brain Center Rudolf Magnus, University Medical Center Utrecht UMCU, Utrecht, The Netherlands Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands Electronic address
    Schizophr Res 150:303-11. 2013
    ..Therefore, we aimed to examine whether the COMT Val(158)Met polymorphism (rs4680) moderates the interaction between childhood maltreatment and cannabis use on psychotic symptoms in the general population...
  10. doi BDNF Val66Met homozygosity does not influence plasma BDNF levels in healthy human subjects
    Jurjen J Luykx
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht UMCU, Utrecht, The Netherlands
    Prog Neuropsychopharmacol Biol Psychiatry 43:185-7. 2013
    ..In conclusion, these results add to a growing body of evidence indicating that allelic variation at rs6265 does not have medium to large effects on plasma BDNF concentrations...
  11. doi The association of the alpha-5 subunit of the nicotinic acetylcholine receptor gene and the brain-derived neurotrophic factor gene with different aspects of smoking behavior
    Elemi J Breetvelt
    Departments of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Psychiatr Genet 22:96-8. 2012
    ..Overall, the results confirm the involvement of the CHRNA5 gene in the amount of nicotine use and further suggest involvement of the BDNF gene in smoking behavior...
  12. doi A comorbid anxiety disorder does not result in an excess risk of death among patients with a depressive disorder
    Wijnand Laan
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 135:284-91. 2011
    ..Mortality due to comorbidity of two mental disorders may be even more increased. Therefore, we investigated the mortality among patients with depression, with anxiety and with both diagnoses...
  13. pmc Healthy individuals with auditory verbal hallucinations; who are they? Psychiatric assessments of a selected sample of 103 subjects
    Iris E C Sommer
    Neuroscience Division University Medical Center Utrecht, B01 206, Rudolf Magnus School for Neuroscience, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Bull 36:633-41. 2010
    ..Our data suggest that AVH in otherwise healthy individuals are not an isolated phenomenon but part of a general vulnerability for schizophrenia...
  14. pmc A gene co-expression network in whole blood of schizophrenia patients is independent of antipsychotic-use and enriched for brain-expressed genes
    Simone de Jong
    Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e39498. 2012
    ..This suggests that the MHC increases schizophrenia susceptibility via altered gene expression of regulatory genes in this network...
  15. pmc Expression QTL analysis of top loci from GWAS meta-analysis highlights additional schizophrenia candidate genes
    Simone de Jong
    Department of Medical Genetics, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Hum Genet 20:1004-8. 2012
    ..Our results identify new genes of interest and highlight again the involvement of the MHC region in schizophrenia susceptibility...
  16. doi Schizophrenia risk factors constitute general risk factors for psychiatric symptoms in the population
    Elemi J Breetvelt
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Schizophr Res 120:184-90. 2010
    ..However, to our knowledge no large-scale studies have been conducted which examine the specificity of these risk factors in the general population...
  17. ncbi Negative association between a history of obstetric complications and the number of neurological soft signs in first-episode schizophrenic disorder
    Marco P M Boks
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry B01 206, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Psychiatry Res 149:273-7. 2007
    ..It is possible that the patients with a history of OCs carry fewer genes for schizophrenia (and NSS) and 'needed' the OCs to develop schizophrenia...
  18. doi Advanced paternal age and vulnerability to psychotic-like experiences in the offspring
    Annabel Vreeker
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Psychiatry, The Netherlands
    Schizophr Res 143:74-6. 2013
    ..To investigate whether advanced paternal age is associated with increased psychotic-like experiences (PLEs) and increased sensitivity to Cannabis in the offspring...
  19. doi Increased paternal age and the influence on burden of genomic copy number variation in the general population
    Jacobine E Buizer-Voskamp
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Hum Genet 132:443-50. 2013
    ..While it remains possible that local genomic effects may exist for specific phenotypes, this study indicates that global CNV burden and increased father's age may be independent disease risk factors...
  20. doi Cannabis use and subclinical positive psychotic experiences in early adolescence: findings from a Dutch survey
    Willemijn A van Gastel
    Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Department of Psychiatry, The Netherlands
    Addiction 107:381-7. 2012
    ....
  21. doi The same or different? A phenomenological comparison of auditory verbal hallucinations in healthy and psychotic individuals
    Kirstin Daalman
    Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    J Clin Psychiatry 72:320-5. 2011
    ..It remains unclear whether AVHs at the outer borders of this spectrum are indeed the same phenomenon. Furthermore, specific characteristics of AVHs may be important indicators of a psychotic disorder...
  22. pmc Paternal age and psychiatric disorders: findings from a Dutch population registry
    Jacobine E Buizer-Voskamp
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Schizophr Res 129:128-32. 2011
    ..We measured the association between paternal age and schizophrenia (SCZ), autism spectrum disorders (ASD), major depressive disorder (MDD), and bipolar disorder (BPD) in the Dutch population...
  23. pmc The identification of family subtype based on the assessment of subclinical levels of psychosis in relatives
    Eske M Derks
    University Medical Center Utrecht, Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, AMC APC, room PA1 179 Meibergdreef, Amsterdam, AZ 51105, The Netherlands
    BMC Psychiatry 12:71. 2012
    ..We will introduce a more refined method to distinguish between family subtypes based on psychosis dimension profiles in the relatives of schizophrenia patients...
  24. ncbi Diagnostic criteria for major depressive disorder in cancer patients: a review
    Ng Chong Guan
    University Medical Centre, Utrecht, The Netherlands
    Int J Psychiatry Med 45:73-82. 2013
    ..We therefore review the current state of evidence regarding such diagnostic criteria for major depressive disorder in cancer patients...
  25. pmc The psychiatric case register middle Netherlands
    Hugo M Smeets
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    BMC Psychiatry 11:106. 2011
    ..In 2010 the follow-up period was over ten years. In this paper we describe the content, aims and research potential of this case register...
  26. doi Cannabis with high cannabidiol content is associated with fewer psychotic experiences
    Christian D Schubart
    Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Department of Psychiatry, The Netherlands
    Schizophr Res 130:216-21. 2011
    ..The objective of the current study is to investigate the role of cannabidiol content in the association between cannabis use and psychiatric symptoms in a large non-clinical population of cannabis users...
  27. doi Formal thought disorder in non-clinical individuals with auditory verbal hallucinations
    Iris E Sommer
    The Neuroscience Division University Medical Center Utrecht, Rudolf Magnus School for Neuroscience, Netherlands
    Schizophr Res 118:140-5. 2010
    ..The hypothesis of a shared neurobiological basis would be strengthened by the presence of FTD in individuals who frequently experience AVH, but do not meet DSM-IV criteria for a psychotic disorder...
  28. doi Auditory verbal hallucinations predominantly activate the right inferior frontal area
    Iris E C Sommer
    Neuroscience Division, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Heidelberglaan, Netherlands
    Brain 131:3169-77. 2008
    ..The predominant engagement of the right inferior frontal area during AVH may be related to the typical low semantic complexity and negative emotional content...
  29. doi Treatment of unipolar psychotic depression: a randomized, double-blind study comparing imipramine, venlafaxine, and venlafaxine plus quetiapine
    J Wijkstra
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    Acta Psychiatr Scand 121:190-200. 2010
    ..It remains unclear whether unipolar psychotic depression should be treated with an antidepressant and an antipsychotic or with an antidepressant alone...
  30. doi The involvement of GSK3beta in bipolar disorder: integrating evidence from multiple types of genetic studies
    J J Luykx
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, B01 206, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Eur Neuropsychopharmacol 20:357-68. 2010
    ..Future studies investigating the effects of GSK3beta manipulation in BD seem warranted...
  31. ncbi The genetics of symptom dimensions of schizophrenia: review and meta-analysis
    T Rietkerk
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, B01 206, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Schizophr Res 102:197-205. 2008
    ..However, the genetic background of symptom dimensions is not clear...
  32. ncbi The 2-year stability of neurological soft signs after a first episode of non-affective psychosis
    Marco P M Boks
    Department of Psychiatry, University Hospital Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur Psychiatry 21:288-90. 2006
    ..The numbers of NSS at inclusion and at 2 years follow-up were similar, but there was a significant increase in the numbers of NSS in the sub-group of patients whose dosage of antipsychotic medication had increased over time...
  33. doi Perceived school safety is strongly associated with adolescent mental health problems
    Miesje M Nijs
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Community Ment Health J 50:127-34. 2014
    ..Irrespective of the causal background of this association, school safety deserves attention either as a risk factor or as an indicator of mental health problems. ..
  34. doi Does assessment type matter? A measurement invariance analysis of online and paper and pencil assessment of the Community Assessment of Psychic Experiences (CAPE)
    Marloes Vleeschouwer
    Brain Center Rudolf Magnus, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 9:e84011. 2014
    ..The aim of this study is to test whether the factor structure of the Community Assessment of Psychic Experiences (CAPE) is measurement invariant with respect to online vs. paper and pencil assessment...
  35. doi Epigenetic dynamics in psychiatric disorders: environmental programming of neurodevelopmental processes
    Daniel Kofink
    Department of Neuroscience and Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurosci Biobehav Rev 37:831-45. 2013
    ..We present the current state of knowledge and show that integrative approaches are necessary to further understand the causal pathways between environmental influences, epigenetic modification, and neuronal function...
  36. ncbi Time-dependent changes in altruistic punishment following stress
    Christiaan H Vinkers
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands Electronic address
    Psychoneuroendocrinology 38:1467-75. 2013
    ..Thus, our findings underscore the importance of time as a factor in simple, real-life economic decisions in a stressful social context...
  37. doi The effectiveness of restarted lithium treatment after discontinuation: reviewing the evidence for discontinuation-induced refractoriness
    Christine de Vries
    Altrecht Institute for Mental Health Care, Utrecht, The Netherlands
    Bipolar Disord 15:645-9. 2013
    ..We sought to determine whether the risk of relapse in patients with bipolar disorder is higher after discontinuation and restart of lithium treatment as compared to continuous lithium treatment in these same patients...
  38. pmc Season of sampling and season of birth influence serotonin metabolite levels in human cerebrospinal fluid
    Jurjen J Luykx
    Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    PLoS ONE 7:e30497. 2012
    ..Animal studies have revealed seasonal patterns in cerebrospinal fluid (CSF) monoamine (MA) turnover. In humans, no study had systematically assessed seasonal patterns in CSF MA turnover in a large set of healthy adults...
  39. doi The prevalence and pharmacotherapy of depression in cancer patients
    Chong Guan Ng
    Julius Center for Health Sciences and Primary Care, University Medical Centre, Utrecht, The Netherlands
    J Affect Disord 131:1-7. 2011
    ..We investigate the prevalence of depression in cancer and review the current state of evidence regarding the effectiveness of drug treatment of depression in this group...
  40. ncbi Increased psychophysiological parameters of attention in non-psychotic individuals with auditory verbal hallucinations
    Remko van Lutterveld
    Neuroscience Division, University Medical Center Utrecht and Rudolf Magnus Institute for Neuroscience, Utrecht, The Netherlands
    Schizophr Res 121:153-9. 2010
    ..However, AVH are part of extensive and variable symptomatology in schizophrenia. For this reason non-psychotic individuals with AVH as an isolated symptom provide an excellent opportunity to investigate this relationship...
  41. doi Long-term response to successful acute pharmacological treatment of psychotic depression
    Jaap Wijkstra
    Rudolf Magnus Institute of Neuroscience, Department of Psychiatry, University Medical Center Utrecht, Utrecht, The Netherlands
    J Affect Disord 123:238-42. 2010
    ..Data about follow-up after acute pharmacological treatment of psychotic depression are scarce...
  42. ncbi Neurological soft signs discriminating mood disorders from first episode schizophrenia
    M P M Boks
    Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Acta Psychiatr Scand 110:29-35. 2004
    ..To investigate the specificity of neurological soft signs (NSS) for first episode schizophrenia compared with mood disorders...
  43. ncbi Influence of antipsychotic agents on neurological soft signs and dyskinesia in first episode psychosis
    Marco P M Boks
    Nottinghamshire Healthcare Trust, Queens Medical Centre, Psychiatry Outpatients, B Floor South Block, Nottingham NG7 2UH, UK
    Psychiatry Res 119:167-70. 2003
    ..This suggests that the type of antipsychotic medication does not influence NSS, but that atypical antipsychotics are associated with less dyskinesia in the early stages of treatment...