Willeke A M Blokx

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. ncbi Retinoids strongly and selectively correlate with keratin 13 and not keratin 19 expression in cutaneous warts of renal transplant recipients
    Willeke A M Blokx
    Department of Pathology, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Arch Dermatol 138:61-5. 2002
  2. ncbi Initial spontaneous remission of posttransplantation Epstein Barr virus-related B-cell lymphoproliferative disorder of the skin in a renal transplant recipient: case report and review of the literature on cutaneous B-cell posttransplantation lymphoprolife
    Willeke A M Blokx
    Department of Pathology, University Medical Center St Radboud, Nijmegen, The Netherland
    Am J Dermatopathol 24:414-22. 2002
  3. doi Expression of p14ARF, p16INK4a and p53 in relation to HPV in (pre-)malignant squamous skin tumours
    Heidi V N Küsters-Vandevelde
    Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Cell Mol Med 13:2148-57. 2009
  4. ncbi Fluorescence diagnosis in keratinocytic intraepidermal neoplasias
    Tim Smits
    Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Am Acad Dermatol 57:824-31. 2007
  5. doi Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination
    Erik H J G Aarntzen
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    Cancer Res 73:19-29. 2013
  6. doi Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4+ and CD8+ T cells responses in stage III and IV melanoma patients
    Erik H J G Aarntzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Clin Cancer Res 18:5460-70. 2012
  7. ncbi Acitretin treatment in (pre)malignant skin disorders of renal transplant recipients: Histologic and immunohistochemical effects
    Jurgen V Smit
    Departments of Dermatology, University Medical Center, Nijmegen, The Netherlands
    J Am Acad Dermatol 50:189-96. 2004
  8. doi Fluorescence diagnosis in actinic keratosis and squamous cell carcinoma
    Marloes M Kleinpenning
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Photodermatol Photoimmunol Photomed 26:297-302. 2010
  9. ncbi Aneuploidy and proliferation in keratinocytic intraepidermal neoplasias
    Tim Smits
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Exp Dermatol 16:81-6. 2007
  10. ncbi INK4-ARF and p53 mutations in metastatic cutaneous squamous cell carcinoma: case report and archival study on the use of Ink4a-ARF and p53 mutation analysis in identification of the corresponding primary tumor
    Willeke A M Blokx
    Department of Pathology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Surg Pathol 29:125-30. 2005

Collaborators

Detail Information

Publications25

  1. ncbi Retinoids strongly and selectively correlate with keratin 13 and not keratin 19 expression in cutaneous warts of renal transplant recipients
    Willeke A M Blokx
    Department of Pathology, University Medical Center St Radboud, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Arch Dermatol 138:61-5. 2002
    ..To compare the expression of keratin (K) 13 and K19 in cutaneous warts of renal transplant recipients (RTRs) and immunocompetent individuals (ICIs)...
  2. ncbi Initial spontaneous remission of posttransplantation Epstein Barr virus-related B-cell lymphoproliferative disorder of the skin in a renal transplant recipient: case report and review of the literature on cutaneous B-cell posttransplantation lymphoprolife
    Willeke A M Blokx
    Department of Pathology, University Medical Center St Radboud, Nijmegen, The Netherland
    Am J Dermatopathol 24:414-22. 2002
    ....
  3. doi Expression of p14ARF, p16INK4a and p53 in relation to HPV in (pre-)malignant squamous skin tumours
    Heidi V N Küsters-Vandevelde
    Department of Pathology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Cell Mol Med 13:2148-57. 2009
    ..P14, p16 and p53 expressions are independent of immune status. Our data indicate that in immunosuppressed patients, beta-PV together with ultraviolet radiation act synergetic in promoting carcinogenesis...
  4. ncbi Fluorescence diagnosis in keratinocytic intraepidermal neoplasias
    Tim Smits
    Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Am Acad Dermatol 57:824-31. 2007
    ..As different tissue types have distinct capabilities to accumulate protoporphyrin-IX, fluorescence diagnosis with aminolevulinic acid-induced porphyrin (FDAP) could be used to discriminate between different tissue types...
  5. doi Targeting CD4(+) T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination
    Erik H J G Aarntzen
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre RUNMC, Nijmegen, The Netherlands
    Cancer Res 73:19-29. 2013
    ..0089). In conclusion, coactivating TAA-specific CD4(+) T-helper cells with DCs pulsed with both MHC class I and II-restricted epitopes augments TAA-specific CD8(+) T-cell responses, contributing to improved clinical responses...
  6. doi Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4+ and CD8+ T cells responses in stage III and IV melanoma patients
    Erik H J G Aarntzen
    Department of Tumor Immunology, Nijmegen Centre for Molecular Life Sciences, Nijmegen, The Netherlands
    Clin Cancer Res 18:5460-70. 2012
    ..We investigated the immunologic and clinical responses to vaccination with mRNA-electroporated DC in stage III and IV melanoma patients...
  7. ncbi Acitretin treatment in (pre)malignant skin disorders of renal transplant recipients: Histologic and immunohistochemical effects
    Jurgen V Smit
    Departments of Dermatology, University Medical Center, Nijmegen, The Netherlands
    J Am Acad Dermatol 50:189-96. 2004
    ..However, no histologic and immunohistochemical studies have been performed to further substantiate these observations...
  8. doi Fluorescence diagnosis in actinic keratosis and squamous cell carcinoma
    Marloes M Kleinpenning
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Photodermatol Photoimmunol Photomed 26:297-302. 2010
    ..Previous results demonstrated higher fluorescence ratios in squamous cell carcinoma (SCC) compared with actinic keratoses (AKs)...
  9. ncbi Aneuploidy and proliferation in keratinocytic intraepidermal neoplasias
    Tim Smits
    Department of Dermatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Exp Dermatol 16:81-6. 2007
    ..Ki67 expression appears a valuable marker in the classification of KINs...
  10. ncbi INK4-ARF and p53 mutations in metastatic cutaneous squamous cell carcinoma: case report and archival study on the use of Ink4a-ARF and p53 mutation analysis in identification of the corresponding primary tumor
    Willeke A M Blokx
    Department of Pathology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Surg Pathol 29:125-30. 2005
    ..The major limitation was formed by insufficient DNA quality in archival tissue...
  11. doi CDKN2A but not TP53 mutations nor HPV presence predict poor outcome in metastatic squamous cell carcinoma of the skin
    Heidi V N Küsters-Vandevelde
    Department of Pathology, Canisius Wilhelmina Hospital, 6500 GS Nijmegen, The Netherlands
    Int J Cancer 126:2123-32. 2010
    ..In most cases, CDKN2A and TP53 mutations are early genetic events in CSCC tumorigenesis. The possible role of HPV in metastatic CSCC needs further exploration...
  12. ncbi CDKN2A (INK4A-ARF) mutation analysis to distinguish cutaneous melanoma metastasis from a second primary melanoma
    Willeke A M Blokx
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Surg Pathol 31:637-41. 2007
    ..This case illustrates that molecular analysis can contribute to the sometimes-difficult differentiation between a second primary melanoma and a melanoma metastasis...
  13. doi Metastatic melanoma mimicking solitary fibrous tumor: report of two cases
    Elise M Bekers
    Department of Pathology, Radboud University Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Virchows Arch 464:247-51. 2014
    ..Mutational analysis detected BRAF and NRAS mutations in the primary and secondary lesions, respectively. This result confirmed the diagnosis of recurrent/metastastic melanoma. ..
  14. ncbi NRAS mutations are more prevalent than KIT mutations in melanoma of the female urogenital tract-A study of 24 cases from the Netherlands
    Adriana C H van Engen-van Grunsven
    Department of Pathology, Radboud University Medical Center, P O Box 9101, Nijmegen, 6500 HB, The Netherlands Electronic address
    Gynecol Oncol 134:10-4. 2014
    ..The aim of this study was to evaluate a series of primary melanomas of the female urogenital tract for oncogenic mutations in KIT, NRAS and BRAF in order to identify patients who may be amenable to targeted therapy...
  15. pmc Early identification of antigen-specific immune responses in vivo by [18F]-labeled 3'-fluoro-3'-deoxy-thymidine ([18F]FLT) PET imaging
    Erik H J G Aarntzen
    Department of Tumor Immunology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 108:18396-9. 2011
    ..This technique allows for early discrimination of responding from nonresponding patients in anti-cancer vaccination and aid physicians in individualized decisionmaking...
  16. ncbi Type I collagen synthesis parallels the conversion of keratinocytic intraepidermal neoplasia to cutaneous squamous cell carcinoma
    Leon C L T van Kempen
    Department of Pathology, University Medical Centre Nijmegen, The Netherlands
    J Pathol 204:333-9. 2004
    ..These data indicate that type I collagen synthesis by fibroblasts parallels the malignant transformation of human KIN to cSCC...
  17. doi No non-sentinel node involvement in melanoma patients with limited Breslow thickness and low sentinel node tumour load
    Thomas Bogenrieder
    Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands
    Histopathology 59:318-26. 2011
    ..The aim of the present study was to predict the absence of non-SN metastases in a multicentre study of patients with a positive SN based on primary melanoma features and SN tumour load...
  18. ncbi P16 and p53 expression in (pre)malignant epidermal tumors of renal transplant recipients and immunocompetent individuals
    Willeke A M Blokx
    Department of Pathology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Mod Pathol 16:869-78. 2003
    ..Furthermore, HKIN lesions express significantly more p16 than LKINs and SCCs...
  19. doi In vivo diagnosis of basal cell carcinoma subtype by reflectance confocal microscopy
    Malou Peppelman
    Department of Dermatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Dermatology 227:255-62. 2013
    ..Currently, RCM is mainly used for the diagnosis of melanoma and nonmelanoma skin cancer including basal cell carcinoma (BCC). Until now, it has not been possible to distinguish between subtypes of BCC using RCM...
  20. doi Preparing pathology for personalized medicine: possibilities for improvement of the pre-analytical phase
    Patricia J T A Groenen
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Histopathology 59:1-7. 2011
    ..Optimal, standardized procedures are crucial if a high standard of test results is to be achieved, which is what each patient deserves...
  21. pmc Improved discrimination of melanotic schwannoma from melanocytic lesions by combined morphological and GNAQ mutational analysis
    Heidi V N Küsters-Vandevelde
    Department of Pathology, Canisius Wilhelmina Hospital, Nijmegen, The Netherlands
    Acta Neuropathol 120:755-64. 2010
    ..We conclude that a detailed analysis of morphology combined with GNAQ mutational analysis can aid in the differential diagnosis of melanotic schwannoma with leptomeningeal melanocytic lesions...
  22. pmc Clinical characteristics of cutaneous melanoma and second primary malignancies in a dutch hospital-based cohort of cutaneous melanoma patients
    Haike M J van der Velden
    Department of Dermatology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Dermatol Res Pract 2009:479183. 2009
    ..In conclusion, 48 patients developed a subsequent malignancy. As nonmelanoma skin cancer is the most frequent second malignancy, our results subscribe to the necessity of follow-up by a dermatologist...
  23. doi Development of carcinoid tumour in hormonally treated adenocarcinoma of the prostate
    Joery P F Molenaar
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Eur Urol 56:874-7; quiz 876. 2009
    ..Early recognition of the carcinoid syndrome is crucial, as surgical cure is not possible after metastasis. We provide a brief review of recent literature...
  24. pmc Ultrastructural proof of polyomavirus in Merkel cell carcinoma tumour cells and its absence in small cell carcinoma of the lung
    Charlotte T A H Wetzels
    Department of Pathology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 4:e4958. 2009
    ..So far the actual presence of the virus in MCC tumour cells on a morphological level has not been demonstrated, and the presence of MCPyV in other small cell neuroendocrine carcinomas has not been studied yet...
  25. ncbi Immunohistochemical effects of temporary cessation of long-term acitretin treatment in keratinocytic intraepidermal neoplasia of renal transplant recipients
    Willeke A M Blokx
    Arch Dermatol 139:671-3. 2003