P J Blankestijn

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint MASTERPLAN: study of the role of nurse practitioners in a multifactorial intervention to reduce cardiovascular risk in chronic kidney disease patients
    Arjan D Van Zuilen
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Nephrol 21:261-7. 2008
  2. ncbi request reprint Sympathetic hyperactivity--a hidden enemy in chronic kidney disease patients
    Peter J Blankestijn
    Department of Nephrology, University Medical Center, Utrecht, Netherlands
    Perit Dial Int 27:S293-7. 2007
  3. ncbi request reprint Sympathetic hyperactivity in haemodialysis patients is reduced by short daily haemodialysis
    Oliver Zilch
    DIANET Dialysis Centers Utrecht, Utrecht, The Netherlands
    J Hypertens 25:1285-9. 2007
  4. pmc Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity
    Eva E Vink
    Department of Nephrology, University Medical Center Utrecht Utrecht, Netherlands
    Front Physiol 3:29. 2012
  5. pmc Differences between hospitals in attainment of parathyroid hormone treatment targets in chronic kidney disease do not reflect differences in quality of care
    Mieke J Peeters
    Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Nephrol 13:82. 2012
  6. pmc Effect of online hemodiafiltration on all-cause mortality and cardiovascular outcomes
    Muriel P C Grooteman
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Soc Nephrol 23:1087-96. 2012
  7. pmc Fibroblast growth factor 23 is associated with proteinuria and smoking in chronic kidney disease: an analysis of the MASTERPLAN cohort
    Marc G Vervloet
    Department of Nephrology and ICaR VU, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Nephrol 13:20. 2012
  8. pmc An animal paired crossover ePTFE arteriovenous graft model
    Abdelkarime K Jahrome
    Department of Vascular Surgery, The Netherlands
    Ann Surg Innov Res 4:7. 2010
  9. pmc Clinical profile of eprosartan: a different angiotensin II receptor blocker
    P J Blankestijn
    Department of Nephrology, University Medical Center, Utrecht, The Netherlands
    Cardiovasc Hematol Agents Med Chem 6:253-7. 2008
  10. doi request reprint Hemodiafiltration: clinical evidence and remaining questions
    Peter J Blankestijn
    Department of Nephrology, University Medical Center, Utrecht, The Netherlands
    Kidney Int 77:581-7. 2010

Collaborators

Detail Information

Publications47

  1. ncbi request reprint MASTERPLAN: study of the role of nurse practitioners in a multifactorial intervention to reduce cardiovascular risk in chronic kidney disease patients
    Arjan D Van Zuilen
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Nephrol 21:261-7. 2008
    ..Moreover, in only 1 patient were all risk factors within the limits as defined in various guidelines, which underscores the relevance of our initiative...
  2. ncbi request reprint Sympathetic hyperactivity--a hidden enemy in chronic kidney disease patients
    Peter J Blankestijn
    Department of Nephrology, University Medical Center, Utrecht, Netherlands
    Perit Dial Int 27:S293-7. 2007
    ....
  3. ncbi request reprint Sympathetic hyperactivity in haemodialysis patients is reduced by short daily haemodialysis
    Oliver Zilch
    DIANET Dialysis Centers Utrecht, Utrecht, The Netherlands
    J Hypertens 25:1285-9. 2007
    ..Haemodialysis patients often have sympathetic hyperactivity. The hypothesis of this study was that a switch from three times weekly to short daily dialysis could affect sympathetic hyperactivity...
  4. pmc Evidence and consequences of the central role of the kidneys in the pathophysiology of sympathetic hyperactivity
    Eva E Vink
    Department of Nephrology, University Medical Center Utrecht Utrecht, Netherlands
    Front Physiol 3:29. 2012
    ..As a consequence, renal denervation may be an attractive option to treat sympathetic hyperactivity. The review will also focus on first results and the still remaining questions of this new treatment option...
  5. pmc Differences between hospitals in attainment of parathyroid hormone treatment targets in chronic kidney disease do not reflect differences in quality of care
    Mieke J Peeters
    Department of Nephrology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    BMC Nephrol 13:82. 2012
    ..In this analysis we explored additional parameters to explain differences between centers in attainment of parathyroid hormone (PTH) treatment targets...
  6. pmc Effect of online hemodiafiltration on all-cause mortality and cardiovascular outcomes
    Muriel P C Grooteman
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Soc Nephrol 23:1087-96. 2012
    ..On-treatment analysis suggests the possibility of a survival benefit among patients who receive high-volume hemodiafiltration, although this subgroup finding requires confirmation...
  7. pmc Fibroblast growth factor 23 is associated with proteinuria and smoking in chronic kidney disease: an analysis of the MASTERPLAN cohort
    Marc G Vervloet
    Department of Nephrology and ICaR VU, VU University Medical Centre, Amsterdam, The Netherlands
    BMC Nephrol 13:20. 2012
    ..The relation of FGF23 with other renal and non-renal cardiovascular risk factors is not well established...
  8. pmc An animal paired crossover ePTFE arteriovenous graft model
    Abdelkarime K Jahrome
    Department of Vascular Surgery, The Netherlands
    Ann Surg Innov Res 4:7. 2010
    ..This model was limited concerning graft length. In the present technical report, we describe a modification of our model allowing the assessment of long AVGs...
  9. pmc Clinical profile of eprosartan: a different angiotensin II receptor blocker
    P J Blankestijn
    Department of Nephrology, University Medical Center, Utrecht, The Netherlands
    Cardiovasc Hematol Agents Med Chem 6:253-7. 2008
    ..The distinct properties of this non-biphenyl, non-tetrazole ARB might be relevant in the effort to reduce cardiovascular risk, also beyond its blood pressure lowering capacity...
  10. doi request reprint Hemodiafiltration: clinical evidence and remaining questions
    Peter J Blankestijn
    Department of Nephrology, University Medical Center, Utrecht, The Netherlands
    Kidney Int 77:581-7. 2010
    ..However, this technique is offered to only a minority of patients. In this review, we summarize the available clinical evidence on hemodiafiltration and define still remaining questions...
  11. pmc Role of residual renal function in phosphate control and anemia management in chronic hemodialysis patients
    E Lars Penne
    Department of Nephrology, Room F03 223, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Clin J Am Soc Nephrol 6:281-9. 2011
    ..The aim of this study was to investigate the role of RRF, expressed as GFR, in phosphate and anemia management in chronic HD patients...
  12. ncbi request reprint Nurse practitioners improve quality of care in chronic kidney disease: two-year results of a randomised study
    A D van Zuilen
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neth J Med 69:517-26. 2011
    ..Here we evaluate whether strict implementation of guidelines aimed at multiple targets with the aid of nurse practitioners (NP) improves management in patients with CKD...
  13. doi request reprint Short-term effects of online hemodiafiltration on phosphate control: a result from the randomized controlled Convective Transport Study (CONTRAST)
    E Lars Penne
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Kidney Dis 55:77-87. 2010
    ..Hyperphosphatemia is an independent risk factor for all-cause and cardiovascular mortality in hemodialysis (HD) patients. Phosphate control often is unsuccessful using conventional dialysis therapies...
  14. ncbi request reprint Hospital specific factors affect quality of blood pressure treatment in chronic kidney disease
    A D van Zuilen
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neth J Med 69:229-36. 2011
    ..Several determinants have been identified which affect BP control. In the current analysis we evaluated differences in achieved BP and achievement of the BP goal between hospitals and explored possible explanations...
  15. pmc Percutaneous renal denervation for the treatment of resistant essential hypertension; the first Dutch experience
    M Voskuil
    Department of Cardiology, University Medical Center Utrecht, Room E 01 207, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Neth Heart J 19:319-23. 2011
    ..In this paper we describe our first experience with a novel percutaneous treatment modality using renal artery radiofrequency (RF) ablation...
  16. ncbi request reprint Graft surveillance: venous pressure, access flow, or the combination?
    J H Smits
    Department of Nephrology, University Medical Center, The Netherlands
    Kidney Int 59:1551-8. 2001
    ..The aims of our randomized multicenter studies were to compare outcome in patients with grafts monitored by VP or Qa (study A) or monitored by VP or the combination of VP and Qa (study B)...
  17. ncbi request reprint Cardiovascular risk factors in renal transplant patients: cyclosporin A versus tacrolimus
    G Ligtenberg
    Department of Nephrology and Hypertension, University Medical Center, Room F03 226, Post Box 85500, 3508 GA, Utrecht, The Netherlands
    J Am Soc Nephrol 12:368-73. 2001
    ..Elective conversion from CsA to tacrolimus in stable renal transplant recipients may lead to attenuation of cardiovascular morbidity and chronic transplant nephropathy in the long term...
  18. doi request reprint Cryoplasty of the venous anastomosis for prevention of intimal hyperplasia in a validated porcine arteriovenous graft model
    H J T A M Huijbregts
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Vasc Endovasc Surg 39:620-6. 2010
    ..In this animal study, we investigated if preventive cryoplasty could reduce intimal hyperplasia (IH) at the venous anastomosis...
  19. ncbi request reprint MRA of hemodialysis access grafts and fistulae using selective contrast injection and flow interruption
    C Bos
    Department of Radiology, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Magn Reson Med 45:557-61. 2001
    ..When filling is satisfactory, a 3D acquisition is started. The feasibility of this selective contrast-enhanced MR angiography technique is demonstrated in four Cimino-fistulae and four PTFE grafts. Magn Reson Med 45:557-561, 2001...
  20. ncbi request reprint Sympathetic activity is increased in polycystic kidney disease and is associated with hypertension
    I H Klein
    Department of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands
    J Am Soc Nephrol 12:2427-33. 2001
    ..This study indicates that MSNA is increased in hypertensive PKD patients regardless of renal function. The data support the idea that sympathetic hyperactivity contributes to the pathogenesis of hypertension in PKD...
  21. doi request reprint Aliskiren reduces sympathetic nerve activity and blood pressure in chronic kidney disease patients
    Laima Siddiqi
    Department of Nephrology and Hypertension, University Medical Centre Utrecht, Utrecht, The Netherlands
    Nephrol Dial Transplant 26:2930-4. 2011
    ..Hypertensive chronic kidney disease (CKD) patients often have sympathetic hyperactivity. In this pilot study, we evaluated the effect of 6 weeks treatment with aliskiren on sympathetic activity in hypertensive Stages 2-4 CKD patients...
  22. ncbi request reprint Sympathetic hyperactivity in chronic kidney disease: pathogenesis, clinical relevance, and treatment
    Jutta Neumann
    Department of Nephrology, University Medical Center Utrecht, The Netherlands
    Kidney Int 65:1568-76. 2004
    ....
  23. ncbi request reprint Rationale and design of the MASTERPLAN study: Multifactorial approach and superior treatment efficacy in renal patients with the aid of nurse practitioners
    Arjan D Van Zuilen
    Department of Nephrology and Hypertension, University Medical Center Utrecht The Netherlands
    J Nephrol 18:30-4. 2005
    ..We propose that this will also hold for the CKD population...
  24. ncbi request reprint Sympathetic nerve activity is inappropriately increased in chronic renal disease
    Inge H H T Klein
    Departments of Nephrology and Clinical Neurophysiology, University Medical Center Utrecht, The Netherlands
    J Am Soc Nephrol 14:3239-44. 2003
    ..It is concluded that in hypertensive patients with renal parenchymal disease, sympathetic activity is inappropriately high for the volume status and that reduction of nephron number in itself does not influence sympathetic activity...
  25. ncbi request reprint Sympathetic hyperactivity in hypertensive chronic kidney disease patients is reduced during standard treatment
    Jutta Neumann
    Department of Nephrology, University Medical Center, Utrecht, The Netherlands
    Hypertension 49:506-10. 2007
    ..In conclusion, sympathetic hyperactivity occurs in a substantial proportion of hypertensive CKD patients. Angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker treatment reduces but does not normalize MSNA...
  26. ncbi request reprint Volume-independent mechanisms of hypertension in hemodialysis patients: clinical implications
    Peter J Blankestijn
    Department of Nephrology, University Medical Center, Utrecht, The Netherlands
    Semin Dial 17:265-9. 2004
    ..Medications aimed at reducing renin and sympathetic activity may improve the cardiovascular prognosis, independent of its effect on blood pressure. This knowledge has important implications for the choice of treatment in HD patients...
  27. ncbi request reprint Sympathetic activation markedly reduces endothelium-dependent, flow-mediated vasodilation
    Michel L Hijmering
    Department of Internal Medicine, Eemland Hospital, Amersfoort, The Netherlands
    J Am Coll Cardiol 39:683-8. 2002
    ..We sought to evaluate whether increased sympathetic outflow may interfere with flow-mediated dilation (FMD)...
  28. doi request reprint Decreased access resistance in haemodialysis patients with upper arm arteriovenous fistulae
    Wil A M A van der Mark
    Nephrol Dial Transplant 23:2105-6; author reply 2106-7. 2008
  29. doi request reprint Short-term sympathetic baroreflex sensitivity increases at lower blood pressures
    Leonard J van Schelven
    Department of Medical Technology and Clinical Physics, University Medical Center Utrecht, The Netherlands
    Clin Neurophysiol 119:869-79. 2008
    ..SymBRS is known to vary with conditions, for instance during cold pressor testing. We investigated whether symBRS is affected by infusions of phenylephrine and nitroprusside...
  30. pmc Hemodialysis arteriovenous fistula patency revisited: results of a prospective, multicenter initiative
    Henricus J T Huijbregts
    University Medical Center Utrecht, Department of Nephrology, 3508 GA Utrecht, The Netherlands
    Clin J Am Soc Nephrol 3:714-9. 2008
    ..This prospective, multicenter study used standardized definitions to analyze patency rates and potential risk factors that affect functional patency and late arteriovenous fistula functionality...
  31. ncbi request reprint Haemodiafiltration: promise for the future?
    Neelke C van der Weerd
    Nephrol Dial Transplant 23:438-43. 2008
  32. ncbi request reprint Short- and long-term functional effects of percutaneous transluminal angioplasty in hemodialysis vascular access
    Joke van der Linden
    Department of Internal Medicine, Rijnmond Zuid Medical Center, Clara Location, Rotterdam, The Netherlands
    J Am Soc Nephrol 13:715-20. 2002
    ..Qa values before PTA and the increase in Qa were correlated with long-term outcomes, whereas angiographic results were not. These data, combined with literature data, suggest that there is optimal timing for PTA...
  33. ncbi request reprint Underestimation of access flow by ultrasound dilution flow measurements
    Clemens Bos
    Image Sciences Institute, University Medical Center Utrecht, The Netherlands
    Phys Med Biol 47:481-9. 2002
    ..Apart from the ultrasound dilution technique, these findings are applicable to other recently proposed methods for measuring access flow that employ the reversed needle configuration...
  34. ncbi request reprint Percutaneous thrombolysis of thrombosed haemodialysis access grafts: comparison of three mechanical devices
    Henk F M Smits
    Department of Radiology, University Medical Center, Utrecht, The Netherlands
    Nephrol Dial Transplant 17:467-73. 2002
    ....
  35. ncbi request reprint Subtle involvement of the sympathetic nervous system in amyotrophic lateral sclerosis
    P Liam Oey
    Department of Clinical Neurophysiology, The Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Muscle Nerve 25:402-8. 2002
    ..The higher sympathetic activity is postulated to be due to changes in modulation of the sympathetic system, whereas the absence of the SSR is probably caused by disruption of the reflex pathway...
  36. ncbi request reprint Hemodialysis access imaging: comparison of flow-interrupted contrast-enhanced MR angiography and digital subtraction angiography
    Johannes H M Smits
    Department of Nephrology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Radiology 225:829-34. 2002
    ..To compare flow-interrupted contrast material-enhanced magnetic resonance (MR) angiography with conventional digital subtraction angiography (DSA) for hemodialysis access imaging...
  37. ncbi request reprint Enalapril and losartan reduce sympathetic hyperactivity in patients with chronic renal failure
    Inge H H T Klein
    Department of Nephrology, University Medical Center Utrecht, The Netherlands
    J Am Soc Nephrol 14:425-30. 2003
    ....
  38. ncbi request reprint Sympathetic hyperactivity in chronic renal failure: a wake-up call
    Hein A Koomans
    Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Soc Nephrol 15:524-37. 2004
    ..After discussion of mechanisms and effects of the sympathetic hyperactivity, a case is made for increased application of specific adrenergic blockers in patients with CRF...
  39. ncbi request reprint Sympathetic hyperactivity in chronic kidney disease
    Peter J Blankestijn
    Nephrol Dial Transplant 19:1354-7. 2004
  40. ncbi request reprint Moxonidine normalizes sympathetic hyperactivity in patients with eprosartan-treated chronic renal failure
    Jutta Neumann
    Department of Nephrology, University Medical Center, Utrecht, The Netherlands
    J Am Soc Nephrol 15:2902-7. 2004
    ..Sympathetic hyperactivity is associated with poor cardiovascular outcomes, implying that reduction might be beneficial to the patients. The addition of moxonidine to angiotensin II antagonist treatment might be appropriate...
  41. ncbi request reprint Hemodialysis access graft failure: time to revisit an unmet clinical need?
    Joris I Rotmans
    Department of Vascular Medicine, Academic Medical Center, Amsterdam The Netherlands
    J Nephrol 18:9-20. 2005
    ..Simultaneously, continuous efforts should be undertaken to increase the percentage of patients utilizing AV fistulas, which remains the best form of permanent vascular access (VA) for HD...
  42. ncbi request reprint Forearm venous distensibility predicts successful arteriovenous fistula
    Joke van der Linden
    Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands
    Am J Kidney Dis 47:1013-9. 2006
    ..This maturation fails in up to 50%. We hypothesize that impairment of forearm venous distensibility, ie, the ability of veins to adjust to increased pressure, is related to AVF failure...
  43. ncbi request reprint End-stage renal disease causes an imbalance between endothelial and smooth muscle progenitor cells
    Peter E Westerweel
    Dept of Vascular Medicine, F02 126, Univ Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Am J Physiol Renal Physiol 292:F1132-40. 2007
    ..This EPC-SPC imbalance may contribute to the acceleration of CVD in ESRD patients and could offer novel therapeutic targets...
  44. ncbi request reprint Resolving controversies regarding hemodiafiltration versus hemodialysis: the Dutch Convective Transport Study
    E Lars Penne
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    Semin Dial 18:47-51. 2005
    ..This prospective randomized trial was designed to compare online hemodiafiltration with low-flux hemodialysis with respect to cardiovascular morbidity and mortality...
  45. ncbi request reprint Accelerated increase of arteriovenous fistula use in haemodialysis centres: results of the multicentre CIMINO initiative
    Henricus J T A M Huijbregts
    Department of Nephrology, Julius Centre for Health Sciences and Primary Care, University Medical Center Utrecht, Room F03 223, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Nephrol Dial Transplant 22:2595-600. 2007
    ..A multicentre guidelines implementation programme, CIMINO, was initiated aiming at increasing the use of AVFs...
  46. ncbi request reprint Hospital specific aspects predominantly determine primary failure of hemodialysis arteriovenous fistulas
    Henricus J T A M Huijbregts
    Department of Nephrology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 45:962-7. 2007
    ....
  47. ncbi request reprint Contribution of volume overload and angiotensin II to the increased pulse wave velocity of hemodialysis patients
    J L Tycho Vuurmans
    Department of Nephrology and Hypertension, University Medical Center, Utrecht, The Netherlands
    J Am Soc Nephrol 13:177-83. 2002
    ..Monitoring and correcting of arterial pressure waves is feasible and may be an important tool in the treatment of patients with end-stage renal disease...