Johannes W J Bijlsma

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi Low-dose glucocorticoid therapy in rheumatoid arthritis: an obligatory therapy
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann N Y Acad Sci 1193:123-6. 2010
  2. ncbi Osteoarthritis: an update with relevance for clinical practice
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet 377:2115-26. 2011
  3. ncbi Patient benefit-risk in arthritis--a rheumatologist's perspective
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Rheumatology (Oxford) 49:ii11-17. 2010
  4. ncbi Are glucocorticoids DMARDs?
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Box 85 500, 3508 GA Utrecht, The Netherlands
    Ann N Y Acad Sci 1069:268-74. 2006
  5. ncbi Optimal treatment of rheumatoid arthritis: EULAR recommendations for clinical practice
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, The Netherlands
    Pol Arch Med Wewn 120:347-53. 2010
  6. ncbi [Local treatment for persistent inflammatory arthritis of the knee: intra-articular injection of glucocorticoids and bed rest]
    J W J Bijlsma
    Universitair Medisch Centrum Utrecht, Utrecht
    Ned Tijdschr Geneeskd 152:1956-8. 2008
  7. ncbi Neuroendocrine immune system involvement in rheumatology
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Ann N Y Acad Sci 1069:xviii-xxiv. 2006
  8. ncbi [Further definition of the role of COX-2 inhibitors and NSAIDs in patients with nociceptive pain]
    J W J Bijlsma
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, GA Utrecht
    Ned Tijdschr Geneeskd 151:795-8. 2007
  9. ncbi Glucocorticoid chronotherapy in rheumatoid arthritis
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, 3508 GA Utrecht, Netherlands
    Lancet 371:183-4. 2008
  10. ncbi Strategies for the prevention and management of osteoarthritis of the hip and knee
    J W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, P O Box 85 500, 3508 GA, Utrecht, The Netherlands
    Best Pract Res Clin Rheumatol 21:59-76. 2007

Detail Information

Publications156 found, 100 shown here

  1. ncbi Low-dose glucocorticoid therapy in rheumatoid arthritis: an obligatory therapy
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann N Y Acad Sci 1193:123-6. 2010
    ..It becomes clear that the net effect of low-dose GCs in the treatment of rheumatoid arthritis favors the beneficial aspects of these drugs above the negative aspects. Prudent use of GCs can be recommended...
  2. ncbi Osteoarthritis: an update with relevance for clinical practice
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet 377:2115-26. 2011
    ..In the coming years, a better definition of osteoarthritis is expected by delineating different phenotypes of the disease. Treatment targeted more specifically at these phenotypes might lead to improved outcomes...
  3. ncbi Patient benefit-risk in arthritis--a rheumatologist's perspective
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Rheumatology (Oxford) 49:ii11-17. 2010
    ..Rheumatologists must be vigilant in assessing benefit-risk when prescribing a Cox-2 selective inhibitor or non-selective NSAID and should choose appropriate agents for each individual patient...
  4. ncbi Are glucocorticoids DMARDs?
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Box 85 500, 3508 GA Utrecht, The Netherlands
    Ann N Y Acad Sci 1069:268-74. 2006
    ..The evidence is carefully evaluated and discussed. The ultimate conclusion is that indeed glucocorticoids are DMARDs and are especially useful in early RA...
  5. ncbi Optimal treatment of rheumatoid arthritis: EULAR recommendations for clinical practice
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, The Netherlands
    Pol Arch Med Wewn 120:347-53. 2010
    ..The guidelines described in this article will help physicians to actually do so...
  6. ncbi [Local treatment for persistent inflammatory arthritis of the knee: intra-articular injection of glucocorticoids and bed rest]
    J W J Bijlsma
    Universitair Medisch Centrum Utrecht, Utrecht
    Ned Tijdschr Geneeskd 152:1956-8. 2008
    ..There are some indications that a period of strict bed rest after treatment is beneficial. Intra-articular glucocorticoids should not be administered more frequently than three times per year in the same joint...
  7. ncbi Neuroendocrine immune system involvement in rheumatology
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Ann N Y Acad Sci 1069:xviii-xxiv. 2006
  8. ncbi [Further definition of the role of COX-2 inhibitors and NSAIDs in patients with nociceptive pain]
    J W J Bijlsma
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, GA Utrecht
    Ned Tijdschr Geneeskd 151:795-8. 2007
    ....
  9. ncbi Glucocorticoid chronotherapy in rheumatoid arthritis
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, 3508 GA Utrecht, Netherlands
    Lancet 371:183-4. 2008
  10. ncbi Strategies for the prevention and management of osteoarthritis of the hip and knee
    J W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, P O Box 85 500, 3508 GA, Utrecht, The Netherlands
    Best Pract Res Clin Rheumatol 21:59-76. 2007
    ..Education and self-management are very important to prevent overuse and to use the joints in the most adequate way...
  11. ncbi Elevated expression of interleukin-7 receptor in inflamed joints mediates interleukin-7-induced immune activation in rheumatoid arthritis
    Sarita A Y Hartgring
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 60:2595-605. 2009
    ..To evaluate the expression and functional ability of the high-affinity interleukin-7 receptor (IL-7Ralpha) in patients with rheumatoid arthritis (RA)...
  12. ncbi Prevention of glucocorticoid induced osteoporosis with alendronate or alfacalcidol: relations of change in bone mineral density, bone markers, and calcium homeostasis
    Johannes W G Jacobs
    Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Rheumatol 34:1051-7. 2007
    ....
  13. ncbi High incidence rate of vertebral fractures during chronic prednisone treatment, in spite of bisphosphonate or alfacalcidol use. Extension of the alendronate or alfacalcidol in glucocorticoid-induced osteoporosis-trial
    Jos N Hoes
    Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, The Netherlands
    Clin Exp Rheumatol 28:354-9. 2010
    ..In the present observational open follow-up study of the STOP-trial, we report the long-term effects of risk factors on the incidence and pattern of vertebral fractures, assessed using the Genant method...
  14. ncbi Persistence of interleukin 7 activity and levels on tumour necrosis factor alpha blockade in patients with rheumatoid arthritis
    Joel A G van Roon
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 66:664-9. 2007
    ..In addition, the effect of TNFalpha blockade on IL7 activity and on IL7 levels was studied...
  15. ncbi Increase of body mass index in a tight controlled methotrexate-based strategy with prednisone in early rheumatoid arthritis: Side effect of the prednisone or better control of disease activity?
    Maud S Jurgens
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Care Res (Hoboken) 65:88-93. 2013
    ....
  16. ncbi The relation between cartilage biomarkers (C2C, C1,2C, CS846, and CPII) and the long-term outcome of rheumatoid arthritis patients within the CAMERA trial
    Marije F Bakker
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Arthritis Res Ther 13:R70. 2011
    ....
  17. ncbi Intra-articular glucocorticoid injections decrease the number of steroid hormone receptor positive cells in synovial tissue of patients with persistent knee arthritis
    Marlies C van der Goes
    Department of Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 71:1552-8. 2012
    ....
  18. ncbi Misclassification of disease activity when assessing individual patients with early rheumatoid arthritis using disease activity indices that do not include joints of feet
    Marije F Bakker
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 71:830-5. 2012
    ....
  19. ncbi Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact-dependent activation of CD4(+) T cells and macrophages
    Joel A G van Roon
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 52:1700-10. 2005
    ..To determine the level of intraarticular expression of interleukin-7 (IL-7) in patients with rheumatoid arthritis (RA) and to investigate the mechanisms by which IL-7 facilitates activation of CD4(+) T cells and monocyte/macrophages in RA...
  20. ncbi Health and physiological effects of an emotional disclosure intervention adapted for application at home: a randomized clinical trial in rheumatoid arthritis
    Henriët van Middendorp
    Department of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands
    Psychother Psychosom 78:145-51. 2009
    ..This study was the first to examine neuroendocrine and immune changes after emotional disclosure in patients with rheumatoid arthritis...
  21. ncbi A shift in the balance of inhibitory and activating Fcgamma receptors on monocytes toward the inhibitory Fcgamma receptor IIb is associated with prevention of monocyte activation in rheumatoid arthritis
    Siska Wijngaarden
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 50:3878-87. 2004
    ..A change in the FcgammaR balance toward the inhibitory FcgammaRIIb may offer a novel treatment strategy for preventing the pleiotropic activity of FcgammaR-triggered macrophages...
  22. ncbi Initiation of degenerative joint damage by experimental bleeding combined with loading of the joint: a possible mechanism of hemophilic arthropathy
    Michel J J Hooiveld
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 50:2024-31. 2004
    ..This might reflect a possible mechanism of joint damage in hemophilia...
  23. ncbi Is radiation synovectomy for arthritis of the knee more effective than intraarticular treatment with glucocorticoids? Results of an eighteen-month, randomized, double-blind, placebo-controlled, crossover trial
    Zalima N Jahangier
    Dept of Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Arthritis Rheum 52:3391-402. 2005
    ....
  24. ncbi Blockade of the interleukin-7 receptor inhibits collagen-induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators
    Sarita A Y Hartgring
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 62:2716-25. 2010
    ..To study the effects of interleukin-7 receptor α-chain (IL-7Rα) blockade on collagen-induced arthritis (CIA) and to investigate the effects on T cell numbers, T cell activity, and levels of proinflammatory mediators...
  25. ncbi Proinflammatory mediator-induced reversal of CD4+,CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis
    Jocea M R van Amelsfort
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 56:732-42. 2007
    ..The purpose of the present study was to investigate whether particular proinflammatory mediators that are associated with RA could abrogate CD4+,CD25+ Treg-mediated suppression...
  26. ncbi Impact of self-reported comorbidity on physical and mental health status in early symptomatic osteoarthritis: the CHECK (Cohort Hip and Cohort Knee) study
    Janet Wesseling
    Department of Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Rheumatology (Oxford) 52:180-8. 2013
    ..To describe the relationship between comorbidity (absolute number as well as the presence of specific comorbidities) and pain, physical functioning and mental health status of participants with early symptomatic OA of the hip or knee...
  27. ncbi Dealing with emotions when the ability to cry is hampered: emotion processing and regulation in patients with primary Sjögren's syndrome
    Ninke van Leeuwen
    Department of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands
    Clin Exp Rheumatol 30:492-8. 2012
    ..The aim of this study was to examine differences in emotion processing and regulation between people with and without Sjögren's syndrome and correlations of emotion processing and regulation with mental well-being...
  28. ncbi Changes in macrophage inhibitory factor correlate with changes in bone mineral density in glucocorticoid-treated patients with rheumatoid arthritis
    Jos N Hoes
    Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, F02 127, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Rheumatology (Oxford) 50:1921-4. 2011
    ..To investigate whether changes in bone density and turnover are associated with changes in inflammatory mediators in RA patients treated with glucocorticoids (GCs) upon vitamin D treatment in comparison with alendronate treatment...
  29. ncbi Pretreatment macrophage infiltration of the synovium predicts the clinical effect of both radiation synovectomy and intra-articular glucocorticoids
    Z N Jahangier
    Department of Rheumatology and Clinical Immunology, F02 127, University Medical Center Utrecht, Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 65:1286-92. 2006
    ..To explore whether pretreatment features of synovial tissue in patients with gonarthritis could predict the clinical effect of radiation synovectomy with yttrium-90 (90Y) and glucocorticoids or with intra-articular glucocorticoids alone...
  30. ncbi Clinical efficacy of leflunomide in primary Sjogren's syndrome is associated with regulation of T-cell activity and upregulation of IL-7 receptor α expression
    Angela Bikker
    Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 71:1934-41. 2012
    ..To investigate whether the immunomodulatory capacities of leflunomide are associated with clinical efficacy in the treatment of primary Sjögren's syndrome (SS) in a phase II pilot study...
  31. ncbi IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Rα
    Angela Bikker
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Rheumatology (Oxford) 51:996-1005. 2012
    ....
  32. ncbi Look beyond the disease activity score of 28 joints (DAS28): tender points influence the DAS28 in patients with rheumatoid arthritis
    Evelien Ton
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Rheumatol 39:22-7. 2012
    ..To explore the influence of tender points (TP) on the Disease Activity Score assessing 28 joints (DAS28) in patients with rheumatoid arthritis (RA)...
  33. ncbi Low-dose prednisone inclusion in a methotrexate-based, tight control strategy for early rheumatoid arthritis: a randomized trial
    Marije F Bakker
    Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, and Diakonessenhuis, Utrecht, The Netherlands
    Ann Intern Med 156:329-39. 2012
    ..Treatment strategies for tight control of early rheumatoid arthritis (RA) are highly effective but can be improved...
  34. ncbi Effectiveness of behavioral graded activity in patients with osteoarthritis of the hip and/or knee: A randomized clinical trial
    Cindy Veenhof
    Netherlands Institute for Health Services Research, Utrecht, The Netherlands
    Arthritis Rheum 55:925-34. 2006
    ..The BGA intervention is intended to increase activity in the long term and consists of an exercise program with booster sessions, using operant treatment principles...
  35. ncbi Prediction of vertebral fractures is specific for gender and site of bone mineral density measurement
    Johannes W G Jacobs
    Department of Rheumatology and Clinical Immunology, F02 127, University Medical Center Utrecht, Box 85500, 3508 GA Utrecht, The Netherlands
    J Rheumatol 37:149-54. 2010
    ..To investigate basic assumptions of prediction models for future vertebral fractures...
  36. ncbi Differential cytokine profiles in juvenile idiopathic arthritis subtypes revealed by cluster analysis
    Henk Jan van den Ham
    Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands
    Rheumatology (Oxford) 48:899-905. 2009
    ..In particular, we focus on juvenile idiopathic arthritis (JIA), a multifactorial autoimmune disorder that ultimately leads to chronic inflammation of the joints...
  37. ncbi Functional Health Assessment Questionnaire (HAQ) and Psychological HAQ Are Associated with and Predicted by Different Factors in Rheumatoid Arthritis
    Suzanne M M Verstappen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    J Rheumatol 34:1837-40. 2007
    ..To evaluate the association between clinical, demographic, and psychological factors and the functional Health Assessment Questionnaire (HAQ) and psychological HAQ (PSHAQ) in patients with rheumatoid arthritis (RA)...
  38. ncbi The combination of the biomarkers urinary C-terminal telopeptide of type II collagen, serum cartilage oligomeric matrix protein, and serum chondroitin sulfate 846 reflects cartilage damage in hemophilic arthropathy
    Nathalie W D Jansen
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 60:290-8. 2009
    ....
  39. ncbi CD4(+)CD25(+) regulatory T cells in rheumatoid arthritis: differences in the presence, phenotype, and function between peripheral blood and synovial fluid
    Jocea M R van Amelsfort
    University Medical Centre Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 50:2775-85. 2004
    ..We investigated the presence, phenotype, and function of CD4(+)CD25(+) regulatory T cells in peripheral blood (PB) and synovial fluid (SF) from patients with rheumatoid arthritis (RA)...
  40. ncbi Pan-DR-binding Hsp60 self epitopes induce an interleukin-10-mediated immune response in rheumatoid arthritis
    Huib de Jong
    University Medical Centre Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 60:1966-76. 2009
    ..This study was undertaken to characterize the disease specificity and function of pan-DR-binding Hsp60-derived epitopes as possible modulators of autoimmune inflammation in RA...
  41. ncbi The clinical effect of glucocorticoids in patients with rheumatoid arthritis may be masked by decreased use of additional therapies
    Amalia A van Everdingen
    University Medical Center, Utrecht, The Netherlands
    Arthritis Rheum 51:233-8. 2004
    ..We sought to investigate whether this discrepancy would extend to variables of well-being...
  42. ncbi Can simple ultrasonography predict the clinical effect of intra-articular injection therapy of the knee joint?
    Zalima N Jahangier
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Rheumatol 30:749-55. 2011
    ..Simple baseline US measurements fail to predict the final clinical effect of intra-articular treatment of the knee at 6 months, in contrast to early US changes of synovial thickness 3 months after therapy...
  43. ncbi Performance of a multi-biomarker score measuring rheumatoid arthritis disease activity in the CAMERA tight control study
    Marije F Bakker
    Correspondence to Marije F Bakker, UMC Utrecht, Department of Rheumatology and Clinical Immunology, Utrecht PO BOX 85500, The Netherlands
    Ann Rheum Dis 71:1692-7. 2012
    ....
  44. ncbi Elevation of cartilage AGEs does not accelerate initiation of canine experimental osteoarthritis upon mild surgical damage
    Petra A J M Vos
    Rheumatology and Clinical Immunology F02 127, University Medical Centre Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    J Orthop Res 30:1398-404. 2012
    ..As such, elevated AGEs do not unambiguously accelerate the development of early canine OA upon minimal surgical damage...
  45. ncbi Exposure of human cartilage tissue to low concentrations of blood for a short period of time leads to prolonged cartilage damage: an in vitro study
    Nathalie W D Jansen
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 56:199-207. 2007
    ..This study was carried out to test the in vitro thresholds of exposure time and concentration that lead to irreversible joint damage, to add to the discussion on the usefulness of aspiration of the joint after a hemorrhage...
  46. ncbi Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study
    Simon C Mastbergen
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Res Ther 8:R2. 2006
    ..NSAIDs with low COX-2/COX-1 selectivity exhibit adverse direct effects on OA cartilage, whereas high COX-2/COX-1 selective NSAIDs did not show such effects and might even have cartilage reparative properties...
  47. ncbi Which patients with osteoarthritis of hip and/or knee benefit most from behavioral graded activity?
    Cindy Veenhof
    NIVEL Netherlands Institute for Health Services Research, Utrecht, The Netherlands
    Int J Behav Med 14:86-91. 2007
    ..05). Patients with a relatively low level of physical functioning benefit more from BGA compared to UC. Compared to UC, BGA is the preferred treatment option in patients with a low level of physical functioning...
  48. ncbi Selective elimination of synovial inflammatory macrophages in rheumatoid arthritis by an Fcgamma receptor I-directed immunotoxin
    Joel A G van Roon
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 48:1229-38. 2003
    ....
  49. ncbi Followup radiographic data on patients with rheumatoid arthritis who participated in a two-year trial of prednisone therapy or placebo
    Johannes W G Jacobs
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 54:1422-8. 2006
    ..Our goal was to investigate whether this beneficial effect persisted after the end of the trial...
  50. ncbi Glucocorticoids in rheumatoid arthritis: effects on erosions and bone
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann N Y Acad Sci 966:82-90. 2002
    ..The management of the (side) effects of glucocorticoids on bone has clearly improved in the last years. These two developments lead to a further optimizing of glucocorticoid treatment in patients with rheumatoid arthritis...
  51. ncbi Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)
    S M M Verstappen
    University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 66:1443-9. 2007
    ..To investigate whether intensive treatment with methotrexate (MTX) according to a strict protocol and a computerised decision program is more beneficial compared to conventional treatment with MTX in early rheumatoid arthritis...
  52. ncbi Celecoxib: considerations regarding its potential disease-modifying properties in osteoarthritis
    Manon C Zweers
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, F02, 127, 3508 GA Utrecht, The Netherlands
    Arthritis Res Ther 13:239. 2011
    ..Can celecoxib be considered a disease-modifying osteoarthritic drug? In this review, these direct effects of celecoxib on cartilage, bone, and synoviocytes in OA treatment are discussed...
  53. ncbi Psychometric evaluation of osteoarthritis questionnaires: a systematic review of the literature
    Cindy Veenhof
    Netherlands Institute for Health Services Research, Utrecht, The Netherlands
    Arthritis Rheum 55:480-92. 2006
  54. ncbi Diversity of regulatory T cells to control arthritis
    Joel A G van Roon
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Best Pract Res Clin Rheumatol 20:897-913. 2006
    ....
  55. ncbi Cortisol during the day in patients with systemic lupus erythematosus or primary Sjogren's syndrome
    Marlies C van der Goes
    Department of Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Rheumatol 38:285-8. 2011
    ..To compare the level and change of cortisol during the day of patients with systemic lupus erythematosus (SLE) and primary Sjögren's syndrome (pSS) with low and high erythrocyte sedimentation rate (ESR)...
  56. ncbi Five-year followup of rheumatoid arthritis patients after early treatment with disease-modifying antirheumatic drugs versus treatment according to the pyramid approach in the first year
    Suzan M M Verstappen
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 48:1797-807. 2003
    ..This indicates that a more aggressive treatment approach in early RA is required, and that treatment should be continued for a prolonged period of time, in order to maintain the advantages obtained in the first year...
  57. ncbi Tissue structure modification in knee osteoarthritis by use of joint distraction: an open 1-year pilot study
    Femke Intema
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 70:1441-6. 2011
    ..Modification of joint tissue damage is challenging in late-stage osteoarthritis (OA). Few options are available for treating end-stage knee OA other than joint replacement...
  58. ncbi Selective COX-2 inhibition prevents proinflammatory cytokine-induced cartilage damage
    S C Mastbergen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Rheumatology (Oxford) 41:801-8. 2002
    ..Celecoxib, by diminishing COX-2 activity, prevents these adverse effects without having a direct effect on healthy cartilage...
  59. ncbi Steady progression of osteoarthritic features in the canine groove model
    A C A Marijnissen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Osteoarthritis Cartilage 10:282-9. 2002
    ..The present study evaluates this groove model at 20 and 40 weeks after induction, to assess whether the osteoarthritic features progress in time...
  60. ncbi The canine 'groove' model, compared with the ACLT model of osteoarthritis
    A C A Marijnissen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Osteoarthritis Cartilage 10:145-55. 2002
    ..The latter is expected to make the 'groove' model more sensitive to treatment...
  61. ncbi The intra-articular distribution of 90yttrium does not influence the clinical outcome of radiation synovectomy of the knee
    Z N Jahangier
    Department of Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 66:1110-2. 2007
    ..To assess the impact of the intra-articular distribution of (90)yttrium-citrate ((90)Y) on the clinical effect of radiosynoviorthesis (RSO) of the knee and on (90)Y leakage from this joint...
  62. ncbi A combination of illness invalidation from the work environment and helplessness is associated with embitterment in patients with FM
    David Blom
    Department of Clinical and Health Psychology, Utrecht University, PO Box 80140, 3508TC, Utrecht, The Netherlands
    Rheumatology (Oxford) 51:347-53. 2012
    ..The aim of this study in employed people with FM was to test the hypothesis that embitterment is a function of the joint experience of invalidation from the work environment and helplessness regarding one's illness...
  63. ncbi Clinical aspects of immune neuroendocrine mechanisms in rheumatic diseases
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Rheum Dis Clin North Am 31:xiii-xvi. 2005
  64. ncbi Differentiation of naive CD4+ T cells towards T helper 2 cells is not impaired in rheumatoid arthritis patients
    Joel A G van Roon
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Arthritis Res Ther 5:R269-76. 2003
    ..The perpetuation of arthritogenic T-cell activity in RA therefore seems not to be the result of intrinsic defects of naive CD4+ T cells to develop towards suppressive memory Th2 cells...
  65. ncbi Current view of glucocorticoid co-therapy with DMARDs in rheumatoid arthritis
    Jos N Hoes
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Nat Rev Rheumatol 6:693-702. 2010
    ..Better monitoring of glucocorticoid use will also improve this ratio, and help to allay both patient and rheumatologist concerns about treatment-related adverse effects...
  66. ncbi Developments in glucocorticoid therapy
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Box 85500, 3508 GA Utrecht, The Netherlands
    Rheum Dis Clin North Am 31:1-17, vii. 2005
    ..One is the improvement in new GC compounds--designer GCs, alterations in bioactivity, and alterations in formulations. The other is a better understanding and management of the toxicity of GCs...
  67. ncbi [The Dutch College of General Practitioners' "Gout" Standard: a response from rheumatologists]
    J W G Jacobs
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 146:295-6. 2002
    ..The most important criticism concerns the supposed diagnostic value of serum urate levels: close examination of the data suggests that this value is very limited...
  68. ncbi Trends in economic consequences of rheumatoid arthritis over two subsequent years
    S M M Verstappen
    University Medical Center Utrecht, The Netherlands
    Rheumatology (Oxford) 46:968-74. 2007
    ..To examine changes in direct costs and in working status over 2 yrs in patients with rheumatoid arthritis (RA)...
  69. ncbi A good response to early DMARD treatment of patients with rheumatoid arthritis in the first year predicts remission during follow up
    S M M Verstappen
    University Medical Centre Utrecht, Department of Rheumatology and Clinical Immunology, PO Box 85500, 3508 GA Utrecht, Netherlands
    Ann Rheum Dis 64:38-43. 2005
    ..To describe the frequency and duration of remission in the Utrecht rheumatoid arthritis cohort of patients followed since diagnosis, and the clinical and treatment characteristics of patients with remission v those without...
  70. ncbi [Rheumatoid arthritis: early detection may nip it in the bud]
    J W J Bijlsma
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 149:685-7. 2005
    ..Recently a Dutch clinical trial was started with this objective. Patients at risk will be randomised to receive dexamethasone or placebo treatment...
  71. ncbi Radiation synovectomy with yttrium-90 for persisting arthritis has direct harmful effects on human cartilage that cannot be prevented by co-administration of glucocorticoids: an in vitro study
    Z N Jahangier
    Department of Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 65:1384-9. 2006
    ..In that study, it seemed that in patients treated by radiation synovectomy, progression of radiographic joint damage occurred...
  72. ncbi Interleukin-7-aggravated joint inflammation and tissue destruction in collagen-induced arthritis is associated with T-cell and B-cell activation
    Sarita A Y Hartgring
    Department of Rheumatology and Clinical Immunology, UMC Utrecht, Heidelberglaan 100, Utrecht, PO Box 85500 F02, 127 3508 GA, The Netherlands
    Arthritis Res Ther 14:R137. 2012
    ..We sought to investigate the capacity of interleukin (IL)-7 to enhance collagen-induced arthritis and to study by what mechanisms this is achieved...
  73. ncbi Physical activity and physical activity cognitions are potential factors maintaining fatigue in patients with primary Sjogren's syndrome
    Eveline J M Wouters
    Department of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands
    Ann Rheum Dis 71:668-73. 2012
    ..Fatigue is a prevalent and debilitating problem in Sjögren's syndrome. It has been suggested that physical activity and cognitions about physical activity can influence fatigue...
  74. ncbi Improved multiplex immunoassay performance in human plasma and synovial fluid following removal of interfering heterophilic antibodies
    Wilco de Jager
    Department of Pediatric Immunology, University Medical Center Utrecht, Wilhelmina Children's Hospital, Utrecht, The Netherlands
    J Immunol Methods 300:124-35. 2005
    ..We show that pre-absorption with protein-L is a powerful tool for removal of interfering immunoglobulins from human bodily fluids to be used in immunoassays for studying changes in protein patterns...
  75. ncbi Emotions and emotional approach and avoidance strategies in fibromyalgia
    Henriët van Middendorp
    Department of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands
    J Psychosom Res 64:159-67. 2008
    ..This study examined emotions and emotion-regulation strategies in women with fibromyalgia and in controls, and how these variables relate to symptoms of fibromyalgia...
  76. ncbi Alendronate or alfacalcidol in glucocorticoid-induced osteoporosis
    Ron N J de Nijs
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    N Engl J Med 355:675-84. 2006
    ..Treatment with glucocorticoids is associated with bone loss starting soon after therapy is initiated and an increased risk of fracture...
  77. ncbi Glucocorticoid receptor downregulation in early diagnosed rheumatoid arthritis
    A Margriet Huisman
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Ann N Y Acad Sci 966:64-7. 2002
    ..Since normal glucocorticoid receptor expression was found in the male population with early-diagnosed RA, it remains questionable if glucocorticoid receptor expression is causally involved in pathogenesis of RA...
  78. ncbi Immature articular cartilage is more susceptible to blood-induced damage than mature articular cartilage: an in vivo animal study
    Michel J J Hooiveld
    University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 48:396-403. 2003
    ....
  79. ncbi Interleukin-10 protects against blood-induced joint damage
    Nathalie W D Jansen
    Rheumatology and Clinical Immunology, UMC Utrecht, The Netherlands
    Br J Haematol 142:953-61. 2008
    ..Taken together, although effects were obtained in vitro, IL-10 protects against blood-induced joint damage and might be further evaluated as candidate in treatment of tissue damaging effects of joint haemorrhages...
  80. ncbi [The anticitrulline antibody test: unsuitable for screening for rheumatoid arthritis]
    J W G Jacobs
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, Utrecht
    Ned Tijdschr Geneeskd 152:69-70. 2008
    ....
  81. ncbi Knee Images Digital Analysis (KIDA): a novel method to quantify individual radiographic features of knee osteoarthritis in detail
    A C A Marijnissen
    Rheumatology and Clinical Immunology, UMC Utrecht, The Netherlands
    Osteoarthritis Cartilage 16:234-43. 2008
    ..Objective assessment, however, remains difficult. The goal of the present study was to evaluate a novel digital method to analyse standard knee radiographs...
  82. ncbi Monitoring adverse events of low-dose glucocorticoid therapy: EULAR recommendations for clinical trials and daily practice
    M C van der Goes
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Ann Rheum Dis 69:1913-9. 2010
    ..To develop recommendations on monitoring for adverse events (AEs) of low-dose glucocorticoid (GC) therapy (≤7.5 mg prednisone or equivalent daily) in clinical trials and daily practice...
  83. ncbi Are switches from oral to subcutaneous methotrexate or addition of ciclosporin to methotrexate useful steps in a tight control treatment strategy for rheumatoid arthritis? A post hoc analysis of the CAMERA study
    M F Bakker
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, F02 127, PO Box 85500, Utrecht 3508 GA, The Netherlands
    Ann Rheum Dis 69:1849-52. 2010
    ....
  84. ncbi The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment
    T N de Boer
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Osteoarthritis Cartilage 17:482-8. 2009
    ..The objective was to substantiate these beneficial effects in an in vivo (clinical) study with celecoxib treatment of patients with severe knee osteoarthritis (OA) and subsequent evaluation of cartilage tissue ex vivo...
  85. ncbi In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model
    F Intema
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Osteoarthritis Cartilage 18:691-8. 2010
    ..This model is characterized by intra-joint variability with respect to cartilage damage (predominantly medial) and loading (lateral unloading due to a shifted axis)...
  86. ncbi Does loading influence the severity of cartilage degeneration in the canine Groove-model of OA?
    Petra Vos
    Department of Rheumatology and Clinical Immunology, University Medical Center, P O Box 95500, Utrecht, The Netherlands
    J Orthop Res 27:1332-8. 2009
    ..The present study demonstrates that in the Groove-model intensified loading is not a prerequisite for the development of OA, although it adds to some extent to the severity of the OA...
  87. ncbi Patient and rheumatologist perspectives on glucocorticoids: an exercise to improve the implementation of the European League Against Rheumatism (EULAR) recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases
    M C van der Goes
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 69:1015-21. 2010
    ....
  88. ncbi Degenerated and healthy cartilage are equally vulnerable to blood-induced damage
    N W D Jansen
    Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 67:1468-73. 2008
    ..Joint bleeds have a direct adverse effect on joint cartilage, leading to joint deterioration and, ultimately, to disability...
  89. ncbi CHECK (Cohort Hip and Cohort Knee): similarities and differences with the Osteoarthritis Initiative
    J Wesseling
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 68:1413-9. 2009
    ....
  90. ncbi Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study
    S M M Verstappen
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 69:1044-8. 2010
    ....
  91. ncbi Very rapid clearance after a joint bleed in the canine knee cannot prevent adverse effects on cartilage and synovial tissue
    N W D Jansen
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Osteoarthritis Cartilage 17:433-40. 2009
    ..As a possible explanation for this discrepancy, we studied the clearance rate of blood from the canine knee joints...
  92. ncbi Interleukin-7 induced immunopathology in arthritis
    S A Y Hartgring
    Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 65:iii69-74. 2006
    ..Together this suggests that IL-7 is an important cytokine in several rheumatic conditions, capable of inducing inflammation and immunopathology. Thus it may be an important target for immunotherapy...
  93. ncbi Utility and direct costs: ankylosing spondylitis compared with rheumatoid arthritis
    S M M Verstappen
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 66:727-31. 2007
    ..To compare utility and disease-specific direct costs between patients with ankylosing spondylitis (AS) and patients with rheumatoid arthritis (RA) in the Netherlands...
  94. ncbi Tight control in the treatment of rheumatoid arthritis: efficacy and feasibility
    M F Bakker
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 66:iii56-60. 2007
    ..Tight control is a treatment strategy tailored to the individual patient with RA, which aims to achieve a predefined level of low disease activity or remission within a certain period of time...
  95. ncbi Joint surgery in the Utrecht Rheumatoid Arthritis Cohort: the effect of treatment strategy
    S M M Verstappen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 65:1506-11. 2006
    ....
  96. ncbi Down-regulation of activating Fcgamma receptors on monocytes of patients with rheumatoid arthritis upon methotrexate treatment
    S Wijngaarden
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands
    Rheumatology (Oxford) 44:729-34. 2005
    ..g. during antibody-based therapy of RA...
  97. ncbi Glucocorticoids in the treatment of early and late RA
    J W J Bijlsma
    Department of Rheumatology and Clinical Immunology (F02.127, University Medical Centre Utrecht, P.O. Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 62:1033-7. 2003
  98. ncbi Synthesis and release of human cartilage matrix proteoglycans are differently regulated by nitric oxide and prostaglandin-E2
    S C Mastbergen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 67:52-8. 2008
    ..Prostaglandin-E2 is the main product formed by COX-2. We therefore evaluate the role of prostaglandin-E2 in relation to nitric oxide in disturbing cartilage proteoglycan turnover...
  99. ncbi [Gout and diuretics; still an issue]
    J W G Jacobs
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, F02 127, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 151:458-60. 2007
    ..Therefore, the generally accepted guideline still stands that if gout develops during diuretic therapy, this medication should be stopped if possible...
  100. ncbi [TNF-blocking drugs and infection; recommendations for daily practice]
    J W G Jacobs
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, Huispost Fo2 127, Postbus 85 500, 358 GA Utrecht
    Ned Tijdschr Geneeskd 151:588-93. 2007
    ..Flu vaccination during anti-TNF therapy is indicated. Travel vaccinations with live microbial inocula should not be given...
  101. ncbi Determinants of direct costs in Dutch rheumatoid arthritis patients
    S M M Verstappen
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 63:817-24. 2004
    ....