Johannes W J Bijlsma

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. pmc Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study
    Simon C Mastbergen
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Res Ther 8:R2. 2006
  2. pmc Glucocorticoids in the treatment of early and late RA
    J W J Bijlsma
    Department of Rheumatology and Clinical Immunology F02 127, University Medical Centre Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 62:1033-7. 2003
  3. ncbi request reprint [Rheumatoid arthritis: early detection may nip it in the bud]
    J W J Bijlsma
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 149:685-7. 2005
  4. ncbi request reprint Developments in glucocorticoid therapy
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Box 85500, 3508 GA Utrecht, The Netherlands
    Rheum Dis Clin North Am 31:1-17, vii. 2005
  5. ncbi request reprint Glucocorticoids in rheumatoid arthritis: effects on erosions and bone
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann N Y Acad Sci 966:82-90. 2002
  6. ncbi request reprint Clinical aspects of immune neuroendocrine mechanisms in rheumatic diseases
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Rheum Dis Clin North Am 31:xiii-xvi. 2005
  7. ncbi request reprint Analgesia and the patient with osteoarthritis
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Ther 9:189-97. 2002
  8. ncbi request reprint Neuroendocrine immune mechanisms in rheumatic diseases
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Ultrecht, The Netherlands
    Trends Immunol 23:59-61. 2002
  9. ncbi request reprint [Withdrawal of rofecoxib: a sign to be careful with coxibs in patients with increased cardiovascular risk]
    J W J Bijlsma
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 148:2162-4. 2004
  10. pmc Patient centred outcomes in osteoarthritis
    J W J Bijlsma
    Ann Rheum Dis 64:1-2. 2005

Collaborators

Detail Information

Publications67

  1. pmc Differential direct effects of cyclo-oxygenase-1/2 inhibition on proteoglycan turnover of human osteoarthritic cartilage: an in vitro study
    Simon C Mastbergen
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Res Ther 8:R2. 2006
    ..NSAIDs with low COX-2/COX-1 selectivity exhibit adverse direct effects on OA cartilage, whereas high COX-2/COX-1 selective NSAIDs did not show such effects and might even have cartilage reparative properties...
  2. pmc Glucocorticoids in the treatment of early and late RA
    J W J Bijlsma
    Department of Rheumatology and Clinical Immunology F02 127, University Medical Centre Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 62:1033-7. 2003
  3. ncbi request reprint [Rheumatoid arthritis: early detection may nip it in the bud]
    J W J Bijlsma
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 149:685-7. 2005
    ..Recently a Dutch clinical trial was started with this objective. Patients at risk will be randomised to receive dexamethasone or placebo treatment...
  4. ncbi request reprint Developments in glucocorticoid therapy
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Box 85500, 3508 GA Utrecht, The Netherlands
    Rheum Dis Clin North Am 31:1-17, vii. 2005
    ..One is the improvement in new GC compounds--designer GCs, alterations in bioactivity, and alterations in formulations. The other is a better understanding and management of the toxicity of GCs...
  5. ncbi request reprint Glucocorticoids in rheumatoid arthritis: effects on erosions and bone
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann N Y Acad Sci 966:82-90. 2002
    ..The management of the (side) effects of glucocorticoids on bone has clearly improved in the last years. These two developments lead to a further optimizing of glucocorticoid treatment in patients with rheumatoid arthritis...
  6. ncbi request reprint Clinical aspects of immune neuroendocrine mechanisms in rheumatic diseases
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Rheum Dis Clin North Am 31:xiii-xvi. 2005
  7. ncbi request reprint Analgesia and the patient with osteoarthritis
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Ther 9:189-97. 2002
    ..A promising option for the future is the development of symptomatic slow-acting drugs for osteoarthritis that possess structure-modifying properties...
  8. ncbi request reprint Neuroendocrine immune mechanisms in rheumatic diseases
    Johannes W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Ultrecht, The Netherlands
    Trends Immunol 23:59-61. 2002
  9. ncbi request reprint [Withdrawal of rofecoxib: a sign to be careful with coxibs in patients with increased cardiovascular risk]
    J W J Bijlsma
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 148:2162-4. 2004
    ....
  10. pmc Patient centred outcomes in osteoarthritis
    J W J Bijlsma
    Ann Rheum Dis 64:1-2. 2005
  11. doi request reprint Does loading influence the severity of cartilage degeneration in the canine Groove-model of OA?
    Petra Vos
    Department of Rheumatology and Clinical Immunology, University Medical Center, P O Box 95500, Utrecht, The Netherlands
    J Orthop Res 27:1332-8. 2009
    ..The present study demonstrates that in the Groove-model intensified loading is not a prerequisite for the development of OA, although it adds to some extent to the severity of the OA...
  12. ncbi request reprint Trends in economic consequences of rheumatoid arthritis over two subsequent years
    S M M Verstappen
    University Medical Center Utrecht, The Netherlands
    Rheumatology (Oxford) 46:968-74. 2007
    ..To examine changes in direct costs and in working status over 2 yrs in patients with rheumatoid arthritis (RA)...
  13. pmc Interleukin 7 stimulates tumour necrosis factor alpha and Th1 cytokine production in joints of patients with rheumatoid arthritis
    J A G van Roon
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 62:113-9. 2003
    ..Interleukin 7 (IL7), a T cell growth factor and a regulator of Th1 and Th2 cytokine production, is produced by synoviocytes from patients with RA...
  14. ncbi request reprint Clinical significance of quantitative immunohistology in labial salivary glands for diagnosing Sjogren's syndrome
    J M van Woerkom
    Department of Rheumatology and Clinical Immunology, F02 127 University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Rheumatology (Oxford) 45:470-7. 2006
    ..However, this distinction might be difficult because of the lack of a gold standard for pSS. We studied the clinical significance of quantitative immunohistology (QIH) in labial salivary glands for diagnosing pSS...
  15. ncbi request reprint The canine 'groove' model, compared with the ACLT model of osteoarthritis
    A C A Marijnissen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Osteoarthritis Cartilage 10:145-55. 2002
    ..The present study evaluates a canine model of degenerative cartilage damage, mimicking OA, which is induced without making use of permanent joint instability...
  16. pmc Pretreatment macrophage infiltration of the synovium predicts the clinical effect of both radiation synovectomy and intra-articular glucocorticoids
    Z N Jahangier
    Department of Rheumatology and Clinical Immunology, F02 127, University Medical Center Utrecht, Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 65:1286-92. 2006
    ..To explore whether pretreatment features of synovial tissue in patients with gonarthritis could predict the clinical effect of radiation synovectomy with yttrium-90 (90Y) and glucocorticoids or with intra-articular glucocorticoids alone...
  17. pmc Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)
    S M M Verstappen
    University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 66:1443-9. 2007
    ..To investigate whether intensive treatment with methotrexate (MTX) according to a strict protocol and a computerised decision program is more beneficial compared to conventional treatment with MTX in early rheumatoid arthritis...
  18. doi request reprint Cartilage proteoglycan aggrecan epitopes induce proinflammatory autoreactive T-cell responses in rheumatoid arthritis and osteoarthritis
    H de Jong
    Department of Paediatric Immunology, University Medical Center Utrecht, 3584 EA Utrecht, The Netherlands
    Ann Rheum Dis 69:255-62. 2010
    ..To explore potential T-cell epitopes of the core protein of human cartilage proteoglycan aggrecan (PG) in patients with rheumatoid arthritis (RA) or osteoarthritis...
  19. doi request reprint The chondroprotective effect of selective COX-2 inhibition in osteoarthritis: ex vivo evaluation of human cartilage tissue after in vivo treatment
    T N de Boer
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Osteoarthritis Cartilage 17:482-8. 2009
    ..The objective was to substantiate these beneficial effects in an in vivo (clinical) study with celecoxib treatment of patients with severe knee osteoarthritis (OA) and subsequent evaluation of cartilage tissue ex vivo...
  20. ncbi request reprint Down-regulation of activating Fcgamma receptors on monocytes of patients with rheumatoid arthritis upon methotrexate treatment
    S Wijngaarden
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Rheumatology (Oxford) 44:729-34. 2005
    ..To determine the effect of methotrexate (MTX) on expression levels of activating receptors for IgG (FcgammaRs) on monocytes of rheumatoid arthritis (RA) patients in relation to changes in disease activity...
  21. pmc Salivary gland and peripheral blood T helper 1 and 2 cell activity in Sjögren's syndrome compared with non-Sjögren's sicca syndrome
    J M van Woerkom
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, The Netherlands
    Ann Rheum Dis 64:1474-9. 2005
    ..Additionally, to study relationships of local and peripheral Th cell activities with each other and with disease activity measures...
  22. pmc Joint surgery in the Utrecht Rheumatoid Arthritis Cohort: the effect of treatment strategy
    S M M Verstappen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 65:1506-11. 2006
    ....
  23. pmc Productivity costs among patients with rheumatoid arthritis: the influence of methods and sources to value loss of productivity
    S M M Verstappen
    University Medical Centre Utrecht, Department of Rheumatology and Clinical Immunology, F02 127, PO Box 85500, 3508 GA Utrecht, Netherlands
    Ann Rheum Dis 64:1754-60. 2005
    ..To assess productivity costs incurred by rheumatoid arthritis, comprising paid as well as household productivity costs, from a societal perspective, using different methods...
  24. pmc Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis
    S M M Verstappen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Arthritis Res Ther 8:R31. 2006
    ....
  25. pmc Depletion of synovial macrophages in rheumatoid arthritis by an anti-FcgammaRI-calicheamicin immunoconjugate
    J A G van Roon
    Department of Rheumatology and Clinical Immunology, University Medical Centre Utrecht, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 64:865-70. 2005
    ..Monocytes/macrophages have an important and versatile role in joint inflammation and destruction in rheumatoid arthritis (RA)...
  26. ncbi request reprint Fcgamma receptor expression levels on monocytes are elevated in rheumatoid arthritis patients with high erythrocyte sedimentation rate who do not use anti-rheumatic drugs
    S Wijngaarden
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Rheumatology (Oxford) 42:681-8. 2003
    ..In addition, FcgammaR expression levels were determined on RA synovial fluid macrophages and compared with those in RA peripheral blood...
  27. ncbi request reprint Steady progression of osteoarthritic features in the canine groove model
    A C A Marijnissen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Osteoarthritis Cartilage 10:282-9. 2002
    ..The present study evaluates this groove model at 20 and 40 weeks after induction, to assess whether the osteoarthritic features progress in time...
  28. ncbi request reprint [The Dutch College of General Practitioners' "Gout" Standard: a response from rheumatologists]
    J W G Jacobs
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 146:295-6. 2002
    ..The most important criticism concerns the supposed diagnostic value of serum urate levels: close examination of the data suggests that this value is very limited...
  29. ncbi request reprint Low-dose glucocorticoids in early rheumatoid arthritis: discordant effects on bone mineral density and fractures?
    A A van Everdingen
    Department of Rheumatology and Clinical Immunology, University Medical Center, Utrecht, The Netherlands
    Clin Exp Rheumatol 21:155-60. 2003
    ..The study duration was 2 years, with an open follow-up during the third year. Patients were randomly allocated to receive 10 mg prednisone or placebo...
  30. pmc Th2 mediated regulation in RA and the spondyloarthropathies
    J A G van Roon
    UMC Utrecht, The Netherlands
    Ann Rheum Dis 61:951-4. 2002
  31. pmc A good response to early DMARD treatment of patients with rheumatoid arthritis in the first year predicts remission during follow up
    S M M Verstappen
    University Medical Centre Utrecht, Department of Rheumatology and Clinical Immunology, PO Box 85500, 3508 GA Utrecht, Netherlands
    Ann Rheum Dis 64:38-43. 2005
    ..To describe the frequency and duration of remission in the Utrecht rheumatoid arthritis cohort of patients followed since diagnosis, and the clinical and treatment characteristics of patients with remission v those without...
  32. ncbi request reprint Prevention and treatment of glucocorticoid-induced osteoporosis with active vitamin D3 analogues: a review with meta-analysis of randomized controlled trials including organ transplantation studies
    R N J de Nijs
    Department of Rheumatology and Clinical Immunology, F02 127, University Medical Center Utrecht, PO Box 85500, 3508 GA, The Netherlands
    Osteoporos Int 15:589-602. 2004
    ..Bisphosphonates, however, are more effective in preserving bone and decreasing the risk of vertebral fractures than active vitamin D3 analogues...
  33. ncbi request reprint Overview of work disability in rheumatoid arthritis patients as observed in cross-sectional and longitudinal surveys
    S M M Verstappen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Arthritis Rheum 51:488-97. 2004
  34. pmc Determinants of direct costs in Dutch rheumatoid arthritis patients
    S M M Verstappen
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 63:817-24. 2004
    ....
  35. ncbi request reprint Working status among Dutch patients with rheumatoid arthritis: work disability and working conditions
    S M M Verstappen
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology, F02 127, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Rheumatology (Oxford) 44:202-6. 2005
    ..To assess work disability and variables associated with work disability among Dutch patients with rheumatoid arthritis (RA)...
  36. doi request reprint Patient and rheumatologist perspectives on glucocorticoids: an exercise to improve the implementation of the European League Against Rheumatism (EULAR) recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases
    M C van der Goes
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 69:1015-21. 2010
    ....
  37. ncbi request reprint Selective COX-2 inhibition prevents proinflammatory cytokine-induced cartilage damage
    S C Mastbergen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Rheumatology (Oxford) 41:801-8. 2002
    ..This study evaluated the in vitro effect of the selective cyclooxygenase-2 (COX) inhibitor celecoxib on cartilage matrix turnover under normal and inflammatory conditions...
  38. pmc Tight control in the treatment of rheumatoid arthritis: efficacy and feasibility
    M F Bakker
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 66:iii56-60. 2007
    ..Tight control is a treatment strategy tailored to the individual patient with RA, which aims to achieve a predefined level of low disease activity or remission within a certain period of time...
  39. doi request reprint Very rapid clearance after a joint bleed in the canine knee cannot prevent adverse effects on cartilage and synovial tissue
    N W D Jansen
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Osteoarthritis Cartilage 17:433-40. 2009
    ..As a possible explanation for this discrepancy, we studied the clearance rate of blood from the canine knee joints...
  40. doi request reprint Are switches from oral to subcutaneous methotrexate or addition of ciclosporin to methotrexate useful steps in a tight control treatment strategy for rheumatoid arthritis? A post hoc analysis of the CAMERA study
    M F Bakker
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, F02 127, PO Box 85500, Utrecht 3508 GA, The Netherlands
    Ann Rheum Dis 69:1849-52. 2010
    ....
  41. ncbi request reprint [The anticitrulline antibody test: unsuitable for screening for rheumatoid arthritis]
    J W G Jacobs
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, Utrecht
    Ned Tijdschr Geneeskd 152:69-70. 2008
    ....
  42. pmc Radiation synovectomy with yttrium-90 for persisting arthritis has direct harmful effects on human cartilage that cannot be prevented by co-administration of glucocorticoids: an in vitro study
    Z N Jahangier
    Department of Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 65:1384-9. 2006
    ..In that study, it seemed that in patients treated by radiation synovectomy, progression of radiographic joint damage occurred...
  43. pmc Utility and direct costs: ankylosing spondylitis compared with rheumatoid arthritis
    S M M Verstappen
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 66:727-31. 2007
    ..To compare utility and disease-specific direct costs between patients with ankylosing spondylitis (AS) and patients with rheumatoid arthritis (RA) in the Netherlands...
  44. pmc Interleukin-7 induced immunopathology in arthritis
    S A Y Hartgring
    Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 65:iii69-74. 2006
    ..Together this suggests that IL-7 is an important cytokine in several rheumatic conditions, capable of inducing inflammation and immunopathology. Thus it may be an important target for immunotherapy...
  45. doi request reprint Adverse events and factors associated with toxicity in patients with early rheumatoid arthritis treated with methotrexate tight control therapy: the CAMERA study
    S M M Verstappen
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology, F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 69:1044-8. 2010
    ....
  46. ncbi request reprint [The practice guideline 'Dermatomyositis, polymyositis and sporadic inclusion body myositis']
    J E Hoogendijk
    Universitair Medisch Centrum Utrecht, Utrecht
    Ned Tijdschr Geneeskd 149:2104-11. 2005
    ..Physical activity does not have a negative effect on the course of these diseases. The long-term prognosis ofdermatomyositis and polymyositis is not well known. The clinical course of sIBM is slowly progressive...
  47. doi request reprint In early OA, thinning of the subchondral plate is directly related to cartilage damage: results from a canine ACLT-meniscectomy model
    F Intema
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Osteoarthritis Cartilage 18:691-8. 2010
    ..This model is characterized by intra-joint variability with respect to cartilage damage (predominantly medial) and loading (lateral unloading due to a shifted axis)...
  48. ncbi request reprint Treatment of rheumatoid arthritis patients with anti-TNF-alpha monoclonal antibody is accompanied by down-regulation of the activating Fcgamma receptor I on monocytes
    S Wijngaarden
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Clin Exp Rheumatol 26:89-95. 2008
    ..To study the effect of anti-TNF-alpha therapy on activating IgG Fc receptor (FcgammaR) expression on monocytes of RA patients in relation to changes in disease activity...
  49. ncbi request reprint Down regulation of glucocorticoid receptors in early-diagnosed rheumatoid arthritis
    A A van Everdingen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Clin Exp Rheumatol 20:463-8. 2002
    ..This phenomenon might play a role in the aetio-pathogenesis of RA. Therefore we studied GR expression, as well as the serum cortisol levels, in patients with recently diagnosed RA...
  50. doi request reprint Degenerated and healthy cartilage are equally vulnerable to blood-induced damage
    N W D Jansen
    Rheumatology and Clinical Immunology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 67:1468-73. 2008
    ..Joint bleeds have a direct adverse effect on joint cartilage, leading to joint deterioration and, ultimately, to disability...
  51. pmc EULAR evidence-based recommendations on the management of systemic glucocorticoid therapy in rheumatic diseases
    J N Hoes
    Department of Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Ann Rheum Dis 66:1560-7. 2007
    ..To develop evidence-based recommendations for the management of systemic glucocorticoid (GC) therapy in rheumatic diseases...
  52. ncbi request reprint Synthesis and release of human cartilage matrix proteoglycans are differently regulated by nitric oxide and prostaglandin-E2
    S C Mastbergen
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 67:52-8. 2008
    ..Prostaglandin-E2 is the main product formed by COX-2. We therefore evaluate the role of prostaglandin-E2 in relation to nitric oxide in disturbing cartilage proteoglycan turnover...
  53. ncbi request reprint [Further definition of the role of COX-2 inhibitors and NSAIDs in patients with nociceptive pain]
    J W J Bijlsma
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, GA Utrecht
    Ned Tijdschr Geneeskd 151:795-8. 2007
    ....
  54. ncbi request reprint [Gout and diuretics; still an issue]
    J W G Jacobs
    Universitair Medisch Centrum Utrecht, afd Reumatologie en Klinische Immunologie, F02 127, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 151:458-60. 2007
    ..Therefore, the generally accepted guideline still stands that if gout develops during diuretic therapy, this medication should be stopped if possible...
  55. ncbi request reprint Glucocorticoid receptor up-regulation in early rheumatoid arthritis treated with low dose prednisone or placebo
    A M Huisman
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, PO Box 85000, 3508 GA Utrecht, The Netherlands
    Clin Exp Rheumatol 21:217-20. 2003
    ..With this in mind we determined in a double blind, placebo controlled study at baseline and yearly the GR number in PBMC...
  56. ncbi request reprint Transition of rheumatologic care, from teenager to adult: which health assessment questionnaire can be best used?
    P A van Pelt
    Department of Paediatric Immunology, Wilhelmina Children s Hospital, University Medical Centre Utrecht, The Netherlands
    Clin Exp Rheumatol 28:281-6. 2010
    ..This requires a transfer of specific measurements, which evaluate disease profiles such as functional ability. One of the most common measurements is the Health Assessment Questionnaire (HAQ)...
  57. ncbi request reprint The effect of dehydroepiandrosterone on lumbar spine bone mineral density in patients with quiescent systemic lupus erythematosus
    A Hartkamp
    Department of Rheumatology and Clinical Immunology, University Medical Center, 3508 GA Utrecht, The Netherlands
    Arthritis Rheum 50:3591-5. 2004
    ..We evaluated the effects on lumbar BMD of oral DHEA, 200 mg/day, for 1 year in female patients with quiescent systemic lupus erythematosus (SLE)...
  58. doi request reprint Increased expression of interleukin-7 in labial salivary glands of patients with primary Sjögren's syndrome correlates with increased inflammation
    A Bikker
    University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Arthritis Rheum 62:969-77. 2010
    ..To study the expression levels and immunostimulatory capacities of interleukin-7 (IL-7) in primary Sjögren's syndrome...
  59. ncbi request reprint Haemoglobin-derived iron-dependent hydroxyl radical formation in blood-induced joint damage: an in vitro study
    M J J Hooiveld
    Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Rheumatology (Oxford) 42:784-90. 2003
    ..The present study is to elucidate the mechanism by which blood, as present in whole blood, may cause this cartilage damage...
  60. doi request reprint Adverse events of low- to medium-dose oral glucocorticoids in inflammatory diseases: a meta-analysis
    J N Hoes
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 68:1833-8. 2009
    ..To systematically analyse the literature on reported adverse events of low- to medium-dose glucocorticoids during >or=1 month for inflammatory diseases...
  61. ncbi request reprint Strategies for the prevention and management of osteoarthritis of the hip and knee
    J W J Bijlsma
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, P O Box 85 500, 3508 GA, Utrecht, The Netherlands
    Best Pract Res Clin Rheumatol 21:59-76. 2007
    ..Education and self-management are very important to prevent overuse and to use the joints in the most adequate way...
  62. ncbi request reprint [Local treatment for persistent inflammatory arthritis of the knee: intra-articular injection of glucocorticoids and bed rest]
    J W J Bijlsma
    Universitair Medisch Centrum Utrecht, Utrecht
    Ned Tijdschr Geneeskd 152:1956-8. 2008
    ..There are some indications that a period of strict bed rest after treatment is beneficial. Intra-articular glucocorticoids should not be administered more frequently than three times per year in the same joint...
  63. pmc CHECK (Cohort Hip and Cohort Knee): similarities and differences with the Osteoarthritis Initiative
    J Wesseling
    University Medical Center Utrecht, Department of Rheumatology and Clinical Immunology F02 127, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 68:1413-9. 2009
    ....
  64. ncbi request reprint Effect of dehydroepiandrosterone administration on fatigue, well-being, and functioning in women with primary Sjögren syndrome: a randomised controlled trial
    A Hartkamp
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, Utrecht, The Netherlands
    Ann Rheum Dis 67:91-7. 2008
    ..These are common features of primary Sjögren syndrome (pSS). We investigated the effects of DHEA administration on fatigue, well-being, and functioning in women with pSS...
  65. pmc The intra-articular distribution of 90yttrium does not influence the clinical outcome of radiation synovectomy of the knee
    Z N Jahangier
    Department of Rheumatology and Clinical Immunology F02 127, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Ann Rheum Dis 66:1110-2. 2007
    ..To assess the impact of the intra-articular distribution of (90)yttrium-citrate ((90)Y) on the clinical effect of radiosynoviorthesis (RSO) of the knee and on (90)Y leakage from this joint...
  66. doi request reprint Monitoring adverse events of low-dose glucocorticoid therapy: EULAR recommendations for clinical trials and daily practice
    M C van der Goes
    Department of Rheumatology and Clinical Immunology, University Medical Center Utrecht, The Netherlands
    Ann Rheum Dis 69:1913-9. 2010
    ..To develop recommendations on monitoring for adverse events (AEs) of low-dose glucocorticoid (GC) therapy (≤7.5 mg prednisone or equivalent daily) in clinical trials and daily practice...
  67. ncbi request reprint Variability of fatigue during the day in patients with primary Sjögren's syndrome, systemic lupus erythematosus, and rheumatoid arthritis
    M L van Oers
    Department of Clinical and Health Psychology, Utrecht University, Utrecht, The Netherlands
    Clin Exp Rheumatol 28:715-21. 2010
    ..The aim of this study was to examine and compare in patients with these diseases the course of fatigue within the first hour after awakening and during the day, and to examine sleep disturbance as a potential determinant of fatigue...