G J Biessels

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi request reprint Diabetes and cognitive impairment. Clinical diagnosis and brain imaging in patients attending a memory clinic
    Geert Jan Biessels
    Department of Neurology, G03 228, University Medical Center Utrecht, 85500, 3508 GA, Utrecht, The Netherlands
    J Neurol 253:477-82. 2006
  2. ncbi request reprint Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI?
    Geert Jan Biessels
    Department of Neurology, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands
    Diabetes 63:2244-52. 2014
  3. doi request reprint Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions
    Geert Jan Biessels
    Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands Electronic address
    Lancet Diabetes Endocrinol 2:246-55. 2014
  4. ncbi request reprint Sweet memories: 20 years of progress in research on cognitive functioning in diabetes
    Geert Jan Biessels
    Department of Neurology, UMC Utrecht Stroke Centre, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, The Netherlands Electronic address
    Eur J Pharmacol 719:153-60. 2013
  5. ncbi request reprint Risk of dementia in diabetes mellitus: a systematic review
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Netherlands
    Lancet Neurol 5:64-74. 2006
  6. pmc Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus
    G J Biessels
    The Alzheimer Center, Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:304-7. 2006
  7. doi request reprint Caffeine, diabetes, cognition, and dementia
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    J Alzheimers Dis 20:S143-50. 2010
  8. doi request reprint Cognitive dysfunction and diabetes: implications for primary care
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, The Netherlands
    Prim Care Diabetes 1:187-93. 2007
  9. ncbi request reprint Cognition and diabetes: a lifespan perspective
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, The Netherlands
    Lancet Neurol 7:184-90. 2008
  10. ncbi request reprint The impact of diabetes on cognition: what can be learned from rodent models?
    Geert Jan Biessels
    Department of Neurology, G03 228, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Neurobiol Aging 26:36-41. 2005

Detail Information

Publications86

  1. ncbi request reprint Diabetes and cognitive impairment. Clinical diagnosis and brain imaging in patients attending a memory clinic
    Geert Jan Biessels
    Department of Neurology, G03 228, University Medical Center Utrecht, 85500, 3508 GA, Utrecht, The Netherlands
    J Neurol 253:477-82. 2006
    ....
  2. ncbi request reprint Brain changes underlying cognitive dysfunction in diabetes: what can we learn from MRI?
    Geert Jan Biessels
    Department of Neurology, Brain Center Rudolf Magnus, University Medical Center, Utrecht, The Netherlands
    Diabetes 63:2244-52. 2014
    ..A better understanding of the underlying mechanisms is necessary to establish interventions that will improve long-term cognitive outcomes for patients with type 1 and type 2 diabetes. ..
  3. doi request reprint Dementia and cognitive decline in type 2 diabetes and prediabetic stages: towards targeted interventions
    Geert Jan Biessels
    Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, Netherlands Electronic address
    Lancet Diabetes Endocrinol 2:246-55. 2014
    ..We identify possible opportunities for intervention to improve cognitive outcomes in people with type 2 diabetes, and suggest how treatment can be tailored to individual risk profiles and comorbidities. ..
  4. ncbi request reprint Sweet memories: 20 years of progress in research on cognitive functioning in diabetes
    Geert Jan Biessels
    Department of Neurology, UMC Utrecht Stroke Centre, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, The Netherlands Electronic address
    Eur J Pharmacol 719:153-60. 2013
    ..Although this could take another 20 years, the research from Willem Hendrik and his group brought us an important step in the right direction. ..
  5. ncbi request reprint Risk of dementia in diabetes mellitus: a systematic review
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Netherlands
    Lancet Neurol 5:64-74. 2006
    ..Further high quality studies need to be initiated, with objective diabetes assessment, together with reliable methods to establish the contribution of vascular disease and other comorbidity to dementia...
  6. pmc Increased cortical atrophy in patients with Alzheimer's disease and type 2 diabetes mellitus
    G J Biessels
    The Alzheimer Center, Department of Neurology, VU Medical Center, Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 77:304-7. 2006
    ..The risk of Alzheimer's disease (AD) is increased in type 2 diabetes (DM2). This increased risk has been attributed to vascular comorbidity, but other mechanisms, such as accelerated ageing of the brain, have also been implicated...
  7. doi request reprint Caffeine, diabetes, cognition, and dementia
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    J Alzheimers Dis 20:S143-50. 2010
    ....
  8. doi request reprint Cognitive dysfunction and diabetes: implications for primary care
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, The Netherlands
    Prim Care Diabetes 1:187-93. 2007
    ..Given the recent progress in this field, new treatments to prevent cognitive impairment in patients with diabetes may hopefully become available in the near future...
  9. ncbi request reprint Cognition and diabetes: a lifespan perspective
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, The Netherlands
    Lancet Neurol 7:184-90. 2008
    ....
  10. ncbi request reprint The impact of diabetes on cognition: what can be learned from rodent models?
    Geert Jan Biessels
    Department of Neurology, G03 228, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Neurobiol Aging 26:36-41. 2005
    ..Because clinically relevant cognitive deficits mainly occur in elderly patients with type 2 diabetes, the challenge for researchers in this field will be to further develop adequate models...
  11. doi request reprint Microvascular determinants of cognitive decline and brain volume change in elderly patients with type 2 diabetes
    Jeroen de Bresser
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Dement Geriatr Cogn Disord 30:381-6. 2010
    ..The present study examined the relationship between microvascular complications and cognitive decline and the development of structural brain abnormalities over a period of 4 years in patients with type 2 diabetes mellitus (T2DM)...
  12. doi request reprint Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors
    Yael D Reijmer
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center, Utrecht, The Netherlands
    Diabetes Metab Res Rev 27:195-202. 2011
    ..Type 2 diabetes mellitus is associated with an increased risk of cognitive decline and dementia. We examined brain imaging correlates and vascular and metabolic risk factors of accelerated cognitive decline in patients with type 2 diabetes...
  13. doi request reprint Cognitive dysfunction and its clinical and radiological determinants in patients with symptomatic arterial disease and diabetes
    A M Tiehuis
    Department of Radiology, University Medical Center Utrecht, The Netherlands
    J Neurol Sci 283:170-4. 2009
    ..In patients with symptomatic arterial disease, we studied the effect of DM2 on cognition and identified clinical and radiological determinants for impaired cognition in patients with DM2...
  14. ncbi request reprint Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment
    G J Biessels
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, PO Box 80040, 3508 TA, Utrecht, Netherlands
    Brain Res 800:125-35. 1998
    ..The pre-training experiment suggests that the performance deficit of diabetic rats in the spatial version of the water maze is related to difficulties in learning the procedures of the maze rather than to impairments of spatial learning...
  15. pmc Cerebral perfusion in relation to cognitive function and type 2 diabetes
    A M Tiehuis
    Department of Radiology and Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetologia 51:1321-6. 2008
    ..In the general population, cerebral hypoperfusion is a risk factor for cognitive dysfunction and dementia. Reduced cerebral perfusion may account for cognitive impairments in diabetic patients relative to controls...
  16. pmc A 4 year follow-up study of cognitive functioning in patients with type 2 diabetes mellitus
    E van den Berg
    Department of Neurology G03 228, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Diabetologia 53:58-65. 2010
    ..How this cognitive profile evolves over time is uncertain. The present study aims to provide detailed information on the evolution of cognitive decrements in type 2 diabetes over time...
  17. doi request reprint Dementia risk score predicts cognitive impairment after a period of 15 years in a nondemented population
    Yael D Reijmer
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Utrecht, The Netherlands
    Dement Geriatr Cogn Disord 31:152-7. 2011
    ..We examined whether a previously designed dementia risk score based on midlife vascular risk profiles also predicts cognitive impairment 15 years later...
  18. doi request reprint Albuminuria and cognitive functioning in an older population: the Hoorn study
    S M Heringa
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands s m heringa umcutrecht nl
    Dement Geriatr Cogn Disord 32:182-7. 2011
    ..We examined the association between albuminuria, as a marker of microvascular damage, and cognition in older individuals...
  19. doi request reprint Cerebral cortical thickness in patients with type 2 diabetes
    Manon Brundel
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    J Neurol Sci 299:126-30. 2010
    ..It is unclear whether this atrophy is global or if there are areas with particular vulnerability. We compared regional cortical atrophy between patients with T2DM and controls and examined determinants of atrophy within the T2DM group...
  20. pmc Metabolic and vascular determinants of impaired cognitive performance and abnormalities on brain magnetic resonance imaging in patients with type 2 diabetes
    S M Manschot
    Rudolf Magnus Institute of Neuroscience, Department of Neurology, G03 228, University Medical Center, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Diabetologia 50:2388-97. 2007
    ..The present study aimed to identify metabolic and vascular factors that are associated with impaired cognitive performance and abnormalities on brain MRI in patients with type 2 diabetes...
  21. ncbi request reprint Diabetes mellitus concomitantly facilitates the induction of long-term depression and inhibits that of long-term potentiation in hippocampus
    A Artola
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Eur J Neurosci 22:169-78. 2005
    ..Persistent facilitation of LTD and inhibition of LTP may contribute to learning and memory impairments associated with diabetes mellitus...
  22. ncbi request reprint Peripheral and central neurologic complications in type 2 diabetes mellitus: no association in individual patients
    S M Manschot
    Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center, Utrecht, The Netherlands
    J Neurol Sci 264:157-62. 2008
    ..We conclude that peripheral neuropathy in patients with DM2 is not related to cognitive dysfunction and brain abnormalities. This indicates that central and peripheral neurological complications of DM2 might have different etiologies...
  23. ncbi request reprint The effect of gamma-linolenic acid-alpha-lipoic acid on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats
    G J Biessels
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center, Utrecht, The Netherlands
    J Neurol Sci 182:99-106. 2001
    ..However, the compound does reverse established deficits in long-term potentiation, suggesting that at least part of its activity is specifically directed at synaptic plasticity...
  24. ncbi request reprint In vivo glucose detection by homonuclear spectral editing
    R A de Graaf
    Department of Experimental In Vivo NMR, Image Sciences Institute, Utrecht University, Utrecht, The Netherlands
    Magn Reson Med 43:621-6. 2000
    ..Next, the sequence was used for in vivo glucose detection in normal rat brain during D-glucose infusion and in the brain of diabetic rats prior to and following insulin infusion...
  25. doi request reprint Predictive value of thrombus attenuation on thin-slice non-contrast CT for persistent occlusion after intravenous thrombolysis
    J M Niesten
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 37:116-22. 2014
    ..We investigated the relationship between thrombus density and recanalization and whether persistent occlusions can be predicted by Hounsfield unit (HU) measurements...
  26. doi request reprint Visual cerebral microbleed detection on 7T MR imaging: reliability and effects of image processing
    J de Bresser
    Department of Neurology, University Medical Center Utrecht, G03 228, PO Box 85500, Heidelberglaan 100, 3508 GA Utrecht, The Netherlands
    AJNR Am J Neuroradiol 34:E61-4. 2013
    ..Automated lesion-detection techniques may be required to optimally benefit from the increased spatial resolution offered by 7T MR imaging...
  27. ncbi request reprint The metabolic syndrome is associated with decelerated cognitive decline in the oldest old
    E van den Berg
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurology 69:979-85. 2007
    ..The metabolic syndrome also appears to predispose to cognitive dysfunction and dementia. In this study the association between the metabolic syndrome and cognitive function was examined in a population of the oldest old...
  28. doi request reprint Relationship between thrombus attenuation and different stroke subtypes
    J M Niesten
    Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, HP 01 132, 3584, CX, Utrecht, The Netherlands
    Neuroradiology 55:1071-9. 2013
    ..The aim of our study was to determine the relationship between presence of a hyperdense vessel sign and thrombus density with different stroke subtypes...
  29. ncbi request reprint Effects of changes in glucose concentration on synaptic plasticity in hippocampal slices
    A Kamal
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, PO Box 80040, 3508 TA, Utrecht, The Netherlands
    Brain Res 824:238-42. 1999
    ..Paired-pulse facilitation (PPF) experiments showed that the medium glucose concentration did not significantly influence potentiation of the second response...
  30. doi request reprint Construction of periventricular white matter hyperintensity maps by spatial normalization of the lateral ventricles
    Cynthia Jongen
    Department of Radiology, Image Sciences Institute, University Medical Center Utrecht, Q0S 459, 3508 GA Utrecht, The Netherlands
    Hum Brain Mapp 30:2056-62. 2009
    ..The proposed method is particularly suited to analyze WMH distribution differences at the level of the lateral ventricles between large groups of patients...
  31. doi request reprint Insight in cognition: self-awareness of performance across cognitive domains
    Linda A Schoo
    Experimental Psychology, Helmholtz Institute and Utrecht University, Utrecht, The Netherlands
    Appl Neuropsychol Adult 20:95-102. 2013
    ..22 was found. These results suggest that self-awareness is domain-specific, and although it is adaptive to the experience of mental effort, it is most dependent on preexisting beliefs about one's own cognitive abilities...
  32. doi request reprint Subjecting acute ischemic stroke patients to continuous tube feeding and an intensive computerized protocol establishes tight glycemic control
    N D Kruyt
    Department of Neurology, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100 DE, Amsterdam, The Netherlands
    Neurocrit Care 12:62-8. 2010
    ..The aim of the present study was to investigate if safe, effective and feasible TGC can be achieved with continuous tube feeding and a computerized treatment protocol...
  33. doi request reprint Beta-cell dysfunction and insulin resistance after subarachnoid haemorrhage
    N D Kruyt
    Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Neuroendocrinology 93:126-32. 2011
    ..Although in these patients hyperglycaemia is commonly ascribed to insulin resistance, there is little understanding of underlying mechanisms...
  34. ncbi request reprint Automated and visual scoring methods of cerebral white matter hyperintensities: relation with age and cognitive function
    A M Tiehuis
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 25:59-66. 2008
    ..We compared an automated and two visual WMH scoring methods in their relations with age and cognitive function...
  35. ncbi request reprint Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin-diabetic rats
    Sanne M Manschot
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, The Netherlands
    Brain Res 966:274-82. 2003
    ..These findings suggest that vasculopathy plays a role in the development of cerebral dysfunction in diabetic rats...
  36. ncbi request reprint Synaptic plasticity in the diabetic brain: advanced aging?
    A Artola
    Department of Medical Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Prog Brain Res 138:305-14. 2002
  37. doi request reprint Markers of low-grade inflammation and endothelial dysfunction are related to reduced information processing speed and executive functioning in an older population - the Hoorn Study
    S M Heringa
    University Medical Center Utrecht, Brain Center Rudolf Magnus, Department of Neurology, Utrecht, The Netherlands Electronic address
    Psychoneuroendocrinology 40:108-18. 2014
    ..This study shows that low-grade inflammation and endothelial dysfunction contribute to reduced information processing speed and executive functioning in an older population...
  38. doi request reprint High mean fasting glucose levels independently predict poor outcome and delayed cerebral ischaemia after aneurysmal subarachnoid haemorrhage
    N D Kruyt
    Department of Neurology, H2 222 Academic Medical Centre, University of Amsterdam, PO Box 22700, 1100 DE Amsterdam, The Netherlands
    J Neurol Neurosurg Psychiatry 79:1382-5. 2008
    ..Hyperglycaemia has been related to poor outcome and delayed cerebral ischaemia (DCI) after aneurysmal subarachnoid haemorrhage (aSAH)...
  39. ncbi request reprint Hyperglycemia and cognitive outcome after ischemic stroke
    N D Kruyt
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, The Netherlands
    J Neurol Sci 270:141-7. 2008
    ..Post-stroke hyperglycemia (HG) is associated with poor physical recovery, in particular in patients with cortical stroke. We tested whether HG is also associated with cognitive impairment after ischemic stroke...
  40. ncbi request reprint Cerebral metabolism in streptozotocin-diabetic rats: an in vivo magnetic resonance spectroscopy study
    G J Biessels
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, The Netherlands
    Diabetologia 44:346-53. 2001
    ..Reductions in N-acetylaspartate levels in the brain of STZ-diabetic rats were shown by 1H spectroscopy, which could present a marker for early metabolic or functional abnormalities in cerebral neurones in diabetes...
  41. ncbi request reprint Type 2 diabetes, cognitive function and dementia: vascular and metabolic determinants
    E van den Berg
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Drugs Today (Barc) 42:741-54. 2006
    ..Furthermore, potential determinants of impaired cognition in type 2 diabetes are addressed both from the perspective of statistical associations and from a mechanistic point of view...
  42. ncbi request reprint Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?
    G J Biessels
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Biochem Soc Trans 33:1041-4. 2005
    ..In this paper, the evidence for the association between DM2 and dementia and for each of these underlying mechanisms will be reviewed, with emphasis on the role of insulin itself...
  43. ncbi request reprint The impact of diabetes mellitus on cognitive decline in the oldest of the old: a prospective population-based study
    E van den Berg
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Diabetologia 49:2015-23. 2006
    ..As part of the Leiden 85-plus Study we studied the effects of diabetes on cognition in the oldest old...
  44. ncbi request reprint A detailed profile of cognitive dysfunction and its relation to psychological distress in patients with type 2 diabetes mellitus
    Augustina M A Brands
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    J Int Neuropsychol Soc 13:288-97. 2007
    ..Contrary to our hypothesis, cognitive disturbances and psychological distress thus seem independent symptoms of the same disease...
  45. doi request reprint White matter lesions and brain atrophy: more than shared risk factors? A systematic review
    Auke P A Appelman
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 28:227-42. 2009
    ....
  46. ncbi request reprint Cognitive performance, psychological well-being, and brain magnetic resonance imaging in older patients with type 1 diabetes
    Augustina M A Brands
    Department of Neurology, Univaersity Medial Center, Utrecht, The Netherlands
    Diabetes 55:1800-6. 2006
    ..We conclude that cognition in older type 1 diabetic patients is only mildly disturbed. Chronic exposure to hyperglycemia is in itself, even at older age, apparently not sufficient to have considerable impact on the brain...
  47. doi request reprint Subfields of the hippocampal formation at 7 T MRI: in vivo volumetric assessment
    L E M Wisse
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuroimage 61:1043-9. 2012
    ..Our data give evidence that this can be done in a reliable manner. Segmentation of subfields in the full-length of the hippocampus may bolster the study of the etiology neuropsychiatric diseases...
  48. pmc Automated measurement of brain and white matter lesion volume in type 2 diabetes mellitus
    C Jongen
    Image Sciences Institute, University Medical Center Utrecht, Q0S 459, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Diabetologia 50:1509-16. 2007
    ..In this study we used an automated segmentation technique to investigate the association of type 2 diabetes, several diabetes-related risk factors and cognition with cerebral tissue and WML volumes...
  49. ncbi request reprint Voxel-based morphometry demonstrates reduced grey matter density on brain MRI in patients with diabetic retinopathy
    A M Wessels
    Department of Medical Psychology, VU University Medical Center, Van der Boechorststraat 7, 1081 BT, Amsterdam, The Netherlands
    Diabetologia 49:2474-80. 2006
    ..The aim of our study was to use magnetic resonance imaging (MRI) to establish whether long-term hyperglycaemia, resulting in advanced retinopathy, contributes to structural changes in the brain (reduced grey matter)...
  50. ncbi request reprint Cerebrovascular reserve capacity is preserved in a population-based sample of patients with type 2 diabetes mellitus
    C A M M van Oers
    University Medical Centre, Department of Neurology, Utrecht, The Netherlands
    Cerebrovasc Dis 22:46-50. 2006
    ..We aimed to examine CVR in a population-based sample of DM2 patients...
  51. ncbi request reprint Glutathione and alpha-lipoate in diabetic rats: nerve function, blood flow and oxidative state
    P S van Dam
    University Medical Center, Utrecht, The Netherlands
    Eur J Clin Invest 31:417-24. 2001
    ..Therefore, we evaluated the effects of the antioxidants glutathione and alpha-lipoic acid on both nerve microcirculation and the antioxidative capacity and lipid peroxidation in experimentally diabetic rats...
  52. doi request reprint Visualization of cerebral microbleeds with dual-echo T2*-weighted magnetic resonance imaging at 7.0 T
    Mandy M A Conijn
    Department of Radiology, University Medical Center Utrecht, Utrecht, Netherlands
    J Magn Reson Imaging 32:52-9. 2010
    ..To assess the visualization of cerebral microbleeds with dual echo T2*-weighted imaging at 7.0 T magnetic resonance imaging (MRI)...
  53. ncbi request reprint No evidence of microbleeds in ALS patients at 7 Tesla MRI
    Esther Verstraete
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht
    Amyotroph Lateral Scler 11:555-7. 2010
    ..We performed T2*-weighed imaging which enables whole-brain in vivo detection of cerebral microbleeds and hemosiderin deposits in humans. No microbleeds were found in patients with ALS...
  54. pmc Progression of cerebral atrophy and white matter hyperintensities in patients with type 2 diabetes
    Jeroen de Bresser
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetes Care 33:1309-14. 2010
    ..How these brain-imaging abnormalities evolve over time is unknown. The present study aims to quantify cerebral atrophy and WMH progression over 4 years in type 2 diabetes...
  55. ncbi request reprint Brain magnetic resonance imaging correlates of impaired cognition in patients with type 2 diabetes
    Sanne M Manschot
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Diabetes 55:1106-13. 2006
    ..We conclude that cognitive impairments in patients with type 2 diabetes are not only associated with subcortical ischemic changes in the brain, but also with increased brain atrophy...
  56. doi request reprint Ten-year time course of risk factors for increased carotid intima-media thickness: the Hoorn Study
    Esther van den Berg
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 17:168-74. 2010
    ..Levels of vascular risk factors that are associated with increased IMT change over time. This study aimed to examine the time course of vascular risk factors in older persons with 'high' versus 'low' IMT over a 10-year period...
  57. ncbi request reprint Cardiopulmonary bypass and long-term neurocognitive dysfunction in the rat
    Jan M Dieleman
    Division of Perioperative Care and Emergency Medicine, University Medical Center Utrecht, PO Box 85500, mail stop Q04 2 313, 3508 GA Utrecht, The Netherlands
    Life Sci 79:551-8. 2006
    ..Similar cytokine patterns in both operated groups suggest that surgical trauma rather than exposure of blood to extra-corporeal circuit was probably responsible for the inflammatory response...
  58. ncbi request reprint MR spectroscopy of cerebral white matter in type 2 diabetes; no association with clinical variables and cognitive performance
    Audrey Tiehuis
    Department of Radiology Hp E01 332, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Neuroradiology 52:155-61. 2010
    ..We investigated whether abnormalities in neuronal metabolism or membrane integrity in normal appearing cerebral white matter are associated with cognitive impairment in patients with DM2...
  59. ncbi request reprint Structural brain imaging in diabetes: a methodological perspective
    Cynthia Jongen
    Department of Neurology Image Sciences Institute, University Medical Center Utrecht, Q0S 459, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Eur J Pharmacol 585:208-18. 2008
    ..The findings of previous imaging studies in diabetes are discussed from a methodological perspective and recommendations for future research are given...
  60. ncbi request reprint Cognitive functioning in elderly persons with type 2 diabetes and metabolic syndrome: the Hoorn study
    Esther van den Berg
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Dement Geriatr Cogn Disord 26:261-9. 2008
    ..Cognitive decrements may already develop in these early stages...
  61. doi request reprint Type 2 diabetes mellitus, hypertension, dyslipidemia and obesity: A systematic comparison of their impact on cognition
    Esther van den Berg
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Biochim Biophys Acta 1792:470-81. 2009
    ..Decline was found in all cognitive domains, although the effects on cognitive speed, mental flexibility and memory were most consistent. Methodological aspects of included studies and implications of these findings are discussed...
  62. pmc Cognition in the early stage of type 2 diabetes
    Carla Ruis
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Diabetes Care 32:1261-5. 2009
    ..Possible risk factors were also addressed...
  63. ncbi request reprint Cognitive functioning and brain MRI in patients with type 1 and type 2 diabetes mellitus: a comparative study
    Augustina M A Brands
    Helmholtz Instituut, Department of Experimental Psychology, Utrecht University, Utrecht, The Netherlands
    Dement Geriatr Cogn Disord 23:343-50. 2007
    ..It has been suggested that cognitive impairments are more pronounced in DM2 than in DM1, but studies that directly compare the effects of these 2 types of DM on cognition are lacking...
  64. doi request reprint Blood pressure levels in pre-diabetic stages are associated with worse cognitive functioning in patients with type 2 diabetes
    Esther van den Berg
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Diabetes Metab Res Rev 25:657-64. 2009
    ..The present study compared the vascular risk factor profile over the preceding 16 years between T2DM patients with good cognitive functioning and those with poor cognitive functioning...
  65. doi request reprint A comparison of MR based segmentation methods for measuring brain atrophy progression
    Jeroen de Bresser
    Image Sciences Institute, University Medical Center Utrecht, The Netherlands
    Neuroimage 54:760-8. 2011
    ..For measurements of volume change, SIENA showed the best performance. kNN is a good alternative if volume change measurements of other brain structures are required...
  66. ncbi request reprint Physical activity, structural brain changes and cognitive decline. The SMART-MR study
    M Kooistra
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, The Netherlands
    Atherosclerosis 234:47-53. 2014
    ..We aimed to examine the cross-sectional and prospective relationship between leisure time physical activity, brain MRI abnormalities and cognitive performance in patients with vascular disease...
  67. doi request reprint Cerebral microbleeds on MR imaging: comparison between 1.5 and 7T
    M M A Conijn
    Department of Radiology, University Medical Center Utrecht, The Netherlands
    AJNR Am J Neuroradiol 32:1043-9. 2011
    ..This study aims to compare the visualization of microbleeds with 3D T2*-weighted imaging at 1.5T with 3D dual-echo T2*-weighted imaging at 7T...
  68. ncbi request reprint Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review
    Raoul P Kloppenborg
    Department of Neurology, Academic Medical Center, Amsterdam, The Netherlands
    Eur J Pharmacol 585:97-108. 2008
    ..Later in life diabetes appears to convey the highest risk of dementia. This review shows that vascular risk factors should be regarded as a major target for preventive measures, but that timing of such measures appears to be critical...
  69. ncbi request reprint Ageing and diabetes: implications for brain function
    Geert Jan Biessels
    Department of Medical Pharmacology of the Rudolf Magnus Institute for Neurosciences, University Medical Centre, Utrecht, Netherlands
    Eur J Pharmacol 441:1-14. 2002
    ..In addition, the possible role of cerebrovascular changes, oxidative stress, nonenzymatic protein glycation, insulin and alterations in neuronal calcium homeostasis are addressed...
  70. ncbi request reprint Neuronal Ca2+ disregulation in diabetes mellitus
    Geert Jan Biessels
    Department of Medical Pharmacology of the Rudolf Magnus Institute for Neuroscience, University Medical Centre, Utrecht, The Netherlands
    Eur J Pharmacol 447:201-9. 2002
    ..Preliminary studies indicate that nimodipine may also improve Ca(2+)-dependent forms of synaptic plasticity in the hippocampus of diabetic rats...
  71. ncbi request reprint Glycemia and levels of cerebrospinal fluid amyloid and tau in patients attending a memory clinic
    Lieza G Exalto
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    J Am Geriatr Soc 58:1318-21. 2010
    ..To determine the association between markers of glycemia and cerebrospinal fluid (CSF) amyloid beta 1-42 (Abeta42) and tau levels in patients attending a memory clinic...
  72. ncbi request reprint Insulin inhibits extracellular regulated kinase 1/2 phosphorylation in a phosphatidylinositol 3-kinase (PI3) kinase-dependent manner in Neuro2a cells
    L P van der Heide
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, The Netherlands
    J Neurochem 86:86-91. 2003
    ..We conclude that PI3K is an important integrator of insulin signalling in Neuro2a cells as it regulates activation of PKB and inhibition of ERK1/2, and is sensitive to the duration of the insulin stimulus...
  73. doi request reprint Diagnostic accuracy of CT perfusion imaging for detecting acute ischemic stroke: a systematic review and meta-analysis
    J M Biesbroek
    Department of Radiology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 35:493-501. 2013
    ..The aim of the current study was to determine the sensitivity and specificity of CT perfusion (CTP) for the detection of ischemic stroke by performing a systematic review and meta-analysis of published reports...
  74. doi request reprint An update on type 2 diabetes, vascular dementia and Alzheimer's disease
    L G Exalto
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Exp Gerontol 47:858-64. 2012
    ....
  75. ncbi request reprint Effects of the Ca2+ antagonist nimodipine on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats
    Geert Jan Biessels
    Department of Medical Pharmacology of the Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Brain Res 1035:86-93. 2005
    ..It is concluded that nimodipine can partially prevent early functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats but is unable to reverse late deficits...
  76. ncbi request reprint Cerebral dysfunction in type 1 diabetes: effects of insulin, vascular risk factors and blood-glucose levels
    Augustina M A Brands
    Department of Neurology, G03 228, University Medical Center, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Eur J Pharmacol 490:159-68. 2004
    ..Interestingly, the differences in the "cognitive profile" between type 1 and type 2 diabetes also suggest a critical role for disturbances of insulin action in the central nervous system...
  77. ncbi request reprint The effects of type 1 diabetes on cognitive performance: a meta-analysis
    Augustina M A Brands
    Department of Neurology, University Medical Center, Utrecht, The Netherlands
    Diabetes Care 28:726-35. 2005
    ..To investigate the exact nature and magnitude of cognitive impairments in patients with type 1 diabetes and the possible association with other disease variables, such as recurrent episodes of hypoglycemia and metabolic control...
  78. doi request reprint Hyperglycemia and clinical outcome in aneurysmal subarachnoid hemorrhage: a meta-analysis
    Nyika D Kruyt
    Department of Neurology, Academic Medical Centre, University of Amsterdam PO Box 22700, 1100 DE Amsterdam, The Netherlands
    Stroke 40:e424-30. 2009
    ..Hyperglycemia may worsen outcome after aneurysmal subarachnoid hemorrhage. We performed a systematic review to investigate the relation between admission hyperglycemia and outcome after aneurysmal subarachnoid hemorrhage...
  79. ncbi request reprint Synaptic transmission changes in the pyramidal cells of the hippocampus in streptozotocin-induced diabetes mellitus in rats
    Amer Kamal
    Utrecht University, Department of Medical Pharmacology and Anatomy, Rudolf Magnus Institute of Neurosciences, Universitietsweg 100, Utrecht, The Netherlands
    Brain Res 1073:276-80. 2006
    ..The defects in diabetic slices could be related to pre- as well as postsynaptic changes, and these defects play an important role in the synaptic plasticity changes seen in STZ-induced diabetic animals...
  80. ncbi request reprint Effects of a phorbol ester and cyclosporin A on hippocampal synaptic plasticity in streptozotocin-induced-diabetic rats: reduced sensitivity to phorbol esters
    Amer Kamal
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology, University Medical Centre Utrecht, Universiteitsweg 100, 3584 CG, Utrecht, TheNetherlands
    Neurosci Lett 339:45-8. 2003
    ..In conclusion, these data show a reduced response to PDB in STZ-diabetic rats, and indicate that the lack of LTP induction in these animals is not due to increased PP2B activity...
  81. ncbi request reprint Nerve conduction velocity and evoked potential latencies in streptozotocin-diabetic rats: effects of treatment with an angiotensin converting enzyme inhibitor
    Sanne M Manschot
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, Netherlands
    Diabetes Metab Res Rev 19:469-77. 2003
    ..The present study examined if prevention and intervention treatment with the angiotensin converting enzyme inhibitor enalapril could improve peripheral and central neurophysiological deficits in streptozotocin-diabetic rats...
  82. pmc Hyperglycemia in aneurysmal subarachnoid hemorrhage: a potentially modifiable risk factor for poor outcome
    Nyika D Kruyt
    Department of Neurology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    J Cereb Blood Flow Metab 30:1577-87. 2010
    ....
  83. doi request reprint Hyperglycemia in acute ischemic stroke: pathophysiology and clinical management
    Nyika D Kruyt
    Department of Neurology, Academic Medical Center, University of Amsterdam, PO Box 22700, 1100 DE, Amsterdam, The Netherlands
    Nat Rev Neurol 6:145-55. 2010
    ..Finally, we provide directions on the use of insulin treatment strategies to control hyperglycemia in this patient group...
  84. ncbi request reprint Brain imaging in patients with diabetes: a systematic review
    Barbera van Harten
    Medisch Centrum Leeuwarden, Postbus 888, 8901 BR Leeuwarden, Netherlands
    Diabetes Care 29:2539-48. 2006
  85. ncbi request reprint Glucose, insulin and the brain: modulation of cognition and synaptic plasticity in health and disease: a preface
    Geert Jan Biessels
    Eur J Pharmacol 490:1-4. 2004
    ..These subjects will be covered from various angles, from the level of molecular neurosciences, to the level of applied neuropsychology...
  86. doi request reprint Diabetes increases atrophy and vascular lesions on brain MRI in patients with symptomatic arterial disease
    Audrey M Tiehuis
    Stroke 39:1600-3. 2008
    ..Macrovascular disease has been described as a determinant for brain MRI changes in DM2, but little is known about the involvement of other DM2-related factors...