G J Biessels

Summary

Affiliation: University Medical Center Utrecht
Country: The Netherlands

Publications

  1. ncbi Neuronal Ca2+ disregulation in diabetes mellitus
    Geert Jan Biessels
    Department of Medical Pharmacology of the Rudolf Magnus Institute for Neuroscience, University Medical Centre, Utrecht, The Netherlands
    Eur J Pharmacol 447:201-9. 2002
  2. ncbi Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment
    G J Biessels
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, PO Box 80040, 3508 TA, Utrecht, Netherlands
    Brain Res 800:125-35. 1998
  3. ncbi Ageing and diabetes: implications for brain function
    Geert Jan Biessels
    Department of Medical Pharmacology of the Rudolf Magnus Institute for Neurosciences, University Medical Centre, Utrecht, Netherlands
    Eur J Pharmacol 441:1-14. 2002
  4. doi Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors
    Yael D Reijmer
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center, Utrecht, The Netherlands
    Diabetes Metab Res Rev 27:195-202. 2011
  5. pmc Cerebral perfusion in relation to cognitive function and type 2 diabetes
    A M Tiehuis
    Department of Radiology and Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetologia 51:1321-6. 2008
  6. ncbi Diabetes mellitus concomitantly facilitates the induction of long-term depression and inhibits that of long-term potentiation in hippocampus
    A Artola
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Eur J Neurosci 22:169-78. 2005
  7. doi Dementia risk score predicts cognitive impairment after a period of 15 years in a nondemented population
    Yael D Reijmer
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Utrecht, The Netherlands
    Dement Geriatr Cogn Disord 31:152-7. 2011
  8. doi Microvascular determinants of cognitive decline and brain volume change in elderly patients with type 2 diabetes
    Jeroen de Bresser
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Dement Geriatr Cogn Disord 30:381-6. 2010
  9. ncbi The effect of gamma-linolenic acid-alpha-lipoic acid on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats
    G J Biessels
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center, Utrecht, The Netherlands
    J Neurol Sci 182:99-106. 2001
  10. ncbi Effects of nimodipine on sciatic nerve blood flow and vasa nervorum responsiveness in the diabetic rat
    A C Kappelle
    Department of Medical Pharmacology, Rudolf Magnus Institute, University of Utrecht, Netherlands
    Eur J Pharmacol 250:43-9. 1993

Collaborators

Detail Information

Publications42

  1. ncbi Neuronal Ca2+ disregulation in diabetes mellitus
    Geert Jan Biessels
    Department of Medical Pharmacology of the Rudolf Magnus Institute for Neuroscience, University Medical Centre, Utrecht, The Netherlands
    Eur J Pharmacol 447:201-9. 2002
    ..Preliminary studies indicate that nimodipine may also improve Ca(2+)-dependent forms of synaptic plasticity in the hippocampus of diabetic rats...
  2. ncbi Water maze learning and hippocampal synaptic plasticity in streptozotocin-diabetic rats: effects of insulin treatment
    G J Biessels
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, PO Box 80040, 3508 TA, Utrecht, Netherlands
    Brain Res 800:125-35. 1998
    ..The pre-training experiment suggests that the performance deficit of diabetic rats in the spatial version of the water maze is related to difficulties in learning the procedures of the maze rather than to impairments of spatial learning...
  3. ncbi Ageing and diabetes: implications for brain function
    Geert Jan Biessels
    Department of Medical Pharmacology of the Rudolf Magnus Institute for Neurosciences, University Medical Centre, Utrecht, Netherlands
    Eur J Pharmacol 441:1-14. 2002
    ..In addition, the possible role of cerebrovascular changes, oxidative stress, nonenzymatic protein glycation, insulin and alterations in neuronal calcium homeostasis are addressed...
  4. doi Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors
    Yael D Reijmer
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center, Utrecht, The Netherlands
    Diabetes Metab Res Rev 27:195-202. 2011
    ..Type 2 diabetes mellitus is associated with an increased risk of cognitive decline and dementia. We examined brain imaging correlates and vascular and metabolic risk factors of accelerated cognitive decline in patients with type 2 diabetes...
  5. pmc Cerebral perfusion in relation to cognitive function and type 2 diabetes
    A M Tiehuis
    Department of Radiology and Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands
    Diabetologia 51:1321-6. 2008
    ..In the general population, cerebral hypoperfusion is a risk factor for cognitive dysfunction and dementia. Reduced cerebral perfusion may account for cognitive impairments in diabetic patients relative to controls...
  6. ncbi Diabetes mellitus concomitantly facilitates the induction of long-term depression and inhibits that of long-term potentiation in hippocampus
    A Artola
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Eur J Neurosci 22:169-78. 2005
    ..Persistent facilitation of LTD and inhibition of LTP may contribute to learning and memory impairments associated with diabetes mellitus...
  7. doi Dementia risk score predicts cognitive impairment after a period of 15 years in a nondemented population
    Yael D Reijmer
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Utrecht, The Netherlands
    Dement Geriatr Cogn Disord 31:152-7. 2011
    ..We examined whether a previously designed dementia risk score based on midlife vascular risk profiles also predicts cognitive impairment 15 years later...
  8. doi Microvascular determinants of cognitive decline and brain volume change in elderly patients with type 2 diabetes
    Jeroen de Bresser
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Dement Geriatr Cogn Disord 30:381-6. 2010
    ..The present study examined the relationship between microvascular complications and cognitive decline and the development of structural brain abnormalities over a period of 4 years in patients with type 2 diabetes mellitus (T2DM)...
  9. ncbi The effect of gamma-linolenic acid-alpha-lipoic acid on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats
    G J Biessels
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center, Utrecht, The Netherlands
    J Neurol Sci 182:99-106. 2001
    ..However, the compound does reverse established deficits in long-term potentiation, suggesting that at least part of its activity is specifically directed at synaptic plasticity...
  10. ncbi Effects of nimodipine on sciatic nerve blood flow and vasa nervorum responsiveness in the diabetic rat
    A C Kappelle
    Department of Medical Pharmacology, Rudolf Magnus Institute, University of Utrecht, Netherlands
    Eur J Pharmacol 250:43-9. 1993
    ....
  11. ncbi The metabolic syndrome is associated with decelerated cognitive decline in the oldest old
    E van den Berg
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurology 69:979-85. 2007
    ..The metabolic syndrome also appears to predispose to cognitive dysfunction and dementia. In this study the association between the metabolic syndrome and cognitive function was examined in a population of the oldest old...
  12. ncbi Effects of changes in glucose concentration on synaptic plasticity in hippocampal slices
    A Kamal
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, Utrecht University, PO Box 80040, 3508 TA, Utrecht, The Netherlands
    Brain Res 824:238-42. 1999
    ..Paired-pulse facilitation (PPF) experiments showed that the medium glucose concentration did not significantly influence potentiation of the second response...
  13. doi Predictive value of thrombus attenuation on thin-slice non-contrast CT for persistent occlusion after intravenous thrombolysis
    J M Niesten
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 37:116-22. 2014
    ..We investigated the relationship between thrombus density and recanalization and whether persistent occlusions can be predicted by Hounsfield unit (HU) measurements...
  14. ncbi In vivo glucose detection by homonuclear spectral editing
    R A de Graaf
    Department of Experimental In Vivo NMR, Image Sciences Institute, Utrecht University, Utrecht, The Netherlands
    Magn Reson Med 43:621-6. 2000
    ..Next, the sequence was used for in vivo glucose detection in normal rat brain during D-glucose infusion and in the brain of diabetic rats prior to and following insulin infusion...
  15. ncbi Peripheral and central neurologic complications in type 2 diabetes mellitus: no association in individual patients
    S M Manschot
    Rudolf Magnus Institute of Neuroscience, Department of Neurology, University Medical Center, Utrecht, The Netherlands
    J Neurol Sci 264:157-62. 2008
    ..We conclude that peripheral neuropathy in patients with DM2 is not related to cognitive dysfunction and brain abnormalities. This indicates that central and peripheral neurological complications of DM2 might have different etiologies...
  16. ncbi Glutathione and alpha-lipoate in diabetic rats: nerve function, blood flow and oxidative state
    P S van Dam
    University Medical Center, Utrecht, The Netherlands
    Eur J Clin Invest 31:417-24. 2001
    ..Therefore, we evaluated the effects of the antioxidants glutathione and alpha-lipoic acid on both nerve microcirculation and the antioxidative capacity and lipid peroxidation in experimentally diabetic rats...
  17. doi Insight in cognition: self-awareness of performance across cognitive domains
    Linda A Schoo
    Experimental Psychology, Helmholtz Institute and Utrecht University, Utrecht, The Netherlands
    Appl Neuropsychol Adult 20:95-102. 2013
    ..22 was found. These results suggest that self-awareness is domain-specific, and although it is adaptive to the experience of mental effort, it is most dependent on preexisting beliefs about one's own cognitive abilities...
  18. ncbi Automated and visual scoring methods of cerebral white matter hyperintensities: relation with age and cognitive function
    A M Tiehuis
    Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 25:59-66. 2008
    ..We compared an automated and two visual WMH scoring methods in their relations with age and cognitive function...
  19. ncbi Increased spike broadening and slow afterhyperpolarization in CA1 pyramidal cells of streptozotocin-induced diabetic rats
    A Kamal
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, UMC Utrecht, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Neuroscience 118:577-83. 2003
    ..These data underscore the notion that the diabetic brain at the neuronal level shares properties with brain aging...
  20. ncbi Synaptic plasticity in the diabetic brain: advanced aging?
    A Artola
    Department of Medical Pharmacology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Universiteitsweg 100, 3584 CG Utrecht, The Netherlands
    Prog Brain Res 138:305-14. 2002
  21. ncbi Type 2 diabetes, cognitive function and dementia: vascular and metabolic determinants
    E van den Berg
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Drugs Today (Barc) 42:741-54. 2006
    ..Furthermore, potential determinants of impaired cognition in type 2 diabetes are addressed both from the perspective of statistical associations and from a mechanistic point of view...
  22. ncbi The impact of diabetes mellitus on cognitive decline in the oldest of the old: a prospective population-based study
    E van den Berg
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Diabetologia 49:2015-23. 2006
    ..As part of the Leiden 85-plus Study we studied the effects of diabetes on cognition in the oldest old...
  23. ncbi Cerebral metabolism in streptozotocin-diabetic rats: an in vivo magnetic resonance spectroscopy study
    G J Biessels
    Department of Medical Pharmacology, Rudolf Magnus Institute for Neurosciences, University Medical Center Utrecht, The Netherlands
    Diabetologia 44:346-53. 2001
    ..Reductions in N-acetylaspartate levels in the brain of STZ-diabetic rats were shown by 1H spectroscopy, which could present a marker for early metabolic or functional abnormalities in cerebral neurones in diabetes...
  24. pmc Automated measurement of brain and white matter lesion volume in type 2 diabetes mellitus
    C Jongen
    Image Sciences Institute, University Medical Center Utrecht, Q0S 459, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Diabetologia 50:1509-16. 2007
    ..In this study we used an automated segmentation technique to investigate the association of type 2 diabetes, several diabetes-related risk factors and cognition with cerebral tissue and WML volumes...
  25. ncbi Insulin inhibits extracellular regulated kinase 1/2 phosphorylation in a phosphatidylinositol 3-kinase (PI3) kinase-dependent manner in Neuro2a cells
    L P van der Heide
    Rudolf Magnus Institute of Neuroscience, Department of Pharmacology and Anatomy, University Medical Center Utrecht, The Netherlands
    J Neurochem 86:86-91. 2003
    ..We conclude that PI3K is an important integrator of insulin signalling in Neuro2a cells as it regulates activation of PKB and inhibition of ERK1/2, and is sensitive to the duration of the insulin stimulus...
  26. doi Relationship between thrombus attenuation and different stroke subtypes
    J M Niesten
    Department of Radiology, University Medical Center Utrecht, Heidelberglaan 100, HP 01 132, 3584, CX, Utrecht, The Netherlands
    Neuroradiology 55:1071-9. 2013
    ..The aim of our study was to determine the relationship between presence of a hyperdense vessel sign and thrombus density with different stroke subtypes...
  27. ncbi Cerebrovascular reserve capacity is preserved in a population-based sample of patients with type 2 diabetes mellitus
    C A M M van Oers
    University Medical Centre, Department of Neurology, Utrecht, The Netherlands
    Cerebrovasc Dis 22:46-50. 2006
    ..We aimed to examine CVR in a population-based sample of DM2 patients...
  28. doi The posterior parietal paradox: Why do functional magnetic resonance imaging and lesion studies on episodic memory produce conflicting results?
    L A Schoo
    Experimental Psychology, Helmholtz Institute, Utrecht University, The Netherlands
    J Neuropsychol 5:15-38. 2011
    ..Future patient studies might profit from specifically taking these cognitive factors into consideration in the task design...
  29. ncbi Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?
    G J Biessels
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Biochem Soc Trans 33:1041-4. 2005
    ..In this paper, the evidence for the association between DM2 and dementia and for each of these underlying mechanisms will be reviewed, with emphasis on the role of insulin itself...
  30. doi An update on type 2 diabetes, vascular dementia and Alzheimer's disease
    L G Exalto
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Exp Gerontol 47:858-64. 2012
    ....
  31. doi Subfields of the hippocampal formation at 7 T MRI: in vivo volumetric assessment
    L E M Wisse
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuroimage 61:1043-9. 2012
    ..Our data give evidence that this can be done in a reliable manner. Segmentation of subfields in the full-length of the hippocampus may bolster the study of the etiology neuropsychiatric diseases...
  32. ncbi The impact of diabetes on cognition: what can be learned from rodent models?
    Geert Jan Biessels
    Department of Neurology, G03 228, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Neurobiol Aging 26:36-41. 2005
    ..Because clinically relevant cognitive deficits mainly occur in elderly patients with type 2 diabetes, the challenge for researchers in this field will be to further develop adequate models...
  33. doi Cognition and diabetes: a lifespan perspective
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, The Netherlands
    Lancet Neurol 7:184-90. 2008
    ....
  34. ncbi Glucose, insulin and the brain: modulation of cognition and synaptic plasticity in health and disease: a preface
    Geert Jan Biessels
    Eur J Pharmacol 490:1-4. 2004
    ..These subjects will be covered from various angles, from the level of molecular neurosciences, to the level of applied neuropsychology...
  35. ncbi Diabetes and cognitive impairment. Clinical diagnosis and brain imaging in patients attending a memory clinic
    Geert Jan Biessels
    Department of Neurology, G03 228, University Medical Center Utrecht, 85500, 3508 GA, Utrecht, The Netherlands
    J Neurol 253:477-82. 2006
    ....
  36. ncbi Angiotensin converting enzyme inhibition partially prevents deficits in water maze performance, hippocampal synaptic plasticity and cerebral blood flow in streptozotocin-diabetic rats
    Sanne M Manschot
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, The Netherlands
    Brain Res 966:274-82. 2003
    ..These findings suggest that vasculopathy plays a role in the development of cerebral dysfunction in diabetic rats...
  37. ncbi Risk of dementia in diabetes mellitus: a systematic review
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Netherlands
    Lancet Neurol 5:64-74. 2006
    ..Further high quality studies need to be initiated, with objective diabetes assessment, together with reliable methods to establish the contribution of vascular disease and other comorbidity to dementia...
  38. ncbi Cognitive functioning and brain MRI in patients with type 1 and type 2 diabetes mellitus: a comparative study
    Augustina M A Brands
    Helmholtz Instituut, Department of Experimental Psychology, Utrecht University, Utrecht, The Netherlands
    Dement Geriatr Cogn Disord 23:343-50. 2007
    ..It has been suggested that cognitive impairments are more pronounced in DM2 than in DM1, but studies that directly compare the effects of these 2 types of DM on cognition are lacking...
  39. ncbi Nerve conduction velocity and evoked potential latencies in streptozotocin-diabetic rats: effects of treatment with an angiotensin converting enzyme inhibitor
    Sanne M Manschot
    Department of Pharmacology and Anatomy, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, Netherlands
    Diabetes Metab Res Rev 19:469-77. 2003
    ..The present study examined if prevention and intervention treatment with the angiotensin converting enzyme inhibitor enalapril could improve peripheral and central neurophysiological deficits in streptozotocin-diabetic rats...
  40. ncbi The effects of type 1 diabetes on cognitive performance: a meta-analysis
    Augustina M A Brands
    Department of Neurology, University Medical Center, Utrecht, The Netherlands
    Diabetes Care 28:726-35. 2005
    ..To investigate the exact nature and magnitude of cognitive impairments in patients with type 1 diabetes and the possible association with other disease variables, such as recurrent episodes of hypoglycemia and metabolic control...
  41. ncbi Effects of the Ca2+ antagonist nimodipine on functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats
    Geert Jan Biessels
    Department of Medical Pharmacology of the Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    Brain Res 1035:86-93. 2005
    ..It is concluded that nimodipine can partially prevent early functional deficits in the peripheral and central nervous system of streptozotocin-diabetic rats but is unable to reverse late deficits...
  42. doi Cognitive dysfunction and diabetes: implications for primary care
    Geert Jan Biessels
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, The Netherlands
    Prim Care Diabetes 1:187-93. 2007
    ..Given the recent progress in this field, new treatments to prevent cognitive impairment in patients with diabetes may hopefully become available in the near future...