T L Beumer

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. ncbi request reprint Regulatory role of p27kip1 in the mouse and human testis
    T L Beumer
    Department of Cell Biology, Utrecht University Medical School, The Netherlands
    Endocrinology 140:1834-40. 1999
  2. ncbi request reprint The role of the tumor suppressor p53 in spermatogenesis
    T L Beumer
    Department of Cell Biology, Medical School, P O Box 80 157, 3508 TD Utrecht, The Netherlands
    Cell Death Differ 5:669-77. 1998
  3. ncbi request reprint Involvement of the D-type cyclins in germ cell proliferation and differentiation in the mouse
    T L Beumer
    Department of Cell Biology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
    Biol Reprod 63:1893-8. 2000
  4. ncbi request reprint P21(Cip1/WAF1) expression in the mouse testis before and after X irradiation
    T L Beumer
    Department of Cell Biology, Medical School, University of Utrecht, The Netherlands
    Mol Reprod Dev 47:240-7. 1997
  5. ncbi request reprint Effective generation of very low density lipoprotein receptor transgenic mice by overlapping genomic DNA fragments: high testis expression and disturbed spermatogenesis
    P J Tacken
    Department of Human and Clinical Genetics, Leiden University Medical Center, The Netherlands
    Transgenic Res 10:211-21. 2001

Collaborators

  • D G de Rooij
  • P J Tacken
  • R R Frants
  • L M Havekes
  • A van der Zee
  • R J Florijn
  • M H Hofker
  • K W van Dijk
  • M J Gijpels

Detail Information

Publications5

  1. ncbi request reprint Regulatory role of p27kip1 in the mouse and human testis
    T L Beumer
    Department of Cell Biology, Utrecht University Medical School, The Netherlands
    Endocrinology 140:1834-40. 1999
    ..Finally, we show that the expression of p27kip1 transiently increases by a factor of 3 after x-irradiation in whole testicular lysates. Hence, p27kip1 seems to be involved in the cellular response after DNA damage...
  2. ncbi request reprint The role of the tumor suppressor p53 in spermatogenesis
    T L Beumer
    Department of Cell Biology, Medical School, P O Box 80 157, 3508 TD Utrecht, The Netherlands
    Cell Death Differ 5:669-77. 1998
    ..Furthermore, after irradiation, p53 is important in the removal of lethally damaged spermatogonia...
  3. ncbi request reprint Involvement of the D-type cyclins in germ cell proliferation and differentiation in the mouse
    T L Beumer
    Department of Cell Biology, University Medical Center Utrecht, 3584 CX, Utrecht, The Netherlands
    Biol Reprod 63:1893-8. 2000
    ..In spermatogonia, cyclins D(1) and D(3) seem to be involved in cell cycle regulation, whereas cyclin D(2) likely has a role in spermatogonial differentiation...
  4. ncbi request reprint P21(Cip1/WAF1) expression in the mouse testis before and after X irradiation
    T L Beumer
    Department of Cell Biology, Medical School, University of Utrecht, The Netherlands
    Mol Reprod Dev 47:240-7. 1997
    ..These data imply that p21(Cip1/WAF1) is a factor which could be important during the meiotic prophase in spermatocytes and repair mechanisms in these cells, but not in spermatogonial cell cycle delay or apoptosis induction...
  5. ncbi request reprint Effective generation of very low density lipoprotein receptor transgenic mice by overlapping genomic DNA fragments: high testis expression and disturbed spermatogenesis
    P J Tacken
    Department of Human and Clinical Genetics, Leiden University Medical Center, The Netherlands
    Transgenic Res 10:211-21. 2001
    ..Furthermore, male VLDLR-Tg mice transmitted the transgene to their progeny with low frequencies. This could imply that VLDLR overexpression in the germ cells disturbed spermatogenesis...