Rolf M F Berger

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. doi request reprint FUTURE-2: Results from an open-label, long-term safety and tolerability extension study using the pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion
    Rolf M F Berger
    Center For Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children s Hospital, University Medical Centre, Groningen, The Netherlands Electronic address
    Int J Cardiol 202:52-8. 2016
  2. pmc Clinical features of paediatric pulmonary hypertension: a registry study
    Rolf M F Berger
    Centre for Congenital Heart Diseases Paediatric Cardiology, Beatrix Children s Hospital, University Medical Centre Groningen, University of Groningen, Netherlands
    Lancet 379:537-46. 2012
  3. doi request reprint Sildenafil add-on therapy in paediatric pulmonary arterial hypertension, experiences of a national referral centre
    Johannes M Douwes
    Department of Paediatric Cardiology, Centre for Congenital Heart Diseases, Beatrix Children s Hospital, University Medical Centre Groningen, Groningen, The Netherlands
    Heart 100:224-30. 2014
  4. doi request reprint Quantification of ventricular volume load in the context of a bidirectional cavopulmonary shunt: a theoretical treatise
    Tjark Ebels
    Department of Cardiothoracic Surgery, Centre for Congenital Heart Diseases, University Medical Centre Groningen, Groningen, The Netherlands
    Ann Thorac Surg 93:2022-7. 2012
  5. doi request reprint Pulmonary valve replacement: twenty-six years of experience with mechanical valvar prostheses
    Hendrik G Freling
    Center For Congenital Heart Diseases, University Medical Center Groningen, Groningen, The Netherlands Department of Radiology, University Medical Center Groningen, Groningen, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
    Ann Thorac Surg 99:905-10. 2015
  6. doi request reprint Distinct loading conditions reveal various patterns of right ventricular adaptation
    Marinus A J Borgdorff
    Center For Congenital Heart Diseases, Division of Pediatric Cardiology, Beatrix Children s Hospital, University Medical Center Groningen, Groningen, The Netherlands
    Am J Physiol Heart Circ Physiol 305:H354-64. 2013
  7. doi request reprint Survival differences in pediatric pulmonary arterial hypertension: clues to a better understanding of outcome and optimal treatment strategies
    Willemijn M H Zijlstra
    Center For Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 63:2159-69. 2014
  8. doi request reprint Pulmonary regurgitant volume is superior to fraction using background-corrected phase contrast MRI in determining the severity of regurgitation in repaired tetralogy of Fallot
    Thomas M Gorter
    Department of Radiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Int J Cardiovasc Imaging 31:1169-77. 2015
  9. doi request reprint Effect of right ventricular outflow tract obstruction on right ventricular volumes and exercise capacity in patients with repaired tetralogy of fallot
    Hendrik G Freling
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
    Am J Cardiol 113:719-23. 2014
  10. doi request reprint Ventricular remodelling after pulmonary valve replacement: comparison between pressure-loaded and volume-loaded right ventricles
    Thomas M Gorter
    Department of Pediatric Cardiology, Center For Congenital Heart Diseases, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Netherlands
    Interact Cardiovasc Thorac Surg 19:95-101. 2014

Collaborators

Detail Information

Publications51

  1. doi request reprint FUTURE-2: Results from an open-label, long-term safety and tolerability extension study using the pediatric FormUlation of bosenTan in pUlmonary arterial hypeRtEnsion
    Rolf M F Berger
    Center For Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children s Hospital, University Medical Centre, Groningen, The Netherlands Electronic address
    Int J Cardiol 202:52-8. 2016
    ..The subsequent phase III, open-label, long-term extension study, FUTURE-2, aimed to provide long-term tolerability, safety and exploratory efficacy data...
  2. pmc Clinical features of paediatric pulmonary hypertension: a registry study
    Rolf M F Berger
    Centre for Congenital Heart Diseases Paediatric Cardiology, Beatrix Children s Hospital, University Medical Centre Groningen, University of Groningen, Netherlands
    Lancet 379:537-46. 2012
    ..The Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension (TOPP) registry is a global, prospective study designed to provide information about demographics, treatment, and outcomes in paediatric pulmonary hypertension...
  3. doi request reprint Sildenafil add-on therapy in paediatric pulmonary arterial hypertension, experiences of a national referral centre
    Johannes M Douwes
    Department of Paediatric Cardiology, Centre for Congenital Heart Diseases, Beatrix Children s Hospital, University Medical Centre Groningen, Groningen, The Netherlands
    Heart 100:224-30. 2014
    ..The purpose of this study was to determine the effect of sildenafil add-on therapy in paediatric PAH patients treated with bosentan...
  4. doi request reprint Quantification of ventricular volume load in the context of a bidirectional cavopulmonary shunt: a theoretical treatise
    Tjark Ebels
    Department of Cardiothoracic Surgery, Centre for Congenital Heart Diseases, University Medical Centre Groningen, Groningen, The Netherlands
    Ann Thorac Surg 93:2022-7. 2012
    ..However, additional pulmonary blood flow can be deleterious for ventricular functioning and development as it increases functional ventricular volume load...
  5. doi request reprint Pulmonary valve replacement: twenty-six years of experience with mechanical valvar prostheses
    Hendrik G Freling
    Center For Congenital Heart Diseases, University Medical Center Groningen, Groningen, The Netherlands Department of Radiology, University Medical Center Groningen, Groningen, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
    Ann Thorac Surg 99:905-10. 2015
    ..However, large studies reporting long-term mortality and valve-related complications are missing...
  6. doi request reprint Distinct loading conditions reveal various patterns of right ventricular adaptation
    Marinus A J Borgdorff
    Center For Congenital Heart Diseases, Division of Pediatric Cardiology, Beatrix Children s Hospital, University Medical Center Groningen, Groningen, The Netherlands
    Am J Physiol Heart Circ Physiol 305:H354-64. 2013
    ..We conclude that different types of loading result in distinct patterns of RV adaptation. This is of importance for the approach to patients with chronically increased RV load and for experimental studies in various types of RV failure. ..
  7. doi request reprint Survival differences in pediatric pulmonary arterial hypertension: clues to a better understanding of outcome and optimal treatment strategies
    Willemijn M H Zijlstra
    Center For Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Am Coll Cardiol 63:2159-69. 2014
    ....
  8. doi request reprint Pulmonary regurgitant volume is superior to fraction using background-corrected phase contrast MRI in determining the severity of regurgitation in repaired tetralogy of Fallot
    Thomas M Gorter
    Department of Radiology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB, Groningen, The Netherlands
    Int J Cardiovasc Imaging 31:1169-77. 2015
    ..Non-corrected assessment of PR may result in the misclassification of patients. Our data suggest that the use of PR volume is favourable in the follow-up of patients with repaired TOF...
  9. doi request reprint Effect of right ventricular outflow tract obstruction on right ventricular volumes and exercise capacity in patients with repaired tetralogy of fallot
    Hendrik G Freling
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Interuniversity Cardiology Institute of the Netherlands, Utrecht, The Netherlands
    Am J Cardiol 113:719-23. 2014
    ..Therefore, exercise capacity may be of importance and should additionally be taken in consideration to RV volumes and function in patients with tetralogy of Fallot and PR...
  10. doi request reprint Ventricular remodelling after pulmonary valve replacement: comparison between pressure-loaded and volume-loaded right ventricles
    Thomas M Gorter
    Department of Pediatric Cardiology, Center For Congenital Heart Diseases, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Netherlands
    Interact Cardiovasc Thorac Surg 19:95-101. 2014
    ..PVR thereby decreases the progression of RV dilatation and/or hypertrophy. This study investigates RV remodelling patterns after PVR in patients with either pressure, volume or combined volume- and pressure-loaded RVs...
  11. doi request reprint The Fontan circulation and the liver: A magnetic resonance diffusion-weighted imaging study
    Djoeke Wolff
    Center For Congenital Heart Diseases, Department of Pediatric Cardiology Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, The Netherlands Electronic address
    Int J Cardiol 202:595-600. 2016
    ....
  12. doi request reprint Clinical symptoms of right ventricular failure in experimental chronic pressure load are associated with progressive diastolic dysfunction
    Marinus A J Borgdorff
    Center For Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children s Hospital, The Netherlands Cardiovascular Center laboratory for Experimental Cardiology, Graduate School of Medical Sciences, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands Electronic address
    J Mol Cell Cardiol 79:244-53. 2015
    ..The mechanisms of RVF are unknown. We used an experimental approach based upon clinical signs of RVF to delineate functional and biological processes associated with RVF...
  13. doi request reprint Sildenafil treatment in established right ventricular dysfunction improves diastolic function and attenuates interstitial fibrosis independent from afterload
    Marinus A Borgdorff
    Center For Congenital Heart Diseases, Division of Pediatric Cardiology, Beatrix Children s Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands and
    Am J Physiol Heart Circ Physiol 307:H361-9. 2014
    ..These results indicate that sildenafil treatment has therapeutic potential for established RV dysfunction. ..
  14. doi request reprint Identification of treatment goals in paediatric pulmonary arterial hypertension
    Mark Jan Ploegstra
    Center For Congenital Heart Diseases, Dept of Paediatric Cardiology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur Respir J 44:1616-26. 2014
    ..The identification of these variables allows for the introduction of goal-oriented treatment strategies in paediatric PAH. ..
  15. doi request reprint Pediatric pulmonary hypertension in the Netherlands: epidemiology and characterization during the period 1991 to 2005
    Rosa Laura E van Loon
    Department of Pediatric Cardiology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Circulation 124:1755-64. 2011
    ..This study describes the nationwide epidemiological features of pediatric PH in the Netherlands during a 15-year period and the clinical course of pediatric PAH...
  16. doi request reprint Frequency and prognostic significance of hemoptysis in pediatric pulmonary arterial hypertension
    Marcus T R Roofthooft
    Department of Pediatric Cardiology, Center For Congenital Heart Diseases, Beatrix Children s Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands National Referral Center for Children with Pulmonary Hypertension, Beatrix Children s Hospital, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands Electronic address
    Am J Cardiol 112:1505-9. 2013
    ..In conclusion, the occurrence of hemoptysis in pediatric IPAH/HPAH and PAH-CHD increases with time since diagnosis, is a serious condition, and is, in case of life-threatening hemoptysis, associated with poor outcome...
  17. doi request reprint The role of disturbed blood flow in the development of pulmonary arterial hypertension: lessons from preclinical animal models
    Michael G Dickinson
    Center For Congenital Heart Diseases, Division of Pediatric Cardiology Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 305:L1-14. 2013
    ..In this review we will summarize the current knowledge obtained from PAH animal models associated with disturbed pulmonary blood flow and address questions for future treatment strategies for PAH. ..
  18. doi request reprint Physiological interaction of heart and lung in thoracic irradiation
    Ghazaleh Ghobadi
    Department of Radiation Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Int J Radiat Oncol Biol Phys 84:e639-46. 2012
    ..In addition to lung dose, coirradiation of the heart is a known risk factor in the development RILT. The aim of this study was to identify the underlying physiology of the interaction between lung and heart in thoracic irradiation...
  19. doi request reprint Prognostic factors in pediatric pulmonary arterial hypertension: A systematic review and meta-analysis
    Mark Jan Ploegstra
    Centre for Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children s Hospital, University Medical Centre Groningen, University of Groningen, The Netherlands Electronic address
    Int J Cardiol 184:198-207. 2015
    ..The aim of this study was to identify and evaluate prognostic factors in pediatric PAH by a systematic review of the literature and to summarize the prognostic value of currently reported prognostic factors using meta-analysis...
  20. doi request reprint Left ventricular outflow tract obstruction: should cardiac screening be offered to first-degree relatives?
    Wilhelmina S Kerstjens-Frederikse
    Department of Genetics, University Medical Centre Groningen, Groningen, The Netherlands
    Heart 97:1228-32. 2011
    ..To determine whether offering cardiac screening to relatives of patients with left ventricular outflow tract obstructions (LVOTOs) would be justified...
  21. ncbi request reprint Treprostinil in advanced experimental pulmonary hypertension: beneficial outcome without reversed pulmonary vascular remodeling
    Mirjam E van Albada
    Department of Pediatrics, Division of Pediatric Cardiology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Cardiovasc Pharmacol 48:249-54. 2006
    ..Although regression of pulmonary vascular remodeling has been suggested as therapeutic mechanism, its mode of action remains unknown...
  22. ncbi request reprint Persistent pulmonary hypertension of the newborn with transposition of the great arteries
    Marcus T R Roofthooft
    Department of Paediatric Cardiology, Beatrix Children s Hospital, Groningen, The Netherlands
    Ann Thorac Surg 83:1446-50. 2007
    ..However, data on its incidence and prognosis are scarce and originate mostly from the era before introduction of inhaled nitric oxide (iNO) therapy for PPHN...
  23. ncbi request reprint Severe pregnancy-induced deterioration of truncal valve regurgitation in an adolescent patient with repaired truncus arteriosus
    Elke S Hoendermis
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Cardiology 109:177-9. 2008
    ..Despite severe and symptomatic deterioration of truncal valve regurgitation, she successfully delivered a healthy child, and the valve function recovered within 2 weeks postpartum...
  24. pmc Down syndrome and aberrant right subclavian artery
    Marcus T R Roofthooft
    Department of Paediatric Cardiology, Beatrix Children s Hospital, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700, Groningen, The Netherlands
    Eur J Pediatr 167:1033-6. 2008
    ..The presence of ARSA is not synonymous to the cause of feeding problems in patients with DS and corrective surgery of this vascular anomaly should be restricted to selected cases...
  25. doi request reprint Drug management of fetal tachyarrhythmias: are we ready for a systematic and evidence-based approach?
    Freek van den Heuvel
    Department of Pediatric Cardiology, Beatrix Childrens Hospital, University Medical Center Groningen, University of Groningen, The Netherlands
    Pacing Clin Electrophysiol 31:S54-7. 2008
    ..An international registry is proposed as an important step toward obtaining the necessary data to develop evidence-based management strategies...
  26. doi request reprint Biological serum markers in the management of pediatric pulmonary arterial hypertension
    Mirjam E van Albada
    Department of Pediatrics, Division of Pediatric Cardiology, Beatrix Children s Hospital University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    Pediatr Res 63:321-7. 2008
    ..The data indicate that these markers can be used to monitor treatment effects and predict mortality in pediatric PAH...
  27. doi request reprint Menstrual cycle and its disorders in women with congenital heart disease
    Willem Drenthen
    Department of Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Congenit Heart Dis 3:277-83. 2008
    ..To investigate the age at menarche, the prevalence of menstrual cycle (interval) disorders, and determinants in women with congenital heart disease (CHD)...
  28. doi request reprint Pulse densitometer indocyanine green dilution curves: a simple applicable and accurate method for determination of cardiac shunts
    Arend Bergstra
    Thorax Center Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Congenit Heart Dis 4:362-8. 2009
    ..We therefore investigated the feasibility of a new technique, non-invasive pulse densitometry (PD) in patients with intracardiac shunts and compared its results with the established standards: cuvette densitometry (CD) and oximetry (OX)...
  29. ncbi request reprint Prostacyclin therapy increases right ventricular capillarisation in a model for flow-associated pulmonary hypertension
    Mirjam E van Albada
    Department of Pediatrics, Division of Pediatric Cardiology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Pharmacol 549:107-16. 2006
    ..However, these effects may be attributed to effects on cardiac rather than on pulmonary vascular remodeling...
  30. doi request reprint A critical role for Egr-1 during vascular remodelling in pulmonary arterial hypertension
    Michael G Dickinson
    Center For Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children s Hospital and Laboratory CardioVascular Center, GUIDE, University Medical Center Groningen, University of Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Cardiovasc Res 103:573-84. 2014
    ..Its effect on disease development, however, is unknown. We aimed to uncover a novel role for Egr-1 as a molecular inductor for disease development in PAH...
  31. doi request reprint Six-minute walking distance and decrease in oxygen saturation during the six-minute walk test in pediatric pulmonary arterial hypertension
    Johannes M Douwes
    Center For Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, The Netherlands Electronic address
    Int J Cardiol 202:34-9. 2016
    ..To investigate the prognostic value of the 6-minute walking distance (6-MWD), transcutaneous saturation (tcSO2) and heart rate (HR) obtained during the 6-minute walk test (6-MWT) in pediatric pulmonary arterial hypertension (PAH)...
  32. doi request reprint Right ventricular failure due to chronic pressure load: What have we learned in animal models since the NIH working group statement?
    Marinus A J Borgdorff
    Department of Pediatrics, Center For Congenital Heart Diseases, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Heart Fail Rev 20:475-91. 2015
    ..The use of recently developed animal models will aid in further understanding of the pathobiology of RV failure and development of new therapeutic strategies. ..
  33. doi request reprint Effects of sildenafil on invasive haemodynamics and exercise capacity in heart failure patients with preserved ejection fraction and pulmonary hypertension: a randomized controlled trial
    Elke S Hoendermis
    Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Eur Heart J 36:2565-73. 2015
    ..Phosphodiesterase (PDE)-5 inhibition may be of value in this population, but data are scarce and inconclusive...
  34. doi request reprint Off-pump hepatic to azygos connection via thoracotomy for relief of fistulas after a Kawashima procedure: Ten-year results
    Sara C Arrigoni
    Department of Congenital Cardiothoracic Surgery, University Medical Centre Groningen, Groningen, The Netherlands Electronic address
    J Thorac Cardiovasc Surg 149:1524-30. 2015
    ..Redirection of hepatic venous flow to the pulmonary circulation mostly leads to the regression of the arteriovenous fistulas...
  35. doi request reprint A cornerstone of heart failure treatment is not effective in experimental right ventricular failure
    Marinus A Borgdorff
    Center For Congenital Heart Diseases, Pediatric Cardiology, Beatrix Children s Hospital, University of Groningen, University Medical Center Groningen, The Netherlands Electronic address
    Int J Cardiol 169:183-9. 2013
    ..We investigated the effects of combination treatment of aldosterone-blocker eplerenone+angiotensin II receptor blocker losartan (Ep/Lo) on RV remodeling and function in a model of RV failure due to increased pressure load...
  36. doi request reprint Trends in mortality (1975-2011) after one- and two-stage Fontan surgery, including bidirectional Glenn through Fontan completion
    Djoeke Wolff
    Department of Pediatric Cardiology, Center For Congenital Heart Diseases, Beatrix Children s Hospital, University Medical Center Groningen, Groningen, Netherlands
    Eur J Cardiothorac Surg 45:602-9. 2014
    ..The purpose of this study was to investigate the trends in the overall mortality of all patients who underwent a BCPS or one-stage Fontan procedure at our institution in the period of 1975-2011...
  37. doi request reprint Sildenafil enhances systolic adaptation, but does not prevent diastolic dysfunction, in the pressure-loaded right ventricle
    Marinus A J Borgdorff
    Center For Congenital Heart Diseases, Division of Pediatric Cardiology, Beatrix Children s Hospital, University of Groningen, University Medical Center Groningen, 9713 AV Groningen, The Netherlands
    Eur J Heart Fail 14:1067-74. 2012
    ..We aimed to demonstrate that the phosphodiesterase 5A inhibitor sildenafil can prevent adverse remodelling and improve function in chronic abnormal RV overload, independent from effects on the pulmonary vasculature...
  38. doi request reprint Gene expression profile in flow-associated pulmonary arterial hypertension with neointimal lesions
    Mirjam E van Albada
    Center for Congenital Heart Disease, Beatrix Children s Hospital, Groningen, The Netherlands
    Am J Physiol Lung Cell Mol Physiol 298:L483-91. 2010
    ..These pathways, associated with the development of angioproliferative lesions as well as with the response to therapy in PAH, may provide new therapeutic targets...
  39. doi request reprint Atrial septal defects versus ventricular septal defects in BREATHE-5, a placebo-controlled study of pulmonary arterial hypertension related to Eisenmenger's syndrome: a subgroup analysis
    Rolf M F Berger
    University Medical Center, University of Groningen, Groningen, The Netherlands
    Int J Cardiol 144:373-8. 2010
    ..We compared the effects of bosentan and placebo in patients with isolated ASD (ASD subgroup) versus patients with isolated VSD or both defects (VSD subgroup)...
  40. doi request reprint Current and advancing treatments for pulmonary arterial hypertension in childhood
    Willemijn M H Zijlstra
    Center For Congenital Heart Diseases, Department of Pediatric Cardiology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Expert Rev Respir Med 8:615-28. 2014
    ..We also discuss potential treatment goals and how the available data can be translated into treatment strategies in pediatric PAH. ..
  41. doi request reprint Pulsatile haemodynamic parameters are predictors of survival in paediatric pulmonary arterial hypertension
    Johannes M Douwes
    Centre for Congenital Heart Diseases, Department of Paediatric Cardiology, Beatrix Children s Hospital, University Medical Centre Groningen, University of Groningen, The Netherlands Electronic address
    Int J Cardiol 168:1370-7. 2013
    ..The aim of this study was to determine the prognostic value of PACi and PSVi in paediatric PAH...
  42. doi request reprint The effect of additional pulmonary blood flow on timing of the total cavopulmonary connection
    Ymkje J van Slooten
    Department of Cardiothoracic Surgery, Center For Congenital Heart Diseases, University Medical Center Groningen, Groningen, The Netherlands
    Ann Thorac Surg 93:2028-33. 2012
    ..The staged Fontan procedure is used to palliate functionally univentricular hearts. The effect of additional pulmonary blood flow combined with a bidirectional cavopulmonary shunt in these patients remains a controversial subject...
  43. doi request reprint Pulmonary arterial hypertension in congenital cardiac disease--the need for refinement of the Evian-Venice classification
    Mirjam E van Albada
    Department of Paediatric and Congenital Cardiology, University Medical Center Groningen, University of Groningen, The Netherlands
    Cardiol Young 18:10-7. 2008
    ..In addition, we discuss briefly the data currently available on the effectiveness of the new anti-proliferative drugs in patients with the Eisenmenger syndrome...
  44. doi request reprint Effect of balloon atrial septostomy on cerebral oxygenation in neonates with transposition of the great arteries
    Michelle E van der Laan
    Division of Neonatology, Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Pediatr Res 73:62-7. 2013
    ..The aim of this study was to determine the effect of balloon atrial septostomy (BAS) on cerebral oxygenation in neonates with transposition of the great arteries (TGA)...
  45. doi request reprint Mast cell inhibition improves pulmonary vascular remodeling in pulmonary hypertension
    Beatrijs Bartelds
    Beatrix Children s Hospital, University Medical Center Groningen, Groningen, The Netherlands
    Chest 141:651-60. 2012
    ..The aim of this study was to test the effect of mast cell stabilization on pulmonary vascular remodeling in experimental PAH...
  46. doi request reprint The challenges in paediatric pulmonary arterial hypertension
    Maurice Beghetti
    Paediatric Cardiology Unit, Children s University Hospital Geneva, Geneva, Switzerland Centre for Congenital Heart Diseases, Dept of Pediatric Cardiology, Beatrix Children s Hospital, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Eur Respir Rev 23:498-504. 2014
    ....
  47. ncbi request reprint Pulmonary vascular remodeling in congenital heart disease: enhanced expression of heat shock proteins
    Ralph Geiger
    Department of Pediatric Cardiology, Center For Congenital Heart Diseases, University Medical Center Groningen, University of Groningen
    Indian J Biochem Biophys 46:482-90. 2009
    ..HSP-27 and HSP-70 are increasingly expressed in the advanced proliferative lesions of this disease...
  48. doi request reprint Clinical characterization of pediatric pulmonary hypertension: complex presentation and diagnosis
    Rosa Laura E van Loon
    Department of Pediatric Cardiology, University Medical Center, University of Groningen, Groningen, The Netherlands
    J Pediatr 155:176-82.e1. 2009
    ..To describe the clinical presentation of pediatric pulmonary arterial hypertension (PAH) and the intricacies of how to classify pediatric PAH according to the Venice classification...
  49. doi request reprint Low complication rates with totally implantable access port use in epoprostenol treatment of pulmonary hypertension
    Michael G Dickinson
    Beatrix Children s Hospital, University Medical Center Groningen, University of Groningen, The Netherlands
    J Heart Lung Transplant 28:273-9. 2009
    ..In this study, we aimed to outline the complications associated with the use of a totally implantable access port (TIAP) and their consequences in continuous intravenous epoprostenol treatment...
  50. ncbi request reprint Long-term effect of bosentan in adults versus children with pulmonary arterial hypertension associated with systemic-to-pulmonary shunt: does the beneficial effect persist?
    Rosa Laura E van Loon
    Department of Pediatrics, Division of Pediatric Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am Heart J 154:776-82. 2007
    ..Data on long-term response to bosentan in adults and especially children with pulmonary arterial hypertension (PAH) associated with systemic-to-pulmonary shunt are scarce...
  51. doi request reprint Outcome of pediatric patients with pulmonary arterial hypertension in the era of new medical therapies
    Rosa Laura E van Loon
    Department of Pediatric Cardiology, University Medical Center Groningen, Groningen, The Netherlands
    Am J Cardiol 106:117-24. 2010
    ..Start of second-generation drugs initially induced clinical improvements, but these effects decreased after longer follow-up...