A L Bartels

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Striatal dopa and glucose metabolism in PD patients with freezing of gait
    Anna L Bartels
    Neurology Department of the University Medical Center Groningen, The Netherlands
    Mov Disord 21:1326-32. 2006
  2. pmc Cyclooxygenase and neuroinflammation in Parkinson's disease neurodegeneration
    Anna L Bartels
    Dept of Neurology, University Medical Centre Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Curr Neuropharmacol 8:62-8. 2010
  3. pmc Fluorodeoxyglucose and C-Choline positron emission tomography for distinction of metastatic plexopathy and neuritis: a case report
    Anna L Bartels
    Departments of Neurology, University Medical Center Groningen, Groningen, The Netherlands
    Cases J 2:9323. 2009
  4. ncbi request reprint 11C-verapamil to assess P-gp function in human brain during aging, depression and neurodegenerative disease
    A L Bartels
    Dept of Neurology, University Medical Center Groningen, The Netherlands
    Curr Top Med Chem 10:1775-84. 2010
  5. doi request reprint Parkinson's disease: the syndrome, the pathogenesis and pathophysiology
    Anna L Bartels
    Department of Neurology, University Medical Centre Groningen, University of Groningen, The Netherlands
    Cortex 45:915-21. 2009
  6. doi request reprint Brain imaging in patients with freezing of gait
    Anna L Bartels
    Department of Neurology, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    Mov Disord 23:S461-7. 2008
  7. doi request reprint Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration
    Anna L Bartels
    Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Neurobiol Aging 30:1818-24. 2009
  8. doi request reprint Blood-brain barrier P-glycoprotein function is not impaired in early Parkinson's disease
    A L Bartels
    Department of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands
    Parkinsonism Relat Disord 14:505-8. 2008
  9. pmc Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA
    A L Bartels
    Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    J Neural Transm 115:1001-9. 2008
  10. ncbi request reprint Neuroinflammation in the pathophysiology of Parkinson's disease: evidence from animal models to human in vivo studies with [11C]-PK11195 PET
    Anna L Bartels
    Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Mov Disord 22:1852-6. 2007

Collaborators

Detail Information

Publications17

  1. ncbi request reprint Striatal dopa and glucose metabolism in PD patients with freezing of gait
    Anna L Bartels
    Neurology Department of the University Medical Center Groningen, The Netherlands
    Mov Disord 21:1326-32. 2006
    ..In conclusion, in freezing PD, caudate uptake of FDG and FDOPA was reduced, whereas putamen FDOPA decrease was associated with FDG increase. Right hemisphere circuitry seemed to be more affected in freezing patients...
  2. pmc Cyclooxygenase and neuroinflammation in Parkinson's disease neurodegeneration
    Anna L Bartels
    Dept of Neurology, University Medical Centre Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Curr Neuropharmacol 8:62-8. 2010
    ..This article reviews the involvement of COX in neuroinflammation, specifically focussing at the role of selective COX-2 inhibition in neuroinflammation and neurodegeneration in Parkinson's disease...
  3. pmc Fluorodeoxyglucose and C-Choline positron emission tomography for distinction of metastatic plexopathy and neuritis: a case report
    Anna L Bartels
    Departments of Neurology, University Medical Center Groningen, Groningen, The Netherlands
    Cases J 2:9323. 2009
    ..Fluorodeoxyglucose positron emission tomography may, however be non-specific as infectious processes are depicted as well...
  4. ncbi request reprint 11C-verapamil to assess P-gp function in human brain during aging, depression and neurodegenerative disease
    A L Bartels
    Dept of Neurology, University Medical Center Groningen, The Netherlands
    Curr Top Med Chem 10:1775-84. 2010
    ..In this review, we highlight changes of P-gp function, as measured with VPM-PET, in aging and in the pathogenesis and progression of neurodegenerative disease, as well as their role in depressive disorders...
  5. doi request reprint Parkinson's disease: the syndrome, the pathogenesis and pathophysiology
    Anna L Bartels
    Department of Neurology, University Medical Centre Groningen, University of Groningen, The Netherlands
    Cortex 45:915-21. 2009
    ..Here an overview of the pathogenesis, basic pathophysiology and clinical problems of PD will be given...
  6. doi request reprint Brain imaging in patients with freezing of gait
    Anna L Bartels
    Department of Neurology, University Medical Center Groningen UMCG, University of Groningen, Groningen, The Netherlands
    Mov Disord 23:S461-7. 2008
    ..For future investigation of FOG, it is suggested to design PET and fMRI studies which concentrate on activation of neuropsychological and sensory integration circuits...
  7. doi request reprint Blood-brain barrier P-glycoprotein function decreases in specific brain regions with aging: a possible role in progressive neurodegeneration
    Anna L Bartels
    Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Neurobiol Aging 30:1818-24. 2009
    ..Moreover, decreased BBB P-gp function with aging could be a mechanism by which age acts as the main risk factor for the development of neurodegenerative disease...
  8. doi request reprint Blood-brain barrier P-glycoprotein function is not impaired in early Parkinson's disease
    A L Bartels
    Department of Neurology, University Medical Centre Groningen, University of Groningen, Groningen, Netherlands
    Parkinsonism Relat Disord 14:505-8. 2008
    ..In the present study, a larger variation in V(d) of (R)-[(11)C]-verapamil was seen in the PD group as compared to the control group. However, decreased BBB P-gp function in early stage PD patients could not be confirmed...
  9. pmc Decreased blood-brain barrier P-glycoprotein function in the progression of Parkinson's disease, PSP and MSA
    A L Bartels
    Department of Neurology, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    J Neural Transm 115:1001-9. 2008
    ..Lower [11C]-verapamil uptake in midbrain and frontal regions of de novo PD patients could indicate a regional up-regulation of P-gp function...
  10. ncbi request reprint Neuroinflammation in the pathophysiology of Parkinson's disease: evidence from animal models to human in vivo studies with [11C]-PK11195 PET
    Anna L Bartels
    Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Mov Disord 22:1852-6. 2007
    ..In vivo PET studies are discussed. These methods provide a means to monitor in vivo potential clinical relevance of antiinflammatory treatment strategies in PD...
  11. ncbi request reprint Blood-brain barrier P-glycoprotein function in neurodegenerative disease
    A L Bartels
    Department of Neurology, University Medical Center Groningen, The Netherlands
    Curr Pharm Des 17:2771-7. 2011
    ..This review highlights the role of altered P-gp function in the pathogenesis and progression of neurodegenerative disease. Also the implications of alterations in P-gp function for the treatment of these diseases are discussed...
  12. doi request reprint [11C]-PK11195 PET: quantification of neuroinflammation and a monitor of anti-inflammatory treatment in Parkinson's disease?
    A L Bartels
    Department of Neurology, University Medical Centre Groningen, Hanzeplein 1, 9700 RB Groningen, The Netherlands
    Parkinsonism Relat Disord 16:57-9. 2010
    ..This pilot study assessed the use of [(11)C]-PK11195 PET to quantify neuroinflammation and evaluate the ability of COX-2 inhibition to reduce neuroinflammation in PD patients...
  13. doi request reprint Regional increase in P-glycoprotein function in the blood-brain barrier of patients with chronic schizophrenia: a PET study with [(11)C]verapamil as a probe for P-glycoprotein function
    Onno L de Klerk
    Department of Psychiatry, University Medical Center Groningen UMCG, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Psychiatry Res 183:151-6. 2010
    ..The decrease of [(11)C]verapamil uptake correlates with an increased activity of the P-gp pump. Increased P-gp activity may be a factor in drug resistance in schizophrenia, induced by the use of antipsychotic agents...
  14. doi request reprint Typical cerebral metabolic patterns in neurodegenerative brain diseases
    Laura K Teune
    Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands
    Mov Disord 25:2395-404. 2010
    ..This implies that an early diagnosis in individual patients can be made by comparing each subject's metabolic findings with a complete database of specific disease related patterns...
  15. doi request reprint Handedness and dominant side of symptoms in Parkinson's disease
    Anouk van der Hoorn
    Department of Neurology, University Medical Centre Groningen, University of Groningen, Hanzeplein 1, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Parkinsonism Relat Disord 17:58-60. 2011
    ..602). Right-handedness thus appeared to be associated with right-sided dominance of PD symptoms, while the group of left-handed patients was too small to draw conclusions from. Possible explanations are discussed...
  16. doi request reprint Fused FDG-PET and MRI imaging of Takayasu arteritis in vertebral arteries
    Anna L Bartels
    Department of Neurology, University Medical Center Groningen, Groningen, The Netherlands
    Ann Nucl Med 23:753-6. 2009
    ..The fusion of PET and MRI images may be helpful in establishing the diagnosis of active Takayasu arteritis in rare localizations such as the vertebral arteries...
  17. ncbi request reprint Gait dynamics in Parkinson's disease: relationship to Parkinsonian features, falls and response to levodopa
    Joanna D Schaafsma
    Movement Disorders Unit, Department of Neurology, Tel Aviv Sourasky Medical Center, and Sackler School of Medicine, Tel Aviv University, 6 Weizmann Street, Tel Aviv 64239, Israel
    J Neurol Sci 212:47-53. 2003
    ....