Stephan J L Bakker

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi request reprint Microalbuminuria and C-reactive protein: similar messengers of cardiovascular risk?
    Stephan J L Bakker
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Curr Hypertens Rep 7:379-84. 2005
  2. ncbi request reprint Metabolic syndrome: a fata morgana?
    Stephan J L Bakker
    Department of Internal Medicine, University Hospital Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:15-20. 2007
  3. ncbi request reprint Albuminuria: what can we expect from the determination of nonimmunoreactive albumin?
    Stephan J L Bakker
    Department of Internal Medicine, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Curr Hypertens Rep 11:111-7. 2009
  4. doi request reprint Skin-autofluorescence is an independent predictor of graft loss in renal transplant recipients
    Jasper W L Hartog
    Department of Internal Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Transplantation 87:1069-77. 2009
  5. doi request reprint Gender differences in predictors of the decline of renal function in the general population
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:505-12. 2008
  6. doi request reprint N-terminal pro-B-type natriuretic peptide and mortality in renal transplant recipients versus the general population
    Leendert H Oterdoom
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transplantation 87:1562-70. 2009
  7. ncbi request reprint Elevated levels of C-reactive protein independently predict accelerated deterioration of graft function in renal transplant recipients
    Rutger M van Ree
    Department of Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:246-53. 2007
  8. doi request reprint External validation of the KORA S4/F4 prediction models for the risk of developing type 2 diabetes in older adults: the PREVEND study
    Ali Abbasi
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Epidemiol 27:47-52. 2012
  9. ncbi request reprint Risk factors for chronic transplant dysfunction and cardiovascular disease are related to accumulation of advanced glycation end-products in renal transplant recipients
    Jasper W L Hartog
    University Medical Center Groningen, University of Groningen, Department of Medicine, Division of Nephrology, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 21:2263-9. 2006
  10. doi request reprint Urinary creatinine excretion reflecting muscle mass is a predictor of mortality and graft loss in renal transplant recipients
    Leendert H Oterdoom
    Department of Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 86:391-8. 2008

Detail Information

Publications122 found, 100 shown here

  1. ncbi request reprint Microalbuminuria and C-reactive protein: similar messengers of cardiovascular risk?
    Stephan J L Bakker
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Curr Hypertens Rep 7:379-84. 2005
    ....
  2. ncbi request reprint Metabolic syndrome: a fata morgana?
    Stephan J L Bakker
    Department of Internal Medicine, University Hospital Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:15-20. 2007
  3. ncbi request reprint Albuminuria: what can we expect from the determination of nonimmunoreactive albumin?
    Stephan J L Bakker
    Department of Internal Medicine, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Curr Hypertens Rep 11:111-7. 2009
    ....
  4. doi request reprint Skin-autofluorescence is an independent predictor of graft loss in renal transplant recipients
    Jasper W L Hartog
    Department of Internal Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Transplantation 87:1069-77. 2009
    ..AGEs are nephrotoxic and potential effectors of cardiovascular mortality. We investigated whether skin-AF predicted graft loss after kidney transplantation...
  5. doi request reprint Gender differences in predictors of the decline of renal function in the general population
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:505-12. 2008
    ..These studies show that there are gender differences in the standard predictors of the decline in renal function...
  6. doi request reprint N-terminal pro-B-type natriuretic peptide and mortality in renal transplant recipients versus the general population
    Leendert H Oterdoom
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transplantation 87:1562-70. 2009
    ..Mortality rates are higher in renal transplant recipients (RTR) than in the general population (GP). It is unknown what risk factors account for this difference...
  7. ncbi request reprint Elevated levels of C-reactive protein independently predict accelerated deterioration of graft function in renal transplant recipients
    Rutger M van Ree
    Department of Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:246-53. 2007
    ..In this prospective study, we investigated whether CRP could be of use as a clinical marker for early identification of renal transplant recipients at increased risk of deterioration of graft function...
  8. doi request reprint External validation of the KORA S4/F4 prediction models for the risk of developing type 2 diabetes in older adults: the PREVEND study
    Ali Abbasi
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Epidemiol 27:47-52. 2012
    ..However, the models need to be corrected for intercept and slope to acquire good calibration for application in a different setting...
  9. ncbi request reprint Risk factors for chronic transplant dysfunction and cardiovascular disease are related to accumulation of advanced glycation end-products in renal transplant recipients
    Jasper W L Hartog
    University Medical Center Groningen, University of Groningen, Department of Medicine, Division of Nephrology, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 21:2263-9. 2006
    ..We aimed to investigate which factors are associated with tissue AGE accumulation in renal transplant recipients...
  10. doi request reprint Urinary creatinine excretion reflecting muscle mass is a predictor of mortality and graft loss in renal transplant recipients
    Leendert H Oterdoom
    Department of Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 86:391-8. 2008
    ..Skeletal muscle mainly determines peripheral insulin resistance, and could therefore affect outcome...
  11. doi request reprint Urinary creatinine excretion, an indirect measure of muscle mass, is an independent predictor of cardiovascular disease and mortality in the general population
    Leendert H Oterdoom
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Atherosclerosis 207:534-40. 2009
    ..We aimed to determine whether muscle mass, as reflected by 24h urinary creatinine excretion, is associated with CVD and whether this depends on insulin resistance...
  12. doi request reprint Plasma procalcitonin is associated with obesity, insulin resistance, and the metabolic syndrome
    Ali Abbasi
    Department of Epidemiology, University Medical Center Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 95:E26-31. 2010
    ..Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation...
  13. doi request reprint Impact of depression on long-term outcome after renal transplantation: a prospective cohort study
    Dorien M Zelle
    Department of Nephrology, University of Groningen, University Medical Center Groningen, The Netherlands
    Transplantation 94:1033-40. 2012
    ..We investigated the determinants of depression in renal transplantation recipients (RTRs) and the association with cardiovascular (CV) and all-cause-mortality and graft failure...
  14. pmc A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy
    Alaa Alkhalaf
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Diabetes Care 33:1598-601. 2010
    ..To investigate the effect of benfotiamine on urinary albumin excretion (UAE) and the tubular damage marker kidney injury molecule-1 (KIM-1) in patients with type 2 diabetes and nephropathy...
  15. doi request reprint High plasma hemopexin activity is an independent risk factor for late graft failure in renal transplant recipients
    Jan A Krikken
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transpl Int 23:805-12. 2010
    ..This suggests that Hx measurement, next to measurement of creatinine clearance and UP, could be of value for the identification of RTRs at risk for graft failure...
  16. pmc Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease
    Esther Meijer
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Clin J Am Soc Nephrol 6:361-8. 2011
    ..However, it is unknown whether endogenous vasopressin concentration is associated with disease severity in patients with ADPKD...
  17. doi request reprint Albuminuria, proteinuria, and novel urine biomarkers as predictors of long-term allograft outcomes in kidney transplant recipients
    Ferdau L Nauta
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 57:733-43. 2011
    ....
  18. doi request reprint Copeptin, a surrogate marker of vasopressin, is associated with microalbuminuria in a large population cohort
    Esther Meijer
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 77:29-36. 2010
    ..If future studies show that this association is causal, then drinking more water or pharmacological intervention to decrease plasma vasopressin may have beneficial effects on the kidney, especially in the elderly...
  19. pmc Liver function tests and risk prediction of incident type 2 diabetes: evaluation in two independent cohorts
    Ali Abbasi
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    PLoS ONE 7:e51496. 2012
    ..Liver function tests might predict the risk of type 2 diabetes. An independent study evaluating utility of these markers compared with an existing prediction model is yet lacking...
  20. doi request reprint Do albuminuria and hs-CRP add to the International Diabetes Federation definition of the metabolic syndrome in predicting outcome?
    Marije van der Velde
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University Hospital Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 27:2275-83. 2012
    ....
  21. pmc Influence of age and measure of eGFR on the association between renal function and cardiovascular events
    Marije van der Velde
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin J Am Soc Nephrol 5:2053-9. 2010
    ..This study investigates whether the association between estimated GFR (eGFR) and cardiovascular (CV) outcome differs for different measures of eGFR and different age groups...
  22. doi request reprint Is high-sensitive C-reactive protein a biomarker for functional somatic symptoms? A population-based study
    Lineke M Tak
    Interdisciplinary Center for Psychiatric Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Brain Behav Immun 23:1014-9. 2009
    ..12, 95% CI 1.03-1.21). We conclude that the level of hs-CRP is not a biomarker for the total number of FSS in the general population. The association between hs-CRP and musculoskeletal and general FSS needs further study...
  23. doi request reprint Plasma procalcitonin is an independent predictor of graft failure late after renal transplantation
    Rutger M van Ree
    Department of Internal Medicine, Renal Transplant Program, University Medical Center Groningen and University of Groningen, 9700 RB Groningen, The Netherlands
    Transplantation 88:279-87. 2009
    ....
  24. pmc Peroxiredoxin 4, a novel circulating biomarker for oxidative stress and the risk of incident cardiovascular disease and all-cause mortality
    Ali Abbasi
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    J Am Heart Assoc 1:e002956. 2012
    ..We subsequently examined the incremental value of Prx4 for the risk prediction of CVD compared with the Framingham risk score (FRS)...
  25. doi request reprint Nonesterified fatty acids and development of graft failure in renal transplant recipients
    Astrid Klooster
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 95:1383-9. 2013
    ..To this end, we prospectively investigated the association of fasting concentrations of circulating nonesterified FA (NEFA) with the development of graft failure in RTR...
  26. doi request reprint SLC22A2 is associated with tubular creatinine secretion and bias of estimated GFR in renal transplantation
    Anna Reznichenko
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Physiol Genomics 45:201-9. 2013
    ..39 [1.16-1.67], P = 0.00065, and 1.23 [1.02-1.48], P = 0.042, for rs3127573 and rs316009, respectively. Neither SNP was associated with GF. Thus, SLC22A2 is associated with phenotypes of net tubular creatinine secretion and ESRD...
  27. pmc UMOD as a susceptibility gene for end-stage renal disease
    Anna Reznichenko
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, A Deusinglaan 1, Groningen 9713AV, The Netherlands
    BMC Med Genet 13:78. 2012
    ..The association of rs12917707 with end-stage renal disease (ESRD) in a recent case-control study was only nominally significant...
  28. doi request reprint Plasma renin and outcome in the community: data from PREVEND
    Rudolf A de Boer
    Department of Cardiology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, Groningen 9713GZ, The Netherlands
    Eur Heart J 33:2351-9. 2012
    ..The renin-angiotensin system plays a central role in patients with established cardiovascular (CV) disease, but the prognostic effect of plasma renin in the community is unclear...
  29. pmc Low physical activity and risk of cardiovascular and all-cause mortality in renal transplant recipients
    Dorien M Zelle
    Department of Nephrology, University Medical Center Groningen, Sector A, PO Box 30001, 9700 RB, Groningen, The Netherlands
    Clin J Am Soc Nephrol 6:898-905. 2011
    ..This is largely unexplored in renal transplant recipients (RTRs). We studied whether PA is associated with cardiovascular and all-cause mortality in a prospective cohort of RTR...
  30. pmc Glomerular and tubular damage markers are elevated in patients with diabetes
    Ferdau L Nauta
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Diabetes Care 34:975-81. 2011
    ....
  31. doi request reprint Copeptin, a surrogate marker for vasopressin, is associated with kidney function decline in subjects with autosomal dominant polycystic kidney disease
    Wendy E Boertien
    Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 27:4131-7. 2012
    ..It is, however, unknown whether endogenous vasopressin concentration is associated with kidney function decline in subjects with ADPKD...
  32. doi request reprint Albuminuria assessed from first-morning-void urine samples versus 24-hour urine collections as a predictor of cardiovascular morbidity and mortality
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Epidemiol 168:897-905. 2008
    ..To predict cardiovascular morbidity and all-cause mortality, measuring ACR in a first-morning-void urine sample is a good alternative to measuring 24-hour UAE...
  33. doi request reprint Smoking is a risk factor for graft failure and mortality after renal transplantation
    Pramod K Agarwal
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Am J Nephrol 34:26-31. 2011
    ..Smoking in renal transplant recipients (RTR) is an acknowledged cardiovascular risk factor. It is, however, unclear whether smoking also increases the risk of graft failure (GF)...
  34. doi request reprint Alcohol consumption, new onset of diabetes after transplantation, and all-cause mortality in renal transplant recipients
    Dorien M Zelle
    Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 92:203-9. 2011
    ..Therefore, we investigated the association of alcohol consumption with new onset of diabetes after transplantation (NODAT), mortality, and graft failure in RTR...
  35. ncbi request reprint High-sensitive troponin T and N-terminal pro-B type natriuretic peptide are associated with cardiovascular events despite the cross-sectional association with albuminuria and glomerular filtration rate
    Lieneke Scheven
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, PO Box 30 001 AA53, 9700 RB, Groningen, The Netherlands
    Eur Heart J 33:2272-81. 2012
    ....
  36. pmc Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy
    Alaa Alkhalaf
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e40427. 2012
    ..We investigated the effect of benfotiamine on markers of these pathways in patients with type 2 diabetes and nephropathy...
  37. doi request reprint Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1
    Niek Verweij
    Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Hypertension 61:602-8. 2013
    ..The discovery of genetic variants in the kallikrein-kinin system and in the genes encoding pre-pro-ET-1 and pre-pro-ADM provides novel insights into the (co-)regulation of these vasoactive peptides in the vascular system...
  38. doi request reprint Albuminuria, estimated GFR, traditional risk factors, and incident cardiovascular disease: the PREVEND (Prevention of Renal and Vascular Endstage Disease) study
    Paul A Smink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 60:804-11. 2012
    ..This study assessed the contribution of each separately in correctly identifying individuals at cardiovascular risk in the general population beyond traditional risk markers...
  39. pmc CUBN as a novel locus for end-stage renal disease: insights from renal transplantation
    Anna Reznichenko
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e36512. 2012
    ..Thus, we identified CUBN rs7918972 as a novel risk variant for renal function loss in two independent settings: ESRD in native kidneys and GF in transplanted kidneys...
  40. pmc First morning voids are more reliable than spot urine samples to assess microalbuminuria
    Elsbeth C Witte
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Am Soc Nephrol 20:436-43. 2009
    ..In conclusion, measurement of albuminuria in a first morning void, preferably as the ACR, is more reliable than a spot urine sample to diagnose and monitor microalbuminuria...
  41. pmc Screening for albuminuria identifies individuals at increased renal risk
    Marije van der Velde
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 20:852-62. 2009
    ..Screening for albuminuria identifies patients at increased risk for progressive renal disease, 40 to 50% of whom were previously undiagnosed or untreated...
  42. ncbi request reprint Effect of withdrawal of pravastatin therapy on C-reactive protein and low-density lipoprotein cholesterol
    Pim van der Harst
    Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 100:1548-51. 2007
    ..In conclusion, withdrawal from pravastatin treatment resulted in an increase in CRP to approximately baseline levels, which is not related to the increase in LDL cholesterol...
  43. ncbi request reprint Fasting insulin modifies the relation between age and renal function
    Leendert H Oterdoom
    Department of Medicine, University Medical Center Groningen, Hanzeplein 1, Postbus 30 001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:1587-92. 2007
    ..This population-based study is the first to investigate whether fasting insulin concentrations modify the relationship between age and renal function in a general non-diabetic population...
  44. doi request reprint CCR5Delta32 genotype is associated with outcome in type 2 diabetes mellitus
    Friso L H Muntinghe
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Diabetes Res Clin Pract 86:140-5. 2009
    ..To test whether the genetic variant CCR5Delta32 in the CC-chemokine receptor 5, which is known to lead to CCR5 deficiency, is associated with mortality in type 2 diabetes patients...
  45. doi request reprint Cardiovascular and renal outcome in subjects with K/DOQI stage 1-3 chronic kidney disease: the importance of urinary albumin excretion
    Auke H Brantsma
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 23:3851-8. 2008
    ..In this study we evaluated cardiovascular and renal outcome in subjects with stage 1 and 2 CKD. For comparison, we also studied these outcomes in stage 3 CKD...
  46. doi request reprint N-terminal pro-B-type natriuretic peptide is an independent predictor of cardiovascular morbidity and mortality in the general population
    Gerard C M Linssen
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur Heart J 31:120-7. 2010
    ..However, their prognostic value in the general population is less well established. The purpose of our study was to investigate the prognostic properties of NT-proBNP for death and cardiovascular (CV) events in the general population...
  47. doi request reprint Role of HDL cholesterol and estimates of HDL particle composition in future development of type 2 diabetes in the general population: the PREVEND study
    Ali Abbasi
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen 9700 RB, The Netherlands
    J Clin Endocrinol Metab 98:E1352-9. 2013
    ....
  48. pmc Central body fat distribution associates with unfavorable renal hemodynamics independent of body mass index
    Arjan J Kwakernaak
    Department of Medicine, University Medical Center Groningen, The Netherlands
    J Am Soc Nephrol 24:987-94. 2013
    ..Thus, these results suggest that central body fat distribution, independent of BMI, is associated with an unfavorable pattern of renal hemodynamic measures that could underlie the increased renal risk reported in observational studies...
  49. doi request reprint Incidence of impaired renal function after lung transplantation
    Merel E Hellemons
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    J Heart Lung Transplant 31:238-43. 2012
    ..We aimed to study changes in recipient characteristics in conjunction with incidence of impaired renal function in consecutive series of lung transplant recipients (LTRs)...
  50. doi request reprint Fasting insulin is a stronger cardiovascular risk factor in women than in men
    Leendert H Oterdoom
    Department of Internal Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
    Atherosclerosis 203:640-6. 2009
    ..In parallel with diabetes, fasting hyperinsulinaemia reflecting insulin resistance in non-diabetic subjects is associated with an increased risk for cardiovascular disease, which is more pronounced in women than in men...
  51. doi request reprint Copeptin, a surrogate marker of vasopressin, is associated with accelerated renal function decline in renal transplant recipients
    Esther Meijer
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transplantation 88:561-7. 2009
    ..Whether endogenous VP is a renal risk factor in humans has not been investigated yet. We aimed to investigate whether, in renal transplant recipients, VP concentration is associated with change in renal function during follow-up...
  52. ncbi request reprint C-reactive protein and microalbuminuria differ in their associations with various domains of vascular disease
    Erik M Stuveling
    Department of Internal Medicine, University Medical Centre Groningen, Groningen, The Netherlands
    Atherosclerosis 172:107-14. 2004
    ..Thus, CRP and MA are risk markers for vascular disease, each showing a different risk profiling for different vascular beds...
  53. pmc Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells
    Marco van der Toorn
    Department of Pathology and Medical Biology, Laboratory of Allergology and Pulmonary Diseases, University Medical Center Groningen, University of Groningen, The
    Am J Physiol Lung Cell Mol Physiol 297:L109-14. 2009
    ..Lipophilic components in CS disturb mitochondrial function, which contributes to increased intracellular generation of ROS. Our results are of importance in understanding the systemic effects of smoking observed in patients with COPD...
  54. doi request reprint Association of urinary biomarkers with disease severity in patients with autosomal dominant polycystic kidney disease: a cross-sectional analysis
    Esther Meijer
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 56:883-95. 2010
    ....
  55. ncbi request reprint Body mass index and creatinine clearance are associated with steady-state serum concentrations of the cell damage marker S100B in renal transplant recipients
    Sascha Gross
    Kidney Center, Dept of Internal Medicine, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands
    Med Sci Monit 16:CR318-24. 2010
    ....
  56. ncbi request reprint What predicts progression and regression of urinary albumin excretion in the nondiabetic population?
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 18:637-45. 2007
    ....
  57. pmc Extended prognostic value of urinary albumin excretion for cardiovascular events
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 19:1785-91. 2008
    ..Future studies are required to determine the optimal interval of repeat testing and its cost-effectiveness...
  58. doi request reprint Short-term vitamin D3 supplementation lowers plasma renin activity in patients with stable chronic heart failure: an open-label, blinded end point, randomized prospective trial (VitD-CHF trial)
    Nicolas F Schroten
    Department of Cardiology, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    Am Heart J 166:357-364.e2. 2013
    ..Vitamin D may inhibit renin transcription and lower PRA. We investigated whether vitamin D3 (VitD3) supplementation lowers PRA in CHF patients...
  59. pmc Vitamin k intake and plasma desphospho-uncarboxylated matrix Gla-protein levels in kidney transplant recipients
    Paul Y Boxma
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e47991. 2012
    ..The high dp-ucMGP levels may result in an increased risk for arterial calcification. Whether increasing vitamin K intake may have health benefits for kidney transplant recipients should be addressed by future studies...
  60. doi request reprint Plasma bilirubin and late graft failure in renal transplant recipients
    Petronella E Deetman
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transpl Int 25:876-81. 2012
    ..If our findings are confirmed by other studies, intervention with endogenous or exogenous bilirubin may be of interest for long-term preservation of renal function in RTR...
  61. doi request reprint An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection: a post-hoc analysis of the RENAAL and IDNT trials
    Paul A Smink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 30:1022-8. 2012
    ..Treatment with the angiotensin receptor blocker (ARB) losartan lowers SUA in contrast to other ARBs. Whether reductions in SUA during ARB therapy are associated with cardiovascular protection is unclear. We aimed to investigate this...
  62. ncbi request reprint Low levels of sRAGE are associated with increased risk for mortality in renal transplant recipients
    Sascha Gross
    Kidney Center, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 84:659-63. 2007
    ..In this study we investigated determinants of endogenous sRAGE in renal transplant recipients and whether sRAGE was associated with mortality and graft loss...
  63. doi request reprint Albuminuria: all you need to predict outcomes in chronic kidney disease?
    Ron T Gansevoort
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Opin Nephrol Hypertens 19:513-8. 2010
    ..In current approaches, further evaluation will only include measurement of albuminuria in case of eGFR less than 60 ml/min/1.73 m. We will review whether this screening approach is correct...
  64. ncbi request reprint Aldosterone, from (patho)physiology to treatment in cardiovascular and renal damage
    Femke Waanders
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, The Netherlands
    Curr Vasc Pharmacol 9:594-605. 2011
    ..It is obligatory that future clinical studies on the effects of MR blockade on end-organ damage take into account the sodium status...
  65. ncbi request reprint Abdominal obesity and smoking are important determinants of C-reactive protein in renal transplant recipients
    Rutger M van Ree
    Renal Transplant Program, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 20:2524-31. 2005
    ..However, it may also reflect a low-grade immune-mediated response to the graft. In this study we investigated the factors associated with CRP in a renal transplant population...
  66. doi request reprint Renoprotective effects of long-term oral nicotine in a rat model of spontaneous proteinuria
    Pramod K Agarwal
    Dept of Internal Medicine, Experimental Nephrology, University Medical Center Groningen, Antonius Deusinglaan 1, Groningen, The Netherlands
    Am J Physiol Renal Physiol 302:F895-904. 2012
    ..We further suggest evaluating nicotine as a potential additional therapeutic option for treating proteinuric kidney diseases...
  67. ncbi request reprint Advanced glycation end-products (AGEs) and heart failure: pathophysiology and clinical implications
    Jasper W L Hartog
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Eur J Heart Fail 9:1146-55. 2007
    ..In this review, the role of AGEs in the development of heart failure and the role of AGE intervention as a possible treatment for heart failure are discussed...
  68. ncbi request reprint Impact of statins in microalbuminuric subjects with the metabolic syndrome: a substudy of the PREVEND Intervention Trial
    Christiane A Geluk
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Postbus 30001, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Eur Heart J 26:1314-20. 2005
    ..We evaluated the impact of pravastatin treatment on the incidence of major adverse cardiac events in microalbuminuric subjects with the metabolic syndrome...
  69. pmc High protein intake associates with cardiovascular events but not with loss of renal function
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University Hospital Groningen, Groningen, Netherlands
    J Am Soc Nephrol 20:1797-804. 2009
    ..In summary, in the general population, high protein intake does not promote accelerated decline of renal function but does associate with an increased risk for cardiovascular events...
  70. ncbi request reprint Cyclosporin A-induced oxidative stress is not the consequence of an increase in mitochondrial membrane potential
    Marco van der Toorn
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    FEBS J 274:3003-12. 2007
    ..Neither mitochondria, effects on P-glycoprotein nor inhibition of calcineurin therefore play a role in cyclosporin A-induced oxidative stress and disturbed Ca2+ homeostasis...
  71. ncbi request reprint Impact of weight change on albuminuria in the general population
    Aminu K Bello
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:1619-27. 2007
    ..The impact of weight change on albuminuria and its possible mechanism has not been studied yet in the general population. We investigated this issue in a cohort of the Northern European population...
  72. doi request reprint Screening and monitoring for albuminuria: the performance of the HemoCue point-of-care system
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:377-83. 2008
    ....
  73. pmc MRI-determined fat content of human liver, pancreas and kidney
    Paul E Sijens
    Department of Radiology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    World J Gastroenterol 16:1993-8. 2010
    ..To assess and correlate the lipid content of various organs in obese subjects and in persons with a normal body weight...
  74. ncbi request reprint Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects
    Annemieke Roos
    Department of Endocrinology, University Medical Center Groningen and University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 92:491-6. 2007
    ..Thyroid disease and the metabolic syndrome are both associated with cardiovascular disease...
  75. doi request reprint Kidney injury molecule-1 in renal disease
    Femke Waanders
    Kidney Centre, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    J Pathol 220:7-16. 2010
    ..Finally, the potential of KIM-1 as biomarker of renal damage, as a predictor of renal function decline and its perspectives for monitoring therapy response, are discussed...
  76. doi request reprint Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hum Mol Genet 19:387-95. 2010
    ..011), fractional UA excretion (P = 3.36 x 10(-5)) and high-sensitive CRP (P = 1.18 x 10(-3)) also after adjusting for serum UA levels. We argue that GCKR locus affects serum UA levels through a factor that also affects triglycerides...
  77. ncbi request reprint Clinical and prognostic value of advanced glycation end-products in chronic heart failure
    Jasper W L Hartog
    Department of Cardiology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur Heart J 28:2879-85. 2007
    ..We aimed to determine whether plasma levels of N(epsilon)-(carboxymethyl)lysine (CML) and N(epsilon)-(carboxyethyl)lysine (CEL), two well-known AGEs, are related to the severity and prognosis of CHF...
  78. ncbi request reprint Macroalbuminuria is a better risk marker than low estimated GFR to identify individuals at risk for accelerated GFR loss in population screening
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 17:2582-90. 2006
    ..However, macroalbuminuria is a better risk marker than low eGFR or erythrocyturia to identify in population screening of individuals who are at risk for accelerated GFR loss...
  79. ncbi request reprint Macroalbuminuria and microalbuminuria: do both predict renal and cardiovascular events with similar strength?
    Paul E de Jong
    Department of Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    J Nephrol 20:375-80. 2007
    ..When promoting routine screening for albuminuria, one should realize, moreover, that such projects will most likely be much more cost-effective when directed to preventing not only renal end points, but also CV end points...
  80. doi request reprint Obesity and impaired renal function: potential for lifestyle intervention?
    Eva Corpeleijn
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Epidemiol 24:275-80. 2009
    ..After the recent success of lifestyle intervention to prevent diabetes, further research is needed to show the effects of lifestyle changes to prevent and reduce obesity-related morbidity, including chronic kidney disease...
  81. ncbi request reprint C-reactive protein is associated with renal function abnormalities in a non-diabetic population
    Erik M Stuveling
    Internal Medicine, Trial Coordination Center, Department of Cardiology Thoraxcenter, University Hospital Groningen, and Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Kidney Int 63:654-61. 2003
    ..We hypothesized that elevated CRP levels are associated with renal function abnormalities...
  82. doi request reprint Possible contribution of cytomegalovirus infection to the high risk of (recurrent) venous thrombosis after renal transplantation
    Willem M Lijfering
    Division of Haemostasis, Thrombosis and Rheology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Thromb Haemost 99:127-32. 2008
    ..Prospective studies are warranted to establish this observation, which suggests that CMV infection influences the high risk of (recurrent) venous thrombosis in renal transplant recipients...
  83. ncbi request reprint C-reactive protein and angiographic characteristics of stable and unstable coronary artery disease: data from the prospective PREVEND cohort
    Christiane A Geluk
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, The Netherlands
    Atherosclerosis 196:372-82. 2008
    ..In addition, we investigated the association with coronary events during follow up in the total PREVEND population...
  84. ncbi request reprint Tissue thiamine deficiency as potential cause of delayed graft function after kidney transplantation: thiamine supplementation of kidney donors may improve transplantation outcome
    Astrid Klooster
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    Med Hypotheses 69:873-8. 2007
    ..We therefore hypothesize that a suboptimal tissue thiamine status is a cause of delayed graft function after renal transplantation, and that it can be prevented with thiamine supplementation...
  85. ncbi request reprint Low dietary sodium and exogenous angiotensin II infusion decrease plasma adiponectin concentrations in healthy men
    A Titia Lely
    Department of Internal Medicine, Division of Nephrology, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Clin Endocrinol Metab 92:1821-6. 2007
    ..Adiponectin has antiinflammatory and vascular protective effects and may improve insulin sensitivity. Animal data suggest a role of the renin-angiotensin aldosterone system (RAAS) in the regulation of adiponectin...
  86. doi request reprint Oleic acid loading does not add to the nephrotoxic effect of albumin in an amphibian and chronic rat model of kidney injury
    Mirjan M van Timmeren
    University Medical Center Groningen, University of Groningen, Department of Pathology and Laboratory Medicine, Groningen, The Netherlands
    Nephrol Dial Transplant 23:3814-23. 2008
    ..p. injection of albumin selectively targeted open but not closed nephrons and was used to prevent removal of fatty acids from albumin in the circulation...
  87. doi request reprint Circulating markers of endothelial dysfunction interact with proteinuria in predicting mortality in renal transplant recipients
    Rutger M van Ree
    The Renal Transplant Program, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Transplantation 86:1713-9. 2008
    ..We investigated whether urinary protein excretion (UPE) is correlated with markers of ED and whether these markers affect the association of proteinuria with mortality in renal transplant recipients (RTR)...
  88. pmc High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients
    Mirjan M van Timmeren
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
    Transplantation 84:1625-30. 2007
    ..Urinary KIM-1 excretion has been quantified as biomarker of renal damage. We prospectively studied whether urinary KIM-1 predicts graft loss, independent of renal function and proteinuria...
  89. ncbi request reprint Tubular kidney injury molecule-1 in protein-overload nephropathy
    Mirjan M van Timmeren
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Am J Physiol Renal Physiol 291:F456-64. 2006
    ..These results implicate involvement of Kim-1 in the pathogenesis of proteinuria-induced renal damage/repair. Urinary Kim-1 levels may serve as a marker of proteinuria-induced renal damage...
  90. ncbi request reprint Addition of oleic acid to delipidated bovine serum albumin aggravates renal damage in experimental protein-overload nephrosis
    Mirjan M van Timmeren
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 20:2349-57. 2005
    ..To investigate whether NEFA aggravate renal structural damage, we studied the effects of NEFA addition to delipidated bovine serum albumin (BSA) in protein-overload nephropathy...
  91. ncbi request reprint The effect of cholesteryl ester transfer protein -629C->A promoter polymorphism on high-density lipoprotein cholesterol is dependent on serum triglycerides
    Susanna E Borggreve
    Department of Endocrinology, University Medical Centre Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 90:4198-204. 2005
    ..The effect of the closely linked CETP TaqIB polymorphism on HDL-C has been suggested to be modified by obesity and hyperinsulinemia...
  92. ncbi request reprint Evaluation of measures of urinary albumin excretion
    Ronald T Gansevoort
    Department of Nephrology, University Medical Center, Groningen, The Netherlands
    Am J Epidemiol 164:725-7. 2006
    ..Consequently, values for the within-person coefficient of variation will therefore be different when they are measured in a portion of a 24-hour urine collection in comparison with a spot morning urine sample...
  93. ncbi request reprint Update on microalbuminuria as a biomarker in renal and cardiovascular disease
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, The Netherlands bDepartment of Internal Medicine, The Netherlands
    Curr Opin Nephrol Hypertens 15:631-6. 2006
    ..To discuss recently published papers on the potential use of albuminuria as a predictor of cardiovascular and renal disease...
  94. doi request reprint Proteinuria-associated endothelial dysfunction is strain dependent
    Nadir Ulu
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Am J Nephrol 30:209-17. 2009
    ..Therefore, we studied aortic endothelial function in Munich Wistar Fromter (MWF) and fawn-hooded hypertensive (FHH) inbred rat strains with genetic proteinuria to determine the specific impact of proteinuria on the development of ED...
  95. doi request reprint Selection on albuminuria enhances the efficacy of screening for cardiovascular risk factors
    Akin Ozyilmaz
    Division of Nephrology, Department of Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 25:3560-8. 2010
    ..As albuminuria is easy to measure, we tested whether a screening approach in which detailed risk factor measurement is done only after selection of subjects with an elevated albuminuria results in a higher yield of subjects at risk...
  96. pmc initial angiotensin receptor blockade-induced decrease in albuminuria is associated with long-term renal outcome in type 2 diabetic patients with microalbuminuria: a post hoc analysis of the IRMA-2 trial
    Merel E Hellemons
    Department of Clinical Pharmacology, University ofGroningen, Groningen, The Netherlands
    Diabetes Care 34:2078-83. 2011
    ....
  97. ncbi request reprint Metabolic syndrome is associated with impaired long-term renal allograft function; not all component criteria contribute equally
    Aiko P J de Vries
    Renal Transplant Program, Groningen University Medical Center, Groningen, The Netherlands
    Am J Transplant 4:1675-83. 2004
    ..Only systolic blood pressure and hypertriglyceridemia were independently associated with impaired renal allograft function beyond 1 year post-transplant in multivariate analyses...
  98. ncbi request reprint Validation of insulin resistance indexes in a stable renal transplant population
    Leendert H Oterdoom
    Renal Transplant Program, University of Groningen and University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, Netherlands
    Diabetes Care 28:2424-9. 2005
    ..The purpose of this study was to investigate the validity of established insulin resistance indexes, based on fasting blood parameters, in a stable renal transplant population...
  99. ncbi request reprint Supplementation with anti-oxidants Vitamin C and E decreases cyclosporine A trough-levels in renal transplant recipients
    Aiko P J de Vries
    Nephrol Dial Transplant 21:231-2. 2006
  100. ncbi request reprint Insulin resistance as putative cause of chronic renal transplant dysfunction
    Aiko P J de Vries
    Division of Nephrology Department of Medicine, Groningen University Medical Center, Groningen, The Netherlands
    Am J Kidney Dis 41:859-67. 2003
    ....
  101. ncbi request reprint A pilot study into measurements of markers of atherosclerosis in periodontitis
    Efstratios Leivadaros
    Department of Periodontology, Academic Center for Dentistry Amsterdam ACTA, University of Amsterdam and Vrije University, Amsterdam, The Netherlands
    J Periodontol 76:121-8. 2005
    ..Periodontitis may be a possible risk factor for atherosclerosis. The current pilot study explored arterial wall thickness and other variables associated with atherosclerosis in healthy subjects with and without periodontitis...