Stephan J L Bakker

Summary

Affiliation: University Medical Center Groningen
Country: The Netherlands

Publications

  1. ncbi Metabolic syndrome: a fata morgana?
    Stephan J L Bakker
    Department of Internal Medicine, University Hospital Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:15-20. 2007
  2. ncbi Microalbuminuria and C-reactive protein: similar messengers of cardiovascular risk?
    Stephan J L Bakker
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Curr Hypertens Rep 7:379-84. 2005
  3. ncbi Albuminuria: what can we expect from the determination of nonimmunoreactive albumin?
    Stephan J L Bakker
    Department of Internal Medicine, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Curr Hypertens Rep 11:111-7. 2009
  4. ncbi Skin-autofluorescence is an independent predictor of graft loss in renal transplant recipients
    Jasper W L Hartog
    Department of Internal Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Transplantation 87:1069-77. 2009
  5. ncbi N-terminal pro-B-type natriuretic peptide and mortality in renal transplant recipients versus the general population
    Leendert H Oterdoom
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transplantation 87:1562-70. 2009
  6. ncbi Gender differences in predictors of the decline of renal function in the general population
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:505-12. 2008
  7. ncbi External validation of the KORA S4/F4 prediction models for the risk of developing type 2 diabetes in older adults: the PREVEND study
    Ali Abbasi
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Epidemiol 27:47-52. 2012
  8. ncbi Risk factors for chronic transplant dysfunction and cardiovascular disease are related to accumulation of advanced glycation end-products in renal transplant recipients
    Jasper W L Hartog
    University Medical Center Groningen, University of Groningen, Department of Medicine, Division of Nephrology, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 21:2263-9. 2006
  9. ncbi Plasma procalcitonin is associated with obesity, insulin resistance, and the metabolic syndrome
    Ali Abbasi
    Department of Epidemiology, University Medical Center Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 95:E26-31. 2010
  10. ncbi Urinary creatinine excretion reflecting muscle mass is a predictor of mortality and graft loss in renal transplant recipients
    Leendert H Oterdoom
    Department of Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 86:391-8. 2008

Detail Information

Publications108 found, 100 shown here

  1. ncbi Metabolic syndrome: a fata morgana?
    Stephan J L Bakker
    Department of Internal Medicine, University Hospital Groningen, PO Box 30001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:15-20. 2007
  2. ncbi Microalbuminuria and C-reactive protein: similar messengers of cardiovascular risk?
    Stephan J L Bakker
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Curr Hypertens Rep 7:379-84. 2005
    ....
  3. ncbi Albuminuria: what can we expect from the determination of nonimmunoreactive albumin?
    Stephan J L Bakker
    Department of Internal Medicine, University Medical Center Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Curr Hypertens Rep 11:111-7. 2009
    ....
  4. ncbi Skin-autofluorescence is an independent predictor of graft loss in renal transplant recipients
    Jasper W L Hartog
    Department of Internal Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Transplantation 87:1069-77. 2009
    ..AGEs are nephrotoxic and potential effectors of cardiovascular mortality. We investigated whether skin-AF predicted graft loss after kidney transplantation...
  5. ncbi N-terminal pro-B-type natriuretic peptide and mortality in renal transplant recipients versus the general population
    Leendert H Oterdoom
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transplantation 87:1562-70. 2009
    ..Mortality rates are higher in renal transplant recipients (RTR) than in the general population (GP). It is unknown what risk factors account for this difference...
  6. ncbi Gender differences in predictors of the decline of renal function in the general population
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:505-12. 2008
    ..These studies show that there are gender differences in the standard predictors of the decline in renal function...
  7. ncbi External validation of the KORA S4/F4 prediction models for the risk of developing type 2 diabetes in older adults: the PREVEND study
    Ali Abbasi
    Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Eur J Epidemiol 27:47-52. 2012
    ..However, the models need to be corrected for intercept and slope to acquire good calibration for application in a different setting...
  8. ncbi Risk factors for chronic transplant dysfunction and cardiovascular disease are related to accumulation of advanced glycation end-products in renal transplant recipients
    Jasper W L Hartog
    University Medical Center Groningen, University of Groningen, Department of Medicine, Division of Nephrology, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 21:2263-9. 2006
    ..We aimed to investigate which factors are associated with tissue AGE accumulation in renal transplant recipients...
  9. ncbi Plasma procalcitonin is associated with obesity, insulin resistance, and the metabolic syndrome
    Ali Abbasi
    Department of Epidemiology, University Medical Center Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 95:E26-31. 2010
    ..Procalcitonin, a well-known biomarker of sepsis and bacterial infections, is produced by adipose tissue and has potential as a marker for chronic low-grade inflammation...
  10. ncbi Urinary creatinine excretion reflecting muscle mass is a predictor of mortality and graft loss in renal transplant recipients
    Leendert H Oterdoom
    Department of Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 86:391-8. 2008
    ..Skeletal muscle mainly determines peripheral insulin resistance, and could therefore affect outcome...
  11. ncbi Urinary creatinine excretion, an indirect measure of muscle mass, is an independent predictor of cardiovascular disease and mortality in the general population
    Leendert H Oterdoom
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Atherosclerosis 207:534-40. 2009
    ..We aimed to determine whether muscle mass, as reflected by 24h urinary creatinine excretion, is associated with CVD and whether this depends on insulin resistance...
  12. ncbi A double-blind, randomized, placebo-controlled clinical trial on benfotiamine treatment in patients with diabetic nephropathy
    Alaa Alkhalaf
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Diabetes Care 33:1598-601. 2010
    ..To investigate the effect of benfotiamine on urinary albumin excretion (UAE) and the tubular damage marker kidney injury molecule-1 (KIM-1) in patients with type 2 diabetes and nephropathy...
  13. ncbi High plasma hemopexin activity is an independent risk factor for late graft failure in renal transplant recipients
    Jan A Krikken
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transpl Int 23:805-12. 2010
    ..This suggests that Hx measurement, next to measurement of creatinine clearance and UP, could be of value for the identification of RTRs at risk for graft failure...
  14. ncbi Copeptin, a surrogate marker of vasopressin, is associated with disease severity in autosomal dominant polycystic kidney disease
    Esther Meijer
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Clin J Am Soc Nephrol 6:361-8. 2011
    ..However, it is unknown whether endogenous vasopressin concentration is associated with disease severity in patients with ADPKD...
  15. ncbi Copeptin, a surrogate marker of vasopressin, is associated with microalbuminuria in a large population cohort
    Esther Meijer
    Department of Internal Medicine, Division of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 77:29-36. 2010
    ..If future studies show that this association is causal, then drinking more water or pharmacological intervention to decrease plasma vasopressin may have beneficial effects on the kidney, especially in the elderly...
  16. ncbi Elevated levels of C-reactive protein independently predict accelerated deterioration of graft function in renal transplant recipients
    Rutger M van Ree
    Department of Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:246-53. 2007
    ..In this prospective study, we investigated whether CRP could be of use as a clinical marker for early identification of renal transplant recipients at increased risk of deterioration of graft function...
  17. ncbi Albuminuria, proteinuria, and novel urine biomarkers as predictors of long-term allograft outcomes in kidney transplant recipients
    Ferdau L Nauta
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 57:733-43. 2011
    ....
  18. ncbi Do albuminuria and hs-CRP add to the International Diabetes Federation definition of the metabolic syndrome in predicting outcome?
    Marije van der Velde
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University Hospital Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 27:2275-83. 2012
    ....
  19. ncbi Is high-sensitive C-reactive protein a biomarker for functional somatic symptoms? A population-based study
    Lineke M Tak
    Interdisciplinary Center for Psychiatric Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Brain Behav Immun 23:1014-9. 2009
    ..12, 95% CI 1.03-1.21). We conclude that the level of hs-CRP is not a biomarker for the total number of FSS in the general population. The association between hs-CRP and musculoskeletal and general FSS needs further study...
  20. ncbi Plasma procalcitonin is an independent predictor of graft failure late after renal transplantation
    Rutger M van Ree
    Department of Internal Medicine, Renal Transplant Program, University Medical Center Groningen and University of Groningen, 9700 RB Groningen, The Netherlands
    Transplantation 88:279-87. 2009
    ....
  21. ncbi Influence of age and measure of eGFR on the association between renal function and cardiovascular events
    Marije van der Velde
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Clin J Am Soc Nephrol 5:2053-9. 2010
    ..This study investigates whether the association between estimated GFR (eGFR) and cardiovascular (CV) outcome differs for different measures of eGFR and different age groups...
  22. ncbi Low physical activity and risk of cardiovascular and all-cause mortality in renal transplant recipients
    Dorien M Zelle
    Department of Nephrology, University Medical Center Groningen, Sector A, PO Box 30001, 9700 RB, Groningen, The Netherlands
    Clin J Am Soc Nephrol 6:898-905. 2011
    ..This is largely unexplored in renal transplant recipients (RTRs). We studied whether PA is associated with cardiovascular and all-cause mortality in a prospective cohort of RTR...
  23. ncbi Glomerular and tubular damage markers are elevated in patients with diabetes
    Ferdau L Nauta
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Diabetes Care 34:975-81. 2011
    ....
  24. ncbi Albuminuria assessed from first-morning-void urine samples versus 24-hour urine collections as a predictor of cardiovascular morbidity and mortality
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    Am J Epidemiol 168:897-905. 2008
    ..To predict cardiovascular morbidity and all-cause mortality, measuring ACR in a first-morning-void urine sample is a good alternative to measuring 24-hour UAE...
  25. ncbi Smoking is a risk factor for graft failure and mortality after renal transplantation
    Pramod K Agarwal
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Am J Nephrol 34:26-31. 2011
    ..Smoking in renal transplant recipients (RTR) is an acknowledged cardiovascular risk factor. It is, however, unclear whether smoking also increases the risk of graft failure (GF)...
  26. ncbi Alcohol consumption, new onset of diabetes after transplantation, and all-cause mortality in renal transplant recipients
    Dorien M Zelle
    Department of Nephrology, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 92:203-9. 2011
    ..Therefore, we investigated the association of alcohol consumption with new onset of diabetes after transplantation (NODAT), mortality, and graft failure in RTR...
  27. ncbi CUBN as a novel locus for end-stage renal disease: insights from renal transplantation
    Anna Reznichenko
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e36512. 2012
    ..Thus, we identified CUBN rs7918972 as a novel risk variant for renal function loss in two independent settings: ESRD in native kidneys and GF in transplanted kidneys...
  28. ncbi Fasting insulin modifies the relation between age and renal function
    Leendert H Oterdoom
    Department of Medicine, University Medical Center Groningen, Hanzeplein 1, Postbus 30 001, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:1587-92. 2007
    ..This population-based study is the first to investigate whether fasting insulin concentrations modify the relationship between age and renal function in a general non-diabetic population...
  29. ncbi Effect of withdrawal of pravastatin therapy on C-reactive protein and low-density lipoprotein cholesterol
    Pim van der Harst
    Department of Experimental Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Cardiol 100:1548-51. 2007
    ..In conclusion, withdrawal from pravastatin treatment resulted in an increase in CRP to approximately baseline levels, which is not related to the increase in LDL cholesterol...
  30. ncbi CCR5Delta32 genotype is associated with outcome in type 2 diabetes mellitus
    Friso L H Muntinghe
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Diabetes Res Clin Pract 86:140-5. 2009
    ..To test whether the genetic variant CCR5Delta32 in the CC-chemokine receptor 5, which is known to lead to CCR5 deficiency, is associated with mortality in type 2 diabetes patients...
  31. ncbi N-terminal pro-B-type natriuretic peptide is an independent predictor of cardiovascular morbidity and mortality in the general population
    Gerard C M Linssen
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, Hanzeplein 1, PO Box 30 001, 9700 RB Groningen, The Netherlands
    Eur Heart J 31:120-7. 2010
    ..However, their prognostic value in the general population is less well established. The purpose of our study was to investigate the prognostic properties of NT-proBNP for death and cardiovascular (CV) events in the general population...
  32. ncbi Screening for albuminuria identifies individuals at increased renal risk
    Marije van der Velde
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    J Am Soc Nephrol 20:852-62. 2009
    ..Screening for albuminuria identifies patients at increased risk for progressive renal disease, 40 to 50% of whom were previously undiagnosed or untreated...
  33. ncbi First morning voids are more reliable than spot urine samples to assess microalbuminuria
    Elsbeth C Witte
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Antonius Deusinglaan 1, 9713 AV Groningen, The Netherlands
    J Am Soc Nephrol 20:436-43. 2009
    ..In conclusion, measurement of albuminuria in a first morning void, preferably as the ACR, is more reliable than a spot urine sample to diagnose and monitor microalbuminuria...
  34. ncbi Cardiovascular and renal outcome in subjects with K/DOQI stage 1-3 chronic kidney disease: the importance of urinary albumin excretion
    Auke H Brantsma
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 23:3851-8. 2008
    ..In this study we evaluated cardiovascular and renal outcome in subjects with stage 1 and 2 CKD. For comparison, we also studied these outcomes in stage 3 CKD...
  35. ncbi Incidence of impaired renal function after lung transplantation
    Merel E Hellemons
    Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    J Heart Lung Transplant 31:238-43. 2012
    ..We aimed to study changes in recipient characteristics in conjunction with incidence of impaired renal function in consecutive series of lung transplant recipients (LTRs)...
  36. ncbi Fasting insulin is a stronger cardiovascular risk factor in women than in men
    Leendert H Oterdoom
    Department of Internal Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
    Atherosclerosis 203:640-6. 2009
    ..In parallel with diabetes, fasting hyperinsulinaemia reflecting insulin resistance in non-diabetic subjects is associated with an increased risk for cardiovascular disease, which is more pronounced in women than in men...
  37. ncbi Lipid-soluble components in cigarette smoke induce mitochondrial production of reactive oxygen species in lung epithelial cells
    Marco van der Toorn
    Department of Pathology and Medical Biology, Laboratory of Allergology and Pulmonary Diseases, University Medical Center Groningen, University of Groningen, The
    Am J Physiol Lung Cell Mol Physiol 297:L109-14. 2009
    ..Lipophilic components in CS disturb mitochondrial function, which contributes to increased intracellular generation of ROS. Our results are of importance in understanding the systemic effects of smoking observed in patients with COPD...
  38. ncbi Association of urinary biomarkers with disease severity in patients with autosomal dominant polycystic kidney disease: a cross-sectional analysis
    Esther Meijer
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 56:883-95. 2010
    ....
  39. ncbi Body mass index and creatinine clearance are associated with steady-state serum concentrations of the cell damage marker S100B in renal transplant recipients
    Sascha Gross
    Kidney Center, Dept of Internal Medicine, University Medical Center Groningen, Hanzeplein 1, Groningen, The Netherlands
    Med Sci Monit 16:CR318-24. 2010
    ....
  40. ncbi What predicts progression and regression of urinary albumin excretion in the nondiabetic population?
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, PO Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 18:637-45. 2007
    ....
  41. ncbi Copeptin, a surrogate marker of vasopressin, is associated with accelerated renal function decline in renal transplant recipients
    Esther Meijer
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Transplantation 88:561-7. 2009
    ..Whether endogenous VP is a renal risk factor in humans has not been investigated yet. We aimed to investigate whether, in renal transplant recipients, VP concentration is associated with change in renal function during follow-up...
  42. ncbi Extended prognostic value of urinary albumin excretion for cardiovascular events
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 19:1785-91. 2008
    ..Future studies are required to determine the optimal interval of repeat testing and its cost-effectiveness...
  43. ncbi C-reactive protein and microalbuminuria differ in their associations with various domains of vascular disease
    Erik M Stuveling
    Department of Internal Medicine, University Medical Centre Groningen, Groningen, The Netherlands
    Atherosclerosis 172:107-14. 2004
    ..Thus, CRP and MA are risk markers for vascular disease, each showing a different risk profiling for different vascular beds...
  44. ncbi An initial reduction in serum uric acid during angiotensin receptor blocker treatment is associated with cardiovascular protection: a post-hoc analysis of the RENAAL and IDNT trials
    Paul A Smink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    J Hypertens 30:1022-8. 2012
    ..Treatment with the angiotensin receptor blocker (ARB) losartan lowers SUA in contrast to other ARBs. Whether reductions in SUA during ARB therapy are associated with cardiovascular protection is unclear. We aimed to investigate this...
  45. ncbi Low levels of sRAGE are associated with increased risk for mortality in renal transplant recipients
    Sascha Gross
    Kidney Center, Department of Internal Medicine, University Medical Center Groningen, Groningen, The Netherlands
    Transplantation 84:659-63. 2007
    ..In this study we investigated determinants of endogenous sRAGE in renal transplant recipients and whether sRAGE was associated with mortality and graft loss...
  46. ncbi Aldosterone, from (patho)physiology to treatment in cardiovascular and renal damage
    Femke Waanders
    Division of Nephrology, Department of Internal Medicine, University Medical Center Groningen, The Netherlands
    Curr Vasc Pharmacol 9:594-605. 2011
    ..It is obligatory that future clinical studies on the effects of MR blockade on end-organ damage take into account the sodium status...
  47. ncbi Abdominal obesity and smoking are important determinants of C-reactive protein in renal transplant recipients
    Rutger M van Ree
    Renal Transplant Program, University Medical Center Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 20:2524-31. 2005
    ..CRP is not associated with any of the transplant-related factors, except for renal transplant function...
  48. ncbi Albuminuria: all you need to predict outcomes in chronic kidney disease?
    Ron T Gansevoort
    Department of Nephrology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Curr Opin Nephrol Hypertens 19:513-8. 2010
    ..In current approaches, further evaluation will only include measurement of albuminuria in case of eGFR less than 60 ml/min/1.73 m. We will review whether this screening approach is correct...
  49. ncbi Renoprotective effects of long-term oral nicotine in a rat model of spontaneous proteinuria
    Pramod K Agarwal
    Dept of Internal Medicine, Experimental Nephrology, University Medical Center Groningen, Antonius Deusinglaan 1, Groningen, The Netherlands
    Am J Physiol Renal Physiol 302:F895-904. 2012
    ..We further suggest evaluating nicotine as a potential additional therapeutic option for treating proteinuric kidney diseases...
  50. ncbi High protein intake associates with cardiovascular events but not with loss of renal function
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, University Hospital Groningen, Groningen, Netherlands
    J Am Soc Nephrol 20:1797-804. 2009
    ..In summary, in the general population, high protein intake does not promote accelerated decline of renal function but does associate with an increased risk for cardiovascular events...
  51. ncbi Advanced glycation end-products (AGEs) and heart failure: pathophysiology and clinical implications
    Jasper W L Hartog
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen and University of Groningen, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Eur J Heart Fail 9:1146-55. 2007
    ..In this review, the role of AGEs in the development of heart failure and the role of AGE intervention as a possible treatment for heart failure are discussed...
  52. ncbi Impact of statins in microalbuminuric subjects with the metabolic syndrome: a substudy of the PREVEND Intervention Trial
    Christiane A Geluk
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, Postbus 30001, Hanzeplein 1, 9700 RB, Groningen, The Netherlands
    Eur Heart J 26:1314-20. 2005
    ..We evaluated the impact of pravastatin treatment on the incidence of major adverse cardiac events in microalbuminuric subjects with the metabolic syndrome...
  53. ncbi Impact of weight change on albuminuria in the general population
    Aminu K Bello
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, 9700 RB Groningen, The Netherlands
    Nephrol Dial Transplant 22:1619-27. 2007
    ..The impact of weight change on albuminuria and its possible mechanism has not been studied yet in the general population. We investigated this issue in a cohort of the Northern European population...
  54. ncbi Cyclosporin A-induced oxidative stress is not the consequence of an increase in mitochondrial membrane potential
    Marco van der Toorn
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    FEBS J 274:3003-12. 2007
    ..Neither mitochondria, effects on P-glycoprotein nor inhibition of calcineurin therefore play a role in cyclosporin A-induced oxidative stress and disturbed Ca2+ homeostasis...
  55. ncbi Albuminuria, Estimated GFR, Traditional Risk Factors, and Incident Cardiovascular Disease: The PREVEND (Prevention of Renal and Vascular Endstage Disease) Study
    Paul A Smink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Am J Kidney Dis 60:804-11. 2012
    ..This study assessed the contribution of each separately in correctly identifying individuals at cardiovascular risk in the general population beyond traditional risk markers...
  56. ncbi Plasma renin and outcome in the community: data from PREVEND
    Rudolf A de Boer
    Department of Cardiology, University of Groningen, University Medical Centre Groningen, Hanzeplein 1, Groningen 9713GZ, The Netherlands
    Eur Heart J 33:2351-9. 2012
    ..The renin-angiotensin system plays a central role in patients with established cardiovascular (CV) disease, but the prognostic effect of plasma renin in the community is unclear...
  57. ncbi Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy
    Alaa Alkhalaf
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    PLoS ONE 7:e40427. 2012
    ..We investigated the effect of benfotiamine on markers of these pathways in patients with type 2 diabetes and nephropathy...
  58. ncbi Screening and monitoring for albuminuria: the performance of the HemoCue point-of-care system
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Kidney Int 74:377-83. 2008
    ....
  59. ncbi MRI-determined fat content of human liver, pancreas and kidney
    Paul E Sijens
    Department of Radiology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, Groningen, The Netherlands
    World J Gastroenterol 16:1993-8. 2010
    ..To assess and correlate the lipid content of various organs in obese subjects and in persons with a normal body weight...
  60. ncbi Kidney injury molecule-1 in renal disease
    Femke Waanders
    Kidney Centre, University Medical Centre Groningen, University of Groningen, 9700 RB Groningen, The Netherlands
    J Pathol 220:7-16. 2010
    ..Finally, the potential of KIM-1 as biomarker of renal damage, as a predictor of renal function decline and its perspectives for monitoring therapy response, are discussed...
  61. ncbi Replication of the five novel loci for uric acid concentrations and potential mediating mechanisms
    Pim van der Harst
    Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Hum Mol Genet 19:387-95. 2010
    ..011), fractional UA excretion (P = 3.36 x 10(-5)) and high-sensitive CRP (P = 1.18 x 10(-3)) also after adjusting for serum UA levels. We argue that GCKR locus affects serum UA levels through a factor that also affects triglycerides...
  62. ncbi Obesity and impaired renal function: potential for lifestyle intervention?
    Eva Corpeleijn
    Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands
    Eur J Epidemiol 24:275-80. 2009
    ..After the recent success of lifestyle intervention to prevent diabetes, further research is needed to show the effects of lifestyle changes to prevent and reduce obesity-related morbidity, including chronic kidney disease...
  63. ncbi C-reactive protein and angiographic characteristics of stable and unstable coronary artery disease: data from the prospective PREVEND cohort
    Christiane A Geluk
    Department of Cardiology, Thoraxcenter, University Medical Center Groningen, University of Groningen, The Netherlands
    Atherosclerosis 196:372-82. 2008
    ..In addition, we investigated the association with coronary events during follow up in the total PREVEND population...
  64. ncbi Possible contribution of cytomegalovirus infection to the high risk of (recurrent) venous thrombosis after renal transplantation
    Willem M Lijfering
    Division of Haemostasis, Thrombosis and Rheology, University Medical Centre Groningen, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    Thromb Haemost 99:127-32. 2008
    ..Prospective studies are warranted to establish this observation, which suggests that CMV infection influences the high risk of (recurrent) venous thrombosis in renal transplant recipients...
  65. ncbi Thyroid function is associated with components of the metabolic syndrome in euthyroid subjects
    Annemieke Roos
    Department of Endocrinology, University Medical Center Groningen and University of Groningen, P O Box 30001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 92:491-6. 2007
    ..Thyroid disease and the metabolic syndrome are both associated with cardiovascular disease...
  66. ncbi Clinical and prognostic value of advanced glycation end-products in chronic heart failure
    Jasper W L Hartog
    Department of Cardiology, University Medical Center Groningen and University of Groningen, Hanzeplein 1, PO Box 30001, 9700 RB Groningen, The Netherlands
    Eur Heart J 28:2879-85. 2007
    ..We aimed to determine whether plasma levels of N(epsilon)-(carboxymethyl)lysine (CML) and N(epsilon)-(carboxyethyl)lysine (CEL), two well-known AGEs, are related to the severity and prognosis of CHF...
  67. ncbi Macroalbuminuria is a better risk marker than low estimated GFR to identify individuals at risk for accelerated GFR loss in population screening
    Nynke Halbesma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, The Netherlands
    J Am Soc Nephrol 17:2582-90. 2006
    ..However, macroalbuminuria is a better risk marker than low eGFR or erythrocyturia to identify in population screening of individuals who are at risk for accelerated GFR loss...
  68. ncbi Macroalbuminuria and microalbuminuria: do both predict renal and cardiovascular events with similar strength?
    Paul E de Jong
    Department of Medicine, University Medical Centre Groningen, University of Groningen, Groningen, The Netherlands
    J Nephrol 20:375-80. 2007
    ..When promoting routine screening for albuminuria, one should realize, moreover, that such projects will most likely be much more cost-effective when directed to preventing not only renal end points, but also CV end points...
  69. ncbi C-reactive protein is associated with renal function abnormalities in a non-diabetic population
    Erik M Stuveling
    Internal Medicine, Trial Coordination Center, Department of Cardiology Thoraxcenter, University Hospital Groningen, and Clinical Pharmacology, University of Groningen, Groningen, The Netherlands
    Kidney Int 63:654-61. 2003
    ..We hypothesized that elevated CRP levels are associated with renal function abnormalities...
  70. ncbi Tissue thiamine deficiency as potential cause of delayed graft function after kidney transplantation: thiamine supplementation of kidney donors may improve transplantation outcome
    Astrid Klooster
    Department of Internal Medicine, University Medical Center Groningen, University of Groningen, The Netherlands
    Med Hypotheses 69:873-8. 2007
    ..We therefore hypothesize that a suboptimal tissue thiamine status is a cause of delayed graft function after renal transplantation, and that it can be prevented with thiamine supplementation...
  71. ncbi Low dietary sodium and exogenous angiotensin II infusion decrease plasma adiponectin concentrations in healthy men
    A Titia Lely
    Department of Internal Medicine, Division of Nephrology, Hanzeplein 1, 9713 GZ Groningen, The Netherlands
    J Clin Endocrinol Metab 92:1821-6. 2007
    ..Adiponectin has antiinflammatory and vascular protective effects and may improve insulin sensitivity. Animal data suggest a role of the renin-angiotensin aldosterone system (RAAS) in the regulation of adiponectin...
  72. ncbi initial angiotensin receptor blockade-induced decrease in albuminuria is associated with long-term renal outcome in type 2 diabetic patients with microalbuminuria: a post hoc analysis of the IRMA-2 trial
    Merel E Hellemons
    Department of Clinical Pharmacology, University ofGroningen, Groningen, The Netherlands
    Diabetes Care 34:2078-83. 2011
    ....
  73. ncbi Evaluation of measures of urinary albumin excretion
    Ronald T Gansevoort
    Department of Nephrology, University Medical Center, Groningen, The Netherlands
    Am J Epidemiol 164:725-7. 2006
    ..Consequently, values for the within-person coefficient of variation will therefore be different when they are measured in a portion of a 24-hour urine collection in comparison with a spot morning urine sample...
  74. ncbi Tubular kidney injury molecule-1 in protein-overload nephropathy
    Mirjan M van Timmeren
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Am J Physiol Renal Physiol 291:F456-64. 2006
    ..These results implicate involvement of Kim-1 in the pathogenesis of proteinuria-induced renal damage/repair. Urinary Kim-1 levels may serve as a marker of proteinuria-induced renal damage...
  75. ncbi Selection on albuminuria enhances the efficacy of screening for cardiovascular risk factors
    Akin Ozyilmaz
    Division of Nephrology, Department of Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 25:3560-8. 2010
    ..As albuminuria is easy to measure, we tested whether a screening approach in which detailed risk factor measurement is done only after selection of subjects with an elevated albuminuria results in a higher yield of subjects at risk...
  76. ncbi Oleic acid loading does not add to the nephrotoxic effect of albumin in an amphibian and chronic rat model of kidney injury
    Mirjan M van Timmeren
    University Medical Center Groningen, University of Groningen, Department of Pathology and Laboratory Medicine, Groningen, The Netherlands
    Nephrol Dial Transplant 23:3814-23. 2008
    ..p. injection of albumin selectively targeted open but not closed nephrons and was used to prevent removal of fatty acids from albumin in the circulation...
  77. ncbi Update on microalbuminuria as a biomarker in renal and cardiovascular disease
    Hiddo J Lambers Heerspink
    Department of Clinical Pharmacology, The Netherlands bDepartment of Internal Medicine, The Netherlands
    Curr Opin Nephrol Hypertens 15:631-6. 2006
    ..To discuss recently published papers on the potential use of albuminuria as a predictor of cardiovascular and renal disease...
  78. ncbi The effect of cholesteryl ester transfer protein -629C->A promoter polymorphism on high-density lipoprotein cholesterol is dependent on serum triglycerides
    Susanna E Borggreve
    Department of Endocrinology, University Medical Centre Groningen, P O Box 30 001, 9700 RB Groningen, The Netherlands
    J Clin Endocrinol Metab 90:4198-204. 2005
    ..The effect of the closely linked CETP TaqIB polymorphism on HDL-C has been suggested to be modified by obesity and hyperinsulinemia...
  79. ncbi Addition of oleic acid to delipidated bovine serum albumin aggravates renal damage in experimental protein-overload nephrosis
    Mirjan M van Timmeren
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Nephrol Dial Transplant 20:2349-57. 2005
    ..To investigate whether NEFA aggravate renal structural damage, we studied the effects of NEFA addition to delipidated bovine serum albumin (BSA) in protein-overload nephropathy...
  80. ncbi Circulating markers of endothelial dysfunction interact with proteinuria in predicting mortality in renal transplant recipients
    Rutger M van Ree
    The Renal Transplant Program, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Transplantation 86:1713-9. 2008
    ..We investigated whether urinary protein excretion (UPE) is correlated with markers of ED and whether these markers affect the association of proteinuria with mortality in renal transplant recipients (RTR)...
  81. ncbi Proteinuria-associated endothelial dysfunction is strain dependent
    Nadir Ulu
    Department of Clinical Pharmacology, University Medical Center Groningen, Groningen, The Netherlands
    Am J Nephrol 30:209-17. 2009
    ..Therefore, we studied aortic endothelial function in Munich Wistar Fromter (MWF) and fawn-hooded hypertensive (FHH) inbred rat strains with genetic proteinuria to determine the specific impact of proteinuria on the development of ED...
  82. ncbi High urinary excretion of kidney injury molecule-1 is an independent predictor of graft loss in renal transplant recipients
    Mirjan M van Timmeren
    Department of Pathology and Laboratory Medicine, University Medical Center Groningen and University of Groningen, The Netherlands
    Transplantation 84:1625-30. 2007
    ..Urinary KIM-1 excretion has been quantified as biomarker of renal damage. We prospectively studied whether urinary KIM-1 predicts graft loss, independent of renal function and proteinuria...
  83. ncbi Acute elevation of plasma non-esterified fatty acids increases pulse wave velocity and induces peripheral vasodilation in humans in vivo
    Niels P Riksen
    Department of Pharmacology Toxicology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Sci (Lond) 113:33-40. 2007
    ..As the adenosine receptor antagonist caffeine could not antagonize the vasodilator response, this response is not mediated by adenosine receptor stimulation...
  84. ncbi Validation of insulin resistance indexes in a stable renal transplant population
    Leendert H Oterdoom
    Renal Transplant Program, University of Groningen and University Medical Center Groningen, P.O. Box 30.001, 9700 RB Groningen, Netherlands
    Diabetes Care 28:2424-9. 2005
    ..In addition to fasting insulin and triglyceride concentrations, of which McAuley's index is composed, only BMI seemed to be independently associated with insulin resistance in this population...
  85. ncbi Apparent loss of urinary albumin during long-term frozen storage: HPLC vs immunonephelometry
    Jacoline W Brinkman
    Department of Clinical Pharmacology, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Clin Chem 53:1520-6. 2007
    ..We investigated whether this technique is affected by sample temperature, particularly freezing...
  86. ncbi Supplementation with anti-oxidants Vitamin C and E decreases cyclosporine A trough-levels in renal transplant recipients
    Aiko P J de Vries
    Nephrol Dial Transplant 21:231-2. 2006
  87. ncbi A pilot study into measurements of markers of atherosclerosis in periodontitis
    Efstratios Leivadaros
    Department of Periodontology, Academic Center for Dentistry Amsterdam (ACTA, University of Amsterdam and Vrije University, Amsterdam, The Netherlands
    J Periodontol 76:121-8. 2005
    ..CONCLUSION: The present pilot study indicates that a full study investigating the relationship between periodontitis and atherosclerosis is warranted...
  88. ncbi Biochemical risk markers: a novel area for better prediction of renal risk?
    Erik M Stuveling
    Nephrol Dial Transplant 20:497-508. 2005
  89. ncbi Metabolic syndrome is associated with impaired long-term renal allograft function; not all component criteria contribute equally
    Aiko P J de Vries
    Renal Transplant Program, Groningen University Medical Center, Groningen, The Netherlands
    Am J Transplant 4:1675-83. 2004
    ..Only systolic blood pressure and hypertriglyceridemia were independently associated with impaired renal allograft function beyond 1 year post-transplant in multivariate analyses...
  90. ncbi C-reactive protein modifies the relationship between blood pressure and microalbuminuria
    Erik M Stuveling
    Department of Medicine, University Medical Center, Groningen, The Netherlands
    Hypertension 43:791-6. 2004
    ..0004). No significant interactions between other risk factors and CRP with respect to the risk of microalbuminuria were encountered. Thus, CRP modifies the relation between blood pressure and microalbuminuria...
  91. ncbi Insulin resistance as putative cause of chronic renal transplant dysfunction
    Aiko P J de Vries
    Division of Nephrology Department of Medicine, Groningen University Medical Center, Groningen, The Netherlands
    Am J Kidney Dis 41:859-67. 2003
    ....
  92. ncbi Urinary albumin excretion and its relation with C-reactive protein and the metabolic syndrome in the prediction of type 2 diabetes
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, P.O. Box 30, 001, 9700 RB, Groningen, Netherlands
    Diabetes Care 28:2525-30. 2005
    ..CONCLUSIONS: UAE predicts type 2 diabetes independent of the metabolic syndrome and other known risk markers of development of type 2 diabetes. The predictive value of UAE was modified by the level of CRP...
  93. ncbi Falsely low urinary albumin concentrations after prolonged frozen storage of urine samples
    Jacoline W Brinkman
    Department of Clinical Pharmacology, University of Groningen and University Medical Center Groningen, The Netherlands
    Clin Chem 51:2181-3. 2005
  94. ncbi Urinary albumin excretion as a predictor of the development of hypertension in the general population
    Auke H Brantsma
    Division of Nephrology, Department of Medicine, University Medical Center Groningen, PO Box 30.001, Groningen, 9700 RB The Netherlands
    J Am Soc Nephrol 17:331-5. 2006
    ..In conclusion, these findings support the hypothesis that mild renal damage may precede the development of hypertension...
  95. ncbi Prolonged frozen storage of urine reduces the value of albuminuria for mortality prediction
    Jacoline W Brinkman
    Clin Chem 53:153-4. 2007
  96. ncbi Determinants of insulin resistance in renal transplant recipients
    Leendert H Oterdoom
    Renal Transplant Program, University Medical Center Groningen and University of Groningen, Groningen, The Netherlands
    Transplantation 83:29-35. 2007
    ..It is not known to date which factors relate to this excess insulin resistance. Therefore, we investigated which factors are related to insulin resistance long-term after renal transplantation...
  97. ncbi Crippling of inflammatory markers as predictors of death by dichotomization and multicollinearity
    Stephan J L Bakker
    Nephrol Dial Transplant 21:2990-1; author reply 2991. 2006
  98. ncbi Early detection of progressive chronic kidney disease: is it feasible?
    Ron T Gansevoort
    J Am Soc Nephrol 17:1218-20. 2006
  99. ncbi Chromium treatment has no effect in patients with poorly controlled, insulin-treated type 2 diabetes in an obese Western population: a randomized, double-blind, placebo-controlled trial
    Nanne Kleefstra
    Department of Internal Medicine, Isala Clinics, Weezenlanden Location, P O Box 10500, 8000 GM Zwolle, Netherlands
    Diabetes Care 29:521-5. 2006
    ..The aim of this study was to determine the effect of chromium treatment on glycemic control in a Western population of insulin-dependent patients with type 2 diabetes...
  100. ncbi Palmitate and oleate have distinct effects on the inflammatory phenotype of human endothelial cells
    Jolita Ciapaite
    Department of Molecular Cell Physiology, Institute for Molecular Cell Biology, VU University, Amsterdam, The Netherlands
    Biochim Biophys Acta 1771:147-54. 2007
    ..Our results indicate that the effects depend on the fatty acid type and may be related to accumulation of LCAC...
  101. ncbi Chromium treatment has no effect in patients with type 2 diabetes in a Western population: a randomized, double-blind, placebo-controlled trial
    Nanne Kleefstra
    Diabetes Centre, Isala Clinics, P O Box 10400, 8000 GK Zwolle, The Netherlands
    Diabetes Care 30:1092-6. 2007
    ..The aim of this study was to determine the effect of chromium treatment in the form of chromium yeast on glycemic control in a Western population of patients with type 2 diabetes who were being treated with oral hypoglycemic agents...