Ale Algra

Summary

Affiliation: University Medical Center
Country: The Netherlands

Publications

  1. ncbi [Roaming through methodology. XII. Pragmatic and pathophysiologic trials: a question of goal formulation]
    A Algra
    Academisch Ziekenhuis, Julius Centrum voor Patiëntgebonden Onderzoek, Utrecht
    Ned Tijdschr Geneeskd 143:514-7. 1999
  2. ncbi Side of brain infarction and long-term risk of sudden death in patients with symptomatic carotid disease
    Ale Algra
    Department of Neurology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 34:2871-5. 2003
  3. ncbi Oral anticoagulants versus antiplatelet therapy for preventing further vascular events after transient ischemic attack or minor stroke of presumed arterial origin
    A Algra
    Department of Neurology, University Medical Center Utrecht, The Netherlands
    Stroke 34:234-5. 2003
  4. ncbi [A new instrument to measure clinical outcomes]
    A Algra
    Universitair Medisch Centrum UMC, afd Neurologie, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 146:604-5. 2002
  5. ncbi A benefit/risk analysis of the prevention of brain ischaemia with anticoagulant drugs: when, how and whom to treat?
    A Algra
    University Department of Neurology and Julius Center for Patient Oriented Research, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 11:100-4. 2001
  6. doi Patients with coronary, cerebrovascular or peripheral arterial obstructive disease differ in risk for new vascular events and mortality: the SMART study
    Sefanja Achterberg
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 17:424-30. 2010
  7. ncbi Prevalence of the metabolic syndrome in patients with coronary heart disease, cerebrovascular disease, peripheral arterial disease or abdominal aortic aneurysm
    Petra M Gorter
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    Atherosclerosis 173:363-9. 2004
  8. doi Asymptomatic carotid artery stenosis and the risk of ischemic stroke according to subtype in patients with clinical manifest arterial disease
    Anne G den Hartog
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 44:1002-7. 2013
  9. ncbi Large subcortical infarcts: clinical features, risk factors, and long-term prognosis compared with cortical and small deep infarcts
    Patricia H A Halkes
    Department of Neurology, Rudolf Magnus Institute, University Medical Center Utrecht, Utrecht, Netherlands
    Stroke 37:1828-32. 2006
  10. ncbi Prevention of glucocorticoid induced osteoporosis with alendronate or alfacalcidol: relations of change in bone mineral density, bone markers, and calcium homeostasis
    Johannes W G Jacobs
    Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Rheumatol 34:1051-7. 2007

Detail Information

Publications123 found, 100 shown here

  1. ncbi [Roaming through methodology. XII. Pragmatic and pathophysiologic trials: a question of goal formulation]
    A Algra
    Academisch Ziekenhuis, Julius Centrum voor Patiëntgebonden Onderzoek, Utrecht
    Ned Tijdschr Geneeskd 143:514-7. 1999
    ..In explanatory trials patient selection is strict and treatment is double-blind and pathophysiologically pure. Often proxy outcome measures are used and emphasis is on per protocol ('on treatment') analysis...
  2. ncbi Side of brain infarction and long-term risk of sudden death in patients with symptomatic carotid disease
    Ale Algra
    Department of Neurology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 34:2871-5. 2003
    ..Current publications suggest increased risk of sudden death in experimental animals with acute right insular lesions and in patients with recent right-sided brain infarction, particularly if the insula is involved...
  3. ncbi Oral anticoagulants versus antiplatelet therapy for preventing further vascular events after transient ischemic attack or minor stroke of presumed arterial origin
    A Algra
    Department of Neurology, University Medical Center Utrecht, The Netherlands
    Stroke 34:234-5. 2003
  4. ncbi [A new instrument to measure clinical outcomes]
    A Algra
    Universitair Medisch Centrum UMC, afd Neurologie, Postbus 85 500, 3508 GA Utrecht
    Ned Tijdschr Geneeskd 146:604-5. 2002
    ..It is not yet clear how many questions are needed to obtain a reliable estimate of the ALDS and therefore the time needed to complete the instrument is still uncertain...
  5. ncbi A benefit/risk analysis of the prevention of brain ischaemia with anticoagulant drugs: when, how and whom to treat?
    A Algra
    University Department of Neurology and Julius Center for Patient Oriented Research, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 11:100-4. 2001
    ..In patients with cerebral ischaemia of presumed arterial origin, anticoagulation with an achieved intensity of 3.0--4.5 proved not to be safe. Results from trials with more moderate anticoagulation regimes are awaited...
  6. doi Patients with coronary, cerebrovascular or peripheral arterial obstructive disease differ in risk for new vascular events and mortality: the SMART study
    Sefanja Achterberg
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 17:424-30. 2010
    ..The risk of new vascular events and mortality is high. Direct comparisons of vascular event rates are scarce...
  7. ncbi Prevalence of the metabolic syndrome in patients with coronary heart disease, cerebrovascular disease, peripheral arterial disease or abdominal aortic aneurysm
    Petra M Gorter
    Julius Centre for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands
    Atherosclerosis 173:363-9. 2004
    ....
  8. doi Asymptomatic carotid artery stenosis and the risk of ischemic stroke according to subtype in patients with clinical manifest arterial disease
    Anne G den Hartog
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 44:1002-7. 2013
    ..We evaluated the risk of ischemic stroke and stratified it according to stroke subtype in patients with ACAS during long-term follow-up...
  9. ncbi Large subcortical infarcts: clinical features, risk factors, and long-term prognosis compared with cortical and small deep infarcts
    Patricia H A Halkes
    Department of Neurology, Rudolf Magnus Institute, University Medical Center Utrecht, Utrecht, Netherlands
    Stroke 37:1828-32. 2006
    ..In this study we compared risk factors, clinical features, and stroke recurrence in a large series of patients with large subcortical, cortical, or small deep infarcts...
  10. ncbi Prevention of glucocorticoid induced osteoporosis with alendronate or alfacalcidol: relations of change in bone mineral density, bone markers, and calcium homeostasis
    Johannes W G Jacobs
    Department of Rheumatology and Clinical Immunology and Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Rheumatol 34:1051-7. 2007
    ....
  11. doi Long-term risk of vascular events after peripheral bypass surgery. A cohort study
    Eline S van Hattum
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Thromb Haemost 108:543-53. 2012
    ..This study provided a detailed insight in the course of PAD long after peripheral bypass surgery and enables individual risk assessment of major fatal and non-fatal ischaemic events by means of cumulative incidences and a risk chart...
  12. doi Excess mortality and cardiovascular events in patients surviving subarachnoid hemorrhage: a nationwide study in Sweden
    Dennis J Nieuwkamp
    Department of Neurology, C03 236, University Medical Center Utrecht, PO Box 85500, 3584 CX Utrecht, The Netherlands
    Stroke 42:902-7. 2011
    ..We compared incidences of vascular diseases, vascular death, and all-cause death after SAH with those in the general population...
  13. doi Prediction rule for cardiovascular events and mortality in peripheral arterial disease patients: data from the prospective Second Manifestations of ARTerial disease (SMART) cohort study
    Ralf W Sprengers
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 50:1369-76. 2009
    ..Stratifying PAD patients according to their risk of secondary events could aid in achieving optimal therapy compliance. To this end we developed a prediction model for secondary cardiovascular events in PAD patients...
  14. doi Metabolic syndrome and vascular risk in patients with peripheral arterial occlusive disease
    Anne L M Vlek
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 50:61-9. 2009
    ..Also, progression and regression of the metabolic syndrome after follow-up are not extensively studied...
  15. ncbi Carotid intima-media thickness is different in large- and small-vessel ischemic stroke: the SMART study
    D Martijn O Pruissen
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    Stroke 38:1371-3. 2007
    ..Common carotid artery intima-media thickness (CCA IMT) is a marker of atherosclerosis. Our aim was to compare CCA IMT between SVD and LVD patients...
  16. doi Calcium homeostasis during magnesium treatment in aneurysmal subarachnoid hemorrhage
    Walter M van den Bergh
    Department of Neurology, University Medical Center, room G03 228, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Neurocrit Care 8:413-7. 2008
    ....
  17. doi Growth rates of intracranial aneurysms: exploring constancy
    Hendrik Koffijberg
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, The Netherlands
    J Neurosurg 109:176-85. 2008
    ..Recent case reports have suggested that aneurysms grow fast in a short period of time. The authors of the present report investigated the plausibility of a constant growth rate for intracranial aneurysms...
  18. doi Cost-effectiveness of preventive treatment of intracranial aneurysms: new data and uncertainties
    Jacoba P Greving
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Neurology 73:258-65. 2009
    ....
  19. doi Brain volumes and cerebrovascular lesions on MRI in patients with atherosclerotic disease. The SMART-MR study
    Mirjam I Geerlings
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    Atherosclerosis 210:130-6. 2010
    ..To estimate brain volumes, white matter lesion (WML) volume and asymptomatic infarcts on MRI in a large cohort of patients with atherosclerotic disease...
  20. doi Prevention with low-dose aspirin plus dipyridamole in patients with disabling stroke
    Diederik W J Dippel
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    Stroke 41:2684-6. 2010
    ..It is unknown whether this also applies to patients with a disabling stroke...
  21. ncbi Hyperhomocysteinemia and risk for peripheral arterial occlusive disease in young women
    Maurice A A J van den Bosch
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    J Vasc Surg 38:772-8. 2003
    ..In this study we assessed hyperhomocysteinemia as a risk factor for PAOD in young women. In addition, we evaluated the effect of joint exposure to hyperhomocysteinemia and traditional risk factors...
  22. ncbi Novel risk factors for peripheral arterial disease in young women
    Daisy G M Bloemenkamp
    Julius Center for General Practice and Patient Oriented Research, Department of Radiology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Med 113:462-7. 2002
    ..To investigate traditional and novel risk factors (homocysteine and C-reactive protein levels, and exposure to infections) for peripheral arterial disease in young women...
  23. pmc Correction: PAIS: paracetamol (acetaminophen) in stroke; protocol for a randomized, double blind clinical trial. [ISCRTN74418480]
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Center, Rotterdam, The Netherlands
    BMC Cardiovasc Disord 8:29. 2008
    ..Therefore, the planned primary analysis of the PAIS study has been changed from fixed dichotomization of the mRS to a sliding dichotomy analysis...
  24. ncbi Functional health and well-being of relatively young women with peripheral arterial disease is decreased but stable after diagnosis
    Daisy G M Bloemenkamp
    Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    J Vasc Surg 38:104-10. 2003
    ..Moreover, potential determinants of HQOL in young women with PAD were studied, ie, traditional cardiovascular risk factors, location of stenosis and time since diagnosis...
  25. ncbi Increased pregnancy loss in young women with aortoiliac disease
    Maurice A A J van den Bosch
    Julius Center for Health Sciences and Primary Care, Room D 01 335, University Medical Center Utrecht, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Atherosclerosis 164:121-7. 2002
    ..In a case-control study designed to investigate risk factors for peripheral arterial occlusive disease in young women, we assessed the risk of miscarriage in these patients according to level of obstruction...
  26. pmc Trigger factors for rupture of intracranial aneurysms in relation to patient and aneurysm characteristics
    Monique H M Vlak
    Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Neurol 259:1298-302. 2012
    ..Why women and patients with aneurysms larger than 5 mm or posterior circulation aneurysms have a higher risk of rupture remains to be settled...
  27. doi Prevalence and prognosis of asymptomatic vertebral artery origin stenosis in patients with clinically manifest arterial disease
    Annette Compter
    Utrecht Stroke Center, Department of Neurology, G 03 228, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Stroke 42:2795-800. 2011
    ..The risk of ischemic stroke in patients with asymptomatic vertebral artery stenosis is unknown. We examined the incidence of posterior circulation ischemic stroke in patients with asymptomatic stenosis of the vertebral artery origin (VAo)...
  28. doi Intra-abdominal fat and metabolic syndrome are associated with larger infrarenal aortic diameters in patients with clinically evident arterial disease
    Petra M Gorter
    Department of Vascular Medicine, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 48:114-20. 2008
    ..The relationship between metabolic syndrome and infrarenal aortic diameter was also assessed in this patient group...
  29. pmc An early rise in body temperature is related to unfavorable outcome after stroke: data from the PAIS study
    Heleen M den Hertog
    Department of Neurology, Erasmus MC University Medical Center Rotterdam, PO Box 2040, 3000 CA, Rotterdam, The Netherlands
    J Neurol 258:302-7. 2011
    ..30; 95% CI 1.05-1.63) and death (aOR 1.51; 95% CI 1.15-1.98). An early rise in body temperature rather than high body temperature on admission is a risk factor for unfavorable outcome in patients with acute stroke...
  30. ncbi Risk of rupture of unruptured intracranial aneurysms in relation to patient and aneurysm characteristics: an updated meta-analysis
    Marieke J H Wermer
    Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 38:1404-10. 2007
    ..We updated our previous review from 1996 on the risk of rupture of unruptured intracranial aneurysms, aiming to include the newly published articles...
  31. doi Bleeding increases the risk of ischemic events in patients with peripheral arterial disease
    Eline S van Hattum
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Circulation 120:1569-76. 2009
    ..Our objective was to assess whether this is also the case in patients with peripheral arterial disease...
  32. doi Trends in vascular risk factors and medication use in patients with various manifestations of vascular diseases or type 2 diabetes mellitus from 1996 to 2007: the Second Manifestations of ARTerial disease study
    Anne Vlek
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Stratenum 6 131, Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 17:628-36. 2010
    ..To investigate time trends in vascular risk factors and medication use for patients referred to a vascular specialist with manifest vascular disease or type 2 diabetes mellitus (DM2)...
  33. doi Independent risk factors for intracranial aneurysms and their joint effect: a case-control study
    Monique H M Vlak
    Department of Neurology and Neurosurgery, Utrecht Stroke Center, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Stroke 44:984-7. 2013
    ..We aimed to identify independent risk factors from lifestyle and medical history for the presence of UIAs and to investigate the combined effect of well-established risk factors...
  34. doi Lifetime risks for aneurysmal subarachnoid haemorrhage: multivariable risk stratification
    Monique H M Vlak
    Department of Neurology and Neurosurgery, Utrecht Stroke Centre, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 84:619-23. 2013
    ..We aimed to estimate incidence and lifetime risks of aSAH according to risk factor profiles...
  35. doi Time is brain(stem) in basilar artery occlusion
    Mervyn D I Vergouwen
    UMC Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Stroke 43:3003-6. 2012
    ..We investigated the relationship between time to recanalization therapy and functional outcome in BAO with data from the Basilar Artery International Cooperation Study (BASICS)...
  36. pmc Occurrence and impact of delayed cerebral ischemia after coiling and after clipping in the International Subarachnoid Aneurysm Trial (ISAT)
    Sanne M Dorhout Mees
    Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, room G03 228, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Neurol 259:679-83. 2012
    ..Impact of DCI on poor outcome did not differ between clipped and coiled patients, except for patients treated within 4 days, in whom DCI resulted more often in poor outcome after coiling than after clipping...
  37. ncbi Interobserver agreement and predictive value for outcome of two rating scales for the amount of extravasated blood after aneurysmal subarachnoid haemorrhage
    Anouk G W van Norden
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Neurol 253:1217-20. 2006
    ..We investigated the interobserver variation of the Hijdra and Fisher scales for the amount of extravasated blood and the predictive values of these scales for delayed cerebral ischemia and outcome...
  38. pmc Achieved serum magnesium concentrations and occurrence of delayed cerebral ischaemia and poor outcome in aneurysmal subarachnoid haemorrhage
    Sanne M Dorhout Mees
    Department of Neurology, University Medical Centre Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 78:729-31. 2007
    ..We assessed the relationship between serum magnesium concentrations achieved with magnesium sulphate therapy 64 mmol/day and the occurrence of DCI and poor outcome in patients with SAH...
  39. ncbi Risk of rebleeding after treatment of acute hydrocephalus in patients with aneurysmal subarachnoid hemorrhage
    Catharine A Hellingman
    Department of Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 38:96-9. 2007
    ..We studied the risk of rebleeding in patients with subarachnoid hemorrhage during treatment for acute hydrocephalus...
  40. doi Local atherosclerotic plaques are a source of prognostic biomarkers for adverse cardiovascular events
    Dominique P V de Kleijn
    Experimental Cardiology G02523, UMC, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 30:612-9. 2010
    ..Because atherosclerosis is considered a systemic disease, we hypothesized that one single atherosclerotic plaque contains ample molecular information that predicts future cardiovascular events in all vascular territories...
  41. doi Comparison of telephone and face-to-face assessment of the modified Rankin Scale
    Paula M Janssen
    Department of Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 29:137-9. 2010
    ..We assessed the validity of a telephone interview in patients who had had an aneurysmal subarachnoid haemorrhage (SAH) by comparing it with a face-to-face assessment...
  42. doi Effect of antiplatelet therapy for endovascular coiling in aneurysmal subarachnoid hemorrhage
    Walter M van den Bergh
    Department of Intensive Care, University Medical Center Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Stroke 40:1969-72. 2009
    ..This strategy is based on uncontrolled case series including also patients with unruptured aneurysms or other lesions. We collected data on effectiveness of antiplatelets in patients with SAH...
  43. ncbi Screening for asymptomatic cardiovascular disease with noninvasive imaging in patients at high-risk and low-risk according to the European Guidelines on Cardiovascular Disease Prevention: the SMART study
    Bertine M B Goessens
    Julius Center for Health Sciences and Primary Care, Utrecht, The Netherlands
    J Vasc Surg 43:525-32. 2006
    ....
  44. doi Brain natriuretic peptide concentrations after aneurysmal subarachnoid hemorrhage: relationship with hypovolemia and hyponatremia
    Sanne M Dorhout Mees
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, P O Box 85500, 3508, Utrecht, The Netherlands
    Neurocrit Care 14:176-81. 2011
    ..The authors investigated whether brain natriuretic peptide (BNP) is related to hypovolemia and hyponatremia after SAH and whether it can differentiate between hypovolemic and non-hypovolemic hyponatremia...
  45. pmc Nurses' prediction of volume status after aneurysmal subarachnoid haemorrhage: a prospective cohort study
    Reinier G Hoff
    Department of Perioperative and Emergency Care, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan, Utrecht, 3584 CX, The Netherlands
    Crit Care 12:R153. 2008
    ..To guide fluid management, regular assessments of volume status must be conducted. We studied the ability of nursing staff to predict hypovolaemia or hypervolaemia, based on their interpretation of available haemodynamic data...
  46. doi Magnesium and aspirin treatment in patients with subarachnoid haemorrhage. Comparison of effects after endovascular and neurosurgical aneurysm occlusion
    Walter M van den Bergh
    Dept of Neurology, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Neurol 256:213-6. 2009
    ..The influence of the method of aneurysm treatment was studied in our randomised MASH trial, which assessed in a factorial design the efficacy of magnesium and aspirin in preventing delayed cerebral ischaemia (DCI) and poor outcome...
  47. ncbi Cognitive functioning and brain MRI in patients with type 1 and type 2 diabetes mellitus: a comparative study
    Augustina M A Brands
    Helmholtz Instituut, Department of Experimental Psychology, Utrecht University, Utrecht, The Netherlands
    Dement Geriatr Cogn Disord 23:343-50. 2007
    ..It has been suggested that cognitive impairments are more pronounced in DM2 than in DM1, but studies that directly compare the effects of these 2 types of DM on cognition are lacking...
  48. doi Nonfocal symptoms are more frequent in patients with vertebral artery than carotid artery stenosis
    Annette Compter
    UMC Utrecht Stroke Center, Department of Neurology and Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 35:378-84. 2013
    ..Therefore, we assessed the prevalence of nonfocal symptoms in patients with a recent TIA or nondisabling ischemic stroke and studied their relation with symptomatic CA or VA stenosis...
  49. doi Cognitive outcome of survivors of space-occupying hemispheric infarction
    Jeannette Hofmeijer
    Department of Neurology, Rijnstate Hospital, Wagnerlaan 55, 6815 AD Arnhem, The Netherlands
    J Neurol 260:1396-403. 2013
    ..Isolated focal neuropsychological deficits were found in only a quarter. Impaired cognitive outcome was associated with worse functional outcome...
  50. doi Surgical decompression for space-occupying cerebral infarction: outcomes at 3 years in the randomized HAMLET trial
    Marjolein Geurts
    Department of Neurology and Neurosurgery, UMC Utrecht Stroke Center, Utrecht, The Netherlands
    Stroke 44:2506-8. 2013
    ..We assessed whether the effects of surgical decompression for space-occupying hemispheric infarction, observed at 1 year, are sustained at 3 years...
  51. ncbi Chlamydia pneumoniae, Helicobacter pylori and cytomegalovirus infections and the risk of peripheral arterial disease in young women
    Daisy G M Bloemenkamp
    Julius Center for Patient Oriented Research, Room D 01 335, University Medical Center Utrecht UMC, P O Box 85500, Heidelberglaan 100, 3508 GA, Utrecht, The Netherlands
    Atherosclerosis 163:149-56. 2002
    ..The positive relation between 'infection burden' and PAD was only found in women with a high CRP level, which indicates that inflammation might be involved in the process that leads to PAD...
  52. doi Risk factors for acute subdural hematoma from intracranial aneurysm rupture
    J Matthijs Biesbroek
    Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurosurgery 71:264-8; discussion 268-9. 2012
    ..Risk factors for the development of an aSDH from aneurysmal rupture are unknown and may help our understanding of how an aSDH develops...
  53. doi Timing of aneurysm treatment after subarachnoid hemorrhage: relationship with delayed cerebral ischemia and poor outcome
    Sanne M Dorhout Mees
    Rudolf Magnus Institute of Neuroscience, Department of Neurology and Neurosurgery, University Medical Center Utrecht, The Netherlands
    Stroke 43:2126-9. 2012
    ..Within the International Subarachnoid Aneurysm Trial we assessed differences in incidence of delayed cerebral ischemia and clinical outcome between different timings of treatment...
  54. doi Effects of carotid endarterectomy or stenting on blood pressure in the International Carotid Stenting Study (ICSS)
    Aysun Altinbas
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, PO Box 85500, G03 228, 3508 GA Utrecht, The Netherlands
    Stroke 42:3491-6. 2011
    ..We compared the effects of CAS and CEA on BP up to 1 year after treatment in the International Carotid Stenting Study...
  55. doi Cerebral small vessel disease and risk of death, ischemic stroke, and cardiac complications in patients with atherosclerotic disease: the Second Manifestations of ARTerial disease-Magnetic Resonance (SMART-MR) study
    Mandy M A Conijn
    Department of Radiology, UMC Utrecht, 3508 GA Utrecht, The Netherlands
    Stroke 42:3105-9. 2011
    ..We assessed whether lacunar infarcts and white matter lesions on MRI increased the risk of vascular and nonvascular death and future vascular events in patients with atherosclerotic disease...
  56. doi A pilot-study to identify the feasibility of an Internet-based coaching programme for changing the vascular risk profile of high-risk patients
    Bertine M B Goessens
    Julius Center for Health Sciences and Primary Care, UMC Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Patient Educ Couns 73:67-72. 2008
    ..To evaluate the feasibility of a web-based coaching programme for vascular risk factor treatment, to describe the patterns of use and to measure changes in risk factors...
  57. doi The quality of life in patients after peripheral bypass surgery deteriorates at long-term follow-up
    Eline S van Hattum
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 53:643-50. 2011
    ....
  58. doi Prothrombotic gene variation in patients with large and small vessel disease
    D Martijn O Pruissen
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuroepidemiology 31:89-92. 2008
    ..Thus claims about genetic associations with specific subtypes of ischemia should be interpreted with caution. The association between F13B His95Arg and LVD requires replication...
  59. doi Accelerated cognitive decline in patients with type 2 diabetes: MRI correlates and risk factors
    Yael D Reijmer
    Department of Neurology, Rudolf Magnus Institute of Neurosciences, University Medical Center, Utrecht, The Netherlands
    Diabetes Metab Res Rev 27:195-202. 2011
    ..Type 2 diabetes mellitus is associated with an increased risk of cognitive decline and dementia. We examined brain imaging correlates and vascular and metabolic risk factors of accelerated cognitive decline in patients with type 2 diabetes...
  60. doi Absence of connexin 40 gene polymorphism, as a marker of undetected atrial fibrillation in patients with unexplained cerebral ischemic events
    Sevasti Maria Chaldoupi
    Departments of Cardiology, University Medical Center Utrecht, The Netherlands
    Eur J Cardiovasc Prev Rehabil 16:616-20. 2009
    ..We examined the prevalence of the minor Cx40 allele in patients with cerebral ischemia and no other cardiovascular disease (CVD), as an indication of underlying idiopathic AF...
  61. doi Trigger factors and their attributable risk for rupture of intracranial aneurysms: a case-crossover study
    Monique H M Vlak
    Department of Neurology and Julius Center, University Medical Center Utrecht, Room STR 7 140, Mailbox STR 6 131, P O Box 85500, 3508 GA Utrecht, The Netherlands
    Stroke 42:1878-82. 2011
    ..We therefore aimed to identify and quantify trigger factors for aneurysmal rupture and to gain insight into the pathophysiology...
  62. ncbi Incidence of recurrent subarachnoid hemorrhage after clipping for ruptured intracranial aneurysms
    Marieke J H Wermer
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center, Utrecht, The Netherlands
    Stroke 36:2394-9. 2005
    ..We studied the incidence of and risk factors for recurrent SAH in patients who regained independence after SAH and in whom all aneurysms were occluded by means of clipping...
  63. ncbi Extent of acute hydrocephalus after aneurysmal subarachnoid hemorrhage as a risk factor for delayed cerebral infarction
    Annelies M Bakker
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 38:2496-9. 2007
    ..Cerebral perfusion is a predictor for DCI. Because acute hydrocephalus may impair cerebral perfusion, we evaluated the predictive value of the extent of acute hydrocephalus on the development of DCI...
  64. ncbi Hypocalcaemia may reduce the beneficial effect of magnesium treatment in aneurysmal subarachnoid haemorrhage
    Jolanda M W Van de Water
    Department of Neurology, University Medical Centre Utrecht, The Netherlands
    Magnes Res 20:130-5. 2007
    ..Hypocalcaemia is associated with an increased risk of DCI and poor outcome and may therefore reduce the potential beneficial effect of magnesium treatment in SAH...
  65. doi Treatment of brain arteriovenous malformations: a systematic review and meta-analysis
    Janneke Van Beijnum
    Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, The Netherlands
    JAMA 306:2011-9. 2011
    ..Outcomes following treatment of brain arteriovenous malformations (AVMs) with microsurgery, embolization, stereotactic radiosurgery (SRS), or combinations vary greatly between studies...
  66. doi Prothrombotic gene variants and mortality after cerebral ischemia of arterial origin
    D Martijn O Pruissen
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Neuroepidemiology 37:109-13. 2011
    ..We hypothesized that such gene variants may also be associated with mortality after cerebral ischemia of arterial origin because of an increased risk of fatal vascular events...
  67. pmc Magnesium for aneurysmal subarachnoid haemorrhage (MASH-2): a randomised placebo-controlled trial
    Sanne M Dorhout Mees
    Utrecht Stroke Center, Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neurosciences, University Medical Center Utrecht, Utrecht, The Netherlands
    Lancet 380:44-9. 2012
    ..We did a trial to test whether magnesium therapy improves outcome after aneurysmal subarachnoid haemorrhage...
  68. pmc Pulmonary edema and blood volume after aneurysmal subarachnoid hemorrhage: a prospective observational study
    Reinier G Hoff
    Department of Perioperative and Emergency Care, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Heidelberglaan 100, Utrecht, The Netherlands
    Crit Care 14:R43. 2010
    ..We prospectively studied intravascular volume in SAH patients with and without PED...
  69. ncbi Secondary stroke prevention with antithrombotic drugs
    Els Lisette Leo Maria De Schryver
    Department of Neurology, Rijnland Ziekenhuis Leiderdorp, The Netherlands
    Curr Vasc Pharmacol 8:129-33. 2010
    ..The recent PRoFESS trial found no differences in the efficacy of aspirin plus dipyridamole and clopidogrel, hence there is no need for major adaptation of the guidelines...
  70. pmc Bilateral carotid artery occlusion with transient or moderately disabling ischaemic stroke: clinical features and long-term outcome
    Suzanne Persoon
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, G03 228, Heidelberglaan 100, 3584 CX, Utrecht, The Netherlands
    J Neurol 256:1728-35. 2009
    ..Although this study was not designed to compare conservative treatment with surgical intervention, the favourable outcome suggests that a policy of medical therapy and control of risk factors may be justified in these patients...
  71. doi Mechanisms of gender-related outcome differences after carotid endarterectomy
    Anne G den Hartog
    Department of Vascular Surgery, University Medical Center Utrecht, Utrecht, The Netherlands
    J Vasc Surg 52:1062-71, 1071.e1-6. 2010
    ..In this review, we aimed to provide an overview of the gender-specific characteristics causing these perioperative and long-term outcome differences between men and women after CEA...
  72. ncbi Antiplatelet drugs in the secondary prevention after stroke: differential efficacy in large versus small vessel disease? A subgroup analysis from ESPS-2
    Marie José Ariesen
    Julius Center for Health Sciences and Primary Care, University Medical Center, Utrecht, The Netherlands
    Stroke 37:134-8. 2006
    ..We assessed whether antiplatelet drugs were more efficacious in large than in small vessel cerebrovascular disease...
  73. doi Symptomatic internal carotid artery occlusion: a long-term follow-up study
    Suzanne Persoon
    Department of Neurology, University Medical Centre Utrecht, G03 228, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Neurol Neurosurg Psychiatry 82:521-6. 2011
    ..Information on outcome of patients with occlusion of the internal carotid artery (ICA) is limited by the short duration of follow-up and lack of haemodynamic studies on the brain...
  74. ncbi Impaired glucose tolerance increases stroke risk in nondiabetic patients with transient ischemic attack or minor ischemic stroke
    Sarah E Vermeer
    Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Stroke 37:1413-7. 2006
    ..Whether impaired glucose tolerance increases the risk of stroke in patients with transient ischemic attack (TIA) or minor ischemic stroke is unknown...
  75. doi Incidence, case fatality, and functional outcome of intracerebral haemorrhage over time, according to age, sex, and ethnic origin: a systematic review and meta-analysis
    Charlotte Jj van Asch
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, Netherlands
    Lancet Neurol 9:167-76. 2010
    ..We aimed to assess the incidence, case fatality, and functional outcome of intracerebral haemorrhage in relation to age, sex, ethnic origin, and time period in studies published since 1980...
  76. ncbi Antiplatelet therapy in aneurysmal subarachnoid hemorrhage: a systematic review
    Sanne M Dorhout Mees
    Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    Stroke 34:2285-9. 2003
    ..Robust evidence, however, is lacking. We performed a systematic meta-analysis to determine whether antiplatelet therapy has a beneficial effect after SAH...
  77. pmc Functional outcome and quality of life 5 and 12.5 years after aneurysmal subarachnoid haemorrhage
    Paut Greebe
    Department of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, Heidelberglaan 100, 3484 CX, Utrecht, The Netherlands
    J Neurol 257:2059-64. 2010
    ..Between the 5 and the 12.5 years follow-up, the improvement in mRS had decreased but patients reported overall a better QoL. Among long-time survivors, QoL may improve more than a decade after SAH...
  78. doi Long-term outcome of patients discharged to a nursing home after aneurysmal subarachnoid hemorrhage
    Paut Greebe
    Departments of Neurology and Neurosurgery, Rudolf Magnus Institute of Neuroscience, Utrecht, The Netherlands
    Arch Phys Med Rehabil 91:247-51. 2010
    ..To study long-term outcome in patients with aneurysmal subarachnoid hemorrhage (SAH) who are relatively young...
  79. doi Risk of aneurysm rupture at intracranial arterial bifurcations
    Nicolien M Van der Kolk
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre, Utrecht, The Netherlands
    Cerebrovasc Dis 30:29-35. 2010
    ....
  80. ncbi Timing of aneurysm surgery in subarachnoid hemorrhage: a systematic review of the literature
    Koen de Gans
    Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurosurgery 50:336-40; discussion 340-2. 2002
    ..A systematic review was conducted to compare early aneurysm surgery (Days 0-3), intermediate surgery (Days 4-7), and late surgery (more than 7 d after subarachnoid hemorrhage)...
  81. ncbi Effectiveness of neurosurgical clip application in patients with aneurysmal subarachnoid hemorrhage
    Eva H Brilstra
    University Department of Neurology and Neurosurgery, University of Utrecht, The Netherlands
    J Neurosurg 97:1036-41. 2002
    ..The authors assessed the magnitude of the reduction in poor outcomes that accompanies a strategy aimed at surgery...
  82. ncbi Electrocardiographic abnormalities and serum magnesium in patients with subarachnoid hemorrhage
    Walter M van den Bergh
    Department of Neurosurgery, University Medical Center Utrecht, Room G03 124, PO Box 85500, 3508 GA Utrecht, The Netherlands
    Stroke 35:644-8. 2004
    ..Because hypomagnesemia is associated with several ECG abnormalities, we studied whether hypomagnesemia mediates ECG abnormalities after SAH...
  83. doi The basilar artery international cooperation study (BASICS)
    Wouter J Schonewille
    Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Int J Stroke 2:220-3. 2007
    ..Our limited knowledge on the outcome in patients with basilar artery occlusion comes from small case series of selected patients...
  84. ncbi Hypomagnesemia after aneurysmal subarachnoid hemorrhage
    Walter M van den Bergh
    Department of Neurosurgery, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurosurgery 52:276-81; discussion 281-2. 2003
    ..We assessed the frequency and time distribution of hypomagnesemia after aneurysmal subarachnoid hemorrhage (SAH) and its relationship to the severity of SAH, delayed cerebral ischemia (DCI), and outcome after 3 months...
  85. ncbi Excimer laser-assisted bypass in aneurysm treatment: short-term outcomes
    Eva H Brilstra
    University Department of Neurology, University of Utrecht, The Netherlands
    J Neurosurg 97:1029-35. 2002
    ..The authors assessed the complications of this procedure and clinical outcomes after the construction of high-flow bypasses in patients with intracranial aneurysms...
  86. ncbi Venous stasis retinopathy in symptomatic carotid artery occlusion: prevalence, cause, and outcome
    Catharina J M Klijn
    University Department of Neurology, University Medical Center Utrecht and the Rudolf Magnus Institute for Neurosciences, Utrecht, The Netherlands
    Stroke 33:695-701. 2002
    ..The aim of this study was to gain insight into the prevalence, cause, and outcome of VSR in patients with symptomatic CAO...
  87. ncbi Study design and outcome measures in studies on aneurysmal subarachnoid hemorrhage
    Irene C van der Schaaf
    Department of Neurology, University Medical Center Utrecht, Utrecht, Netherlands
    Stroke 33:2043-6. 2002
    ..We assessed quality of study design and outcome measures and presence and precision of definitions concerning major complications of SAH in studies evaluating treatment strategies in patients with aneurysmal SAH...
  88. ncbi Risk of Arterial Thrombosis in Relation to Oral Contraceptives (RATIO) study: oral contraceptives and the risk of ischemic stroke
    Jeanet M Kemmeren
    Julius Centre for Patient Oriented Research, University Medical Centre Utrecht, Utrecht, The Netherlands
    Stroke 33:1202-8. 2002
    ..This study assesses the risk of ischemic stroke with several types of oral contraceptives...
  89. ncbi Sudden death
    Ale Algra
    Departments of Neurology and Clinical Epidemology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Adv Neurol 92:221-4. 2003
  90. doi Fluid balance and blood volume measurement after aneurysmal subarachnoid hemorrhage
    Reinier G Hoff
    Rudolf Magnus Institute of Neuroscience, Department of Perioperative and Emergency Care, Q 04 2 303, University Medical Center Utrecht, PO Box 85500, Utrecht 3508 GA, The Netherlands
    Neurocrit Care 8:391-7. 2008
    ..In a prospective observational study we assessed the effectiveness of fluid administration based on regular evaluation of the fluid balance in maintaining normovolemia...
  91. ncbi Epilepsy surgery in tuberous sclerosis: a systematic review
    Floor E Jansen
    Department of Child Neurology, Rudolf Magnus Institute of Neuroscience and Julius Centre for Health Sciences and Primary Care, University Medical Centre, 3508 GA Utrecht, The Netherlands
    Epilepsia 48:1477-84. 2007
    ..A systematic review of the available literature has been undertaken to assess the overall outcome of epilepsy surgery and identify risk factors of seizure recurrence...
  92. ncbi Change in mobility activity in the second year after stroke in a rehabilitation population: who is at risk for decline?
    Iris van Wijk
    Rehabilitation Center De Hoogstraat, Rudolph Magnus Institute of Neuroscience, Department of Rehabilitation, University Medical Center Utrecht, The Netherlands
    Arch Phys Med Rehabil 87:45-50. 2006
    ..To investigate the development of mobility status during the second year after stroke in patients who had had inpatient rehabilitation, and to evaluate risk factors for mobility decline...
  93. ncbi Carotid intima-media thickness and the risk of new vascular events in patients with manifest atherosclerotic disease: the SMART study
    Joke M Dijk
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Huispostnummer Str 6 131, PO Box 85060, 3508 BA Utrecht, The Netherlands
    Eur Heart J 27:1971-8. 2006
    ..Currently, little is known about the relationship between CIMT and new vascular events in patients with manifest arterial disease. We aimed to assess the strength of this relationship...
  94. ncbi Asymptomatic carotid artery stenosis and the risk of new vascular events in patients with manifest arterial disease: the SMART study
    Bertine M B Goessens
    Julius Center for Health Sciences and Primary Care, UMC Utrecht, Utrecht, The Netherlands
    Stroke 38:1470-5. 2007
    ..We examined the relationship between asymptomatic CAS and the risk of subsequent events in this specific group of patients...
  95. doi Genetic association studies in ischaemic stroke: replication failure and prospects
    D Martijn O Pruissen
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Cerebrovasc Dis 27:290-4. 2009
    ..We also make suggestions about the design of genetic association studies in ischaemic stroke with regard to stroke subtype classification, candidate pathways, subgroups, intermediate phenotypes and potential clinical impact...
  96. doi Blood volume measurement to guide fluid therapy after aneurysmal subarachnoid hemorrhage: a prospective controlled study
    Reinier Hoff
    Department of Perioperative and Emergency Care, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 40:2575-7. 2009
    ..In a prospective controlled study we assessed whether fluid management guided by daily measurements of blood volume (BV) reduces the incidence of severe hypovolemia compared to conventional fluid balance guided fluid therapy...
  97. doi The risk of aneurysmal subarachnoid hemorrhage during pregnancy, delivery, and the puerperium in the Utrecht population: case-crossover study and standardized incidence ratio estimation
    Andreas T Tiel Groenestege
    Department of Neurology, G03 225, University Medical Center Utrecht, Utrecht, The Netherlands
    Stroke 40:1148-51. 2009
    ..It is unclear whether the risk of aneurysmal subarachnoid hemorrhage (aSAH) is increased during pregnancy, labor, and the puerperium. We compared the risk of aSAH during this period with the risk outside this period...
  98. ncbi Coagulation factor XIII gene variation, oral contraceptives, and risk of ischemic stroke
    D Martijn O Pruissen
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, The Netherlands
    Blood 111:1282-6. 2008
    ..In conclusion, the F13A1 204Phe allele was strongly associated with ischemic stroke in young women. Oral contraceptive use further increased the risk of ischemic stroke...
  99. doi Configuration of the circle of Willis, direction of flow, and shape of the aneurysm as risk factors for rupture of intracranial aneurysms
    Nicolien K de Rooij
    Dept of Neurology, Rudolf Magnus Institute of Neuroscience, Room H02 128, University Medical Centre Utrecht, PO Box 85500, 3508 GA Utrecht, The Netherlands
    J Neurol 256:45-50. 2009
    ..We studied whether configuration of the circle of Willis, direction of flow towards the aneurysm, and shape of the aneurysm are risk factors for rupture...
  100. doi Anosmia after perimesencephalic nonaneurysmal hemorrhage
    Paut Greebe
    Department of Neurology, H02 128, University Medical Center Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    Stroke 40:2885-6. 2009
    ..Therefore, we studied the prevalence of anosmia in patients with nonaneurysmal perimesencephalic hemorrhage...
  101. ncbi Identifying patients with symptomatic carotid artery disease at high and low risk of severe myocardial infarction and cardiac death
    Peter C Gates
    Neuroscience Department, Geelong Hospital, Geelong, Victoria, Australia
    Stroke 33:2413-6. 2002
    ..This study compared the outlook for patients symptomatic from carotid stenosis with and without a history of symptomatic ischemic heart disease (IHD)...