Miriam Verwei

Summary

Affiliation: TNO Quality of Life
Country: The Netherlands

Publications

  1. ncbi request reprint Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling
    Miriam Verwei
    TNO Quality of Life, PO Box 360, 3700 AJ Zeist, The Netherlands
    Toxicol Lett 165:79-87. 2006
  2. ncbi request reprint Predicted serum folate concentrations based on in vitro studies and kinetic modeling are consistent with measured folate concentrations in humans
    Miriam Verwei
    Business Unit Biosciences, TNO Quality of Life, 3700 AJ Zeist, The Netherlands
    J Nutr 136:3074-8. 2006
  3. ncbi request reprint The binding of folic acid and 5-methyltetrahydrofolate to folate-binding proteins during gastric passage differs in a dynamic in vitro gastrointestinal model
    Miriam Verwei
    Department of Nutritional Physiology, TNO Nutrition and Food Research, 3700 AJ Zeist, The Netherlands
    J Nutr 134:31-7. 2004
  4. ncbi request reprint Folic acid and 5-methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model
    Miriam Verwei
    TNO WU Center for Micronutrient Research, 3700 AJ Zeist, The Netherlands
    J Nutr 133:2377-83. 2003
  5. ncbi request reprint Bioaccessibility of folic acid and (6S)-5-methyltetrahydrofolate decreases after the addition of folate-binding protein to yogurt as studied in a dynamic in vitro gastrointestinal model
    Karin Arkbåge
    Department of Food Science, Swedish University of Agricultural Sciences, SE 750 07 Uppsala, Sweden
    J Nutr 133:3678-83. 2003
  6. ncbi request reprint Effect of folate-binding protein on intestinal transport of folic acid and 5-methyltetrahydrofolate across Caco-2 cells
    Miriam Verwei
    Physiological Sciences Dept, TNO Nutrition and Food Research, 360, 3700 AJ, Zeist, The Netherlands
    Eur J Nutr 44:242-9. 2005

Collaborators

Detail Information

Publications6

  1. ncbi request reprint Prediction of in vivo embryotoxic effect levels with a combination of in vitro studies and PBPK modelling
    Miriam Verwei
    TNO Quality of Life, PO Box 360, 3700 AJ Zeist, The Netherlands
    Toxicol Lett 165:79-87. 2006
    ..It is concluded that a combination of in vitro and in silico techniques appears to be a promising alternative test method for risk assessment of embryotoxic compounds...
  2. ncbi request reprint Predicted serum folate concentrations based on in vitro studies and kinetic modeling are consistent with measured folate concentrations in humans
    Miriam Verwei
    Business Unit Biosciences, TNO Quality of Life, 3700 AJ Zeist, The Netherlands
    J Nutr 136:3074-8. 2006
    ..Finally, this methodology was applied to predict serum folate concentrations after intake of different fortified milk products for 4 wk, showing its benefits for the development of new nutritional products...
  3. ncbi request reprint The binding of folic acid and 5-methyltetrahydrofolate to folate-binding proteins during gastric passage differs in a dynamic in vitro gastrointestinal model
    Miriam Verwei
    Department of Nutritional Physiology, TNO Nutrition and Food Research, 3700 AJ Zeist, The Netherlands
    J Nutr 134:31-7. 2004
    ..This could result in different bioavailability from folic acid- and 5-CH3-H4folate-fortified milk products...
  4. ncbi request reprint Folic acid and 5-methyltetrahydrofolate in fortified milk are bioaccessible as determined in a dynamic in vitro gastrointestinal model
    Miriam Verwei
    TNO WU Center for Micronutrient Research, 3700 AJ Zeist, The Netherlands
    J Nutr 133:2377-83. 2003
    ..However, our results suggest that folic acid remains partly bound to FBP during passage through the small intestine, which reduces the bioaccessibility of folic acid from milk in this model...
  5. ncbi request reprint Bioaccessibility of folic acid and (6S)-5-methyltetrahydrofolate decreases after the addition of folate-binding protein to yogurt as studied in a dynamic in vitro gastrointestinal model
    Karin Arkbåge
    Department of Food Science, Swedish University of Agricultural Sciences, SE 750 07 Uppsala, Sweden
    J Nutr 133:3678-83. 2003
    ..In conclusion, based on the high bioaccessibility of folic acid and 5-CH3-H4folate, yogurt without active FBP can be considered to be an appropriate food matrix for folate fortification...
  6. ncbi request reprint Effect of folate-binding protein on intestinal transport of folic acid and 5-methyltetrahydrofolate across Caco-2 cells
    Miriam Verwei
    Physiological Sciences Dept, TNO Nutrition and Food Research, 360, 3700 AJ, Zeist, The Netherlands
    Eur J Nutr 44:242-9. 2005
    ..While folic acid remained bound to FBP after gastric passage, 5-CH3-H4folate was mainly present as free folate in the duodenal lumen...