D C Rijken

Summary

Affiliation: TNO Prevention and Health
Country: The Netherlands

Publications

  1. ncbi Characterization of the binding of urokinase-type plasminogen activator to the asialoglycoprotein receptor
    D C Rijken
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Thromb Haemost 88:83-8. 2002
  2. ncbi Basic principles in thrombolysis: regulatory role of plasminogen
    D C Rijken
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Thromb Res 103:S41-9. 2001
  3. ncbi Interactions between staphylokinase, plasmin(ogen), and fibrin. Staphylokinase discriminates between free plasminogen and plasminogen bound to partially degraded fibrin
    D V Sakharov
    Gaubius Laboratory, TNO Prevention and Health, P O Box 2215, 2301 CE Leiden, The Netherlands
    J Biol Chem 271:27912-8. 1996
  4. ncbi A new functional assay of thrombin activatable fibrinolysis inhibitor
    A H C Guimaraes
    The Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    J Thromb Haemost 3:1284-92. 2005
  5. pmc Role of the glycosaminoglycan component of thrombomodulin in its acceleration of the inactivation of single-chain urokinase-type plasminogen activator by thrombin
    G A de Munk
    IVVO TNO Gaubius Laboratory, Leiden, The Netherlands
    Biochem J 290:655-9. 1993
  6. ncbi Monoclonal antibodies against the human mannose receptor as a specific marker in flow cytometry and immunohistochemistry for macrophages
    F Noorman
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    J Leukoc Biol 61:63-72. 1997
  7. ncbi The effect of flow on lysis of plasma clots in a plasma environment
    D V Sakharov
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Thromb Haemost 83:469-74. 2000
  8. ncbi Fibrin-specificity of a plasminogen activator affects the efficiency of fibrinolysis and responsiveness to ultrasound: comparison of nine plasminogen activators in vitro
    D V Sakharov
    Gaubius Laboratory, TNO PG, Leiden, The Netherlands
    Thromb Haemost 81:605-12. 1999
  9. ncbi Migration of the activation peptide of thrombin-activatable fibrinolysis inhibitor (TAFI) during SDS-polyacrylamide gel electrophoresis
    A H C Guimaraes
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    J Thromb Haemost 2:780-4. 2004
  10. ncbi Polylysine as a vehicle for extracellular matrix-targeted local drug delivery, providing high accumulation and long-term retention within the vascular wall
    D V Sakharov
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 21:943-8. 2001

Collaborators

  • D V Sakharov
  • R T Hekkenberg
  • C Kluft
  • E A Biessen
  • A Gils
  • J Morser
  • R M Bertina
  • J J Emeis
  • A H C Guimaraes
  • F Noorman
  • N Bovenschen
  • E A Braat
  • E A Schenk-Braat
  • M M Barrett-Bergshoeff
  • M Barrett-Bergshoeff
  • L M Havekes
  • K Mertens
  • B J M van Vlijmen
  • N H van Tilburg
  • H L Vos
  • P J Declerck
  • T J van Berkel
  • J Kuiper
  • J M Grimbergen
  • A F Jie
  • A Collen
  • A van Leeuwen
  • R Bos
  • J Lindeman
  • E van de Bilt
  • E Barbe
  • G A de Munk
  • M Otter
  • A H Voorschuur
  • A J van Zonneveld
  • N U Bang
  • J F Parkinson
  • E Groeneveld

Detail Information

Publications23

  1. ncbi Characterization of the binding of urokinase-type plasminogen activator to the asialoglycoprotein receptor
    D C Rijken
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Thromb Haemost 88:83-8. 2002
    ..coli scarcely bound to the receptor. It is concluded that u-PA bearing non-sulfated GalNAc-GlcNAc elements is specifically recognized by the ASGPr present on liver cells...
  2. ncbi Basic principles in thrombolysis: regulatory role of plasminogen
    D C Rijken
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Thromb Res 103:S41-9. 2001
    ..These mechanisms show that plasminogen plays an important regulatory role in fibrinolysis and thrombolysis...
  3. ncbi Interactions between staphylokinase, plasmin(ogen), and fibrin. Staphylokinase discriminates between free plasminogen and plasminogen bound to partially degraded fibrin
    D V Sakharov
    Gaubius Laboratory, TNO Prevention and Health, P O Box 2215, 2301 CE Leiden, The Netherlands
    J Biol Chem 271:27912-8. 1996
    ..These findings add a new mechanism to the known explanations for the inefficient Pg activation by STA in plasma and specify the mechanism for fibrin-dependent activation of Pg...
  4. ncbi A new functional assay of thrombin activatable fibrinolysis inhibitor
    A H C Guimaraes
    The Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    J Thromb Haemost 3:1284-92. 2005
    ..This assay provides valuable information about the performance of different TAFI isoforms and constitutes a new method for studying the role of TAFI in cardiovascular disease...
  5. pmc Role of the glycosaminoglycan component of thrombomodulin in its acceleration of the inactivation of single-chain urokinase-type plasminogen activator by thrombin
    G A de Munk
    IVVO TNO Gaubius Laboratory, Leiden, The Netherlands
    Biochem J 290:655-9. 1993
    ..It is concluded that the major glycosaminoglycan of TM plays a pivotal role in the inactivation of scu-PA by the TM-thrombin complex, both in the formation and in the activity of the complex...
  6. ncbi Monoclonal antibodies against the human mannose receptor as a specific marker in flow cytometry and immunohistochemistry for macrophages
    F Noorman
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    J Leukoc Biol 61:63-72. 1997
    ..It was concluded that the mAb are useful tools in flow cytometry and immunohistochemistry for the specific detection of cells expressing mannose receptor...
  7. ncbi The effect of flow on lysis of plasma clots in a plasma environment
    D V Sakharov
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Thromb Haemost 83:469-74. 2000
    ..In the case of fibrin-specific lysis, the effect of flow on the speed of fibrinolysis is always beneficial...
  8. ncbi Fibrin-specificity of a plasminogen activator affects the efficiency of fibrinolysis and responsiveness to ultrasound: comparison of nine plasminogen activators in vitro
    D V Sakharov
    Gaubius Laboratory, TNO PG, Leiden, The Netherlands
    Thromb Haemost 81:605-12. 1999
    ..Application of high-frequency ultrasound as an adjunct to thrombolytic therapy may increase the treatment efficiency, particularly in conjunction with fibrin-specific PAs...
  9. ncbi Migration of the activation peptide of thrombin-activatable fibrinolysis inhibitor (TAFI) during SDS-polyacrylamide gel electrophoresis
    A H C Guimaraes
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    J Thromb Haemost 2:780-4. 2004
    ..We identify the 33 000 band as the activation peptide of TAFI and exemplify the use of this information for the characterization of monoclonal antibodies against TAFI...
  10. ncbi Polylysine as a vehicle for extracellular matrix-targeted local drug delivery, providing high accumulation and long-term retention within the vascular wall
    D V Sakharov
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 21:943-8. 2001
    ..In conclusion, by use of the ECM-LDD method, an extremely high concentration and long-term retention of locally delivered drug can be reached. Polycationic molecules can be considered as potential affinity vehicles for ECM-LDD...
  11. pmc alpha 2-Antiplasmin Enschede: dysfunctional alpha 2-antiplasmin molecule associated with an autosomal recessive hemorrhagic disorder
    C Kluft
    Gaubius Institute, Leiden, The Netherlands
    J Clin Invest 80:1391-400. 1987
    ..The residual plasminogen-binding properties do not protect against a hemorrhagic diathesis...
  12. ncbi Monoclonal antibodies against the human mannose receptor that inhibit the binding of tissue-type plasminogen activator
    M Barrett-Bergshoeff
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Thromb Haemost 77:718-24. 1997
    ....
  13. ncbi Cluster mannosides can inhibit mannose receptor-mediated tissue-type plasminogen activator degradation by both rat and human cells
    F Noorman
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Hepatology 26:1303-10. 1997
    ....
  14. ncbi Acceleration of fibrinolysis by high-frequency ultrasound: the contribution of acoustic streaming and temperature rise
    D V Sakharov
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Thromb Res 100:333-40. 2000
    ..The therapeutic advantage of transcutaneous high-frequency ultrasound as an adjunct to thrombolytic therapy may appear limited to the situations where there is no flow in the direct environment of the thrombus...
  15. ncbi On the mechanism of the antifibrinolytic activity of plasma carboxypeptidase B
    D V Sakharov
    Gaubius Laboratory, TNO Prevention and Health, 2301 CE Leiden, The Netherlands
    J Biol Chem 272:14477-82. 1997
    ..This is a likely mechanism for the antifibrinolytic effect of active pCPB...
  16. ncbi Identification of the epidermal growth factor-like domains of thrombomodulin essential for the acceleration of thrombin-mediated inactivation of single-chain urokinase-type plasminogen activator
    E A Schenk-Braat
    TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    Eur J Biochem 268:5562-9. 2001
    ..This differs from the domains that are critical for activation of protein C (EGF-like domains i4-6) and thrombin activatable fibrinolysis inhibitor (EGF-like domains 3-6)...
  17. ncbi Association between thrombin activatable fibrinolysis inhibitor genotype and levels in plasma: comparison of different assays
    A H C Guimaraes
    Gaubius Laboratory, TNO Prevention and Health, 2301 CE Leiden, The Netherlands
    Br J Haematol 124:659-65. 2004
    ..Our results demonstrate that artefacts may arise when measuring TAFI antigen levels by ELISA. Nevertheless, the electroimmunoassay and the Actichrome TAFI assay support a genotype-related variation of TAFI concentration...
  18. ncbi Binding and retention of polycationic peptides and dendrimers in the vascular wall
    D V Sakharov
    Gaubius Laboratory, TNO Prevention and Health, P O Box 2215, 2301 CE Leiden, The Netherlands
    FEBS Lett 537:6-10. 2003
    ..Rationally designed GAG-binding peptides can be useful as affinity vehicles for targeting drugs to the vascular ECM...
  19. ncbi The inactivation of single-chain urokinase-type plasminogen activator by thrombin on cultured human endothelial cells
    E A Braat
    TNO Prevention and Health, Gaubius Laboratory, P O Box 2215, 2301 CE, Leiden, The Netherlands
    Biochim Biophys Acta 1497:351-8. 2000
    ....
  20. ncbi Relationships between structure and function of tissue-type plasminogen activator
    D C Rijken
    Gaubius Institute TNO, Leiden, The Netherlands
    Klin Wochenschr 66:33-9. 1988
    ..Other specific properties of the plasminogen activator, such as its rapid hepatic clearance and its inhibition by plasminogen activator inhibitors have not yet been related to specific domains in the protein structure...
  21. ncbi Characterization of the interaction of a complex of tissue-type plasminogen activator and plasminogen activator inhibitor type 1 with rat liver cells
    J Kuiper
    Division of Biopharmaceutics, Leiden Amsterdam Center for Drug Research, University of Leiden, The Netherlands
    Thromb Haemost 74:1298-304. 1995
    ..LRP on rat parenchymal liver cells is responsible for the uptake and degradation of t-PA-PAI-1 and may therefore be important for the regulation of the t-PA levels in the circulation...
  22. ncbi The B domain of coagulation factor VIII interacts with the asialoglycoprotein receptor
    N Bovenschen
    Department of Plasma Proteins, Sanquin Research at CLB, Amsterdam, The Netherlands
    J Thromb Haemost 3:1257-65. 2005
    ..Because FVIII clearance in the presence of a bolus injection of RAP still occurs fairly efficient, also RAP-independent mechanisms are likely to be involved...
  23. ncbi Hepatocyte-derived fibrinogen-related protein-1 is associated with the fibrin matrix of a plasma clot
    D C Rijken
    Department of Hematology, Erasmus University Medical Center, Rotterdam, The Netherlands
    Biochem Biophys Res Commun 350:191-4. 2006
    ..It is concluded that HFREP-1 (also named hepassocin), a protein with liver cell growth regulatory properties, occurs in plasma and strongly associates with fibrin and possibly fibrinogen...