I Meulenbelt

Summary

Affiliation: TNO Prevention and Health
Country: The Netherlands

Publications

  1. ncbi Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis
    I Meulenbelt
    TNO Prevention and Health, Department of Vascular and Connective Tissue Research, Gaubius Laboratory, Leiden, The Netherlands
    Ann Hum Genet 63:393-400. 1999
  2. ncbi Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP study
    S D Bos
    Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 67:877-9. 2008
  3. ncbi Systemic and local factors are involved in the evolution of erosions in hand osteoarthritis
    J Bijsterbosch
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:326-30. 2011
  4. ncbi Accelerated metacarpal bone mineral density loss is associated with radiographic progressive hand osteoarthritis
    M Güler-Yüksel
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:1625-30. 2011
  5. ncbi Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years
    J Bijsterbosch
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:68-73. 2011
  6. ncbi The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA
    S D Bos
    Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Osteoarthritis Cartilage 17:621-6. 2009
  7. ncbi Validity of joint space width measurements in hand osteoarthritis
    W Y Kwok
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Osteoarthritis Cartilage 19:1349-55. 2011
  8. ncbi Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study
    I Meulenbelt
    Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Osteoarthritis Cartilage 15:379-85. 2007
  9. ncbi Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:320-5. 2011
  10. ncbi Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites
    J L Min
    Leiden University Medical Center, Section of Molecular Epidemiology, Leiden, The Netherlands
    Arthritis Rheum 52:1077-80. 2005

Collaborators

Detail Information

Publications14

  1. ncbi Haplotype analysis of three polymorphisms of the COL2A1 gene and associations with generalised radiological osteoarthritis
    I Meulenbelt
    TNO Prevention and Health, Department of Vascular and Connective Tissue Research, Gaubius Laboratory, Leiden, The Netherlands
    Ann Hum Genet 63:393-400. 1999
    ..3, 95% CI 2.3-12.7). Our results suggest that a specific haplotype of the COL2A1 locus may predispose to generalised ROA...
  2. ncbi Allelic variation at the C-reactive protein gene associates to both hand osteoarthritis severity and serum high sensitive C-reactive protein levels in the GARP study
    S D Bos
    Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Ann Rheum Dis 67:877-9. 2008
    ..To gain more insight into the role of genetic variation of the C-reactive protein (CRP) gene in serum CRP levels and osteoarthritis (OA)...
  3. ncbi Systemic and local factors are involved in the evolution of erosions in hand osteoarthritis
    J Bijsterbosch
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:326-30. 2011
    ..In order to gain insight in the pathogenesis of erosive hand osteoarthritis (OA), the evolution of erosions in hand OA and risk factors involved were investigated...
  4. ncbi Accelerated metacarpal bone mineral density loss is associated with radiographic progressive hand osteoarthritis
    M Güler-Yüksel
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:1625-30. 2011
    ..To study the association between metacarpal bone mineral density (BMD) loss and progressive hand osteoarthritis (OA) over 2 years...
  5. ncbi Clinical and radiographic disease course of hand osteoarthritis and determinants of outcome after 6 years
    J Bijsterbosch
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:68-73. 2011
    ..To investigate the long-term clinical and radiographic disease course of hand osteoarthritis (OA) and determinants of outcome...
  6. ncbi The role of plasma cytokine levels, CRP and Selenoprotein S gene variation in OA
    S D Bos
    Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Osteoarthritis Cartilage 17:621-6. 2009
    ..Investigating the association between plasma levels of cytokines and chemokines, Selenoprotein S (SELS) gene variation and osteoarthritis (OA) subtypes...
  7. ncbi Validity of joint space width measurements in hand osteoarthritis
    W Y Kwok
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Osteoarthritis Cartilage 19:1349-55. 2011
    ..To investigate the validity of joint space width (JSW) measurements in millimeters (mm) in hand osteoarthritis (OA) patients by comparison to controls, grading of joint space narrowing (JSN), and clinical features...
  8. ncbi Clusters of biochemical markers are associated with radiographic subtypes of osteoarthritis (OA) in subject with familial OA at multiple sites. The GARP study
    I Meulenbelt
    Department of Molecular Epidemiology, Leiden University Medical Centre, Leiden, The Netherlands
    Osteoarthritis Cartilage 15:379-85. 2007
    ..To assess the relationship of biochemical markers and radiographic signs of osteoarthritis (ROA) in the subjects with symptomatic osteoarthritis (OA) at multiple sites of the Genetics osteoARthritis and Progression (GARP) study...
  9. ncbi Arthropathy in long-term cured acromegaly is characterised by osteophytes without joint space narrowing: a comparison with generalised osteoarthritis
    M J E Wassenaar
    Department of Endocrinology and Metabolic Diseases, Leiden University Medical Center, Leiden, The Netherlands
    Ann Rheum Dis 70:320-5. 2011
    ....
  10. ncbi Association of the Frizzled-related protein gene with symptomatic osteoarthritis at multiple sites
    J L Min
    Leiden University Medical Center, Section of Molecular Epidemiology, Leiden, The Netherlands
    Arthritis Rheum 52:1077-80. 2005
    ..To confirm the association of 2 variants of the Frizzled-related protein gene (FRZB) with osteoarthritis (OA) of the hip, and to investigate whether these variants also associate with other heritable generalized OA phenotypes...
  11. ncbi Relative efficiency of haplotype frequency estimation in sibships and nuclear families compared to unrelated individuals
    H Putter
    Department of Medical Statistics and Bioinformatics, Leiden University Medical Center, Leiden, The Netherlands
    Hum Hered 64:52-62. 2007
    ..We argue that the relative efficiencies can also be used to correct for dependence in the calculation of standard errors after initially ignoring the dependence in the estimation phase...
  12. ncbi Genetics of human aging. The search for genes contributing to human longevity and diseases of the old
    P E Slagboom
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Ann N Y Acad Sci 908:50-63. 2000
    ..These issues will be illustrated from research on cardiovascular disease and osteoarthritis...
  13. ncbi Summary of the OA biomarkers workshop 2010 - genetics and genomics: new targets in OA
    I Meulenbelt
    Department of Molecular Epidemiology, LUMC, Leiden, The Netherlands
    Osteoarthritis Cartilage 19:1091-4. 2011
    ..With those tools in hand, clinicians and industry can develop protocols to ultimately improve patient care...
  14. ncbi Illness perceptions in patients with osteoarthritis: change over time and association with disability
    J Bijsterbosch
    Department of Rheumatology, Leiden University Medical Center, Leiden, The Netherlands
    Arthritis Rheum 61:1054-61. 2009
    ..To investigate changes in illness perceptions in patients with osteoarthritis (OA) and the association of those changes with disability, and to determine the predictive value of illness perceptions in disability...