Research Topics
| C Frieke KuperSummaryAffiliation: TNO Quality of Life Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
Nasal passages of Göttingen minipigs from the neonatal period to young adultC Frieke Kuper
TNO Research Group Quality and Safety, Zeist, The Netherlands
Toxicol Pathol 40:656-66. 2012....- Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway ratsC Frieke Kuper
TNO Quality of Life, Zeist, The Netherlands
Toxicol Pathol 36:985-98. 2008..The authors conclude that parameters for lung remodeling can be a valuable tool in hazard identification of LMW respiratory allergens... - Hyperplasia of the lymphoepithelium of NALT in rats but not in mice upon 28-day exposure to 15 ppm formaldehyde vaporC Frieke Kuper
Department of Toxicology and Applied Pharmacology, TNO Quality of Life, 3704HE Zeist, The Netherlands
Exp Toxicol Pathol 63:25-32. 2011..It was concluded that hyperplasia of the lymphoepithelium of NALT of rats exposed to 15 ppm was the only distinct effect of FA vapor on local lymphoid tissues (NALT and lymph nodes) of Fischer-344 rats and B3C3F1 mice... - The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway ratC Frieke Kuper
TNO, Quality of Life, Zeist, The Netherlands
Toxicology 246:213-21. 2008.... 
Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult ageC Frieke Kuper
TNO Quality of Life, Toxicology and Applied Pharmacology, AJ Zeist, 3700, The Netherlands
Toxicol Pathol 35:226-32. 2007..Moreover, the type of effects of an immunotoxic agent may vary with age of exposure...- Histopathology of mucosa-associated lymphoid tissueC Frieke Kuper
TNO Nutrition and Food Research, 3704 HE Zeist, The Netherlands
Toxicol Pathol 34:609-15. 2006..Lesions of the nasopharyngeal lymphoid tissue and Peyer's patches include degeneration, inflammation, and both primary and metastatic neoplasia... - Oxazolone (OXA) is a respiratory allergen in Brown Norway ratsC Frieke Kuper
TNO, Quality and Safety, Zeist, The Netherlands
Toxicology 290:59-68. 2011..The results indicate that the contact allergen OXA can also be a respiratory allergen, provided that it is inhaled. Its use as a model contact sensitizer must be reconsidered... - The respiratory allergen glutaraldehyde in the local lymph node assay: sensitization by skin exposure, but not by inhalationJos J van Triel
TNO Quality of Life, Department of Toxicology and Applied Pharmacology, Zeist, The Netherlands
Toxicology 279:115-22. 2011..Within the context of risk assessment in respiratory allergy, our results stress the importance of prevention of skin--besides inhalation-- exposure to aldehydes like GA... - Pre-exposure to sulfur dioxide attenuates most allergic reactions upon trimellitic anhydride challenge in sensitized Brown Norway ratsJosje H E Arts
Toxicology and Applied Pharmacology, TNO Quality of Life, Zeist, The Netherlands
Inhal Toxicol 22:179-91. 2010..However in a few animals, SO(2) appeared to facilitate TMA-induced irritation, probably due to incomplete protection. Overall, SO(2) exposure of TMA-sensitized rats reduced TMA-related allergic respiratory responses in most animals... - Allergic inflammation in the upper respiratory tract of the rat upon repeated inhalation exposure to the contact allergen dinitrochlorobenzene (DNCB)Jos J van Triel
TNO Quality of Life, Department Toxicology and Applied Pharmacology, Zeist, The Netherlands
Toxicology 269:73-80. 2010..Possible progression of the airway inflammation upon long-term exposure should be investigated to support or dismiss discrimination between contact and respiratory allergens in relation to respiratory allergy... - Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 monthsJosje H E Arts
TNO Quality of Life, P O Box 360, 3700 AJ Zeist, The Netherlands
Food Chem Toxicol 45:1856-67. 2007.... - Respiratory allergy and pulmonary irritation to trimellitic anhydride in Brown Norway ratsJosje H E Arts
Toxicology Division, TNO Nutrition and Food Research, Zeist, The Netherlands
Toxicol Appl Pharmacol 187:38-49. 2003..Sensitization-dependent functional changes were accompanied by inflammatory changes characteristic of asthma and biochemical evidence of airway damage... - The respiratory local lymph node assay as a tool to study respiratory sensitizersJosje H E Arts
TNO Quality of Life, Zeist, The Netherlands
Toxicol Sci 106:423-34. 2008..In addition, the contact allergens were as potent as the respiratory allergens, although the potency ranking differed from that in a skin LLNA... - Setting an indoor air exposure limit for formaldehyde: factors of concernJosje H E Arts
Toxicology and Applied Pharmacology, TNO Quality of Life, P O Box 360, 3700 AJ Zeist, The Netherlands
Regul Toxicol Pharmacol 52:189-94. 2008..Forsch. Prax. 11, 347-361], can be considered a safe and appropriate level... - Animal models to test respiratory allergy of low molecular weight chemicals: a guidanceJosje H E Arts
TNO Quality of Life, Toxicology and Applied Pharmacology, P O Box 360, 3700 AJ Zeist, The Netherlands
Methods 41:61-71. 2007..The dermal route as sensitisation route has the advantage of the respiratory tract not being exposed to the allergen prior to challenge which facilitates the distinction between irritant and allergic effects... - The Göttingen minipig® as an alternative non-rodent species for immunogenicity testing: a demonstrator study using the IL-1 receptor antagonist anakinraGeertje J D van Mierlo
Department of Toxicology and Risk Assessment, TNO Triskelion BV, Zeist, The Netherlands
J Immunotoxicol 10:96-105. 2013..However, more studies evaluating additional biopharmaceutical products are needed to support the use of the minipig as an alternative model for (immuno)toxicity testing, including immunogenicity... - Potentially increased sensitivity of pregnant and lactating female rats to immunotoxic agentsAswin Menke
TNO Triskelion BV, Zeist, The Netherlands
Toxicol Pathol 40:255-60. 2012..This explorative study indicates that the innate and adaptive immune system may be especially sensitive to immunotoxicants during pregnancy and lactation... - Toxicity to nasal-associated lymphoid tissueC Frieke Kuper
TNO Nutrition and Food Research, Department of General Toxicology, Division of Toxicology, PO Box 360, 3700 AJ, Zeist, The Netherlands
Toxicol Lett 140:281-5. 2003..Therefore, we recommend to include histopathological examination of NALT in standard guideline-driven inhalation toxicity studies... - Preexposure to amorphous silica particles attenuates but also enhances allergic reactions in trimellitic anhydride-sensitized brown Norway ratsJosje H E Arts
AkzoNobel T and E, Arnhem, The Netherlands
Inhal Toxicol 20:935-48. 2008..Thus, a respiratory particulate irritant like SAS can reduce as well as aggravate certain aspects of TMA-induced respiratory allergy... - Alveolar macrophages suppress non-specific inflammation caused by inhalation challenge with trimellitic anhydride conjugated to albuminDingena L Valstar
Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
Arch Toxicol 80:561-71. 2006..Since effects of inhalation challenge with TMA-BSA are partly different from those of TMA, challenge with the latter is to be preferred for hazard identification... - Alveolar macrophages have a dual role in a rat model for trimellitic anhydride-induced occupational asthmaDingena L Valstar
Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
Toxicol Appl Pharmacol 211:20-9. 2006..AMs seem to have a dual role in this model for TMA-induced occupational asthma since they potentiate the immediate TMA-induced decrease in lung function but tended to dampen the TMA-induced inflammatory reaction 24 h later...