C Frieke Kuper

Summary

Affiliation: TNO Quality of Life
Country: The Netherlands

Publications

  1. doi request reprint Nasal passages of Göttingen minipigs from the neonatal period to young adult
    C Frieke Kuper
    TNO Research Group Quality and Safety, Zeist, The Netherlands
    Toxicol Pathol 40:656-66. 2012
  2. doi request reprint Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway rats
    C Frieke Kuper
    TNO Quality of Life, Zeist, The Netherlands
    Toxicol Pathol 36:985-98. 2008
  3. doi request reprint Hyperplasia of the lymphoepithelium of NALT in rats but not in mice upon 28-day exposure to 15 ppm formaldehyde vapor
    C Frieke Kuper
    Department of Toxicology and Applied Pharmacology, TNO Quality of Life, 3704HE Zeist, The Netherlands
    Exp Toxicol Pathol 63:25-32. 2011
  4. doi request reprint The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat
    C Frieke Kuper
    TNO, Quality of Life, Zeist, The Netherlands
    Toxicology 246:213-21. 2008
  5. ncbi request reprint Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age
    C Frieke Kuper
    TNO Quality of Life, Toxicology and Applied Pharmacology, AJ Zeist, 3700, The Netherlands
    Toxicol Pathol 35:226-32. 2007
  6. ncbi request reprint Histopathology of mucosa-associated lymphoid tissue
    C Frieke Kuper
    TNO Nutrition and Food Research, 3704 HE Zeist, The Netherlands
    Toxicol Pathol 34:609-15. 2006
  7. doi request reprint Oxazolone (OXA) is a respiratory allergen in Brown Norway rats
    C Frieke Kuper
    TNO, Quality and Safety, Zeist, The Netherlands
    Toxicology 290:59-68. 2011
  8. doi request reprint The respiratory allergen glutaraldehyde in the local lymph node assay: sensitization by skin exposure, but not by inhalation
    Jos J van Triel
    TNO Quality of Life, Department of Toxicology and Applied Pharmacology, Zeist, The Netherlands
    Toxicology 279:115-22. 2011
  9. doi request reprint Pre-exposure to sulfur dioxide attenuates most allergic reactions upon trimellitic anhydride challenge in sensitized Brown Norway rats
    Josje H E Arts
    Toxicology and Applied Pharmacology, TNO Quality of Life, Zeist, The Netherlands
    Inhal Toxicol 22:179-91. 2010
  10. doi request reprint Allergic inflammation in the upper respiratory tract of the rat upon repeated inhalation exposure to the contact allergen dinitrochlorobenzene (DNCB)
    Jos J van Triel
    TNO Quality of Life, Department Toxicology and Applied Pharmacology, Zeist, The Netherlands
    Toxicology 269:73-80. 2010

Collaborators

Detail Information

Publications21

  1. doi request reprint Nasal passages of Göttingen minipigs from the neonatal period to young adult
    C Frieke Kuper
    TNO Research Group Quality and Safety, Zeist, The Netherlands
    Toxicol Pathol 40:656-66. 2012
    ....
  2. doi request reprint Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway rats
    C Frieke Kuper
    TNO Quality of Life, Zeist, The Netherlands
    Toxicol Pathol 36:985-98. 2008
    ..The authors conclude that parameters for lung remodeling can be a valuable tool in hazard identification of LMW respiratory allergens...
  3. doi request reprint Hyperplasia of the lymphoepithelium of NALT in rats but not in mice upon 28-day exposure to 15 ppm formaldehyde vapor
    C Frieke Kuper
    Department of Toxicology and Applied Pharmacology, TNO Quality of Life, 3704HE Zeist, The Netherlands
    Exp Toxicol Pathol 63:25-32. 2011
    ..It was concluded that hyperplasia of the lymphoepithelium of NALT of rats exposed to 15 ppm was the only distinct effect of FA vapor on local lymphoid tissues (NALT and lymph nodes) of Fischer-344 rats and B3C3F1 mice...
  4. doi request reprint The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat
    C Frieke Kuper
    TNO, Quality of Life, Zeist, The Netherlands
    Toxicology 246:213-21. 2008
    ....
  5. ncbi request reprint Effects of cyclosporin A and cyclophosphamide on Peyer's patches in rat, exposed in utero and neonatally or during adult age
    C Frieke Kuper
    TNO Quality of Life, Toxicology and Applied Pharmacology, AJ Zeist, 3700, The Netherlands
    Toxicol Pathol 35:226-32. 2007
    ..Moreover, the type of effects of an immunotoxic agent may vary with age of exposure...
  6. ncbi request reprint Histopathology of mucosa-associated lymphoid tissue
    C Frieke Kuper
    TNO Nutrition and Food Research, 3704 HE Zeist, The Netherlands
    Toxicol Pathol 34:609-15. 2006
    ..Lesions of the nasopharyngeal lymphoid tissue and Peyer's patches include degeneration, inflammation, and both primary and metastatic neoplasia...
  7. doi request reprint Oxazolone (OXA) is a respiratory allergen in Brown Norway rats
    C Frieke Kuper
    TNO, Quality and Safety, Zeist, The Netherlands
    Toxicology 290:59-68. 2011
    ..The results indicate that the contact allergen OXA can also be a respiratory allergen, provided that it is inhaled. Its use as a model contact sensitizer must be reconsidered...
  8. doi request reprint The respiratory allergen glutaraldehyde in the local lymph node assay: sensitization by skin exposure, but not by inhalation
    Jos J van Triel
    TNO Quality of Life, Department of Toxicology and Applied Pharmacology, Zeist, The Netherlands
    Toxicology 279:115-22. 2011
    ..Within the context of risk assessment in respiratory allergy, our results stress the importance of prevention of skin--besides inhalation-- exposure to aldehydes like GA...
  9. doi request reprint Pre-exposure to sulfur dioxide attenuates most allergic reactions upon trimellitic anhydride challenge in sensitized Brown Norway rats
    Josje H E Arts
    Toxicology and Applied Pharmacology, TNO Quality of Life, Zeist, The Netherlands
    Inhal Toxicol 22:179-91. 2010
    ..However in a few animals, SO(2) appeared to facilitate TMA-induced irritation, probably due to incomplete protection. Overall, SO(2) exposure of TMA-sensitized rats reduced TMA-related allergic respiratory responses in most animals...
  10. doi request reprint Allergic inflammation in the upper respiratory tract of the rat upon repeated inhalation exposure to the contact allergen dinitrochlorobenzene (DNCB)
    Jos J van Triel
    TNO Quality of Life, Department Toxicology and Applied Pharmacology, Zeist, The Netherlands
    Toxicology 269:73-80. 2010
    ..Possible progression of the airway inflammation upon long-term exposure should be investigated to support or dismiss discrimination between contact and respiratory allergens in relation to respiratory allergy...
  11. ncbi request reprint Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months
    Josje H E Arts
    TNO Quality of Life, P O Box 360, 3700 AJ Zeist, The Netherlands
    Food Chem Toxicol 45:1856-67. 2007
    ....
  12. ncbi request reprint Respiratory allergy and pulmonary irritation to trimellitic anhydride in Brown Norway rats
    Josje H E Arts
    Toxicology Division, TNO Nutrition and Food Research, Zeist, The Netherlands
    Toxicol Appl Pharmacol 187:38-49. 2003
    ..Sensitization-dependent functional changes were accompanied by inflammatory changes characteristic of asthma and biochemical evidence of airway damage...
  13. doi request reprint The respiratory local lymph node assay as a tool to study respiratory sensitizers
    Josje H E Arts
    TNO Quality of Life, Zeist, The Netherlands
    Toxicol Sci 106:423-34. 2008
    ..In addition, the contact allergens were as potent as the respiratory allergens, although the potency ranking differed from that in a skin LLNA...
  14. doi request reprint Setting an indoor air exposure limit for formaldehyde: factors of concern
    Josje H E Arts
    Toxicology and Applied Pharmacology, TNO Quality of Life, P O Box 360, 3700 AJ Zeist, The Netherlands
    Regul Toxicol Pharmacol 52:189-94. 2008
    ..Forsch. Prax. 11, 347-361], can be considered a safe and appropriate level...
  15. ncbi request reprint Animal models to test respiratory allergy of low molecular weight chemicals: a guidance
    Josje H E Arts
    TNO Quality of Life, Toxicology and Applied Pharmacology, P O Box 360, 3700 AJ Zeist, The Netherlands
    Methods 41:61-71. 2007
    ..The dermal route as sensitisation route has the advantage of the respiratory tract not being exposed to the allergen prior to challenge which facilitates the distinction between irritant and allergic effects...
  16. doi request reprint The Göttingen minipig® as an alternative non-rodent species for immunogenicity testing: a demonstrator study using the IL-1 receptor antagonist anakinra
    Geertje J D van Mierlo
    Department of Toxicology and Risk Assessment, TNO Triskelion BV, Zeist, The Netherlands
    J Immunotoxicol 10:96-105. 2013
    ..However, more studies evaluating additional biopharmaceutical products are needed to support the use of the minipig as an alternative model for (immuno)toxicity testing, including immunogenicity...
  17. doi request reprint Potentially increased sensitivity of pregnant and lactating female rats to immunotoxic agents
    Aswin Menke
    TNO Triskelion BV, Zeist, The Netherlands
    Toxicol Pathol 40:255-60. 2012
    ..This explorative study indicates that the innate and adaptive immune system may be especially sensitive to immunotoxicants during pregnancy and lactation...
  18. ncbi request reprint Toxicity to nasal-associated lymphoid tissue
    C Frieke Kuper
    TNO Nutrition and Food Research, Department of General Toxicology, Division of Toxicology, PO Box 360, 3700 AJ, Zeist, The Netherlands
    Toxicol Lett 140:281-5. 2003
    ..Therefore, we recommend to include histopathological examination of NALT in standard guideline-driven inhalation toxicity studies...
  19. ncbi request reprint Preexposure to amorphous silica particles attenuates but also enhances allergic reactions in trimellitic anhydride-sensitized brown Norway rats
    Josje H E Arts
    AkzoNobel T and E, Arnhem, The Netherlands
    Inhal Toxicol 20:935-48. 2008
    ..Thus, a respiratory particulate irritant like SAS can reduce as well as aggravate certain aspects of TMA-induced respiratory allergy...
  20. ncbi request reprint Alveolar macrophages suppress non-specific inflammation caused by inhalation challenge with trimellitic anhydride conjugated to albumin
    Dingena L Valstar
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    Arch Toxicol 80:561-71. 2006
    ..Since effects of inhalation challenge with TMA-BSA are partly different from those of TMA, challenge with the latter is to be preferred for hazard identification...
  21. ncbi request reprint Alveolar macrophages have a dual role in a rat model for trimellitic anhydride-induced occupational asthma
    Dingena L Valstar
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    Toxicol Appl Pharmacol 211:20-9. 2006
    ..AMs seem to have a dual role in this model for TMA-induced occupational asthma since they potentiate the immediate TMA-induced decrease in lung function but tended to dampen the TMA-induced inflammatory reaction 24 h later...