Research Topics
| Stef J KoppelmanSummaryAffiliation: TNO Nutrition and Food Research Country: The Netherlands Publications
| Collaborators
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Detail Information
Publications
Purification and immunoglobulin E-binding properties of peanut allergen Ara h 6: evidence for cross-reactivity with Ara h 2S J Koppelman
TNO Nutrition and Food Research, Zeist, The Netherlands
Clin Exp Allergy 35:490-7. 2005..IgE-binding peanut proteins smaller than 15 kDa were previously identified as potential allergens in the majority of our peanut allergic population...- Heat-induced conformational changes of Ara h 1, a major peanut allergen, do not affect its allergenic propertiesS J Koppelman
TNO Nutrition and Food Research Institute, 3700 AJ Zeist, The Netherlands
J Biol Chem 274:4770-7. 1999.... - Comparison of different immunochemical methods for the detection and quantification of hazelnut proteins in food productsS J Koppelman
Protein Technology Department, TNO Nutrition and Food Research Institute, Zeist, Netherlands
J Immunol Methods 229:107-20. 1999..Since this test does not require serum from patients, it is appropriate for use in the food industry... - Effect of heat-induced aggregation on the IgE binding of patatin (Sol t 1) is dominated by other potato proteinsStef J Koppelman
Department of Protein Technology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands
J Agric Food Chem 50:1562-8. 2002..It is concluded that the heat lability of patatin-IgE interaction is explained by aggregation of patatin with other potato proteins rather than by denaturation of patatin itself... - Detection of soy proteins in processed foods: literature overview and new experimental workStef J Koppelman
TNO Nutrition and Food Research, Zeist, The Netherlands
J AOAC Int 87:1398-407. 2004..The presently developed test is applicable for soy ingredients and soy-containing foods that are processed in different ways. The limit of quantitation is 1 ppm, which is an enormous improvement over earlier described methods... - Reversible denaturation of Brazil nut 2S albumin (Ber e1) and implication of structural destabilization on digestion by pepsinStef J Koppelman
TNO Nutrition and Food Research, Zeist, The Netherlands
J Agric Food Chem 53:123-31. 2005..Whereas native 2S albumin was digested slowly in 1 h, the reduced and alkylated protein was digested completely within 30 s. These results are discussed in view of the potential allergenicity of Brazil nut 2S albumin... - Relevance of Ara h1, Ara h2 and Ara h3 in peanut-allergic patients, as determined by immunoglobulin E Western blotting, basophil-histamine release and intracutaneous testing: Ara h2 is the most important peanut allergenS J Koppelman
TNO Nutrition and Food Research, Zeist, The Netherlands
Clin Exp Allergy 34:583-90. 2004..A number of allergenic proteins in peanut has been described and the relative importance of these allergens is yet to be determined... - Development of an enzyme-linked immunosorbent assay method to detect mustard protein in mustard seed oilStef J Koppelman
TNO Nutrition and Food Research, Zeist, The Netherlands Kerklaan 53, NL 3731 EG De Bilt, The Netherlands
J Food Prot 70:179-83. 2007.... - Digestion of peanut allergens Ara h 1, Ara h 2, Ara h 3, and Ara h 6: a comparative in vitro study and partial characterization of digestion-resistant peptidesStef J Koppelman
TNO Quality of Life, Zeist, The Netherlands
Mol Nutr Food Res 54:1711-21. 2010..This study provides a comprehensive comparison of the digestibility of the major peanut allergens... - Peanut allergen Ara h 3: isolation from peanuts and biochemical characterizationS J Koppelman
TNO Nutrition and Food Research Institute, Zeist, The Netherlands
Allergy 58:1144-51. 2003..Furthermore, posttranslational processing of Ara h 3 affects the IgE-binding properties and is therefore an essential subject of study for research on the allergenicity of Ara h 3... - Purification and substrate specificity of transglutaminases from blood and Streptoverticillium mobaraenseG A de Jong
TNO Nutrition and Food Research Institute, 3700 AJ Zeist, The Netherlands
J Agric Food Chem 49:3389-93. 2001..In addition, differences exist in the necessity of the addition of reducing agents. These differences allow specific applications of blood and bacterial transglutaminases at protein cross-linking in single or complex protein systems... - Is Candida albicans a trigger in the onset of coeliac disease?W F Nieuwenhuizen
Netherlands Organisation for Applied Scientific Research TNO Nutrition and Food Research, PO Box 360, 3700 AJ, Zeist, Netherlands
Lancet 361:2152-4. 2003..Subsequently, C albicans might function as an adjuvant that stimulates antibody formation against HWP1 and gluten, and formation of autoreactive antibodies against tissue transglutaminase and endomysium... - Expanded bed adsorption as a fast technique for the large-scale purification of the complete isoform pool of Ber e 1, the major allergen from Brazil nutsEvelien L van Boxtel
Centre for Protein Technology, Wageningen, The Netherlands
Mol Nutr Food Res 50:275-81. 2006..Thus, using EBA, Ber e 1 can be purified fast and on gram-scale, while having purity equal to that of conventionally purified Ber e 1... - Allergen Ara h 1 occurs in peanuts as a large oligomer rather than as a trimerEvelien L van Boxtel
Laboratory of Food Chemistry, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
J Agric Food Chem 54:7180-6. 2006..As structural characteristics are important for a protein's allergenicity, this finding may imply a different allergenicity for Ara h 1 than previously described... - Determination of pepsin-susceptible and pepsin-resistant epitopes in native and heat-treated peanut allergen Ara h 1Evelien L van Boxtel
Laboratory of Food Chemistry, Wageningen University, P O Box 8129, 6700 EV Wageningen, The Netherlands
J Agric Food Chem 56:2223-30. 2008..Consequently, this unique N-terminal part of Ara h 1 is proposed to be responsible for the allergen's ability to induce systemic allergic reactions... - Proteolytic processing of the peanut allergen Ara h 3Sander R Piersma
FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
Mol Nutr Food Res 49:744-55. 2005.... - Legumin allergens from peanuts and soybeans: effects of denaturation and aggregation on allergenicityEvelien L van Boxtel
Laboratory of Food Chemistry, Wageningen University, EV Wageningen, The Netherlands
Mol Nutr Food Res 52:674-82. 2008..Consequently, these allergens are likely unable to sensitize via the gastro-intestinal tract and cause systemic food allergy symptoms. These proteins might thus be less important allergens than was previously assumed... - Patients with anaphylaxis to pea can have peanut allergy caused by cross-reactive IgE to vicilin (Ara h 1)Marjolein Wensing
Department of Dermatology/Allergology G02.124, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
J Allergy Clin Immunol 111:420-4. 2003..CONCLUSION: Clinically relevant cross-reactivity between pea and peanut does occur. Vicilin homologues in pea and peanut (Ara h 1) are the molecular basis for this cross-reactivity... - Ara h 8, a Bet v 1-homologous allergen from peanut, is a major allergen in patients with combined birch pollen and peanut allergyDiana Mittag
Department of Dermatology, University Hospital, Zurich
J Allergy Clin Immunol 114:1410-7. 2004..CONCLUSIONS: Peanut allergy might be mediated in a subgroup of our patients by means of cross-reaction of Bet v 1 with the homologous peanut allergen Ara h 8... - Peanut allergen Ara h 1 interacts with proanthocyanidins into higher molecular weight complexesEvelien L van Boxtel
Laboratory of Food Chemistry, Wageningen University, P O Box 8129, 6700 EV Wageningen, The Netherlands
J Agric Food Chem 55:8772-8. 2007..Ara h 1 present as the oligomeric complex is assumed to be the representative form of the allergen in which it is consumed by humans... - Peanut allergy: sensitization by peanut oil-containing local therapeutics seems unlikelyKim A B M Peeters
J Allergy Clin Immunol 113:1000-1. 2004 - The distribution of individual threshold doses eliciting allergic reactions in a population with peanut allergyMarjolein Wensing
Department of Dermatology/Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands
J Allergy Clin Immunol 110:915-20. 2002..This is even more important because patients with severe reactions react to lower doses than patients with mild symptoms... - CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitizationFemke van Wijk
Institute for Risk Assessment Sciences, Immunotoxicology, Utrecht University, PO Box 80176, NL 3508 TD Utrecht, The Netherlands
J Immunol 174:174-9. 2005..Furthermore, these data indicate that a profoundly Th2-biased cytokine environment is insufficient to induce allergic responses against dietary Ag...