Stef J Koppelman

Summary

Affiliation: TNO Nutrition and Food Research
Country: The Netherlands

Publications

  1. ncbi Purification and immunoglobulin E-binding properties of peanut allergen Ara h 6: evidence for cross-reactivity with Ara h 2
    S J Koppelman
    TNO Nutrition and Food Research, Zeist, The Netherlands
    Clin Exp Allergy 35:490-7. 2005
  2. ncbi Heat-induced conformational changes of Ara h 1, a major peanut allergen, do not affect its allergenic properties
    S J Koppelman
    TNO Nutrition and Food Research Institute, 3700 AJ Zeist, The Netherlands
    J Biol Chem 274:4770-7. 1999
  3. ncbi Comparison of different immunochemical methods for the detection and quantification of hazelnut proteins in food products
    S J Koppelman
    Protein Technology Department, TNO Nutrition and Food Research Institute, Zeist, Netherlands
    J Immunol Methods 229:107-20. 1999
  4. ncbi Effect of heat-induced aggregation on the IgE binding of patatin (Sol t 1) is dominated by other potato proteins
    Stef J Koppelman
    Department of Protein Technology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands
    J Agric Food Chem 50:1562-8. 2002
  5. ncbi Detection of soy proteins in processed foods: literature overview and new experimental work
    Stef J Koppelman
    TNO Nutrition and Food Research, Zeist, The Netherlands
    J AOAC Int 87:1398-407. 2004
  6. ncbi Reversible denaturation of Brazil nut 2S albumin (Ber e1) and implication of structural destabilization on digestion by pepsin
    Stef J Koppelman
    TNO Nutrition and Food Research, Zeist, The Netherlands
    J Agric Food Chem 53:123-31. 2005
  7. ncbi Relevance of Ara h1, Ara h2 and Ara h3 in peanut-allergic patients, as determined by immunoglobulin E Western blotting, basophil-histamine release and intracutaneous testing: Ara h2 is the most important peanut allergen
    S J Koppelman
    TNO Nutrition and Food Research, Zeist, The Netherlands
    Clin Exp Allergy 34:583-90. 2004
  8. ncbi Development of an enzyme-linked immunosorbent assay method to detect mustard protein in mustard seed oil
    Stef J Koppelman
    TNO Nutrition and Food Research, Zeist, The Netherlands Kerklaan 53, NL 3731 EG De Bilt, The Netherlands
    J Food Prot 70:179-83. 2007
  9. doi Digestion of peanut allergens Ara h 1, Ara h 2, Ara h 3, and Ara h 6: a comparative in vitro study and partial characterization of digestion-resistant peptides
    Stef J Koppelman
    TNO Quality of Life, Zeist, The Netherlands
    Mol Nutr Food Res 54:1711-21. 2010
  10. ncbi Peanut allergen Ara h 3: isolation from peanuts and biochemical characterization
    S J Koppelman
    TNO Nutrition and Food Research Institute, Zeist, The Netherlands
    Allergy 58:1144-51. 2003

Collaborators

Detail Information

Publications23

  1. ncbi Purification and immunoglobulin E-binding properties of peanut allergen Ara h 6: evidence for cross-reactivity with Ara h 2
    S J Koppelman
    TNO Nutrition and Food Research, Zeist, The Netherlands
    Clin Exp Allergy 35:490-7. 2005
    ..IgE-binding peanut proteins smaller than 15 kDa were previously identified as potential allergens in the majority of our peanut allergic population...
  2. ncbi Heat-induced conformational changes of Ara h 1, a major peanut allergen, do not affect its allergenic properties
    S J Koppelman
    TNO Nutrition and Food Research Institute, 3700 AJ Zeist, The Netherlands
    J Biol Chem 274:4770-7. 1999
    ....
  3. ncbi Comparison of different immunochemical methods for the detection and quantification of hazelnut proteins in food products
    S J Koppelman
    Protein Technology Department, TNO Nutrition and Food Research Institute, Zeist, Netherlands
    J Immunol Methods 229:107-20. 1999
    ..Since this test does not require serum from patients, it is appropriate for use in the food industry...
  4. ncbi Effect of heat-induced aggregation on the IgE binding of patatin (Sol t 1) is dominated by other potato proteins
    Stef J Koppelman
    Department of Protein Technology, TNO Nutrition and Food Research Institute, Zeist, The Netherlands
    J Agric Food Chem 50:1562-8. 2002
    ..It is concluded that the heat lability of patatin-IgE interaction is explained by aggregation of patatin with other potato proteins rather than by denaturation of patatin itself...
  5. ncbi Detection of soy proteins in processed foods: literature overview and new experimental work
    Stef J Koppelman
    TNO Nutrition and Food Research, Zeist, The Netherlands
    J AOAC Int 87:1398-407. 2004
    ..The presently developed test is applicable for soy ingredients and soy-containing foods that are processed in different ways. The limit of quantitation is 1 ppm, which is an enormous improvement over earlier described methods...
  6. ncbi Reversible denaturation of Brazil nut 2S albumin (Ber e1) and implication of structural destabilization on digestion by pepsin
    Stef J Koppelman
    TNO Nutrition and Food Research, Zeist, The Netherlands
    J Agric Food Chem 53:123-31. 2005
    ..Whereas native 2S albumin was digested slowly in 1 h, the reduced and alkylated protein was digested completely within 30 s. These results are discussed in view of the potential allergenicity of Brazil nut 2S albumin...
  7. ncbi Relevance of Ara h1, Ara h2 and Ara h3 in peanut-allergic patients, as determined by immunoglobulin E Western blotting, basophil-histamine release and intracutaneous testing: Ara h2 is the most important peanut allergen
    S J Koppelman
    TNO Nutrition and Food Research, Zeist, The Netherlands
    Clin Exp Allergy 34:583-90. 2004
    ..A number of allergenic proteins in peanut has been described and the relative importance of these allergens is yet to be determined...
  8. ncbi Development of an enzyme-linked immunosorbent assay method to detect mustard protein in mustard seed oil
    Stef J Koppelman
    TNO Nutrition and Food Research, Zeist, The Netherlands Kerklaan 53, NL 3731 EG De Bilt, The Netherlands
    J Food Prot 70:179-83. 2007
    ....
  9. doi Digestion of peanut allergens Ara h 1, Ara h 2, Ara h 3, and Ara h 6: a comparative in vitro study and partial characterization of digestion-resistant peptides
    Stef J Koppelman
    TNO Quality of Life, Zeist, The Netherlands
    Mol Nutr Food Res 54:1711-21. 2010
    ..This study provides a comprehensive comparison of the digestibility of the major peanut allergens...
  10. ncbi Peanut allergen Ara h 3: isolation from peanuts and biochemical characterization
    S J Koppelman
    TNO Nutrition and Food Research Institute, Zeist, The Netherlands
    Allergy 58:1144-51. 2003
    ..Peanut allergen Ara h 3 has been the subject of investigation for the last few years. The reported data strongly depend on recombinant Ara h 3, since a purification protocol for Ara h 3 from peanuts was not available...
  11. ncbi Purification and substrate specificity of transglutaminases from blood and Streptoverticillium mobaraense
    G A de Jong
    TNO Nutrition and Food Research Institute, 3700 AJ Zeist, The Netherlands
    J Agric Food Chem 49:3389-93. 2001
    ..In addition, differences exist in the necessity of the addition of reducing agents. These differences allow specific applications of blood and bacterial transglutaminases at protein cross-linking in single or complex protein systems...
  12. ncbi Is Candida albicans a trigger in the onset of coeliac disease?
    W F Nieuwenhuizen
    Netherlands Organisation for Applied Scientific Research TNO Nutrition and Food Research, PO Box 360, 3700 AJ, Zeist, Netherlands
    Lancet 361:2152-4. 2003
    ..Subsequently, C albicans might function as an adjuvant that stimulates antibody formation against HWP1 and gluten, and formation of autoreactive antibodies against tissue transglutaminase and endomysium...
  13. ncbi Expanded bed adsorption as a fast technique for the large-scale purification of the complete isoform pool of Ber e 1, the major allergen from Brazil nuts
    Evelien L van Boxtel
    Centre for Protein Technology, Wageningen, The Netherlands
    Mol Nutr Food Res 50:275-81. 2006
    ..Thus, using EBA, Ber e 1 can be purified fast and on gram-scale, while having purity equal to that of conventionally purified Ber e 1...
  14. ncbi Allergen Ara h 1 occurs in peanuts as a large oligomer rather than as a trimer
    Evelien L van Boxtel
    Laboratory of Food Chemistry, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
    J Agric Food Chem 54:7180-6. 2006
    ..As structural characteristics are important for a protein's allergenicity, this finding may imply a different allergenicity for Ara h 1 than previously described...
  15. doi Determination of pepsin-susceptible and pepsin-resistant epitopes in native and heat-treated peanut allergen Ara h 1
    Evelien L van Boxtel
    Laboratory of Food Chemistry, Wageningen University, P O Box 8129, 6700 EV Wageningen, The Netherlands
    J Agric Food Chem 56:2223-30. 2008
    ..Consequently, this unique N-terminal part of Ara h 1 is proposed to be responsible for the allergen's ability to induce systemic allergic reactions...
  16. ncbi Proteolytic processing of the peanut allergen Ara h 3
    Sander R Piersma
    FOM Institute for Atomic and Molecular Physics, Amsterdam, The Netherlands
    Mol Nutr Food Res 49:744-55. 2005
    ....
  17. doi Legumin allergens from peanuts and soybeans: effects of denaturation and aggregation on allergenicity
    Evelien L van Boxtel
    Laboratory of Food Chemistry, Wageningen University, EV Wageningen, The Netherlands
    Mol Nutr Food Res 52:674-82. 2008
    ..Consequently, these allergens are likely unable to sensitize via the gastro-intestinal tract and cause systemic food allergy symptoms. These proteins might thus be less important allergens than was previously assumed...
  18. ncbi Patients with anaphylaxis to pea can have peanut allergy caused by cross-reactive IgE to vicilin (Ara h 1)
    Marjolein Wensing
    Department of Dermatology Allergology G02 124, University Medical Centre Utrecht, Heidelberglaan 100, 3584 CX Utrecht, The Netherlands
    J Allergy Clin Immunol 111:420-4. 2003
    ..Serologic cross-reactivity among legumes has been described; however, it is rarely clinically significant. In this study 3 patients with a history of anaphylaxis to pea are described who subsequently had symptoms after ingestion of peanut...
  19. ncbi Ara h 8, a Bet v 1-homologous allergen from peanut, is a major allergen in patients with combined birch pollen and peanut allergy
    Diana Mittag
    Department of Dermatology, University Hospital, Zurich
    J Allergy Clin Immunol 114:1410-7. 2004
    ..We recently described patients with soybean allergy mainly mediated by cross-reactivity to birch pollen allergens. A majority of those patients were reported to have peanut allergy...
  20. ncbi Peanut allergen Ara h 1 interacts with proanthocyanidins into higher molecular weight complexes
    Evelien L van Boxtel
    Laboratory of Food Chemistry, Wageningen University, P O Box 8129, 6700 EV Wageningen, The Netherlands
    J Agric Food Chem 55:8772-8. 2007
    ..Ara h 1 present as the oligomeric complex is assumed to be the representative form of the allergen in which it is consumed by humans...
  21. ncbi Peanut allergy: sensitization by peanut oil-containing local therapeutics seems unlikely
    Kim A B M Peeters
    J Allergy Clin Immunol 113:1000-1. 2004
  22. ncbi The distribution of individual threshold doses eliciting allergic reactions in a population with peanut allergy
    Marjolein Wensing
    Department of Dermatology Allergology, University Medical Centre Utrecht, Utrecht, The Netherlands
    J Allergy Clin Immunol 110:915-20. 2002
    ..Individual threshold doses for eliciting allergic reactions need to be elucidated to assess the risks for development of allergic reactions after accidental ingestion of peanut in a population with peanut allergy...
  23. ncbi CTLA-4 signaling regulates the intensity of hypersensitivity responses to food antigens, but is not decisive in the induction of sensitization
    Femke van Wijk
    Institute for Risk Assessment Sciences, Immunotoxicology, Utrecht University, PO Box 80176, NL 3508 TD Utrecht, The Netherlands
    J Immunol 174:174-9. 2005
    ..Furthermore, these data indicate that a profoundly Th2-biased cytokine environment is insufficient to induce allergic responses against dietary Ag...