Leon M J Knippels

Summary

Affiliation: TNO Nutrition and Food Research
Country: The Netherlands

Publications

  1. ncbi request reprint An oral sensitization model in Brown Norway rats to screen for potential allergenicity of food proteins
    L M Knippels
    Department of Target Organ Toxicology, TNO Nutrition and Food Research Institute, AJ Zeist, 3700, The Netherlands
    Methods 19:78-82. 1999
  2. ncbi request reprint Assessment of protein allergenicity: studies in brown norway rats
    Leon M J Knippels
    Experimental Immunology, Department of Target Organ Toxicology, TNO Nutrition and Food Research, 3700 AJ Zeist, The Netherlands
    Ann N Y Acad Sci 964:151-61. 2002
  3. ncbi request reprint Food allergy: what do we learn from animal models?
    Leon M J Knippels
    Experimental Immunology, TNO Nutrition and Food Research, Zeist, The Netherlands
    Curr Opin Allergy Clin Immunol 4:205-9. 2004
  4. ncbi request reprint Recent advances using rodent models for predicting human allergenicity
    Leon M J Knippels
    Experimental Immunology, TNO Nutrition and Food Research, Department Toxicology and Applied Pharmacology, P O Box 360, 3700 AJ Zeist, The Netherlands
    Toxicol Appl Pharmacol 207:157-60. 2005
  5. pmc Assessment of the allergic potential of food protein extracts and proteins on oral application using the brown Norway rat model
    Leon M J Knippels
    TNO Nutrition and Food Research, Department of Target Organ Toxicology, Working Group Experimental Immunology, Zeist, The Netherlands
    Environ Health Perspect 111:233-8. 2003

Detail Information

Publications5

  1. ncbi request reprint An oral sensitization model in Brown Norway rats to screen for potential allergenicity of food proteins
    L M Knippels
    Department of Target Organ Toxicology, TNO Nutrition and Food Research Institute, AJ Zeist, 3700, The Netherlands
    Methods 19:78-82. 1999
    ....
  2. ncbi request reprint Assessment of protein allergenicity: studies in brown norway rats
    Leon M J Knippels
    Experimental Immunology, Department of Target Organ Toxicology, TNO Nutrition and Food Research, 3700 AJ Zeist, The Netherlands
    Ann N Y Acad Sci 964:151-61. 2002
    ..All together, these observations suggest that this BN rat model might provide a suitable animal model to study the allergenicity of food proteins in humans...
  3. ncbi request reprint Food allergy: what do we learn from animal models?
    Leon M J Knippels
    Experimental Immunology, TNO Nutrition and Food Research, Zeist, The Netherlands
    Curr Opin Allergy Clin Immunol 4:205-9. 2004
    ..The research areas that are covered include mechanistic studies, the search for new therapies, as well as screening models for hazard identification of potential allergens...
  4. ncbi request reprint Recent advances using rodent models for predicting human allergenicity
    Leon M J Knippels
    Experimental Immunology, TNO Nutrition and Food Research, Department Toxicology and Applied Pharmacology, P O Box 360, 3700 AJ Zeist, The Netherlands
    Toxicol Appl Pharmacol 207:157-60. 2005
    ..In this paper, recent results are summarized of promising models developed in rat and mouse...
  5. pmc Assessment of the allergic potential of food protein extracts and proteins on oral application using the brown Norway rat model
    Leon M J Knippels
    TNO Nutrition and Food Research, Department of Target Organ Toxicology, Working Group Experimental Immunology, Zeist, The Netherlands
    Environ Health Perspect 111:233-8. 2003
    ..The results obtained show that the Brown Norway rat provides a suitable animal model for food allergy research and for the study of relative allergenicity of existing and novel food proteins...