C Kluft

Summary

Affiliation: TNO Prevention and Health
Country: The Netherlands

Publications

  1. ncbi Determination of the habitual low blood level of C-reactive protein in individuals
    C Kluft
    Department of Vascular and Connective Tissue Research, Gaubius Laboratory, Leiden, The Netherlands
    Ital Heart J 2:172-80. 2001
  2. ncbi Sensitive markers of inflammation make it possible to study the chronic process: the rise of interest in low levels of C-reactive protein
    C Kluft
    Gaubius Laboratory, TNO PG, P O Box 2215, 2301 CE Leiden, The Netherlands
    Vascul Pharmacol 39:99-104. 2002
  3. ncbi Pro-inflammatory effects of oestrogens during use of oral contraceptives and hormone replacement treatment
    C Kluft
    Gaubius Laboratory, TNO PG, Vascular and Connective Tissue Research, Zernikedreef 9, P O Box 2215, 2333 CK Leiden, The Netherlands
    Vascul Pharmacol 39:149-54. 2002
  4. ncbi A prospective study on the effects on hemostasis of two oral contraceptives containing drospirenone in combination with either 30 or 20 microg ethinyl estradiol and a reference containing desogestrel and 30 microg ethinyl estradiol
    Cornelis Kluft
    Gaubius Laboratory, TNO Quality of Life, P O Box 2215, 2301 CE Leiden, The Netherlands
    Contraception 73:336-43. 2006
  5. ncbi Effect of oral contraceptives on haemostasis variables
    C Kluft
    Gaubius Laboratory, TNO PG, Leiden, The Netherlands
    Thromb Haemost 78:315-26. 1997
  6. ncbi Principles of use of surrogate markers and endpoints
    C Kluft
    Gaubius Laboratory, TNO PG, Zernikedreef 9, 2333 CK Leiden, The Netherlands
    Maturitas 47:293-8. 2004
  7. ncbi The fibrinolytic system and thrombotic tendency
    C Kluft
    Gaubius Laboratory, TNO PG, Leiden, The Netherlands
    Pathophysiol Haemost Thromb 33:425-9. 2003
  8. ncbi How to search for the role of gene-environment interactions for lipids in humans
    Cornelis Kluft
    Gaubius Laboratory, TNO PG, P O Box 2215, 2301 CE Leiden, The Netherlands
    Ital Heart J 3:15-7. 2002
  9. ncbi -455G/A polymorphism of the beta-fibrinogen gene is associated with the progression of coronary atherosclerosis in symptomatic men: proposed role for an acute-phase reaction pattern of fibrinogen. REGRESS group
    M P de Maat
    Gaubius Laboratory TNO PG, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 18:265-71. 1998
  10. ncbi The oral bioavailability of pentosan polysulphate sodium in healthy volunteers
    R A Faaij
    Centre for Human Drug Research, Leiden, The Netherlands
    Eur J Clin Pharmacol 54:929-35. 1999

Collaborators

Detail Information

Publications63

  1. ncbi Determination of the habitual low blood level of C-reactive protein in individuals
    C Kluft
    Department of Vascular and Connective Tissue Research, Gaubius Laboratory, Leiden, The Netherlands
    Ital Heart J 2:172-80. 2001
    ..This scheme can serve as a basis for further refinement, discussions and development of sampling and decision limits to be selected from medical and economical perspectives and tested in practice...
  2. ncbi Sensitive markers of inflammation make it possible to study the chronic process: the rise of interest in low levels of C-reactive protein
    C Kluft
    Gaubius Laboratory, TNO PG, P O Box 2215, 2301 CE Leiden, The Netherlands
    Vascul Pharmacol 39:99-104. 2002
    ....
  3. ncbi Pro-inflammatory effects of oestrogens during use of oral contraceptives and hormone replacement treatment
    C Kluft
    Gaubius Laboratory, TNO PG, Vascular and Connective Tissue Research, Zernikedreef 9, P O Box 2215, 2333 CK Leiden, The Netherlands
    Vascul Pharmacol 39:149-54. 2002
    ..It is proposed that the pro-inflammatory effect of oestrogens should be checked for a relationship with the increased risk of thromboembolism for both oral contraceptive and HRT...
  4. ncbi A prospective study on the effects on hemostasis of two oral contraceptives containing drospirenone in combination with either 30 or 20 microg ethinyl estradiol and a reference containing desogestrel and 30 microg ethinyl estradiol
    Cornelis Kluft
    Gaubius Laboratory, TNO Quality of Life, P O Box 2215, 2301 CE Leiden, The Netherlands
    Contraception 73:336-43. 2006
    ..In this open-label, randomized study, we assessed the effects on hemostasis of two combined oral contraceptives containing drospirenone (DRSP) as progestogen component...
  5. ncbi Effect of oral contraceptives on haemostasis variables
    C Kluft
    Gaubius Laboratory, TNO PG, Leiden, The Netherlands
    Thromb Haemost 78:315-26. 1997
    ....
  6. ncbi Principles of use of surrogate markers and endpoints
    C Kluft
    Gaubius Laboratory, TNO PG, Zernikedreef 9, 2333 CK Leiden, The Netherlands
    Maturitas 47:293-8. 2004
    ....
  7. ncbi The fibrinolytic system and thrombotic tendency
    C Kluft
    Gaubius Laboratory, TNO PG, Leiden, The Netherlands
    Pathophysiol Haemost Thromb 33:425-9. 2003
    ....
  8. ncbi How to search for the role of gene-environment interactions for lipids in humans
    Cornelis Kluft
    Gaubius Laboratory, TNO PG, P O Box 2215, 2301 CE Leiden, The Netherlands
    Ital Heart J 3:15-7. 2002
    ..A complication of gene-environment interactions is that in the chain of environmental factor, intermediate phenotype, and pathogenetic process we have the possibility of genetic variability at all levels...
  9. ncbi -455G/A polymorphism of the beta-fibrinogen gene is associated with the progression of coronary atherosclerosis in symptomatic men: proposed role for an acute-phase reaction pattern of fibrinogen. REGRESS group
    M P de Maat
    Gaubius Laboratory TNO PG, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 18:265-71. 1998
    ....
  10. ncbi The oral bioavailability of pentosan polysulphate sodium in healthy volunteers
    R A Faaij
    Centre for Human Drug Research, Leiden, The Netherlands
    Eur J Clin Pharmacol 54:929-35. 1999
    ..The objective of the present study was to assess the oral bioavailability of PPS. However, since specific assays for PPS do not exist, this was done by using primary and secondary effect parameters...
  11. ncbi Performance of semiquantitative and quantitative D-dimer assays in the ECAT external quality assessment program
    M P de Maat
    Gaubius Laboratory, TNO PG, Leiden, The Netherlands
    Semin Thromb Hemost 26:625-30. 2000
    ..In conclusion, D-dimer methods show a large variation, and the quality of the D-dimer assessment could be improved by standardization and by using cut-off ranges...
  12. ncbi Consumption of black and green tea had no effect on inflammation, haemostasis and endothelial markers in smoking healthy individuals
    M P de Maat
    Division of Vascular and Connective Tissue Research, Gaubius Laboratory, TNO PG, Leiden, The Netherlands
    Eur J Clin Nutr 54:757-63. 2000
    ..Secondly, to study the relationship between plasma levels of antioxidants (alpha-tocopherol, beta-carotene and vitamin C) and these acute-phase, cardiovascular risk indicators...
  13. ncbi Determinants of C-reactive protein concentration in blood
    M P de Maat
    Department of Vascular and Connective Tissue Research, Gaubius Laboratory, Leiden, The Netherlands
    Ital Heart J 2:189-95. 2001
    ..Statins decrease the CRP concentration whereas estrogen increases it. With regard to most other drugs no consistent relationship has been reported...
  14. pmc alpha 2-Antiplasmin Enschede: dysfunctional alpha 2-antiplasmin molecule associated with an autosomal recessive hemorrhagic disorder
    C Kluft
    Gaubius Institute, Leiden, The Netherlands
    J Clin Invest 80:1391-400. 1987
    ..The residual plasminogen-binding properties do not protect against a hemorrhagic diathesis...
  15. doi Preincubation in the Prothrombinase-induced Clotting Time test (PiCT) is necessary for in vitro evaluation of fondaparinux and to be avoided for the reversible, direct factor Xa inhibitor, rivaroxaban
    C Kluft
    Centre for Human Drug Research, Leiden, The Netherlands
    Int J Lab Hematol 35:379-84. 2013
    ..There is no clear consensus about tests in vitro that are suitable for evaluating various factor Xa inhibitors. The availability of reversible and irreversible inhibitors further complicates the application of available assays...
  16. ncbi Modified crossed immunoelectrophoresis to study with whole plasma the reversible complex formation of histidine-rich glycoprotein with plasminogen
    C Kluft
    Gaubius Institute TNO, Leiden, The Netherlands
    Thromb Haemost 60:411-4. 1988
    ..The method can be used to assess several aspects of reversible complex formation between plasma proteins, as demonstrated for plasminogen binding of HRG and alpha 2-antiplasmin in whole plasma...
  17. ncbi Decrease of hemostatic cardiovascular risk factors by aggressive vs. conventional atorvastatin treatment in patients with Type 2 diabetes mellitus
    M A Van De Ree
    Department of General Internal Medicine, Leiden University Medical Center and Gaubius Laboratory TNO PG, Leiden, The Netherlands
    J Thromb Haemost 1:1753-7. 2003
    ..Patients with Type 2 diabetes mellitus have increased levels of hemostatic risk variables for cardiovascular disease, such as fibrinogen, von Willebrand factor (VWF), factor (F)VIIa, d-dimer and plasminogen activator inhibitor-1 (PAI-1)...
  18. ncbi Urokinase-type plasminogen activator system predicts risk of cardiovascular events in patients with angina pectoris: results of the ECAPTURE study. European Concerted Action on Prevention from Thrombosis by URokinase Enhancement
    M P de Maat
    Department of Vascular and Connective Tissue Research, Gaubius Laboratory TNO-PG, Leiden, The Netherlands
    Blood Coagul Fibrinolysis 12:453-8. 2001
    ..71 [95% confidence interval (CI), 1.34-5.48] and 2.34 (95% CI, 1.08-5.11), respectively. These results suggest that the urokinase system plays a role in cardiovascular disease...
  19. ncbi Effects of hormone treatment on hemostasis variables
    C Kluft
    Center for Human Drug Research, Leiden, The Netherlands
    Climacteric 10:32-7. 2007
    ..The survey has identified specific biomarkers sensitive to low-dose unopposed and opposed estrogen which can be used to characterize future preparations for HT...
  20. ncbi The long-term within- and between-laboratory variability for assay of antithrombin, and proteins C and S: results derived from the external quality assessment program for thrombophilia screening of the ECAT Foundation
    P Meijer
    ECAT Foundation, Leiden, The Netherlands
    J Thromb Haemost 1:748-53. 2003
    ..It is concluded that improvement of the long-term within-laboratory test performance is the first priority in hemostasis to yield important improvements in the comparability and transferability of laboratory data...
  21. ncbi DNA-polymorphisms and plasma levels of vascular disease risk factors in Greenland Inuit--is there a relation with the low risk of cardiovascular disease in the Inuit?
    M P de Maat
    Department of Thrombosis Research, University of Southern Denmark, Ribe County Hospital, Esbjerg
    Thromb Haemost 81:547-52. 1999
    ....
  22. ncbi Estrogens reduce plasma histidine-rich glycoprotein (HRG) levels in a dose-dependent way
    B C Hennis
    Gaubius Laboratory, TNO PG, Leiden, The Netherlands
    Thromb Haemost 73:484-7. 1995
    ..005). The effect of progestogens administered during low-dose and high-dose estrogen therapy appeared to be minor. The results from these three studies indicate that estrogens reduce plasma HRG levels in a dose-dependent way...
  23. ncbi Logistics and quality control for DNA sampling in large multicenter studies
    R J Nederhand
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    J Thromb Haemost 1:987-91. 2003
    ..From these results we conclude that transport of non-frozen blood by ordinary mail is usable and practical for DNA isolation for polymerase chain reaction in clinical and epidemiological studies...
  24. ncbi Antibodies to Chlamydia pneumoniae and clinical course in patients with unstable angina pectoris
    M P de Maat
    Division of Vascular and Connective Tissue Research, Gaubius Laboratory, Leiden, The Netherlands
    Atherosclerosis 153:499-504. 2000
    ..In conclusion, there was no significant association between antibody titres to C. pneumoniae and risk of events during hospitalisation and the 18-month follow-up period in patients admitted for unstable angina pectoris...
  25. ncbi The harmonization of quantitative test results of different D-dimer methods
    P Meijer
    ECAT Foundation, Gaubius Laboratory, Leiden, The Netherlands
    Semin Vasc Med 5:321-7. 2005
    ..This approach seems to be an adequate solution for overcoming the practical problem of variation of test outcome in different D-dimer assays...
  26. ncbi Disagreement between bedside and laboratory activated partial thromboplastin time and international normalized ratio for various novel anticoagulants
    M J Kemme
    Centre for Human Drug Research, Leiden, The Netherlands
    Blood Coagul Fibrinolysis 12:583-91. 2001
    ..The amount of disagreement depended on the anticoagulant given...
  27. ncbi Blood sample stability at room temperature for counting red and white blood cells and platelets
    S A Vogelaar
    Gaubius Laboratory, TNO PG, Zernikedreef 9, P O Box 2215, 2301 CE Leiden, The Netherlands
    Vascul Pharmacol 39:123-5. 2002
    ..It is concluded that after storage at room temperature over approximately 48 h counts of red, total white cells, platelets and analysis of platelet volume can be combined in one assay session...
  28. ncbi Functional analogy between lipoprotein(a) and plasminogen in the binding to the kringle 4 binding protein, tetranectin
    C Kluft
    Gaubius Institute TNO, Leiden, The Netherlands
    Biochem Biophys Res Commun 161:427-33. 1989
    ..Plasminogen and lipoprotein(a) show functional analogy in their binding to tetranectin, but tetranectin primarily targets at lipoprotein(a)...
  29. ncbi Association of the tumour necrosis factor alpha -308G/A polymorphism with the risk of diabetes in an elderly population-based cohort
    B T Heijmans
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Genes Immun 3:225-8. 2002
    ..In conclusion, the -308G/A polymorphism in the TNF promoter is strongly associated with the risk of diabetes but not cardiovascular mortality in old age...
  30. ncbi Effect of the stromelysin-1 promoter on efficacy of pravastatin in coronary atherosclerosis and restenosis
    M P de Maat
    Gaubius Laboratory TNO PG, Leiden, The Netherlands
    Am J Cardiol 83:852-6. 1999
    ..This variant may therefore act as a predictor, not only of disease progression, but also of response to therapy and risk of restenosis...
  31. ncbi Effects on haemostasis variables by second and third generation combined oral contraceptives: a review of directly comparative studies
    C Kluft
    Gaubius Laboratory, TNO PG, P O Box 2215, Leiden, 2301 CE, The Netherlands
    Curr Med Chem 7:585-91. 2000
    ..In general, direct comparisons of effects of different types of COCs on haemostatic variables are available for only a very few factors, which hampers the drawing of general conclusions with respect to haemostatic consequences...
  32. ncbi Effects of non-oral postmenopausal hormone therapy on markers of cardiovascular risk: a systematic review
    Majoie Hemelaar
    Project Aging Women and Institute for Cardiovascular Research Vrije Universiteit, Department of Obstetrics and Gynecology, VU University Medical Center, Amsterdam, The Netherlands
    Fertil Steril 90:642-72. 2008
    ..Non-oral postmenopausal HT appears not to increase venous thromboembolic risk, whereas the effect on coronary heart disease risk is less clear...
  33. ncbi Genetics of C-reactive protein: new possibilities and complications
    Cornelis Kluft
    Arterioscler Thromb Vasc Biol 23:1956-9. 2003
  34. doi The impact of metabolic syndrome and CRP on vascular phenotype in type 2 diabetes mellitus
    Reza Alizadeh Dehnavi
    Vascular Medicine, Department of General Internal Medicine and Endocrinology, Leiden University Medical Centre, Leiden, The Netherlands
    Eur J Intern Med 19:115-21. 2008
    ..The burden of cardiovascular disease in diabetes mellitus type 2 (DM2) patients is variable. We hypothesize that metabolic syndrome (MS) and low-grade systemic inflammation modify the extent of atherosclerosis in DM2...
  35. ncbi Serum carotenoids and vitamins in relation to markers of endothelial function and inflammation
    Wendy M R van Herpen-Broekmans
    TNO Nutrition and Food Research, Zeist, The Netherlands
    Eur J Epidemiol 19:915-21. 2004
    ..Carotenoids and vitamins could have an antioxidant-mediated tempering influence on endothelial function and inflammation, thereby reducing the risk of atherosclerosis...
  36. ncbi Genetic variation in Fcgamma receptor IIa protects against advanced peripheral atherosclerosis. The Rotterdam Study
    Irene M van der Meer
    Erasmus Medical Center, Department of Epidemiology and Biostatistics, 3000 DR Rotterdam, The Netherlands
    Thromb Haemost 92:1273-6. 2004
    ..52 (0.29-0.93) and 0.45 (0.23-0.86), for heterozygotes and H131 homozygotes, respectively; P trend=0.02). This is the first study showing that the H131 allele of FcgammaRIIa protects against advanced peripheral atherosclerosis...
  37. doi Comparison of a transdermal contraceptive patch vs. oral contraceptives on hemostasis variables
    Cornelis Kluft
    Gaubius Laboratory, TNO Quality of Life, Biomedical Research, Leiden, The Netherlands
    Contraception 77:77-83. 2008
    ....
  38. ncbi No effect of folic acid supplementation in the course of 1 year on haemostasis markers and C-reactive protein in older adults
    Mariska Klerk
    Wageningen Centre for Food Sciences, c o Wageningen University, Division of Human Nutrition, P O Box 8129, 6700 EV Wageningen, The Netherlands
    Thromb Haemost 94:96-100. 2005
    ..Although homocysteine is associated with vascular disease risk in the general population, marked lowering of slightly elevated homocysteine concentrations by one-year folic acid supplementation does not influence haemostasis markers...
  39. ncbi 4G/4G genotype of PAI-1 gene is associated with reduced risk of stroke in elderly
    Tiny Hoekstra
    Division of Human Nutrition, Wageningen University, Netherlands
    Stroke 34:2822-8. 2003
    ..We investigated whether plasma PAI-1 and 4G/5G genotype would predict the occurrence of cardiovascular events at old age...
  40. ncbi Relationship between CRP and clinical course of unstable angina depends on assay method
    Moniek P M de Maat
    Division of Vascular and Connective Tissue Research, Gaubius Laboratory, TNO PG, P O Box 2215, 2301 CE Leiden, The Netherlands
    Vascul Pharmacol 39:113-5. 2002
    ..There is little information about the comparability of the results of different CRP assays and it has also not been evaluated whether different assays give different associations with risk...
  41. ncbi The association between inflammation markers, coronary artery disease and smoking
    Moniek P M de Maat
    Department of Vascular and Connective Tissue Research, Gaubius Laboratory TNO PG, P O Box 2215, 2301 CE Leiden, The Netherlands
    Vascul Pharmacol 39:137-9. 2002
    ..Smoking only had a significant effect on IL-6, and mainly in the controls. In conclusion, inflammation is affected by both smoking and cardiovascular disease...
  42. ncbi The effect of 17 beta-oestradiol on variables of coagulation and fibrinolysis in postmenopausal women with type 2 diabetes mellitus
    Hanny E Brussaard
    Department of Endocrinology and Metabolic Diseases, University Hospital, Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Vascul Pharmacol 39:141-7. 2002
    ..The results indicate that specific attention should be paid to fibrin turnover in studying other categories of women and the effects of the addition of progesterone...
  43. ncbi Comparative effects of a contraceptive vaginal ring delivering a nonandrogenic progestin and continuous ethinyl estradiol and a combined oral contraceptive containing levonorgestrel on hemostasis variables
    Mandana Rad
    Centre for Human Drug Research, Leiden, The Netherlands
    Am J Obstet Gynecol 195:72-7. 2006
    ..This study aimed to compare the effects on hemostasis variables of a contraceptive vaginal ring with those of an oral contraceptive...
  44. ncbi The 4G/5G-polymorphism in the PAI-1 gene is not associated with markers of atherosclerosis in male smokers
    Tiny Hoekstra
    Division of Human Nutrition and Epidemiology, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
    Thromb Res 107:115-9. 2002
  45. ncbi On the route to combined evidence from OC and HRT/ERT
    Sven O Skouby
    Department of Obstetrics and Gynecology, Frederiksberg Hospital, University of Copenhagen, DK 2000 Copenhagen F, Denmark
    Eur J Contracept Reprod Health Care 7:185-98. 2002
  46. ncbi Association between thrombin-activatable fibrinolysis inhibitor (TAFI) and clinical outcome in patients with unstable angina pectoris
    Geert Jan Brouwers
    Department of Hematology, Erasmus Medical Center, Rotterdam, The Netherlands
    Thromb Haemost 90:92-100. 2003
    ..Furthermore, all three polymorphisms contribute independently to plasma TAFI Ag levels, but not to refractiveness...
  47. pmc Quantification of heparin-induced TFPI release: a maximum release at low heparin dose
    Michiel J B Kemme
    Centre for Human Drug Research and Gaubius Laboratory TNO PG, Leiden, The Netherlands
    Br J Clin Pharmacol 54:627-34. 2002
    ..The primary aim was to investigate and quantify this phenomenon during a short low dose heparin infusion. Also, the effects of heparin on tissue plasminogen activator (t-PA) were studied...
  48. ncbi Performance goals for the laboratory testing of antithrombin, protein C and protein S
    Piet Meijer
    ECAT Foundation, Leiden, The Netherlands
    Thromb Haemost 96:584-9. 2006
    ..A useful tool for determining the imprecision (LCV (A) ) and bias is the long-term analytical performance evaluation model as used by the ECAT Foundation...
  49. ncbi Comparison of the impact of vaginal and oral administration of combined hormonal contraceptives on hepatic proteins sensitive to estrogen
    Regine L Sitruk-Ware
    Center for Biomedical Research, Population Council, New York, NY 10021, USA
    Contraception 75:430-7. 2007
    ..We also investigated the effect of delivery route, which is known to modify the hepatic effects of estradiol, but has not been widely studied with EE...
  50. ncbi Association of APOE epsilon2/epsilon3/epsilon4 and promoter gene variants with dementia but not cardiovascular mortality in old age
    Bastiaan T Heijmans
    Gaubius Laboratory, TNO Prevention and Health, Leiden, The Netherlands
    Am J Med Genet 107:201-8. 2002
    ..Furthermore, they emphasize that variation at the APOE locus has a higher impact on the risk of dementia than on the risk of cardiovascular disease in old age...
  51. ncbi Diurnal variation in PAI-1 activity predominantly confined to the 4G-allele of the PAI-1 gene
    Tiny Hoekstra
    Division of Human Nutrition and Epidemiology, Wageningen University, The Netherlands
    Thromb Haemost 88:794-8. 2002
    ..Our findings raise the hypothesis that 5G-homozygotic persons may be relatively protected from diurnal variation in the occurrence of coronary events...
  52. ncbi The 4G5G polymorphism in the gene for PAI-1 and the circadian oscillation of plasma PAI-1
    Johanna G van der Bom
    Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht Van Creveldkliniek, The Netherlands
    Blood 101:1841-4. 2003
    ..Additionally, these findings show that homozygosity for the 4G allele is associated with increased PAI-1 levels during the morning only...
  53. ncbi Long-term analytical performance of hemostasis field methods as assessed by evaluation of the results of an external quality assessment program for antithrombin
    Piet Meijer
    ECAT Foundation, 2301 CE Leiden, The Netherlands
    Clin Chem 48:1011-5. 2002
    ..The aim of this study was to adapt from the field of clinical chemistry a method to assess the long-term analytical performance of hemostasis field methods...
  54. ncbi A model for the harmonisation of test results of different quantitative D-dimer methods
    Piet Meijer
    ECAT Foundation, Leiden, The Netherlands
    Thromb Haemost 95:567-72. 2006
    ..If the harmonisation procedure is included in the calibration procedure by the manufacturers, customers will automatically obtain harmonised test results...
  55. ncbi Genetic influences on fibrinogen, tissue plasminogen activator-antigen and von Willebrand factor in males and females
    Marlies de Lange
    Department of Biological Psychology, Vrije Universiteit, Van der Boechorststraat 1, 1081 BT Amsterdam, The Netherlands
    Thromb Haemost 95:414-9. 2006
    ..Haemostatic factors may account for a significant part of the genetic risk for cardiovascular disease. No difference in genetic architecture for levels of fibrinogen, tPA or vWF was observed between males and females...
  56. ncbi Evidence for a QTL on chromosome 19 influencing LDL cholesterol levels in the general population
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Eur J Hum Genet 11:845-50. 2003
    ..Our study provides strong evidence for the presence of a QTL on chromosome 19 with a major effect on LDL-C plasma levels in outbred Caucasian populations...
  57. ncbi Genetic polymorphisms modify the response of factor VII to oral contraceptive use: an example of gene-environment interaction
    Kitty W M Bloemenkamp
    Department of Obstetrics, Gynaecology and Reproductive Medicine, Leiden University Medical Center, Building 1, H 3 P, P O Box 9600, Leiden 2300 RC, The Netherlands
    Vascul Pharmacol 39:131-6. 2002
    ..We conclude that an individual's genetic variation may contribute to the response of plasma factor VII to oral contraceptive use...
  58. ncbi Relationship of C-reactive protein with components of the metabolic syndrome in normal-weight and overweight elderly
    Tiny Hoekstra
    Division of Human Nutrition, Wageningen University, PO Box 8129, 6700 EV Wageningen, The Netherlands
    Nutr Metab Cardiovasc Dis 15:270-8. 2005
    ..We aimed to explore in more detail the relationship between CRP and other components of the metabolic syndrome in a general population of 605 Dutch elderly individuals aged 65-84 years...
  59. ncbi Stabilization versus inhibition of TAFIa by competitive inhibitors in vitro
    John B Walker
    Henderson Research Centre and McMaster University, Hamilton, Ontario L8V 1C3, Canada
    J Biol Chem 278:8913-21. 2003
    ..The data fit a model whereby only free TAFIa decays. Therefore, the variable effects of competitive inhibitors of TAFIa on fibrinolysis can be rationalized in terms of free TAFIa and lysis time relative to the half-life of TAFIa...
  60. ncbi Variable hypocoagulant effect of fish oil intake in humans: modulation of fibrinogen level and thrombin generation
    Kristof Vanschoonbeek
    Department of Human Biology, Nutrition and Toxicology Research and Cardiovascular Research Institutes of Maastricht, Maastricht University, Maastricht, The Netherlands
    Arterioscler Thromb Vasc Biol 24:1734-40. 2004
    ..We studied how fish oil intake influenced thrombin generation in plasma and which factors were involved herein...
  61. ncbi Combined association and linkage analysis applied to the APOE locus
    Marian Beekman
    Section of Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands
    Genet Epidemiol 26:328-37. 2004
    ....
  62. ncbi Angiotensin-converting enzyme inhibitor trandolapril does not affect C-reactive protein levels in myocardial infarction patients
    Moniek P M de Maat
    Circulation 108:e113. 2003
  63. ncbi Venous thromboembolism during pregnancy is not associated with persistent elevated activated protein C (APC) sensitivity ratio based on the endogenous thrombin potential
    Rainer B Zotz
    Department of Haemostasis and Transfusion Medicine, Heinrich Heine University Medical Center, Dusseldorf, Germany
    Thromb Haemost 93:306-10. 2005
    ..8, 95% CI 0.6-1.1, p=0.10) nor using a cutoff value (nAPCsr cut-off 3.1: odds ratio 1.2, 95% CI 0.3-5.3, p=0.77). Our study demonstrates that nAPCsr is not a risk marker for pregnancy-associated venous thromboembolism...