M C Jong

Summary

Affiliation: TNO Prevention and Health
Country: The Netherlands

Publications

  1. ncbi Effects of fenofibrate on hyperlipidemia and postprandial triglyceride metabolism in human apolipoprotein C1 transgenic mice
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    Atherosclerosis 141:S77-80. 1998
  2. ncbi Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, MGC Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 19:472-84. 1999
  3. ncbi Insights into apolipoprotein C metabolism from transgenic and gene-targeted mice
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    Int J Tissue React 22:59-66. 2000
  4. ncbi Protection from obesity and insulin resistance in mice overexpressing human apolipoprotein C1
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    Diabetes 50:2779-85. 2001
  5. ncbi LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice
    P J Tacken
    Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden 2300 RA, The Netherlands
    J Lipid Res 41:2055-62. 2000
  6. pmc Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, 2301 CE Leiden, The Netherlands
    Biochem J 338:281-7. 1999
  7. ncbi Protection from obesity in mice lacking the VLDL receptor
    J R Goudriaan
    TNO Prevention and Health, Gaubius Laboratory, and MGC Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 21:1488-93. 2001
  8. pmc Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, 2301 CE Leiden, The Netherlands
    J Clin Invest 101:145-52. 1998
  9. ncbi Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, 2301 CE Leiden, The Netherlands
    J Lipid Res 42:1578-85. 2001
  10. pmc In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway
    M C Jong
    TNO Prevention and Health, TNO PG Gaubius Laboratory, Leiden, The Netherlands
    J Clin Invest 98:2259-67. 1996

Collaborators

Detail Information

Publications15

  1. ncbi Effects of fenofibrate on hyperlipidemia and postprandial triglyceride metabolism in human apolipoprotein C1 transgenic mice
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    Atherosclerosis 141:S77-80. 1998
    ....
  2. ncbi Role of ApoCs in lipoprotein metabolism: functional differences between ApoC1, ApoC2, and ApoC3
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, MGC Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 19:472-84. 1999
  3. ncbi Insights into apolipoprotein C metabolism from transgenic and gene-targeted mice
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    Int J Tissue React 22:59-66. 2000
    ....
  4. ncbi Protection from obesity and insulin resistance in mice overexpressing human apolipoprotein C1
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, Leiden, The Netherlands
    Diabetes 50:2779-85. 2001
    ..In conclusion, a marked reduction in the uptake of fatty acids into adipocytes may underlie the protection from obesity and insulin resistance in transgenic mice overexpressing human APOC1...
  5. ncbi LDL receptor deficiency unmasks altered VLDL triglyceride metabolism in VLDL receptor transgenic and knockout mice
    P J Tacken
    Department of Human and Clinical Genetics, Leiden University Medical Center, Leiden 2300 RA, The Netherlands
    J Lipid Res 41:2055-62. 2000
    ..In conclusion, under conditions of LDLR deficiency in combination with high fat feeding or prolonged fasting, the effect of the VLDLR on VLDL triglyceride metabolism was revealed...
  6. pmc Reversal of hyperlipidaemia in apolipoprotein C1 transgenic mice by adenovirus-mediated gene delivery of the low-density-lipoprotein receptor, but not by the very-low-density-lipoprotein receptor
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, 2301 CE Leiden, The Netherlands
    Biochem J 338:281-7. 1999
    ....
  7. ncbi Protection from obesity in mice lacking the VLDL receptor
    J R Goudriaan
    TNO Prevention and Health, Gaubius Laboratory, and MGC Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 21:1488-93. 2001
    ..These results suggest that the VLDLR plays a role in the delivery of VLDL-derived fatty acids into adipose tissue...
  8. pmc Hyperlipidemia and cutaneous abnormalities in transgenic mice overexpressing human apolipoprotein C1
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, 2301 CE Leiden, The Netherlands
    J Clin Invest 101:145-52. 1998
    ..These APOC1 transgenic mice may serve as an interesting in vivo model for the investigation of lipid homeostasis in the skin...
  9. ncbi Apolipoprotein C-III deficiency accelerates triglyceride hydrolysis by lipoprotein lipase in wild-type and apoE knockout mice
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, 2301 CE Leiden, The Netherlands
    J Lipid Res 42:1578-85. 2001
    ..In summary, our studies of apoC3(-/-) mice support the concept that apoC-III is an effective inhibitor of VLDL TG hydrolysis and reveal a potential regulating role for apoC-III with respect to the selective uptake of cholesteryl esters...
  10. pmc In the absence of the low density lipoprotein receptor, human apolipoprotein C1 overexpression in transgenic mice inhibits the hepatic uptake of very low density lipoproteins via a receptor-associated protein-sensitive pathway
    M C Jong
    TNO Prevention and Health, TNO PG Gaubius Laboratory, Leiden, The Netherlands
    J Clin Invest 98:2259-67. 1996
    ..60+/-10 and 38+/-7 mmol/liter, respectively). From these studies we conclude that, in the absence of the LDLR, apoC1 inhibits the hepatic uptake of VLDL via a RAP-sensitive pathway...
  11. ncbi Oxidized VLDL induces less triglyceride accumulation in J774 macrophages than native VLDL due to an impaired extracellular lipolysis
    M C Jong
    TNO Prevention and Health, Gaubius Laboratory, Leiden University Medical Center, Leiden, The Netherlands
    Arterioscler Thromb Vasc Biol 20:144-51. 2000
    ..Thus, from these studies it can be concluded that on oxidation, VLDL becomes less efficient in inducing TG accumulation in J774 cells as a consequence of a defect in apoC2 as an activator for the LPL-mediated extracellular lipolysis...
  12. ncbi In muscle-specific lipoprotein lipase-overexpressing mice, muscle triglyceride content is increased without inhibition of insulin-stimulated whole-body and muscle-specific glucose uptake
    P J Voshol
    TNO Prevention and Health, Division VBO, Leiden, The Netherlands
    Diabetes 50:2585-90. 2001
    ....
  13. ncbi Hyperlipidaemia is associated with increased insulin-mediated glucose metabolism, reduced fatty acid metabolism and normal blood pressure in transgenic mice overexpressing human apolipoprotein C1
    S J Koopmans
    ID TNO Animal Nutrition, Institute for Animal Science and Health, Lelystad, The Netherlands
    Diabetologia 44:437-43. 2001
    ..Primary hyperlipidaemia alone in APOC1 mice does not lead to insulin resistance for glucose metabolism and high blood pressure...
  14. ncbi Apolipoprotein E participates in the regulation of very low density lipoprotein-triglyceride secretion by the liver
    A R Mensenkamp
    Groningen Institute for Drug Studies, University Hospital Groningen, 9713 GZ Groningen
    J Biol Chem 274:35711-8. 1999
    ..These findings indicate a regulatory role of apoE in hepatic VLDL-triglyceride secretion, independent from its role in lipoprotein clearance...
  15. pmc Genomic interval engineering of mice identifies a novel modulator of triglyceride production
    Y Zhu
    Genome Sciences Department, Lawrence Berkeley National Laboratory, One Cyclotron Road, Berkeley, CA 94720, USA
    Proc Natl Acad Sci U S A 97:1137-42. 2000
    ....