Wilbert H M Heijne

Summary

Affiliation: TNO Quality of Life
Country: The Netherlands

Publications

  1. ncbi Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology
    Wilbert H M Heijne
    DSM Food Specialties R and D, Delft, The Netherlands
    Expert Rev Proteomics 2:767-80. 2005
  2. ncbi Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway rats
    C Frieke Kuper
    TNO Quality of Life, Zeist, The Netherlands
    Toxicol Pathol 36:985-98. 2008
  3. ncbi Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach
    Wilbert H M Heijne
    TNO Nutrition and Food Research, P O Box 360, 3700 AJ Zeist, The Netherlands
    Biochem Pharmacol 65:857-75. 2003
  4. ncbi Bromobenzene-induced hepatotoxicity at the transcriptome level
    Wilbert H M Heijne
    Department of Biomolecular Sciences, TNO Nutrition and Food Research, PO Box 360, 3700 AJ Zeist, The Netherlands
    Toxicol Sci 79:411-22. 2004
  5. ncbi Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis
    Wilbert H M Heijne
    TNO Nutrition and Food Research, 3700 AJ Zeist, The Netherlands
    Toxicol Pathol 33:425-33. 2005
  6. ncbi The introduction of toxicogenomics; potential new markers of hepatotoxicity
    Wilbert H M Heijne
    TNO Nutrition and Food Research, Zeist, The Netherlands
    Cancer Biomark 1:41-57. 2005

Detail Information

Publications6

  1. ncbi Systems toxicology: applications of toxicogenomics, transcriptomics, proteomics and metabolomics in toxicology
    Wilbert H M Heijne
    DSM Food Specialties R and D, Delft, The Netherlands
    Expert Rev Proteomics 2:767-80. 2005
    ..Furthermore, the effects of exposure to mixtures could be studied in more detail. This review argues that in the (near) future, human health risk assessment will truly benefit from toxicogenomics (systems toxicology)...
  2. ncbi Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway rats
    C Frieke Kuper
    TNO Quality of Life, Zeist, The Netherlands
    Toxicol Pathol 36:985-98. 2008
    ..The authors conclude that parameters for lung remodeling can be a valuable tool in hazard identification of LMW respiratory allergens...
  3. ncbi Toxicogenomics of bromobenzene hepatotoxicity: a combined transcriptomics and proteomics approach
    Wilbert H M Heijne
    TNO Nutrition and Food Research, P O Box 360, 3700 AJ Zeist, The Netherlands
    Biochem Pharmacol 65:857-75. 2003
    ..A modest overlap in results from proteomics and transcriptomics was found. This work indicates that transcriptomics and proteomics technologies are complementary to each other and provide new possibilities in molecular toxicology...
  4. ncbi Bromobenzene-induced hepatotoxicity at the transcriptome level
    Wilbert H M Heijne
    Department of Biomolecular Sciences, TNO Nutrition and Food Research, PO Box 360, 3700 AJ Zeist, The Netherlands
    Toxicol Sci 79:411-22. 2004
    ..g., CYP4A, metallothioneins), intraday variation in expression levels was found, regardless of the treatment. Selected cDNA microarray measurements were confirmed using the specific and sensitive branched DNA signal amplification assay...
  5. ncbi Profiles of metabolites and gene expression in rats with chemically induced hepatic necrosis
    Wilbert H M Heijne
    TNO Nutrition and Food Research, 3700 AJ Zeist, The Netherlands
    Toxicol Pathol 33:425-33. 2005
    ..A download option appears at the bottom of this abstract. In order to access the full article online, you must either have an individual subscription or a member subscription accessed through www.toxpath.org...
  6. ncbi The introduction of toxicogenomics; potential new markers of hepatotoxicity
    Wilbert H M Heijne
    TNO Nutrition and Food Research, Zeist, The Netherlands
    Cancer Biomark 1:41-57. 2005