Josje H E Arts

Summary

Affiliation: TNO Quality of Life
Country: The Netherlands

Publications

  1. ncbi request reprint Animal models to test respiratory allergy of low molecular weight chemicals: a guidance
    Josje H E Arts
    TNO Quality of Life, Toxicology and Applied Pharmacology, P O Box 360, 3700 AJ Zeist, The Netherlands
    Methods 41:61-71. 2007
  2. doi request reprint Pre-exposure to sulfur dioxide attenuates most allergic reactions upon trimellitic anhydride challenge in sensitized Brown Norway rats
    Josje H E Arts
    Toxicology and Applied Pharmacology, TNO Quality of Life, Zeist, The Netherlands
    Inhal Toxicol 22:179-91. 2010
  3. doi request reprint Allergic inflammation in the upper respiratory tract of the rat upon repeated inhalation exposure to the contact allergen dinitrochlorobenzene (DNCB)
    Jos J van Triel
    TNO Quality of Life, Department Toxicology and Applied Pharmacology, Zeist, The Netherlands
    Toxicology 269:73-80. 2010
  4. doi request reprint Setting an indoor air exposure limit for formaldehyde: factors of concern
    Josje H E Arts
    Toxicology and Applied Pharmacology, TNO Quality of Life, P O Box 360, 3700 AJ Zeist, The Netherlands
    Regul Toxicol Pharmacol 52:189-94. 2008
  5. doi request reprint Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway rats
    C Frieke Kuper
    TNO Quality of Life, Zeist, The Netherlands
    Toxicol Pathol 36:985-98. 2008
  6. doi request reprint The respiratory local lymph node assay as a tool to study respiratory sensitizers
    Josje H E Arts
    TNO Quality of Life, Zeist, The Netherlands
    Toxicol Sci 106:423-34. 2008
  7. doi request reprint The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat
    C Frieke Kuper
    TNO, Quality of Life, Zeist, The Netherlands
    Toxicology 246:213-21. 2008
  8. doi request reprint Inhalation toxicity studies: OECD guidelines in relation to REACH and scientific developments
    Josje H E Arts
    TNO Quality of Life, P O Box 360, 3700 AJ Zeist, The Netherlands
    Exp Toxicol Pathol 60:125-33. 2008
  9. ncbi request reprint Approaches to induce and elicit respiratory allergy: impact of route and intensity of exposure
    Josje H E Arts
    TNO Nutrition and Food Research, P O Box 360, 3700 AJ, Zeist, The Netherlands
    Toxicol Lett 140:213-22. 2003
  10. ncbi request reprint Dose-response relationships and threshold levels in skin and respiratory allergy
    Josje H E Arts
    TNO Quality of Life, Zeist, The Netherlands
    Crit Rev Toxicol 36:219-51. 2006

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Animal models to test respiratory allergy of low molecular weight chemicals: a guidance
    Josje H E Arts
    TNO Quality of Life, Toxicology and Applied Pharmacology, P O Box 360, 3700 AJ Zeist, The Netherlands
    Methods 41:61-71. 2007
    ..The dermal route as sensitisation route has the advantage of the respiratory tract not being exposed to the allergen prior to challenge which facilitates the distinction between irritant and allergic effects...
  2. doi request reprint Pre-exposure to sulfur dioxide attenuates most allergic reactions upon trimellitic anhydride challenge in sensitized Brown Norway rats
    Josje H E Arts
    Toxicology and Applied Pharmacology, TNO Quality of Life, Zeist, The Netherlands
    Inhal Toxicol 22:179-91. 2010
    ..However in a few animals, SO(2) appeared to facilitate TMA-induced irritation, probably due to incomplete protection. Overall, SO(2) exposure of TMA-sensitized rats reduced TMA-related allergic respiratory responses in most animals...
  3. doi request reprint Allergic inflammation in the upper respiratory tract of the rat upon repeated inhalation exposure to the contact allergen dinitrochlorobenzene (DNCB)
    Jos J van Triel
    TNO Quality of Life, Department Toxicology and Applied Pharmacology, Zeist, The Netherlands
    Toxicology 269:73-80. 2010
    ..Possible progression of the airway inflammation upon long-term exposure should be investigated to support or dismiss discrimination between contact and respiratory allergens in relation to respiratory allergy...
  4. doi request reprint Setting an indoor air exposure limit for formaldehyde: factors of concern
    Josje H E Arts
    Toxicology and Applied Pharmacology, TNO Quality of Life, P O Box 360, 3700 AJ Zeist, The Netherlands
    Regul Toxicol Pharmacol 52:189-94. 2008
    ..Forsch. Prax. 11, 347-361], can be considered a safe and appropriate level...
  5. doi request reprint Molecular characterization of trimellitic anhydride-induced respiratory allergy in Brown Norway rats
    C Frieke Kuper
    TNO Quality of Life, Zeist, The Netherlands
    Toxicol Pathol 36:985-98. 2008
    ..The authors conclude that parameters for lung remodeling can be a valuable tool in hazard identification of LMW respiratory allergens...
  6. doi request reprint The respiratory local lymph node assay as a tool to study respiratory sensitizers
    Josje H E Arts
    TNO Quality of Life, Zeist, The Netherlands
    Toxicol Sci 106:423-34. 2008
    ..In addition, the contact allergens were as potent as the respiratory allergens, although the potency ranking differed from that in a skin LLNA...
  7. doi request reprint The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat
    C Frieke Kuper
    TNO, Quality of Life, Zeist, The Netherlands
    Toxicology 246:213-21. 2008
    ....
  8. doi request reprint Inhalation toxicity studies: OECD guidelines in relation to REACH and scientific developments
    Josje H E Arts
    TNO Quality of Life, P O Box 360, 3700 AJ Zeist, The Netherlands
    Exp Toxicol Pathol 60:125-33. 2008
    ..This will be discussed in relation to the evaluation of the safety of thousands of chemicals in a relatively short period of time and scientific developments, including the use of alternatives to animal testing...
  9. ncbi request reprint Approaches to induce and elicit respiratory allergy: impact of route and intensity of exposure
    Josje H E Arts
    TNO Nutrition and Food Research, P O Box 360, 3700 AJ, Zeist, The Netherlands
    Toxicol Lett 140:213-22. 2003
    ..Finally, a correct distinction between respiratory allergens and non-sensitising airway irritants is needed for effective risk assessment and management...
  10. ncbi request reprint Dose-response relationships and threshold levels in skin and respiratory allergy
    Josje H E Arts
    TNO Quality of Life, Zeist, The Netherlands
    Crit Rev Toxicol 36:219-51. 2006
    ..Therefore, especially with regard to respiratory allergy, standardized and validated dose-response test methods are urgently required in order to be able to recommend safe exposure levels for allergens at the workplace...
  11. ncbi request reprint Inhaled formaldehyde: evaluation of sensory irritation in relation to carcinogenicity
    Josje H E Arts
    TNO Quality of Life, Zeist, P O Box 360, 3700 AJ Zeist, The Netherlands
    Regul Toxicol Pharmacol 44:144-60. 2006
    ..In addition, a Benchmark dose (BMD) analysis of sensory irritation was used to estimate response incidences at different formaldehyde concentrations...
  12. ncbi request reprint Evaluation of the sensory irritation test (Alarie test) for the assessment of respiratory tract irritation
    Peter M J Bos
    TNO Nutrition and Food Research, P O Box 360, 3700 AJ Zeist, The Netherlands
    J Occup Environ Med 44:968-76. 2002
    ..It was concluded that the Alarie test is inappropriate to evaluate respiratory tract irritation. In addition, the available data do not support a quantitative potency ranking for man based on the RD50 obtained with experimental animals...
  13. ncbi request reprint Five-day inhalation toxicity study of three types of synthetic amorphous silicas in Wistar rats and post-exposure evaluations for up to 3 months
    Josje H E Arts
    TNO Quality of Life, P O Box 360, 3700 AJ Zeist, The Netherlands
    Food Chem Toxicol 45:1856-67. 2007
    ....
  14. ncbi request reprint Local effects in the respiratory tract: relevance of subjectively measured irritation for setting occupational exposure limits
    Josje H E Arts
    TNO Quality of Life, P O Box 360, 3700 AJ Zeist, The Netherlands
    Int Arch Occup Environ Health 79:283-98. 2006
    ..In this paper it will be discussed as to how far subjectively measured sensory irritation threshold levels can be used to establish OELs...
  15. ncbi request reprint Subacute (28-day) toxicity of furfural in Fischer 344 rats: a comparison of the oral and inhalation route
    Josje H E Arts
    TNO Nutrition and Food Research, Department of Toxicology and Applied Pharmacology, P O Box 360, 3700 AJ Zeist, The Netherlands
    Food Chem Toxicol 42:1389-99. 2004
    ....
  16. ncbi request reprint Alveolar macrophages suppress non-specific inflammation caused by inhalation challenge with trimellitic anhydride conjugated to albumin
    Dingena L Valstar
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    Arch Toxicol 80:561-71. 2006
    ..Since effects of inhalation challenge with TMA-BSA are partly different from those of TMA, challenge with the latter is to be preferred for hazard identification...
  17. ncbi request reprint Respiratory allergy and pulmonary irritation to trimellitic anhydride in Brown Norway rats
    Josje H E Arts
    Toxicology Division, TNO Nutrition and Food Research, Zeist, The Netherlands
    Toxicol Appl Pharmacol 187:38-49. 2003
    ..Sensitization-dependent functional changes were accompanied by inflammatory changes characteristic of asthma and biochemical evidence of airway damage...
  18. ncbi request reprint Preexposure to amorphous silica particles attenuates but also enhances allergic reactions in trimellitic anhydride-sensitized brown Norway rats
    Josje H E Arts
    AkzoNobel T and E, Arnhem, The Netherlands
    Inhal Toxicol 20:935-48. 2008
    ..Thus, a respiratory particulate irritant like SAS can reduce as well as aggravate certain aspects of TMA-induced respiratory allergy...
  19. ncbi request reprint Alveolar macrophages have a dual role in a rat model for trimellitic anhydride-induced occupational asthma
    Dingena L Valstar
    Department of Pharmacology and Pathophysiology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Sorbonnelaan 16, 3584 CA, Utrecht, The Netherlands
    Toxicol Appl Pharmacol 211:20-9. 2006
    ..AMs seem to have a dual role in this model for TMA-induced occupational asthma since they potentiate the immediate TMA-induced decrease in lung function but tended to dampen the TMA-induced inflammatory reaction 24 h later...
  20. ncbi request reprint Particle size-dependent total mass deposition in lungs determines inhalation toxicity of cadmium chloride aerosols in rats. Application of a multiple path dosimetry model
    Flemming R Cassee
    National Institute of Public Health and Environment RIVM, Laboratory of Health Effects Research, PO Box 1, 3720 BA Bilthoven, The Netherlands
    Arch Toxicol 76:277-86. 2002
    ..These findings may have serious impact on the evaluation of the role of various particle sizes in PM10-associated health effects...
  21. ncbi request reprint Toxicity to nasal-associated lymphoid tissue
    C Frieke Kuper
    TNO Nutrition and Food Research, Department of General Toxicology, Division of Toxicology, PO Box 360, 3700 AJ, Zeist, The Netherlands
    Toxicol Lett 140:281-5. 2003
    ..Therefore, we recommend to include histopathological examination of NALT in standard guideline-driven inhalation toxicity studies...