Marcel D Waldinger

Summary

Affiliation: The Hague
Country: The Netherlands

Publications

  1. doi request reprint An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation
    Chris G McMahon
    Australian Center for Sexual Health, Sydney, Australia
    BJU Int 102:338-50. 2008
  2. ncbi request reprint Premature ejaculation: definition and drug treatment
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    Drugs 67:547-68. 2007
  3. ncbi request reprint Dapoxetine treatment of premature ejaculation
    Marcel D Waldinger
    Lancet 368:1869; author reply 1869-70. 2006
  4. ncbi request reprint Oxytocin involvement in SSRI-induced delayed ejaculation: a review of animal studies
    Trynke R de Jong
    Department of Psychopharmacology, Utrecht Institute of Pharmacological Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands
    J Sex Med 4:14-28. 2007
  5. ncbi request reprint Four measures of investigating ejaculatory performance
    Marcel D Waldinger
    J Sex Med 4:520. 2007
  6. doi request reprint Hyposensitization therapy with autologous semen in two Dutch caucasian males: beneficial effects in Postorgasmic Illness Syndrome (POIS; Part 2)
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital, The Hague, The Netherlands
    J Sex Med 8:1171-6. 2011
  7. doi request reprint Geometric mean IELT and premature ejaculation: appropriate statistics to avoid overestimation of treatment efficacy
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Haga Hospital Leyenburg, The Hague, The Netherlands
    J Sex Med 5:492-9. 2008
  8. ncbi request reprint Premature ejaculation: state of the art
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    Urol Clin North Am 34:591-9, vii-viii. 2007
  9. ncbi request reprint The majority of men with lifelong premature ejaculation prefer daily drug treatment: an observation study in a consecutive group of Dutch men
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, Leyweg 275, 2545 CH The Hague, The Netherlands
    J Sex Med 4:1028-37. 2007
  10. doi request reprint Recent advances in the classification, neurobiology and treatment of premature ejaculation
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    Adv Psychosom Med 29:50-69. 2008

Detail Information

Publications62

  1. doi request reprint An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine Ad Hoc Committee for the Definition of Premature Ejaculation
    Chris G McMahon
    Australian Center for Sexual Health, Sydney, Australia
    BJU Int 102:338-50. 2008
    ..To develop a contemporary, evidence-based definition of premature ejaculation (PE)...
  2. ncbi request reprint Premature ejaculation: definition and drug treatment
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    Drugs 67:547-68. 2007
    ....
  3. ncbi request reprint Dapoxetine treatment of premature ejaculation
    Marcel D Waldinger
    Lancet 368:1869; author reply 1869-70. 2006
  4. ncbi request reprint Oxytocin involvement in SSRI-induced delayed ejaculation: a review of animal studies
    Trynke R de Jong
    Department of Psychopharmacology, Utrecht Institute of Pharmacological Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands
    J Sex Med 4:14-28. 2007
    ..Selective serotonin reuptake inhibitors (SSRIs) differ in the severity of induced ejaculation delay. Various studies indicate that oxytocin is involved in sexual behavior...
  5. ncbi request reprint Four measures of investigating ejaculatory performance
    Marcel D Waldinger
    J Sex Med 4:520. 2007
  6. doi request reprint Hyposensitization therapy with autologous semen in two Dutch caucasian males: beneficial effects in Postorgasmic Illness Syndrome (POIS; Part 2)
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital, The Hague, The Netherlands
    J Sex Med 8:1171-6. 2011
    ..Recent data suggest an autoimmunogenic/allergic underlying mechanism...
  7. doi request reprint Geometric mean IELT and premature ejaculation: appropriate statistics to avoid overestimation of treatment efficacy
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Haga Hospital Leyenburg, The Hague, The Netherlands
    J Sex Med 5:492-9. 2008
    ..The intravaginal ejaculation latency time (IELT) behaves in a skewed manner and needs the appropriate statistics for correct interpretation of treatment results...
  8. ncbi request reprint Premature ejaculation: state of the art
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    Urol Clin North Am 34:591-9, vii-viii. 2007
    ..There is insufficient evidence for the ejaculation delaying effects of phosphodiesterase type 5 inhibitors and intracavernous injection of vasoactive drugs...
  9. ncbi request reprint The majority of men with lifelong premature ejaculation prefer daily drug treatment: an observation study in a consecutive group of Dutch men
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, Leyweg 275, 2545 CH The Hague, The Netherlands
    J Sex Med 4:1028-37. 2007
    ..Whether men with lifelong premature ejaculation (PE) prefer on-demand drug treatment to delay ejaculation time to daily drug treatment, has never been studied as a separate study question...
  10. doi request reprint Recent advances in the classification, neurobiology and treatment of premature ejaculation
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    Adv Psychosom Med 29:50-69. 2008
    ..Psychoeducation and reassurance is indicated for men with natural variable PE. Finally, psychotherapy and/or counselling is the first choice of treatment of men with premature-like ejaculatory dysfunction...
  11. ncbi request reprint Changing paradigms from a historical DSM-III and DSM-IV view toward an evidence-based definition of premature ejaculation. Part II--proposals for DSM-V and ICD-11
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    J Sex Med 3:693-705. 2006
    ..In the Diagnostic and Statistical Manual of Mental Disorders (DSM), a descriptive definition for premature ejaculation (PE) that was based on historical assumptions has been accepted...
  12. ncbi request reprint Changing paradigms from a historical DSM-III and DSM-IV view toward an evidence-based definition of premature ejaculation. Part I--validity of DSM-IV-TR
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    J Sex Med 3:682-92. 2006
    ..In addition, the requirement that persistent self-perceived PE, distress, and interpersonal difficulties, in absence of a quantified ejaculation time, are necessary to establish the diagnosis remains disputable...
  13. ncbi request reprint Emerging drugs for premature ejaculation
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, Leyweg 275, 2545 CH, The Hague, The Netherlands
    Expert Opin Emerg Drugs 11:99-109. 2006
    ..The combination of an SSRI and any other compound that immediately strongly raises 5-HT neurotransmission may form the basis for the development of new on-demand drugs to treat PE...
  14. doi request reprint The use of old and recent DSM definitions of premature ejaculation in observational studies: a contribution to the present debate for a new classification of PE in the DSM-V
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    J Sex Med 5:1079-87. 2008
    ..quot; In contrast, the Diagnostic and Statistical Manual of Mental Disorders (4th edition, Text Revision) (DSM-IV-TR) contains the criterion "short ejaculation time," while it lacks "control."..
  15. ncbi request reprint Premature ejaculation: different pathophysiologies and etiologies determine its treatment
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    J Sex Marital Ther 34:1-13. 2008
    ..Moreover, according to the proposed new classification it is likely that only a small number of men with complaints of PE suffer from a neurobiologically determined PE disturbance...
  16. doi request reprint Postorgasmic Illness Syndrome (POIS) in 45 Dutch caucasian males: clinical characteristics and evidence for an immunogenic pathogenesis (Part 1)
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital, The Hague, The Netherlands
    J Sex Med 8:1164-70. 2011
    ..Postorgasmic illness syndrome (POIS) is a combination of local allergic symptoms and transient flu-like illness. In this study, the investigators propose five preliminary criteria to establish the diagnosis...
  17. doi request reprint Stronger evidence for small fiber sensory neuropathy in restless genital syndrome: two case reports in males
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    J Sex Med 8:325-30. 2011
    ..So far, ReGS has only been reported in females...
  18. doi request reprint Restless genital syndrome before and after clitoridectomy for spontaneous orgasms: a case report
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, 2545 CH The Hague, The Netherlands
    J Sex Med 7:1029-34. 2010
    ..Females despairing of restless genital syndrome (ReGS) may request clitoridectomy for treatment of unwanted genital sensations. Aim. The aim of this study was to report persistence of ReGS despite clitoridectomy...
  19. doi request reprint Successful transcutaneous electrical nerve stimulation in two women with restless genital syndrome: the role of adelta- and C-nerve fibers
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    J Sex Med 7:1190-9. 2010
    ..Currently, efficacious treatment of restless genital syndrome (ReGS) is not available...
  20. doi request reprint New insights into restless genital syndrome: static mechanical hyperesthesia and neuropathy of the nervus dorsalis clitoridis
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, Leyweg 275, The Hague2545 CH, The Netherlands
    J Sex Med 6:2778-87. 2009
    ..Systematic study of dysesthetic and paresthetic regions contributing to persistent genital arousal in women with restless genital syndrome (ReGS) is needed for its clinical management...
  21. doi request reprint A five-nation survey to assess the distribution of the intravaginal ejaculatory latency time among the general male population
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, Leyweg 275, The Hague2545 CH, The Netherlands
    J Sex Med 6:2888-95. 2009
    ..The duration of the intravaginal ejaculation latency time (IELT) may give rise to subjective complaints of premature ejaculation (PE) and is usually determined by self-assessment or by stopwatch...
  22. doi request reprint Persistent genital arousal disorder in 18 Dutch women: Part I. MRI, EEG, and transvaginal ultrasonography investigations
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    J Sex Med 6:474-81. 2009
    ..Systematic blood analysis and electroencephalographic (EEG) and magnetic resonance imaging (MRI) study in women with persistent genital arousal disorder (PGAD) are needed to get more insight into the syndrome's etiology and pathogenesis...
  23. doi request reprint Persistent genital arousal disorder in 18 Dutch women: Part II. A syndrome clustered with restless legs and overactive bladder
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    J Sex Med 6:482-97. 2009
    ..A systematic study in women with persistent genital arousal disorder (PGAD) is urgently needed to develop its clinical management...
  24. ncbi request reprint On-demand SSRI treatment of premature ejaculation: pharmacodynamic limitations for relevant ejaculation delay and consequent solutions
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg Haga Hospital, The Hague, The Netherlands
    J Sex Med 2:121-31. 2005
    ..Recently, the idea has emerged that on-demand use of serotonin reuptake inhibitors (SSRIs), particularly short half-life, should be equally effective in delaying ejaculation as daily SSRI treatment of premature ejaculation...
  25. ncbi request reprint Proposal for a definition of lifelong premature ejaculation based on epidemiological stopwatch data
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg HagaHospital, The Hague, and Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    J Sex Med 2:498-507. 2005
    ..Consensus on a definition of premature ejaculation has not yet been reached because of debates based on subjective authority opinions and nonstandardized assessment methods to measure ejaculation time and ejaculation control...
  26. ncbi request reprint A multinational population survey of intravaginal ejaculation latency time
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg HagaHospital, The Hague, and Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, The Netherlands
    J Sex Med 2:492-7. 2005
    ..However, the IELT distribution in the general male population has not been previously assessed...
  27. ncbi request reprint Utility of selective serotonin reuptake inhibitors in premature ejaculation
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg Hospital, 2545 CH The Hague, The Netherlands
    Curr Opin Investig Drugs 5:743-7. 2004
    ..It is postulated that acute treatment with SSRIs, including those with short half-lives, will not produce an ejaculation delay equivalent to that induced by daily treatment of SSRIs...
  28. ncbi request reprint Relevance of methodological design for the interpretation of efficacy of drug treatment of premature ejaculation: a systematic review and meta-analysis
    M D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg Hospital, The Hague, The Netherlands
    Int J Impot Res 16:369-81. 2004
    ..Single-blind studies, open designs, retrospective reporting, or the use of a questionnaire to assess ejaculation time should be avoided...
  29. ncbi request reprint On-demand treatment of premature ejaculation with clomipramine and paroxetine: a randomized, double-blind fixed-dose study with stopwatch assessment
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg Hospital, Leyweg 275, 2545 CH The Hague, The Netherlands
    Eur Urol 46:510-5; discussion 516. 2004
    ....
  30. ncbi request reprint Lifelong premature ejaculation: definition, serotonergic neurotransmission and drug treatment
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg Haga Hospital, Leyweg 275, 2545 CH The Hague, The Netherlands
    World J Urol 23:102-8. 2005
    ....
  31. ncbi request reprint Retarded ejaculation in men: an overview of psychological and neurobiological insights
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg Haga Hospital, Leyweg 275, 2545 CH, The Hague, The Netherlands
    World J Urol 23:76-81. 2005
    ..Psychotherapy may be useful in subgroups, particularly in the absence of effective and safe drugs...
  32. ncbi request reprint Animal models of premature and retarded ejaculation
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg Haga Hospital, Leyweg 275, 2545 CH The Hague, The Netherlands
    World J Urol 23:115-8. 2005
    ..Comparable to the human situation, in a normal population of rats, endophenotypes exist with regard to basal sexual (ejaculatory) performance...
  33. ncbi request reprint Thyroid-stimulating hormone assessments in a Dutch cohort of 620 men with lifelong premature ejaculation without erectile dysfunction
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, and Department of Psychopharmacology, Utrecht University, The Netherlands
    J Sex Med 2:865-70. 2005
    ..Apart from the involvement of central serotonergic neurotransmission on lifelong premature ejaculation, interference of thyroid function has been speculated...
  34. ncbi request reprint Relevance of an evidence-based ejaculation time cutoff point for neurobiological research of premature ejaculation
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, 2545 CH The Hague, The Netherlands
    J Comp Neurol 493:46-50. 2005
    ....
  35. doi request reprint Chronic paroxetine treatment does not affect sexual behavior in hormonally sub-primed female rats despite 5-HT₁(A) receptor desensitization
    Eelke M S Snoeren
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands
    J Sex Med 8:976-88. 2011
    ..However, because SSRIs are used to treat depression, it is unclear whether the problems are caused by the drug, by the depression itself, or an interaction between both...
  36. doi request reprint The serotonin transporter plays an important role in male sexual behavior: a study in serotonin transporter knockout rats
    Johnny S W Chan
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Sorbonnelaan, Utrecht, The Netherlands
    J Sex Med 8:97-108. 2011
    ..Heterozygous (+/-) serotonin transporter (SERT) rats and SERT knockout rats (-/-) have serotonergic disturbances with significant elevations of basal extracellular 5-HT levels...
  37. doi request reprint A new female rat animal model for hypoactive sexual desire disorder; behavioral and pharmacological evidence
    Eelke M S Snoeren
    Department of Psychopharmacology, Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    J Sex Med 8:44-56. 2011
    ..Female sexual dysfunction (FSD) affects 33-48% of women. Female rats with low sexual activity might model FSD...
  38. ncbi request reprint Antidepressants and ejaculation: a double-blind, randomized, fixed-dose study with mirtazapine and paroxetine
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg Hospital, The Hague, The Netherlands
    J Clin Psychopharmacol 23:467-70. 2003
    ..9-fold increase). These results confirm earlier findings that paroxetine, but not mirtazapine, significantly delays orgasm and ejaculation in men with early ejaculation, whereas mirtazapine is devoid of any effect on it...
  39. doi request reprint Premature ejaculation and pharmaceutical company-based medicine: the dapoxetine case
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, HagaHospital Leyenburg, The Hague, The Netherlands
    J Sex Med 5:966-97. 2008
    ..The manufacturer of dapoxetine funded randomized clinical trials to study its effect in premature ejaculation (PE). Financial support by pharmaceutical companies, however, may jeopardize the neutrality of clinical research...
  40. doi request reprint Combination of testosterone and vardenafil increases female sexual functioning in sub-primed rats
    Eelke M S Snoeren
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands
    J Sex Med 8:989-1001. 2011
    ..A recent clinical study shows an increase in sexual drive of HSDD women after cotreatment of testosterone and vardenafil (phosphodiesterase type 5 inhibitor)...
  41. doi request reprint Differences in sexual behaviour in male and female rodents: role of serotonin
    Berend Olivier
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Sorbonnelaan 16, 3584, CA, Utrecht, The Netherlands
    Curr Top Behav Neurosci 8:15-36. 2011
    ..Identification of putative differential or comparable roles in female and male sexual activities requires more research...
  42. ncbi request reprint Postorgasmic illness syndrome: two cases
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg Hospital, Leyweg 275, 2545 CH The Hague, The Netherlands
    J Sex Marital Ther 28:251-5. 2002
    ..Both cases are presented to draw attention to this syndrome for further research regarding etiology, pathogenesis, and treatment...
  43. ncbi request reprint The neurobiological approach to premature ejaculation
    Marcel D Waldinger
    Department of Psychiatry and Neurosexology, Leyenburg Hospital, The Hague, The Netherlands
    J Urol 168:2359-67. 2002
    ..Data showing the neurobiological background of rapid ejaculation was reviewed. In addition, new hypotheses to integrate clinical symptomatology, psychopharmacotherapy and psychotherapy of rapid ejaculation with brain function are provided...
  44. doi request reprint Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation
    Paddy K C Janssen
    Section of Psychopharmacology, Department of Pharmaceutical Sciences and Rudolf Magnus Institute for Neurosciences, Utrecht University, Utrecht, The Netherlands
    J Sex Med 6:276-84. 2009
    ....
  45. ncbi request reprint The selective serotonin re-uptake inhibitors fluvoxamine and paroxetine differ in sexual inhibitory effects after chronic treatment
    Marcel D Waldinger
    Department of Psychopharmacology, Rudolf Magnus Institute for Neurosciences and Utrecht Institute for Parmaceutical Sciences, Faculty of Pharmacy, Utrecht University, Utrecht, The Netherlands
    Psychopharmacology (Berl) 160:283-9. 2002
    ..The selective serotonin re-uptake inhibitors (SSRIs) delay orgasm and ejaculation in men. In men with rapid ejaculation it was shown that, of the SSRIs, paroxetine exerted the strongest delay in ejaculation and fluvoxamine the weakest...
  46. doi request reprint Foot orgasm syndrome: a case report in a woman
    Marcel D Waldinger
    Division of Pharmacology, Utrecht Institute for Pharmaceutical Sciences, Faculty of BetaSciences, Utrecht University, Utrecht, The Netherlands private practice, Amstelveen, The Netherlands Department of Neurosexology, HagaZiekenhuis, Den Haag, The Netherlands
    J Sex Med 10:1926-34. 2013
    ..Spontaneous orgasm triggered from inside the foot has so far not been reported in medical literature...
  47. doi request reprint Drug-induced sexual dysfunction in rats
    Johnny S W Chan
    Department of Psychopharmacology, Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Utrecht, The Netherlands
    Curr Protoc Neurosci . 2010
    ..By comparing the test compound to reference compound(s), sexual (side) effects can be determined...
  48. ncbi request reprint Effects of chronic selective serotonin reuptake inhibitors on 8-OH-DPAT-induced facilitation of ejaculation in rats: comparison of fluvoxamine and paroxetine
    Trynke R de Jong
    Department of Anatomy, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Psychopharmacology (Berl) 179:509-15. 2005
    ..The involvement of 5-HT1A receptors is likely, since 5-HT1A receptor agonists accelerate ejaculation and chronic SSRI treatment is thought to desensitize 5-HT1A receptors...
  49. ncbi request reprint Lifelong premature ejaculation: from authority-based to evidence-based medicine
    Marcel D Waldinger
    BJU Int 95:191. 2005
  50. ncbi request reprint Effects of chronic treatment with fluvoxamine and paroxetine during adolescence on serotonin-related behavior in adult male rats
    Trynke R de Jong
    Department of Anatomy, Radboud University Nijmegen Medical Centre, Intern Mail Nr 230 Postbus 9101 6500 HB, Nijmegen, The Netherlands
    Eur Neuropsychopharmacol 16:39-48. 2006
    ..No differences between the groups were found in the other tests. Apparently, chronic treatment with SSRIs during adolescence may cause mild changes in adult behavior...
  51. ncbi request reprint Individual differences in male rat ejaculatory behaviour: searching for models to study ejaculation disorders
    Tommy Pattij
    Department of Anatomy, University Medical Center St Radboud, Nijmegen, The Netherlands
    Eur J Neurosci 22:724-34. 2005
    ..Further exploring the neurobiological mechanisms underlying these differences may be a promising approach to gain insights into the aetiology of sexual dysfunctions such as premature, retarded or an-ejaculation...
  52. ncbi request reprint The DSM-IV-TR Is an inadequate diagnostic tool for premature ejaculation
    Marcel D Waldinger
    J Sex Med 4:822-3. 2007
  53. doi request reprint Re: François Giuliano, Donald L. Patrick, Hartmut Porst, et Al. for the 3004 study group. Premature ejaculation: results from a five-country European observational study. Eur urol 2008;53:1048-57
    Marcel D Waldinger
    Eur Urol 53:1304-5; author reply 1305-6. 2008
  54. ncbi request reprint Citalopram combined with WAY 100635 inhibits ejaculation and ejaculation-related Fos immunoreactivity
    Trynke R de Jong
    Department of Anatomy, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Eur J Pharmacol 509:49-59. 2005
    ..Citalopram reduced Fos-immunoreactivity in the arcuate hypothalamic nucleus, an area that might link serotonergic neurotransmission to ejaculation...
  55. doi request reprint Not medical solutions, but overmedicalization by pharmaceutical company policies endanger both sexological care, science, and sexual medicine. A commentary
    Marcel D Waldinger
    J Sex Marital Ther 34:179-83. 2008
  56. doi request reprint Translational research into sexual disorders: pharmacology and genomics
    Johnny S W Chan
    Department of Psychopharmacology, Utrecht Institute of Pharmacological Sciences and Rudolf Magnus Institute of Neuroscience, Utrecht University, Utrecht, The Netherlands address
    Eur J Pharmacol 585:426-35. 2008
    ..These preclinical studies and models contribute to a better understanding of the neurobiology of ejaculation and boost the development of novel drug targets to treat ejaculatory disorders such as premature and retarded ejaculation...
  57. doi request reprint An evidence-based definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation
    Chris G McMahon
    Australian Center for Sexual Health, Sydney, Australia
    J Sex Med 5:1590-606. 2008
    ....
  58. ncbi request reprint Serotonin and the neurobiology of the ejaculatory threshold
    Trynke R de Jong
    Department of Anatomy, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Neurosci Biobehav Rev 30:893-907. 2006
    ..Filling in those gaps might help to design specific drugs that alter the ejaculatory threshold, thereby alleviating ejaculatory disorders...
  59. ncbi request reprint Premature ejaculation: a new approach by James H. Semans
    Sidney Glina
    Department of Urology, Instituto H Ellis, Sao Paulo, Brazil
    J Sex Med 4:831-7. 2007
  60. ncbi request reprint Ejaculatory disorders
    Uwe Hartmann
    World J Urol 23:67. 2005
  61. ncbi request reprint Is sexual dysfunctioning a reason for discontinuation in users of selective serotonin reuptake inhibitors?
    Welmoed E E Meijer
    J Clin Psychopharmacol 22:96-8. 2002
  62. doi request reprint Are premature ejaculation symptoms curable?
    Yoram Vardi
    Department of Neuro Urology, Rambam Medical Center, Haifa, Israel
    J Sex Med 5:1546-51. 2008
    ..While premature ejaculation (PE) is the most common sexual dysfunction in men under 40, there is currently no government-approved therapy for its treatment. Is a cure possible?..