Arnoud Sonnenberg

Summary

Affiliation: The Netherlands Cancer Institute
Country: The Netherlands

Publications

  1. ncbi request reprint Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11
    Aimee M Powelka
    Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Traffic 5:20-36. 2004
  2. pmc Carbonic anhydrase 5 regulates acid-base homeostasis in zebrafish
    Ruben Postel
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS ONE 7:e39881. 2012
  3. pmc Kindlin-1 regulates integrin dynamics and adhesion turnover
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS ONE 8:e65341. 2013
  4. pmc Kidney failure in mice lacking the tetraspanin CD151
    Norman Sachs
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 175:33-9. 2006
  5. pmc Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential
    Frances S Kittrell
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 13:R41. 2011
  6. ncbi request reprint Plakins in development and disease
    Arnoud Sonnenberg
    Division of Cell Biology, The Netherlands Cancer Inst, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Exp Cell Res 313:2189-203. 2007
  7. ncbi request reprint Modeling and experimental validation of the binary complex of the plectin actin-binding domain and the first pair of fibronectin type III (FNIII) domains of the beta4 integrin
    Sandy H M Litjens
    Divisions of Cell Biology, and Molecular Carcinogenesis, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 280:22270-7. 2005
  8. ncbi request reprint Current insights into the formation and breakdown of hemidesmosomes
    Sandy H M Litjens
    Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Trends Cell Biol 16:376-83. 2006
  9. doi request reprint Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 122:278-88. 2009
  10. doi request reprint Kindlin-1 mutant zebrafish as an in vivo model system to study adhesion mechanisms in the epidermis
    Ruben Postel
    The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Invest Dermatol 133:2180-90. 2013

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Stimulation-dependent recycling of integrin beta1 regulated by ARF6 and Rab11
    Aimee M Powelka
    Brigham and Women s Hospital, and Department of Medicine, Harvard Medical School, Boston, MA 02115, USA
    Traffic 5:20-36. 2004
    ..Consistent with these observations being relevant for cell motility, mutant forms of ARF6 that affect either actin rearrangement or recycling inhibit the motility of a breast cancer cell line...
  2. pmc Carbonic anhydrase 5 regulates acid-base homeostasis in zebrafish
    Ruben Postel
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS ONE 7:e39881. 2012
    ..Identification of selective modulators of CA5 activity could have a major impact on the development of new therapeutics involved in the treatment of a variety of disorders...
  3. pmc Kindlin-1 regulates integrin dynamics and adhesion turnover
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS ONE 8:e65341. 2013
    ..Thus, these data uncover a role for kindlin-1 in the regulation of integrin trafficking and adhesion turnover...
  4. pmc Kidney failure in mice lacking the tetraspanin CD151
    Norman Sachs
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 175:33-9. 2006
    ..Our results support the hypothesis that CD151 plays a key role in strengthening alpha3beta1-mediated adhesion in podocytes...
  5. pmc Prospective isolation and characterization of committed and multipotent progenitors from immortalized mouse mammary epithelial cells with morphogenic potential
    Frances S Kittrell
    Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Breast Cancer Res 13:R41. 2011
    ....
  6. ncbi request reprint Plakins in development and disease
    Arnoud Sonnenberg
    Division of Cell Biology, The Netherlands Cancer Inst, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Exp Cell Res 313:2189-203. 2007
    ..We will also describe the relationship of these two proteins to the invertebrate plakins, shortstop (shot) in Drosophila and VAB-10 in C. elegans. Finally, we will describe an unusual mammalian plakin, called epiplakin...
  7. ncbi request reprint Modeling and experimental validation of the binary complex of the plectin actin-binding domain and the first pair of fibronectin type III (FNIII) domains of the beta4 integrin
    Sandy H M Litjens
    Divisions of Cell Biology, and Molecular Carcinogenesis, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 280:22270-7. 2005
    ..This is consistent with the proposed model and previously published mutational data. In conclusion, our data support a model in which the CH1 domain of the plectin-ABD associates with the groove between the two FNIII domains of beta4...
  8. ncbi request reprint Current insights into the formation and breakdown of hemidesmosomes
    Sandy H M Litjens
    Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Trends Cell Biol 16:376-83. 2006
    ..In addition, further insight into the functional interplay between alpha3beta1 and alpha6beta4 has contributed to our understanding of hemidesmosome disassembly and cell migration...
  9. doi request reprint Integrin alpha3beta1 inhibits directional migration and wound re-epithelialization in the skin
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 122:278-88. 2009
    ..We suggest that integrin alpha3beta1 delays keratinocyte migration during wound re-epithelialization, by binding to the laminin-332 that is newly deposited on the wound bed...
  10. doi request reprint Kindlin-1 mutant zebrafish as an in vivo model system to study adhesion mechanisms in the epidermis
    Ruben Postel
    The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Invest Dermatol 133:2180-90. 2013
    ..Thus, the rof/kindlin-1 mutant zebrafish provides a unique model system to study epidermal adhesion mechanisms in vivo. ..
  11. ncbi request reprint Analysis of the interactions between BP180, BP230, plectin and the integrin alpha6beta4 important for hemidesmosome assembly
    Jan Koster
    The Netherlands Cancer Institute, Division of Cell Biology, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 116:387-99. 2003
    ....
  12. pmc Phosphorylation of threonine 1736 in the C-terminal tail of integrin β4 contributes to hemidesmosome disassembly
    Evelyne Frijns
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Mol Biol Cell 23:1475-85. 2012
    ..In conclusion, we identify T1736 as a novel phosphorylation site that contributes to the regulation of hemidesmome disassembly, a dynamically regulated process involving the concerted phosphorylation of multiple β4 residues...
  13. pmc EGF-induced MAPK signaling inhibits hemidesmosome formation through phosphorylation of the integrin {beta}4
    Evelyne Frijns
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 285:37650-62. 2010
    ..Collectively, these data demonstrate an important role of β4 phosphorylation on residues Ser-1356 and Ser-1364 in the formation and/or stability of HDs...
  14. pmc Dual Role of alpha6beta4 integrin in epidermal tumor growth: tumor-suppressive versus tumor-promoting function
    Karine Raymond
    Division of Cell Biology and Experimental Animal Pathology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Mol Biol Cell 18:4210-21. 2007
    ..Together, these data show that depending on the mutations involved, alpha6beta4 can either mediate an adhesion-independent tumor-suppressive effect or act as a tumor promotor...
  15. ncbi request reprint Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice
    Karine Raymond
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 118:1045-60. 2005
    ..Our findings clearly demonstrate that, after birth, epidermal differentiation, proliferation and survival all proceed normally in the absence of alpha6beta4, provided that cell adhesion is not compromised...
  16. pmc Nesprin-3 connects plectin and vimentin to the nuclear envelope of Sertoli cells but is not required for Sertoli cell function in spermatogenesis
    Mirjam Ketema
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    Mol Biol Cell 24:2454-66. 2013
    ....
  17. pmc Loss of integrin α3 prevents skin tumor formation by promoting epidermal turnover and depletion of slow-cycling cells
    Norman Sachs
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 109:21468-73. 2012
    ..Therefore, α3β1 critically affects skin carcinogenesis with opposing effects early and late in tumorigenesis...
  18. doi request reprint Nesprin-3 augments peripheral nuclear localization of intermediate filaments in zebrafish
    Ruben Postel
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 124:755-64. 2011
    ..All this shows that nesprin-3 is dispensable for normal development in zebrafish, but important for mediating the association of the intermediate filament system with the nucleus in vivo...
  19. ncbi request reprint Investigation into the mechanism regulating MRP localization
    Iman van den Bout
    Division of Cell Biology, Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands
    Exp Cell Res 314:330-41. 2008
    ....
  20. pmc Specificity of binding of the plectin actin-binding domain to beta4 integrin
    Sandy H M Litjens
    The Netherlands Cancer Institute, Division of Cell Biology, 1066 CX Amsterdam, The Netherlands
    Mol Biol Cell 14:4039-50. 2003
    ..These studies demonstrate the unique property of the plectin-ABD to bind to both F-actin and beta4, and explain why several other ABD-containing proteins that are expressed in basal keratinocytes are not recruited into hemidesmosomes...
  21. pmc Serine phosphorylation of the integrin beta4 subunit is necessary for epidermal growth factor receptor induced hemidesmosome disruption
    Kevin Wilhelmsen
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Mol Biol Cell 18:3512-22. 2007
    ....
  22. pmc Nesprin-3, a novel outer nuclear membrane protein, associates with the cytoskeletal linker protein plectin
    Kevin Wilhelmsen
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Cell Biol 171:799-810. 2005
    ....
  23. doi request reprint Expression of the orphan protein Plet-1 during trichilemmal differentiation of anagen hair follicles
    Karine Raymond
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam, The Netherlands
    J Invest Dermatol 130:1500-13. 2010
    ..The restricted localization in both differentiated ORS and CL cells contacting the hair fiber and epidermal wounds suggests a role for the Plet-1 protein in regulating the interaction of keratinocytes with inert tissues...
  24. doi request reprint Reduced susceptibility to two-stage skin carcinogenesis in mice with epidermis-specific deletion of CD151
    Norman Sachs
    Division of Cell Biology, Amsterdam, The Netherlands
    J Invest Dermatol 134:221-8. 2014
    ..We thus identify CD151 as a critical factor in TPA-dependent skin carcinogenesis. ..
  25. pmc Integrins control motile strategy through a Rho-cofilin pathway
    Erik H J Danen
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Cell Biol 169:515-26. 2005
    ..Thus, alterations in integrin expression profiles allow cells to modulate several critical aspects of the motile machinery through Rho GTPases...
  26. doi request reprint Distinct roles of talin and kindlin in regulating integrin α5β1 function and trafficking
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Curr Biol 22:1554-63. 2012
    ..However, it is unclear how the individual motifs regulate integrin function and trafficking...
  27. ncbi request reprint Requirements for the localization of nesprin-3 at the nuclear envelope and its interaction with plectin
    Mirjam Ketema
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 120:3384-94. 2007
    ..Our studies support a model in which the actin cytoskeleton influences the binding of plectin dimers to dimers of nesprin-3alpha, which in turn are retained at the nuclear envelope through an interaction with Sun proteins...
  28. pmc The fibronectin-binding integrins alpha5beta1 and alphavbeta3 differentially modulate RhoA-GTP loading, organization of cell matrix adhesions, and fibronectin fibrillogenesis
    Erik H J Danen
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands
    J Cell Biol 159:1071-86. 2002
    ..Our findings demonstrate that the pattern of fibronectin receptors expressed on a cell dictates the ability of fibronectin to stimulate RhoA-mediated organization of cell matrix adhesions...
  29. pmc Blood pressure influences end-stage renal disease of Cd151 knockout mice
    Norman Sachs
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Clin Invest 122:348-58. 2012
    ....
  30. pmc Dynamics of the alpha6beta4 integrin in keratinocytes
    Cecile A W Geuijen
    Division of Cell Biology, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Mol Biol Cell 13:3845-58. 2002
    ..This clustering ultimately determines whether alpha6beta4 will inhibit cell migration or not...
  31. ncbi request reprint The regulation of MacMARCKS expression by integrin beta3
    Iman van den Bout
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Exp Cell Res 313:1260-9. 2007
    ..We suggest that the downregulation of MRP by beta3 is not required for increased cell spreading but instead that MRP downregulation is a secondary effect of increased cell spreading...
  32. ncbi request reprint Association of the tetraspanin CD151 with the laminin-binding integrins alpha3beta1, alpha6beta1, alpha6beta4 and alpha7beta1 in cells in culture and in vivo
    Lotus M T Sterk
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 115:1161-73. 2002
    ..These results suggest that the interactions between CD151 and laminin-binding integrins are subject to cell-type-specific regulation...
  33. pmc The Rac activator Tiam1 is required for (alpha)3(beta)1-mediated laminin-5 deposition, cell spreading, and cell migration
    Irene H L Hamelers
    Division of Cell Biology, Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Cell Biol 171:871-81. 2005
    ..Our studies indicate that Tiam1 is a key molecule in alpha3beta1-mediated activation of Rac, which is essential for proper production and secretion of LN5, a requirement for the spreading and migration of keratinocytes...
  34. pmc Epigenetic regulation of galectin-3 expression by β1 integrins promotes cell adhesion and migration
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 287:44684-93. 2012
    ..In conclusion, we identify a functional feedback-loop between β1 integrins and Gal-3 that involves the epigenetic induction of Gal-3 expression during integrin-induced EMT and cell scattering...
  35. ncbi request reprint Integrins in regulation of tissue development and function
    Erik H J Danen
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Pathol 201:632-41. 2003
    ..In this review we briefly explain how integrins can affect so many different aspects of cell behavior and discuss evidence for roles of integrins in tissue development, function, and disease...
  36. doi request reprint Regulation of hemidesmosome disassembly by growth factor receptors
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Curr Opin Cell Biol 20:589-96. 2008
    ..Here, we discuss recent advances that shed light on the residues involved, the identity of the kinases that phosphorylate them, and the interactions that become disrupted by these phosphorylations...
  37. pmc Multiple functions of the integrin alpha6beta4 in epidermal homeostasis and tumorigenesis
    Kevin Wilhelmsen
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cell Biol 26:2877-86. 2006
  38. ncbi request reprint Integrin alpha v beta 3 controls activity and oncogenic potential of primed c-Src
    Stephan Huveneers
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Cancer Res 67:2693-700. 2007
    ..These findings delineate a novel integrin-controlled oncogenic signaling cascade and suggest that the interaction of alpha(v)beta(3) with c-Src may represent a novel target for therapeutic intervention...
  39. doi request reprint Mechanisms of integrin activation and trafficking
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Curr Opin Cell Biol 23:607-14. 2011
    ..Integrin trafficking is strongly regulated by their cytoplasmic tails, and the mechanisms are now being identified...
  40. doi request reprint Cell-matrix adhesion of podocytes in physiology and disease
    Norman Sachs
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Nat Rev Nephrol 9:200-10. 2013
    ..This Review highlights recent advances in our understanding of the cell biology and genetics of podocyte adhesion with special emphasis on glomerular disease...
  41. doi request reprint Nesprin-3: a versatile connector between the nucleus and the cytoskeleton
    Mirjam Ketema
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Biochem Soc Trans 39:1719-24. 2011
    ..We suggest that it helps to stabilize the anchorage of the nucleus within the cytoplasm and maintain the structural integrity and shape of the nucleus...
  42. doi request reprint Unique and redundant functions of integrins in the epidermis
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    FASEB J 24:4133-52. 2010
    ..Furthermore, we discuss human pathologies associated with altered integrin functions in the epidermis...
  43. pmc Integrin-TGF-beta crosstalk in fibrosis, cancer and wound healing
    Coert Margadant
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO Rep 11:97-105. 2010
    ....
  44. ncbi request reprint Integrins in regulation of tissue development and function
    Erik H J Danen
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Pathol 200:471-80. 2003
    ..In this review we briefly explain how integrins can affect so many different aspects of cell behavior and discuss evidence for roles of integrins in tissue development, function, and disease...
  45. ncbi request reprint The structure of a tandem pair of spectrin repeats of plectin reveals a modular organization of the plakin domain
    Arnoud Sonnenberg
    Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Mol Biol 368:1379-91. 2007
    ....
  46. pmc Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits
    Arjan van der Flier
    Netherlands Cancer Institute, Division of Cell Biology, 1066 CX Amsterdams, Netherlands
    J Cell Biol 156:361-76. 2002
    ..These findings suggest that specific combinations of filamin mRNA splicing events modulate the organization of the actin cytoskeleton and the binding affinity for integrins...
  47. ncbi request reprint KASH-domain proteins in nuclear migration, anchorage and other processes
    Kevin Wilhelmsen
    Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Cell Sci 119:5021-9. 2006
    ..The complex thus formed is responsible not only for association with cytoplasmic elements but also for the integrity of the NE itself...
  48. doi request reprint Integrins uncouple Src-induced morphological and oncogenic transformation
    Stephan Huveneers
    Division of Toxicology, Leiden Amsterdam Center for Drug Research, Leiden University, 2300 RA Leiden, The Netherlands
    J Biol Chem 283:13243-51. 2008
    ..Thus, integrins regulate Src-mediated oncogenic transformation and various aspects of morphological transformation through dissociable pathways...
  49. pmc Interaction of the bullous pemphigoid antigen 1 (BP230) and desmoplakin with intermediate filaments is mediated by distinct sequences within their COOH terminus
    Lionel Fontao
    Department of Dermatology, University Hospital, Geneva, Switzerland CH 1211
    Mol Biol Cell 14:1978-92. 2003
    ....
  50. ncbi request reprint Knock-in of integrin beta 1D affects primary but not secondary myogenesis in mice
    Ana Sofia Cachaço
    Department of Animal Biology and Centre for Environmental Biology, Faculty of Sciences, University of Lisbon, 1749 016 Lisbon, Portugal
    Development 130:1659-71. 2003
    ..Together these results demonstrate for the first time distinct roles for beta1 integrins in primary versus secondary myogenesis and that the beta 1A and beta 1D variants are not functionally equivalent in this process...
  51. ncbi request reprint The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins
    Yves Gontier
    Department of Dermatology, University Hospital, HUG, Rue Micheli du Crest 24, 1211 Geneva 14 Switzerland
    J Cell Sci 118:3739-49. 2005
    ..These data shed new light on the complex organization of the Z-disc that is highly relevant to understanding muscular dystrophies...
  52. ncbi request reprint Laminin alpha1 chain mediated reduction of laminin alpha2 chain deficient muscular dystrophy involves integrin alpha7beta1 and dystroglycan
    Kinga I Gawlik
    Department of Experimental Medical Science, Division for Cell and Matrix Biology, University of Lund, BMC B12 221 84 Lund, Sweden
    FEBS Lett 580:1759-65. 2006
    ..We suggest that LNalpha1 chain in part ameliorates the development of LNalpha2 chain deficient muscular dystrophy by retaining the binding sites for integrin alpha7Bbeta1D and alpha-dystroglycan, respectively...
  53. ncbi request reprint The cAMP-Epac-Rap1 pathway regulates cell spreading and cell adhesion to laminin-5 through the alpha3beta1 integrin but not the alpha6beta4 integrin
    Jorrit M Enserink
    Biotechnology Centre of Oslo, University of Oslo, Blindern, N 0317 Oslo, Norway
    J Biol Chem 279:44889-96. 2004
    ..They also define different roles for the laminin-binding integrins in regulated cell adhesion and subsequent cell spreading...
  54. doi request reprint Binding of soluble fibronectin to integrin alpha5 beta1 - link to focal adhesion redistribution and contractile shape
    Stephan Huveneers
    Division of Toxicology, Leiden Amsterdam Center for Drug Research, Einsteinweg 55, Leiden University, Leiden CC, The Netherlands
    J Cell Sci 121:2452-62. 2008
    ....
  55. pmc Opposing roles of integrin alpha6Abeta1 and dystroglycan in laminin-mediated extracellular signal-regulated kinase activation
    Maria Ferletta
    Department of Cell and Molecular Biology, Lund University, Sweden
    Mol Biol Cell 14:2088-103. 2003
    ..We conclude that laminin-1 and -10/11 share the ability to induce ERK activation, that this is regulated by integrin alpha6Abeta1, and suggest a novel role for dystroglycan-binding laminin domains as suppressors of this activation...
  56. pmc Expression of alpha7beta1 integrin splicing variants during skeletal muscle regeneration
    Minna Kääriäinen
    Medical School and the Institute of Medical Technology, University of Tampere, Finland
    Am J Pathol 161:1023-31. 2002
    ..alpha7A and alpha7X1 appear to have a specific role during the dynamic phase of adhesion, whereas alpha7B, alpha7X2, and beta1D predominate during stable adhesion...
  57. ncbi request reprint The PDZ domain of TIP-2/GIPC interacts with the C-terminus of the integrin alpha5 and alpha6 subunits
    Haquima El Mourabit
    Institute for Biochemistry II, Medical Faculty, University of Cologne, Joseph Stelzmann Str 52, 50931 Cologne, Germany
    Matrix Biol 21:207-14. 2002
    ..The integrin alpha6B subunit terminates with a different sequence, SYS, which may represent a new PDZ domain-binding motif...
  58. ncbi request reprint Interaction of filamin A with the integrin beta 7 cytoplasmic domain: role of alternative splicing and phosphorylation
    Mark A Travis
    School of Biological Sciences, 2 205 Stopford Building, Wellcome Trust Centre for Cell Matrix Research, University of Manchester, The Michael Smith Building, Oxford Road, Manchester M13 9PT, UK
    FEBS Lett 569:185-90. 2004
    ..In addition, we provide evidence that phosphorylation of the splice variant region is unlikely to represent the mechanism by which binding is reduced...