Nicola S Russell

Summary

Affiliation: The Netherlands Cancer Institute
Country: The Netherlands

Publications

  1. doi request reprint Novel insights into pathological changes in muscular arteries of radiotherapy patients
    Nicola S Russell
    Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 92:477-83. 2009
  2. pmc The spectrum of ATM missense variants and their contribution to contralateral breast cancer
    Annegien Broeks
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Breast Cancer Res Treat 107:243-8. 2008
  3. doi request reprint Irradiation induces different inflammatory and thrombotic responses in carotid arteries of wildtype C57BL/6J and atherosclerosis-prone ApoE(-/-) mice
    Saske Hoving
    The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 105:365-70. 2012
  4. doi request reprint Anti-inflammatory and anti-thrombotic intervention strategies using atorvastatin, clopidogrel and knock-down of CD40L do not modify radiation-induced atherosclerosis in ApoE null mice
    Saske Hoving
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 101:100-8. 2011
  5. doi request reprint Endoglin haploinsufficiency reduces radiation-induced fibrosis and telangiectasia formation in mouse kidneys
    Marion Scharpfenecker
    Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 92:484-91. 2009
  6. pmc Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study
    Annegien Broeks
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Breast Cancer Res 9:R26. 2007
  7. doi request reprint Radiation-associated breast tumors display a distinct gene expression profile
    Annegien Broeks
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 76:540-7. 2010
  8. doi request reprint ALK1 heterozygosity delays development of late normal tissue damage in the irradiated mouse kidney
    Marion Scharpfenecker
    Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 99:349-55. 2011
  9. pmc NO-donating aspirin and aspirin partially inhibit age-related atherosclerosis but not radiation-induced atherosclerosis in ApoE null mice
    Saske Hoving
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS ONE 5:e12874. 2010
  10. doi request reprint The TGF-β co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney
    Marion Scharpfenecker
    Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 105:313-20. 2012

Collaborators

Detail Information

Publications26

  1. doi request reprint Novel insights into pathological changes in muscular arteries of radiotherapy patients
    Nicola S Russell
    Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 92:477-83. 2009
    ..This study evaluates the nature of underlying pathologic changes occurring in medium-sized muscular arteries following irradiation...
  2. pmc The spectrum of ATM missense variants and their contribution to contralateral breast cancer
    Annegien Broeks
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Breast Cancer Res Treat 107:243-8. 2008
    ..029). Our results indicate that the presence of ATM variants does not have a major impact on the overall risk of CBC. However, the combination of RT and (certain) ATM missense variants seems to accelerate tumour development...
  3. doi request reprint Irradiation induces different inflammatory and thrombotic responses in carotid arteries of wildtype C57BL/6J and atherosclerosis-prone ApoE(-/-) mice
    Saske Hoving
    The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 105:365-70. 2012
    ..We now investigated the mechanism underlying the development of radiation-induced atherosclerosis...
  4. doi request reprint Anti-inflammatory and anti-thrombotic intervention strategies using atorvastatin, clopidogrel and knock-down of CD40L do not modify radiation-induced atherosclerosis in ApoE null mice
    Saske Hoving
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 101:100-8. 2011
    ..In this study we investigated the potential of anti-inflammatory (atorvastatin, CD40L knockout) and anti-thrombotic (clopidogrel) intervention strategies to inhibit radiation-induced atherosclerosis...
  5. doi request reprint Endoglin haploinsufficiency reduces radiation-induced fibrosis and telangiectasia formation in mouse kidneys
    Marion Scharpfenecker
    Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 92:484-91. 2009
    ..If located in the mucosa, irradiation-induced telangiectasia can lead to severe bleeding. Therefore, this study was aimed at investigating the role of endoglin in radiation-induced telangiectasia formation...
  6. pmc Identification of women with an increased risk of developing radiation-induced breast cancer: a case only study
    Annegien Broeks
    Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Breast Cancer Res 9:R26. 2007
    ..Radiation exposure at a young age is one of the strongest risk factors for breast cancer. Germline mutations in genes involved in the DNA-damage repair pathway (DDRP) may render women more susceptible to radiation-induced breast cancer...
  7. doi request reprint Radiation-associated breast tumors display a distinct gene expression profile
    Annegien Broeks
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 76:540-7. 2010
    ..Approximately 90% of the breast cancers in these patients can be attributed to their radiation treatment, rendering such series extremely useful to determine whether a common radiation-associated cause underlies the carcinogenic process...
  8. doi request reprint ALK1 heterozygosity delays development of late normal tissue damage in the irradiated mouse kidney
    Marion Scharpfenecker
    Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 99:349-55. 2011
    ..This study was aimed at investigating the role of ALK1 in late radiation toxicity...
  9. pmc NO-donating aspirin and aspirin partially inhibit age-related atherosclerosis but not radiation-induced atherosclerosis in ApoE null mice
    Saske Hoving
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    PLoS ONE 5:e12874. 2010
    ..In this study we investigated the potential of anti-inflammatory and anti-coagulant intervention strategies to inhibit age-related and radiation-induced atherosclerosis...
  10. doi request reprint The TGF-β co-receptor endoglin regulates macrophage infiltration and cytokine production in the irradiated mouse kidney
    Marion Scharpfenecker
    Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Radiother Oncol 105:313-20. 2012
    ..Results from current studies suggest that this occurs via modulation of the radiation-induced inflammatory response...
  11. doi request reprint Single-dose and fractionated irradiation promote initiation and progression of atherosclerosis and induce an inflammatory plaque phenotype in ApoE(-/-) mice
    Saske Hoving
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 71:848-57. 2008
    ..Here we investigate whether clinically relevant fractionated irradiation schedules and lower single doses also predispose to an inflammatory plaque phenotype...
  12. pmc Radiation- and anthracycline-induced cardiac toxicity and the influence of ErbB2 blocking agents
    Ingar Seemann
    Division of Biological Stress Response H3, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Breast Cancer Res Treat 141:385-95. 2013
    ..Lapatinib did not enhance the risk of radiation or anthracycline-induced cardiac toxicity in mice up to 40 weeks after treatment, but mitochondrial damage was more severe after doxorubicin combined with lapatinib. ..
  13. ncbi request reprint Accurate axillary lymph node dissection is feasible after neoadjuvant chemotherapy
    Marieke E Straver
    Department of Surgery, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Am J Surg 198:46-50. 2009
    ..Recently, lower axillary lymph node retrieval after neoadjuvant chemotherapy was reported. We did not have this experience, and retrospectively analyzed our axillary lymph node dissections (ALNDs)...
  14. doi request reprint Ionizing radiation shifts the PAI-1/ID-1 balance and activates notch signaling in endothelial cells
    Marion Scharpfenecker
    Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 73:506-13. 2009
    ..To investigate the mechanism of such capillary damage, we studied the effect of TGF-beta and Notch signaling in microvascular endothelial cells...
  15. doi request reprint Lymphatic drainage patterns in breast cancer patients who previously underwent mantle field radiation
    Iris M C van der Ploeg
    Department of Surgery, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Ann Surg Oncol 16:2295-9. 2009
    ..The aim of this study was to determine the lymphatic drainage patterns in breast cancer patients who had undergone mantle field radiation for Hodgkin's lymphoma in the past...
  16. doi request reprint Detection of extra-axillary lymph node involvement with FDG PET/CT in patients with stage II-III breast cancer
    Tjeerd S Aukema
    Department of Nuclear Medicine, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Eur J Cancer 46:3205-10. 2010
    ..The aim of this prospective study was to assess the incidence of extra-axillary lymph node involvement on baseline FDG PET/CT in patients with stage II-III breast cancer scheduled for neo-adjuvant chemotherapy...
  17. ncbi request reprint Thalidomide ameliorates inflammation and vascular injury but aggravates tubular damage in the irradiated mouse kidney
    Marion Scharpfenecker
    Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands Electronic address
    Int J Radiat Oncol Biol Phys 89:599-606. 2014
    ..We therefore treated kidney-irradiated mice with the anti-inflammatory and angiogenesis-modulating drug thalidomide in an attempt to prevent the development of late normal tissue damage and radiation nephropathy in the mouse kidney...
  18. doi request reprint Clinical results of image-guided deep inspiration breath hold breast irradiation
    Gerben R Borst
    Department of Radiation Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Int J Radiat Oncol Biol Phys 78:1345-51. 2010
    ....
  19. doi request reprint Endoglin haploinsufficiency attenuates radiation-induced deterioration of kidney function in mice
    Marion Scharpfenecker
    Division of Biological Stress Response, The Netherlands Cancer Institute, Amsterdam, The Netherlands Electronic address
    Radiother Oncol 108:464-8. 2013
    ..This study was aimed at investigating whether reduced tissue damage in Eng(+/-) mice also results in superior kidney function...
  20. ncbi request reprint Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's disease
    Flora E van Leeuwen
    Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Natl Cancer Inst 95:971-80. 2003
    ..Female survivors of Hodgkin's disease (HD) have a strongly elevated risk of breast cancer, but factors responsible for the increased risk are not well known...
  21. ncbi request reprint Excess risk for contralateral breast cancer in CHEK2*1100delC germline mutation carriers
    Annegien Broeks
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam
    Breast Cancer Res Treat 83:91-3. 2004
    ..These results warrant prolonged medical surveillance and may indicate a clinically important interaction between CHEK2 heterozygosity and radiation in the development of contralateral breast cancer...
  22. ncbi request reprint Sophisticated radiotherapy with optimal surgery is the way forward
    Nicola S Russell
    Department of Radiotherapy, The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Curr Opin Oncol 16:529-35. 2004
    ..This review assesses the most recent evidence generated by clinical scientists in the field of radiotherapy for breast cancer...
  23. pmc Ionizing radiation accelerates the development of atherosclerotic lesions in ApoE-/- mice and predisposes to an inflammatory plaque phenotype prone to hemorrhage
    Fiona Anne Stewart
    Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Am J Pathol 168:649-58. 2006
    ..Based on these data, we propose that irradiation accelerates the development of macrophage-rich, inflammatory atherosclerotic lesions prone to intraplaque hemorrhage...
  24. doi request reprint Effects of lycopene on the insulin-like growth factor (IGF) system in premenopausal breast cancer survivors and women at high familial breast cancer risk
    Dorien W Voskuil
    Division of Experimental Therapy and the Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Nutr Cancer 60:342-53. 2008
    ..However, lycopene effects were discordant between the 2 study populations showing beneficial effects in high-risk healthy women but not in breast cancer survivors...
  25. doi request reprint Radiation-induced activation of TGF-beta signaling pathways in relation to vascular damage in mouse kidneys
    Jacqueline J C M Kruse
    Division of Experimental Therapy, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Radiat Res 171:188-97. 2009
    ..We hypothesize that prolonged activation of ALK5 signaling and relative suppression of ALK1 signaling may provide an explanation for the telangiectatic phenotype observed in irradiated kidneys...
  26. ncbi request reprint A comparison in cosmetic outcome between per-operative interstitial breast implants and delayed interstitial breast implants after external beam radiotherapy
    Bradley R Pieters
    The Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Radiother Oncol 67:159-64. 2003
    ..Differences in cosmetic outcome were investigated...