Sebastian M B Nijman

Summary

Affiliation: The Netherlands Cancer Institute
Country: The Netherlands

Publications

  1. ncbi request reprint A genomic and functional inventory of deubiquitinating enzymes
    Sebastian M B Nijman
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cell 123:773-86. 2005
  2. ncbi request reprint The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway
    Sebastian M B Nijman
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cell 17:331-9. 2005
  3. ncbi request reprint Functional annotation of deubiquitinating enzymes using RNA interference
    Annette M G Dirac
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Methods Enzymol 398:554-67. 2005
  4. ncbi request reprint Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
    Thijn R Brummelkamp
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nature 424:797-801. 2003
  5. ncbi request reprint A functional genetic screen identifies TFE3 as a gene that confers resistance to the anti-proliferative effects of the retinoblastoma protein and transforming growth factor-beta
    Sebastian M B Nijman
    Division of Molecular Carcinogenesis and Centre for Biomedical Genetics, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 281:21582-7. 2006
  6. ncbi request reprint Regulation of monoubiquitinated PCNA by DUB autocleavage
    Tony T Huang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 8:339-47. 2006

Collaborators

Detail Information

Publications6

  1. ncbi request reprint A genomic and functional inventory of deubiquitinating enzymes
    Sebastian M B Nijman
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cell 123:773-86. 2005
    ..In addition, we review the literature concerning these enzymes, with particular emphasis on their function, specificity, and the regulation of their activity...
  2. ncbi request reprint The deubiquitinating enzyme USP1 regulates the Fanconi anemia pathway
    Sebastian M B Nijman
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Mol Cell 17:331-9. 2005
    ..We propose that USP1 deubiquitinates FANCD2 when cells exit S phase or recommence cycling after a DNA damage insult and may play a critical role in the FA pathway by recycling FANCD2...
  3. ncbi request reprint Functional annotation of deubiquitinating enzymes using RNA interference
    Annette M G Dirac
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    Methods Enzymol 398:554-67. 2005
    ..This chapter describes how RNA interference against deubiquitinating enzymes can be used to elucidate their function. The application of this technology will greatly improve the functional annotation of this family of proteases...
  4. ncbi request reprint Loss of the cylindromatosis tumour suppressor inhibits apoptosis by activating NF-kappaB
    Thijn R Brummelkamp
    Division of Molecular Carcinogenesis and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Nature 424:797-801. 2003
    ..We show that this effect can be relieved by aspirin derivatives that inhibit NF-kappaB activity, which suggests a therapeutic intervention strategy to restore growth control in patients suffering from familial cylindromatosis...
  5. ncbi request reprint A functional genetic screen identifies TFE3 as a gene that confers resistance to the anti-proliferative effects of the retinoblastoma protein and transforming growth factor-beta
    Sebastian M B Nijman
    Division of Molecular Carcinogenesis and Centre for Biomedical Genetics, The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 281:21582-7. 2006
    ..These observations establish TFE3 as a functional regulator of proliferation and offer a potential mechanism for its involvement in cancer...
  6. ncbi request reprint Regulation of monoubiquitinated PCNA by DUB autocleavage
    Tony T Huang
    Department of Radiation Oncology, Dana Farber Cancer Institute, Harvard Medical School, Boston, MA 02115, USA
    Nat Cell Biol 8:339-47. 2006
    ..Our results define a regulatory mechanism for protein ubiquitination that involves the signal-induced degradation of an inhibitory DUB...