Marie Jose Goumans

Summary

Affiliation: The Netherlands Cancer Institute
Country: The Netherlands

Publications

  1. ncbi request reprint Controlling the angiogenic switch: a balance between two distinct TGF-b receptor signaling pathways
    Marie Jose Goumans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Trends Cardiovasc Med 13:301-7. 2003
  2. ncbi request reprint Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells
    Gudrun Valdimarsdottir
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Circulation 106:2263-70. 2002
  3. pmc Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
    Marie Jose Goumans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO J 21:1743-53. 2002
  4. ncbi request reprint Controlling cell fate by bone morphogenetic protein receptors
    Peter Ten Dijke
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
    Mol Cell Endocrinol 211:105-13. 2003
  5. pmc Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells
    Fumiko Itoh
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam
    EMBO J 23:541-51. 2004
  6. pmc Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction
    Franck Lebrin
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands
    EMBO J 23:4018-28. 2004
  7. ncbi request reprint Regulation of cell proliferation by Smad proteins
    Peter Ten Dijke
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Cell Physiol 191:1-16. 2002
  8. ncbi request reprint Transforming growth factor beta signal transduction
    Sylviane Dennler
    Division of Cellular Biochemistry H3, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Leukoc Biol 71:731-40. 2002
  9. ncbi request reprint Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling
    Marie Jose Goumans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Mol Cell 12:817-28. 2003
  10. ncbi request reprint Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice
    Rita L C Carvalho
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    J Cell Sci 120:4269-77. 2007

Collaborators

Detail Information

Publications10

  1. ncbi request reprint Controlling the angiogenic switch: a balance between two distinct TGF-b receptor signaling pathways
    Marie Jose Goumans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Trends Cardiovasc Med 13:301-7. 2003
    ..This review describes the role of TGF-beta in angiogenesis and some of the controversial issues concerning TGF-beta signaling through ALK1 and ALK5 in ECs...
  2. ncbi request reprint Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells
    Gudrun Valdimarsdottir
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Circulation 106:2263-70. 2002
    ..In the present study, we investigated BMP receptor/Smad expression and signaling in endothelial cells (ECs) and examined the effects of BMP on EC behavior...
  3. pmc Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
    Marie Jose Goumans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO J 21:1743-53. 2002
    ..Our results suggest that TGF-beta regulates the activation state of the endothelium via a fine balance between ALK5 and ALK1 signalling...
  4. ncbi request reprint Controlling cell fate by bone morphogenetic protein receptors
    Peter Ten Dijke
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
    Mol Cell Endocrinol 211:105-13. 2003
    ..Furthermore, recent studies reveal an important effector function for Id1 in various BMP-induced biological responses...
  5. pmc Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells
    Fumiko Itoh
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam
    EMBO J 23:541-51. 2004
    ..Our results support the notion that Herp2 functions as a critical switch downstream of Notch and BMP receptor signaling pathways in ECs...
  6. pmc Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction
    Franck Lebrin
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands
    EMBO J 23:4018-28. 2004
    ..Our results indicate a pivotal role for endoglin in the balance of ALK1 and ALK5 signalling to regulate endothelial cell proliferation...
  7. ncbi request reprint Regulation of cell proliferation by Smad proteins
    Peter Ten Dijke
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Cell Physiol 191:1-16. 2002
    ..Interestingly, TGF-beta may mediate these effects directly on tumor cells via subverted Smad-dependent and/or Smad-independent pathways...
  8. ncbi request reprint Transforming growth factor beta signal transduction
    Sylviane Dennler
    Division of Cellular Biochemistry H3, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Leukoc Biol 71:731-40. 2002
    ..Recent data support the notion that Smads are important intracellular effectors of TGF-beta in immune cells. Here, we review recent advances in TGF-beta signal transduction in immune cells...
  9. ncbi request reprint Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling
    Marie Jose Goumans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Mol Cell 12:817-28. 2003
    ..TGFbeta type II receptor is also required for ALK1 activation by TGFbeta. Interestingly, ALK1 not only induces a biological response opposite to that of ALK5 but also directly antagonizes ALK5/Smad signaling...
  10. ncbi request reprint Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice
    Rita L C Carvalho
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    J Cell Sci 120:4269-77. 2007
    ..Together, the data show that ALK5 is required in ECs and VSMCs for yolk sac vasculogenesis; in the absence of ALK5, ALK4 mediates SMAD2 phosphorylation and consequently SMAalpha expression...