Marie Jose Goumans

Summary

Affiliation: The Netherlands Cancer Institute
Country: The Netherlands

Publications

  1. ncbi Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice
    M J Goumans
    Netherlands Institute for Developmental Biology, Utrecht
    Int J Dev Biol 44:253-65. 2000
  2. ncbi Identification of two distinct functions for TGF-beta in early mouse development
    B A Roelen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
    Differentiation 64:19-31. 1998
  3. pmc Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
    Marie Jose Goumans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO J 21:1743-53. 2002
  4. ncbi Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells
    Gudrun Valdimarsdottir
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Circulation 106:2263-70. 2002
  5. ncbi Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia
    Rita L C Carvalho
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Development 131:6237-47. 2004
  6. ncbi Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling
    Marie Jose Goumans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Mol Cell 12:817-28. 2003
  7. pmc Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells
    Fumiko Itoh
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam
    EMBO J 23:541-51. 2004
  8. ncbi Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice
    Rita L C Carvalho
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    J Cell Sci 120:4269-77. 2007
  9. doi MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells
    Joost P G Sluijter
    University Medical Center Utrecht, Department of Cardiology, Division of Heart and Lungs, Heidelberglaan 100, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 30:859-68. 2010
  10. pmc Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction
    Franck Lebrin
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands
    EMBO J 23:4018-28. 2004

Collaborators

Detail Information

Publications32

  1. ncbi Functional analysis of the TGFbeta receptor/Smad pathway through gene ablation in mice
    M J Goumans
    Netherlands Institute for Developmental Biology, Utrecht
    Int J Dev Biol 44:253-65. 2000
    ..Further analyses of these mice should provide a clearer understanding of the mechanism of TGFbeta action in vascular development and remodelling...
  2. ncbi Identification of two distinct functions for TGF-beta in early mouse development
    B A Roelen
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Utrecht, The Netherlands
    Differentiation 64:19-31. 1998
    ....
  3. pmc Balancing the activation state of the endothelium via two distinct TGF-beta type I receptors
    Marie Jose Goumans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    EMBO J 21:1743-53. 2002
    ..Our results suggest that TGF-beta regulates the activation state of the endothelium via a fine balance between ALK5 and ALK1 signalling...
  4. ncbi Stimulation of Id1 expression by bone morphogenetic protein is sufficient and necessary for bone morphogenetic protein-induced activation of endothelial cells
    Gudrun Valdimarsdottir
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Circulation 106:2263-70. 2002
    ..In the present study, we investigated BMP receptor/Smad expression and signaling in endothelial cells (ECs) and examined the effects of BMP on EC behavior...
  5. ncbi Defective paracrine signalling by TGFbeta in yolk sac vasculature of endoglin mutant mice: a paradigm for hereditary haemorrhagic telangiectasia
    Rita L C Carvalho
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    Development 131:6237-47. 2004
    ....
  6. ncbi Activin receptor-like kinase (ALK)1 is an antagonistic mediator of lateral TGFbeta/ALK5 signaling
    Marie Jose Goumans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Mol Cell 12:817-28. 2003
    ..TGFbeta type II receptor is also required for ALK1 activation by TGFbeta. Interestingly, ALK1 not only induces a biological response opposite to that of ALK5 but also directly antagonizes ALK5/Smad signaling...
  7. pmc Synergy and antagonism between Notch and BMP receptor signaling pathways in endothelial cells
    Fumiko Itoh
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam
    EMBO J 23:541-51. 2004
    ..Our results support the notion that Herp2 functions as a critical switch downstream of Notch and BMP receptor signaling pathways in ECs...
  8. ncbi Compensatory signalling induced in the yolk sac vasculature by deletion of TGFbeta receptors in mice
    Rita L C Carvalho
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584CT Utrecht, The Netherlands
    J Cell Sci 120:4269-77. 2007
    ..Together, the data show that ALK5 is required in ECs and VSMCs for yolk sac vasculogenesis; in the absence of ALK5, ALK4 mediates SMAD2 phosphorylation and consequently SMAalpha expression...
  9. doi MicroRNA-1 and -499 regulate differentiation and proliferation in human-derived cardiomyocyte progenitor cells
    Joost P G Sluijter
    University Medical Center Utrecht, Department of Cardiology, Division of Heart and Lungs, Heidelberglaan 100, Utrecht, The Netherlands
    Arterioscler Thromb Vasc Biol 30:859-68. 2010
    ..We hypothesize that miRNAs are also involved in proliferation/differentiation of the human CMPCs in vitro...
  10. pmc Endoglin promotes endothelial cell proliferation and TGF-beta/ALK1 signal transduction
    Franck Lebrin
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan, Amsterdam, The Netherlands
    EMBO J 23:4018-28. 2004
    ..Our results indicate a pivotal role for endoglin in the balance of ALK1 and ALK5 signalling to regulate endothelial cell proliferation...
  11. ncbi Controlling cell fate by bone morphogenetic protein receptors
    Peter Ten Dijke
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Plesmanlaan 121, Amsterdam 1066 CX, The Netherlands
    Mol Cell Endocrinol 211:105-13. 2003
    ..Furthermore, recent studies reveal an important effector function for Id1 in various BMP-induced biological responses...
  12. ncbi Isolation and expansion of resident cardiac progenitor cells
    Patrick van Vliet
    The Interuniversity Cardiology Institute of The Netherlands, Utrecht, The Netherlands
    Expert Rev Cardiovasc Ther 5:33-43. 2007
    ....
  13. ncbi Endoglin has a crucial role in blood cell-mediated vascular repair
    Linda W Van Laake
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Circulation 114:2288-97. 2006
    ..Although haploinsufficiency is the underlying cause of the disease, HHT1 individuals show great heterogeneity in age of onset, clinical manifestations, and severity...
  14. ncbi The role of stem cells in cardiac regeneration
    Anke M Smits
    Laboratory of Experimental Cardiology, Department of Cardiology, Heart Lung Center, Utrecht, The Netherlands
    J Cell Mol Med 9:25-36. 2005
    ..Here we discuss the potential of the different cell populations and their usefulness in stem cell based therapy to repair the damaged heart...
  15. doi Foetal and adult cardiomyocyte progenitor cells have different developmental potential
    Patrick van Vliet
    Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cell Mol Med 14:861-70. 2010
    ..The potential of adult CMPCs to form mature cardiomyocytes and smooth muscle cells may be essential for cardiac repair after transplantation into the injured heart...
  16. ncbi Regulation of cell proliferation by Smad proteins
    Peter Ten Dijke
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    J Cell Physiol 191:1-16. 2002
    ..Interestingly, TGF-beta may mediate these effects directly on tumor cells via subverted Smad-dependent and/or Smad-independent pathways...
  17. doi Impaired recruitment of HHT-1 mononuclear cells to the ischaemic heart is due to an altered CXCR4/CD26 balance
    Simone Post
    Department of Cardiology, Division Heart and Lung, UMCU, Utrecht, The Netherlands
    Cardiovasc Res 85:494-502. 2010
    ..Stromal cell-derived factor-1alpha (SDF-1alpha) and the chemokine receptor CXCR4 are crucial for homing and negatively influenced by CD26. The aim of this study was to gain insight into the impaired homing of HHT1-MNCs...
  18. doi MicroRNA-1 enhances the angiogenic differentiation of human cardiomyocyte progenitor cells
    Alain van Mil
    Department of Cardiology, Division of Heart and Lungs, University Medical Center Utrecht, Heidelberglaan 100, Room G02 523, 3584 CX, Utrecht, The Netherlands
    J Mol Med (Berl) 91:1001-12. 2013
    ....
  19. ncbi Controlling the angiogenic switch: a balance between two distinct TGF-b receptor signaling pathways
    Marie Jose Goumans
    Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Trends Cardiovasc Med 13:301-7. 2003
    ..This review describes the role of TGF-beta in angiogenesis and some of the controversial issues concerning TGF-beta signaling through ALK1 and ALK5 in ECs...
  20. ncbi Hyperpolarization induces differentiation in human cardiomyocyte progenitor cells
    Patrick van Vliet
    Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, P O Box 85500, 3508 GA, Utrecht, The Netherlands
    Stem Cell Rev 6:178-85. 2010
    ..Thus, hyperpolarization is sufficient to induce differentiation of CMPCs, thereby revealing a novel mechanism for cardiomyogenic differentiation of heart-derived progenitor cells...
  21. doi Human cardiomyocyte progenitor cell transplantation preserves long-term function of the infarcted mouse myocardium
    Anke M Smits
    Department of Cardiology, University Medical Center, Utrecht, The Netherlands
    Cardiovasc Res 83:527-35. 2009
    ..We investigated whether CMPCs or pre-differentiated CMPC-derived cardiomyocytes (CMPC-CM) are able to restore the injured myocardium after MI in mice...
  22. ncbi Involvement of furin-like proprotein convertases in the arterial response to injury
    Joost P G Sluijter
    Experimental Cardiology Laboratory, University Medical Center Utrecht, Utrecht, The Netherlands
    Cardiovasc Res 68:136-43. 2005
    ..We also investigated the effect of an inhibitor of furin-like PCs, alpha1-antitrypsin Portland (alpha1-PDX), on arterial injury following balloon dilation...
  23. ncbi Transforming growth factor beta signal transduction
    Sylviane Dennler
    Division of Cellular Biochemistry H3, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Leukoc Biol 71:731-40. 2002
    ..Recent data support the notion that Smads are important intracellular effectors of TGF-beta in immune cells. Here, we review recent advances in TGF-beta signal transduction in immune cells...
  24. ncbi Toll-like receptor 4 mediates maladaptive left ventricular remodeling and impairs cardiac function after myocardial infarction
    Leo Timmers
    Department of Cardiology, University Medical Center, Utrecht, The Netherlands
    Circ Res 102:257-64. 2008
    ..TLR4 may therefore constitute a novel target in the treatment of ischemic heart failure...
  25. doi Human cardiomyocyte progenitor cells: a short history of nearly everything
    Patrick van Vliet
    Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, The Netherlands
    J Cell Mol Med 16:1669-73. 2012
    ..Here, we aim to provide a comprehensive summary of the past findings and present challenges for future therapeutic potential of CMPCs...
  26. pmc Modulation of TGF-β/BMP-6 expression and increased levels of circulating smooth muscle progenitor cells in a type I diabetes mouse model
    Peter E Westerweel
    Department of Nephrology and Hypertension, University Medical Center Utrecht, Utrecht, The Netherlands
    Cardiovasc Diabetol 9:55. 2010
    ..We hypothesized that SPC differentiation would be increased in diabetes and focused on modulation of TGF-β/BMP-6 signaling as potential underlying mechanism...
  27. doi Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology
    Anke M Smits
    Department of Cardiology, University Medical Center Utrecht, PO Box 85500, 3508 GA, Utrecht, The Netherlands
    Nat Protoc 4:232-43. 2009
    ..Once CMPCs are rapidly dividing ( approximately 1 month after isolation), differentiation can be achieved in 3-4 weeks...
  28. ncbi TGF-beta1 induces efficient differentiation of human cardiomyocyte progenitor cells into functional cardiomyocytes in vitro
    Marie Jose Goumans
    Laboratory of Experimental Cardiology, Department of Cardiology, Division of Heart and Lung, University Medical Center, Heidelberglaan 100, Utrecht, The Netherlands
    Stem Cell Res 1:138-49. 2007
    ..Their scalability and homogeneity are unique and provide an excellent basis for developing physiological, pharmacological, and toxicological assays on human heart cells in vitro...
  29. ncbi Distribution of phosphorylated Smad2 identifies target tissues of TGF beta ligands in mouse development
    Susana M Chuva de Sousa Lopes
    Hubrecht Laboratory, Netherlands Institute for Developmental Biology, Uppsalalaan 8, 3584 CT Utrecht, The Netherlands
    Gene Expr Patterns 3:355-60. 2003
    ..5 these cells were stained. These data document the cells that may have received a TGF beta-like stimulus and illustrate, for the first time, the dynamic regulation in space and time of phosphorylated Smad2 during mouse development...
  30. doi Balance between angiopoietin-1 and angiopoietin-2 is in favor of angiopoietin-2 in atherosclerotic plaques with high microvessel density
    Simone Post
    University Medical Center, Utrecht, The Netherlands
    J Vasc Res 45:244-50. 2008
    ..Ang-1 induces formation of stable vessels, whereas Ang-2 destabilizes the interaction between endothelial cells and their support cells. We studied the expression patterns of Ang-1 and -2 in relation to plaque microvessels...
  31. doi Low oxygen tension positively influences cardiomyocyte progenitor cell function
    Angelique A M Van Oorschot
    Department of Molecular Cell Biology and Center for Biomedical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    J Cell Mol Med 15:2723-34. 2011
    ..In conclusion, short exposure to hypoxia increases migratory and invasive capacities of hCMPCs and prolonged exposure induces proliferation, an angiogenic secretion profile and dampens migration, likely controlled by TSP-2...
  32. ncbi Human stem cells shape the future of cardiac regeneration research
    Rutger J Hassink
    Department of Cardio Thoracic Surgery, Heart Lung Center, Utrecht, The Netherlands
    Int J Cardiol 95:S20-2. 2004