Research Topics
Species | Annegien BroeksSummaryAffiliation: The Netherlands Cancer Institute Country: The Netherlands Publications
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Detail Information
Publications
Combined effects of single nucleotide polymorphisms TP53 R72P and MDM2 SNP309, and p53 expression on survival of breast cancer patientsMarjanka K Schmidt
Departments of Epidemiology, Experimental Therapy and Pathology, Netherlands Cancer Institute, The Netherlands
Breast Cancer Res 11:R89. 2009..We investigated the effects of the germ-line single nucleotide polymorphisms TP53 R72P (215G>C) and MDM2 SNP309 (-410T>G), and p53 protein expression in breast tumors on survival...
IVS10-6T>G, an ancient ATM germline mutation linked with breast cancerAnnegien Broeks
Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Hum Mutat 21:521-8. 2003..Our results predict that this mutation could be widely distributed across Europe and, probably, the Middle East and Western Asia...- Low penetrance breast cancer susceptibility loci are associated with specific breast tumor subtypes: findings from the Breast Cancer Association ConsortiumAnnegien Broeks
Department of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Hum Mol Genet 20:3289-303. 2011..This may eventually result in further improvements in prevention, early detection and treatment... - Identification of women with an increased risk of developing radiation-induced breast cancer: a case only studyAnnegien Broeks
Division of Experimental Therapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Breast Cancer Res 9:R26. 2007..Radiation exposure at a young age is one of the strongest risk factors for breast cancer. Germline mutations in genes involved in the DNA-damage repair pathway (DDRP) may render women more susceptible to radiation-induced breast cancer... - The spectrum of ATM missense variants and their contribution to contralateral breast cancerAnnegien Broeks
Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Breast Cancer Res Treat 107:243-8. 2008..029). Our results indicate that the presence of ATM variants does not have a major impact on the overall risk of CBC. However, the combination of RT and (certain) ATM missense variants seems to accelerate tumour development... - Excess risk for contralateral breast cancer in CHEK2*1100delC germline mutation carriersAnnegien Broeks
Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam
Breast Cancer Res Treat 83:91-3. 2004..These results warrant prolonged medical surveillance and may indicate a clinically important interaction between CHEK2 heterozygosity and radiation in the development of contralateral breast cancer... 
Radiation-associated breast tumors display a distinct gene expression profileAnnegien Broeks
Division of Experimental Therapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Int J Radiat Oncol Biol Phys 76:540-7. 2010..Approximately 90% of the breast cancers in these patients can be attributed to their radiation treatment, rendering such series extremely useful to determine whether a common radiation-associated cause underlies the carcinogenic process...- Breast cancer risk in female survivors of Hodgkin's lymphoma: lower risk after smaller radiation volumesMarie L De Bruin
Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Clin Oncol 27:4239-46. 2009..We assessed the long-term risk of breast cancer (BC) after treatment for Hodgkin's lymphoma (HL). We focused on the volume of breast tissue exposed to radiation and the influence of gonadotoxic chemotherapy (CT)... - Association of the germline TP53 R72P and MDM2 SNP309 variants with breast cancer survival in specific breast tumor subgroupsAlexandra J van den Broek
Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Breast Cancer Res Treat 130:599-608. 2011..TT-genotype HR 2.99, P = 0.06). These results indicate that common polymorphisms in specific pathways may add to the worse prognosis of patients with tumors in which these pathways are affected by somatic alterations... - Breast cancer survival and tumor characteristics in premenopausal women carrying the CHEK2*1100delC germline mutationMarjanka K Schmidt
Department of Epidemiology, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
J Clin Oncol 25:64-9. 2007.... - Do MDM2 SNP309 and TP53 R72P interact in breast cancer susceptibility? A large pooled series from the breast cancer association consortiumMarjanka K Schmidt
Netherlands Cancer Institute, Amsterdam, The Netherlands
Cancer Res 67:9584-90. 2007..This suggests that any effect of these two variants would be very small and possibly confined to subgroups that were not assessed in our present study... - The contribution of CHEK2 to the TP53-negative Li-Fraumeni phenotypeMarielle W G Ruijs
Family Cancer Clinic, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Hered Cancer Clin Pract 7:4. 2009..The prevalence of CHEK2*1100delC differs between populations and has been found to be relatively high in the Netherlands. The question remains nevertheless whether CHEK2 germline mutations contribute to the Li-Fraumeni phenotype... - Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's diseaseFlora E van Leeuwen
Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands
J Natl Cancer Inst 95:971-80. 2003..Female survivors of Hodgkin's disease (HD) have a strongly elevated risk of breast cancer, but factors responsible for the increased risk are not well known... - Are ATM mutations 7271T-->G and IVS10-6T-->G really high-risk breast cancer-susceptibility alleles?Csilla I Szabo
International Agency for Research on Cancer, Lyon, France
Cancer Res 64:840-3. 2004..008. We conclude that the ATM IVS10-6T-->G mutation does not confer a significantly elevated breast cancer risk and that ATM 7271T-->G is a rare event in familial breast cancer... - A common coding variant in CASP8 is associated with breast cancer riskAngela Cox
Sheffield University Medical School, Sheffield S10 2RX, UK
Nat Genet 39:352-8. 2007..02-1.13) and 1.16 (95% c.i.: 1.08-1.25), respectively; P(trend) = 2.8 x 10(-5)). These results demonstrate that common breast cancer susceptibility alleles with small effects on risk can be identified, given sufficiently powerful studies...