P Borst

Summary

Affiliation: The Netherlands Cancer Institute
Country: The Netherlands

Publications

  1. ncbi request reprint The multidrug resistance protein family
    P Borst
    Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands
    Biochim Biophys Acta 1461:347-57. 1999
  2. ncbi request reprint Control of VSG gene expression sites
    P Borst
    The Netherlands Cancer Institute, Division of Molecular Biology and Centre of Biomedical Genetics, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Mol Biochem Parasitol 114:17-27. 2001
  3. ncbi request reprint A family of drug transporters: the multidrug resistance-associated proteins
    P Borst
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam
    J Natl Cancer Inst 92:1295-302. 2000
  4. ncbi request reprint ABC transporters in lipid transport
    P Borst
    Division of Molecular Biology and Centre for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam
    Biochim Biophys Acta 1486:128-44. 2000
  5. pmc Altered MRP is associated with multidrug resistance and reduced drug accumulation in human SW-1573 cells
    E W Eijdems
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Br J Cancer 72:298-306. 1995
  6. ncbi request reprint Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP
    G J Zaman
    Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    FEBS Lett 391:126-30. 1996
  7. pmc Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
    J Wijnholds
    Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Clin Invest 105:279-85. 2000
  8. pmc Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport
    R Evers
    The Netherlands Cancer Institute, Division of Molecular Biology and Center for Biomedical Genetics, Amsterdam
    Br J Cancer 83:366-74. 2000
  9. pmc Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA
    R Evers
    Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Clin Invest 101:1310-9. 1998
  10. pmc MRP3, an organic anion transporter able to transport anti-cancer drugs
    M Kool
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 96:6914-9. 1999

Collaborators

Detail Information

Publications53

  1. ncbi request reprint The multidrug resistance protein family
    P Borst
    Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, Netherlands
    Biochim Biophys Acta 1461:347-57. 1999
    ....
  2. ncbi request reprint Control of VSG gene expression sites
    P Borst
    The Netherlands Cancer Institute, Division of Molecular Biology and Centre of Biomedical Genetics, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Mol Biochem Parasitol 114:17-27. 2001
    ..This review summarizes recent work on the mechanism of site switching and on the way inactive expression sites are kept silent...
  3. ncbi request reprint A family of drug transporters: the multidrug resistance-associated proteins
    P Borst
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam
    J Natl Cancer Inst 92:1295-302. 2000
    ..The physiologic functions of the other MRPs are not known. Whether long-term inhibition of MRPs in humans can be tolerated (assuming that suitable inhibitors will be found) remains to be determined...
  4. ncbi request reprint ABC transporters in lipid transport
    P Borst
    Division of Molecular Biology and Centre for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam
    Biochim Biophys Acta 1486:128-44. 2000
    ..A third example, the ABC transporter involved in the import of long-chain fatty acids into peroxisomes, is discussed in the chapter by Hettema and Tabak in this volume...
  5. pmc Altered MRP is associated with multidrug resistance and reduced drug accumulation in human SW-1573 cells
    E W Eijdems
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Br J Cancer 72:298-306. 1995
    ..This mechanism can be accompanied by other resistance mechanisms, such as reduced topo II alpha mRNA in case of doxorubicin selection...
  6. ncbi request reprint Transport of the glutathione conjugate of ethacrynic acid by the human multidrug resistance protein MRP
    G J Zaman
    Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam, The Netherlands
    FEBS Lett 391:126-30. 1996
    ..This implies that ethacrynic acid may modulate drug resistance of tumor cells not only by inhibiting glutathione S-transferase activity, but also by inhibiting the export of drug conjugates from the cell by MRP...
  7. pmc Multidrug resistance protein 1 protects the choroid plexus epithelium and contributes to the blood-cerebrospinal fluid barrier
    J Wijnholds
    Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    J Clin Invest 105:279-85. 2000
    ..Our results indicate that Mrp1 helps to limit tissue distribution of certain drugs and contributes to the blood-CSF drug-permeability barrier...
  8. pmc Inhibitory effect of the reversal agents V-104, GF120918 and Pluronic L61 on MDR1 Pgp-, MRP1- and MRP2-mediated transport
    R Evers
    The Netherlands Cancer Institute, Division of Molecular Biology and Center for Biomedical Genetics, Amsterdam
    Br J Cancer 83:366-74. 2000
    ..Unexpectedly, export of the organic anion calcein by MDCKII-MRP1 and MDCKII-MRP2 cells is stimulated by Pluronic L61, probably because it relieves the block on entry of calcein AM into the cell by endogenous MDR1 Pgp...
  9. pmc Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA
    R Evers
    Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Clin Invest 101:1310-9. 1998
    ..We conclude that cMOAT is a 5'-adenosine triphosphate binding cassette transporter that potentially might be involved in drug resistance in mammalian cells...
  10. pmc MRP3, an organic anion transporter able to transport anti-cancer drugs
    M Kool
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 96:6914-9. 1999
    ..We discuss the possible function of MRP3 in (hepatic) physiology and its potential contribution to drug resistance of cancer cells...
  11. pmc Multidrug-resistance protein 5 is a multispecific organic anion transporter able to transport nucleotide analogs
    J Wijnholds
    Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 97:7476-81. 2000
    ..We speculate that MRP5 might play a role in some cases of unexplained resistance to thiopurines in acute lymphoblastic leukemia and/or to antiretroviral nucleoside analogs in HIV-infected patients...
  12. ncbi request reprint Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines
    M Kool
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Cancer Res 57:3537-47. 1997
    ..Our results emphasize the need for gene-specific blocks in gene expression to define which transporter contributes to resistance in each resistant cell line...
  13. pmc Mice without phosphatidylcholine transfer protein have no defects in the secretion of phosphatidylcholine into bile or into lung airspaces
    A van Helvoort
    Division of Molecular Biology, Center of Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Proc Natl Acad Sci U S A 96:11501-6. 1999
    ..We discuss how PC might reach the canalicular membrane of the hepatocyte for secretion into the bile, if not by Pc-tp...
  14. pmc Normal viability and altered pharmacokinetics in mice lacking mdr1-type (drug-transporting) P-glycoproteins
    A H Schinkel
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Proc Natl Acad Sci U S A 94:4028-33. 1997
    ..mdr1a/1b (-/-) mice should provide a useful model system to further test the pharmacological roles of the drug-transporting P-gps and to analyze the specificity and effectivity of P-gp-blocking drugs...
  15. ncbi request reprint A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome
    C C Paulusma
    Department of Gastrointestinal and Liver Diseases, Center for Liver and Intestinal Research, Academic Medical Center, Amsterdam, The Netherlands
    Hepatology 25:1539-42. 1997
    ..In the present study, we have isolated the human homologue of rat cmoat, human cMOAT, and analyzed the corresponding cDNA from fibroblasts of a DJS patient for mutations. Our results show that a mutation in this gene is the cause of DJS...
  16. ncbi request reprint Characterization of drug transport by the human multidrug resistance protein 3 (ABCC3)
    N Zelcer
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 276:46400-7. 2001
    ..Even though etoposide glucuronide is an excellent substrate for MRP3, this compound is not involved in the etoposide resistance of our MRP3 cells, as these cells extrude unmodified etoposide rather than etoposide glucuronide...
  17. ncbi request reprint Transport of glutathione prostaglandin A conjugates by the multidrug resistance protein 1
    R Evers
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    FEBS Lett 419:112-6. 1997
    ..We conclude that mouse erythrocytes contain at least two transport systems for PGA2-GS. One of these is mrp1; the other one has not been identified yet, but can be inhibited by methotrexate and cAMP...
  18. pmc Biosynthesis and function of the modified DNA base beta-D-glucosyl-hydroxymethyluracil in Trypanosoma brucei
    F van Leeuwen
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Mol Cell Biol 18:5643-51. 1998
    ..We speculate that these effects are mediated by the packaging of J-containing DNA into a condensed chromatin structure...
  19. ncbi request reprint Expression of human MRP6, a homologue of the multidrug resistance protein gene MRP1, in tissues and cancer cells
    M Kool
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Cancer Res 59:175-82. 1999
    ..Our results suggest that MRP6 does not play a role in the resistance of the resistant cells analyzed, and that MRP6/ARA is only coamplified with MRP1 because of its location immediately next to it on the same chromosome...
  20. ncbi request reprint Characterization of the promoter region of the human MDR3 P-glycoprotein gene
    J J Smit
    The Netherlands Cancer Institute, Division of Molecular Biology, Amsterdam
    Biochim Biophys Acta 1261:44-56. 1995
    ..The promoter region contains several consensus sequences where known or putative liver-specific (C/EBP, HNF5) or lymphoid specific (Pu.1, ets-1) transcription factors may bind...
  21. pmc Vinblastine and sulfinpyrazone export by the multidrug resistance protein MRP2 is associated with glutathione export
    R Evers
    Division of Molecular Biology and Center of Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam
    Br J Cancer 83:375-83. 2000
    ..However, at high sulfinpyrazone concentrations this compound is transported without GSH. Models of MRP action are discussed that could explain these results...
  22. ncbi request reprint Hepatocyte-specific expression of the human MDR3 P-glycoprotein gene restores the biliary phosphatidylcholine excretion absent in Mdr2 (-/-) mice
    A J Smith
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Hepatology 28:530-6. 1998
    ..The excretion of cholesterol is not tightly coupled to the excretion of phospholipids in these mice, because a very low phospholipid excretion level is sufficient to give almost wild-type cholesterol excretion into the bile...
  23. ncbi request reprint Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene
    C C Paulusma
    Department of Gastrointestinal and Liver Diseases, Center for Liver and Intestinal Research, Academic Medical Center, Amsterdam, Netherlands
    Science 271:1126-8. 1996
    ..In the TR(-) rat, a single-nucleotide deletion in this gene resulted in a reduced messenger RNA level and absence of the protein. It is likely that this mutation accounts for the TR(-) phenotype...
  24. pmc Multidrug resistance protein 1 protects the oropharyngeal mucosal layer and the testicular tubules against drug-induced damage
    J Wijnholds
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    J Exp Med 188:797-808. 1998
    ..Our results indicate that specific inhibitors of MRP1 used to reverse MDR, in combination with carcinostatic drugs transported by MRP1, might lead to drug-induced mucositis, (temporary) infertility, and diabetes insipidus...
  25. ncbi request reprint Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies
    G L Scheffer
    Department of Pathology, Free University Hospital, Amsterdam, The Netherlands
    Cancer Res 60:5269-77. 2000
    ....
  26. ncbi request reprint Tissue distribution of the human MDR3 P-glycoprotein
    J J Smit
    The Netherlands Cancer Institute, Division of Molecular Biology, Amsterdam
    Lab Invest 71:638-49. 1994
    ..The MDR1 Pgp can transport drugs; the murine homologue of MDR3, mdr2, was recently shown by us to be involved in transport of the phospholipid phosphatidylcholine (lecithin) into bile...
  27. ncbi request reprint Multidrug resistance and the role of P-glycoprotein knockout mice
    A H Schinkel
    The Netherlands Cancer Institute, Division of Molecular Biology, Amsterdam, The Netherlands
    Eur J Cancer 31:1295-8. 1995
    ..For some drugs, this leads to dramatically increased toxicity, indicating that P-glycoprotein inhibitors should be used with caution in patients...
  28. ncbi request reprint Mice lacking the multidrug resistance protein 1 are resistant to Streptococcus pneumoniae-induced pneumonia
    M J Schultz
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol 166:4059-64. 2001
    ..We conclude that mrp1(-/-) mice are resistant against pneumococcal pneumonia by a mechanism that involves increased release of LTB(4). These results identify mrp1 as a novel target for adjunctive therapy in pneumonia...
  29. ncbi request reprint Genetic dissection of the function of mammalian P-glycoproteins
    P Borst
    The Netherlands Cancer Institute, Department of Molecular Biology, Amsterdam, The Netherlands
    Trends Genet 13:217-22. 1997
    ..Recent experiments with polarized cells support the idea that drug-transporting P-glycoproteins act by flipping drugs from the inner to the outer leaflet of the plasma membrane...
  30. pmc Substantial excretion of digoxin via the intestinal mucosa and prevention of long-term digoxin accumulation in the brain by the mdr 1a P-glycoprotein
    U Mayer
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Br J Pharmacol 119:1038-44. 1996
    ....
  31. ncbi request reprint Changing the end: antigenic variation orchestrated at the telomeres of African trypanosomes
    G Rudenko
    Dept of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Trends Microbiol 6:113-6. 1998
    ..This genomic location at chromosome ends not only allows easy exchange of VSG gene cassettes using various mechanisms of DNA recombination but also appears to play a role in VSG gene expression site control...
  32. pmc cDNA cloning and tissue-specific expression of the phosphatidylcholine transfer protein gene
    T B Geijtenbeek
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Biochem J 316:49-55. 1996
    ..In addition to adult liver, high levels of PC-TP RNA were also found in kidney and testis. The prominent presence of PC-TP in developing and adult liver is compatible with its proposed role in bile formation...
  33. pmc Enhanced oral bioavailability of paclitaxel in mice treated with the P-glycoprotein blocker SDZ PSC 833
    J van Asperen
    Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdam
    Br J Cancer 76:1181-3. 1997
    ..These results encourage further research on the development of a clinically useful oral formulation of paclitaxel...
  34. ncbi request reprint Selection for activation of a new variant surface glycoprotein gene expression site in Trypanosoma brucei can result in deletion of the old one
    G Rudenko
    Department of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Mol Biochem Parasitol 95:97-109. 1998
    ..The fact that we pick up these normally infrequent deletions, indicates that inactivation of the old VSG expression site could be rate limiting during switching in our strain of T. brucei...
  35. ncbi request reprint Thiopurine metabolism and identification of the thiopurine metabolites transported by MRP4 and MRP5 overexpressed in human embryonic kidney cells
    P R Wielinga
    Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam, The Netherlands
    Mol Pharmacol 62:1321-31. 2002
    ..Our results show that all major thiopurine monophosphates important in the efficacy of mercaptopurine treatment are transported by MRP4 and MRP5, although the substrate specificity of the two transporters differs in detail...
  36. ncbi request reprint Mammalian ABC transporters in health and disease
    P Borst
    Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX, Amsterdam, The Netherlands
    Annu Rev Biochem 71:537-92. 2002
    ..c) A rapidly increasing number of ABC transporters are found to play a role in lipid transport. Defects in each of these transporters are involved in human inborn or acquired diseases...
  37. pmc Reduced topoisomerase II activity in multidrug-resistant human non-small cell lung cancer cell lines
    E W Eijdems
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Br J Cancer 71:40-7. 1995
    ..The assay we used, which measures DNA breaks as an end point of topo II activity, could be a good candidate...
  38. ncbi request reprint The potential impact of drug transporters on nucleoside-analog-based antiviral chemotherapy
    P Borst
    Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Antiviral Res 62:1-7. 2004
    ..We briefly review how ABC transporters in general, and MRPs in particular, could affect the disposition and cellular accumulation of antiviral compounds...
  39. ncbi request reprint Altered pharmacokinetics of vinblastine in Mdr1a P-glycoprotein-deficient Mice
    J van Asperen
    Department of Clinical Chemistry, The Netherlands Cancer Institute, Amsterdan, The Netherlands
    J Natl Cancer Inst 88:994-9. 1996
    ..Analysis of the consequences of Pgp blockade has been facilitated by the generation of mice with disrupted mdr1a genes [mdr1a(-/-)]...
  40. ncbi request reprint On the putative co-transport of drugs by multidrug resistance proteins
    P Borst
    Center of Biomedical Genetics, Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    FEBS Lett 580:1085-93. 2006
    ..We conclude that there is no unambiguous proof for co-transport of two different ligands by MRPs, but that cross-stimulated transport can explain the published data...
  41. ncbi request reprint MRP2 and 3 in health and disease
    P Borst
    Division of Molecular Biology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
    Cancer Lett 234:51-61. 2006
    ..Instead, we have found a role for MRP3 in the cellular export of drug-glucuronide conjugates. We discuss problems in extrapolating results obtained for murine MRPs...
  42. ncbi request reprint Genetic mechanisms of drug resistance. A review
    P Borst
    The Netherlands Cancer Institute, Amsterdam
    Acta Oncol 30:87-105. 1991
    ....
  43. pmc The modified base J is the target for a novel DNA-binding protein in kinetoplastid protozoans
    M Cross
    Division of Molecular Biology and Centre of Biomedical Genetics, The Netherlands Cancer Institute, 1066 CX Amsterdam, The Netherlands
    EMBO J 18:6573-81. 1999
    ..The J-binding proteins show 43-63% identity and are unlike any known protein. The discovery of a J-binding protein suggests that J, like methylated cytosine in higher eukaryotes, functions via a protein intermediate...
  44. pmc The identification of hydroxymethyluracil in DNA of Trypanosoma brucei
    J H Gommers-Ampt
    Division of Molecular Biology, The Netherlands Cancer Institute, Amsterdam
    Nucleic Acids Res 21:2039-43. 1993
    ..Because of its high sensitivity, it may also be useful for the detection of the low amounts of HOMedU resulting from oxidative damage of DNA...
  45. pmc Absence of the mdr1a P-Glycoprotein in mice affects tissue distribution and pharmacokinetics of dexamethasone, digoxin, and cyclosporin A
    A H Schinkel
    The Netherlands Cancer Institute, Division of Molecular Biology, Amsterdam, The Netherlands
    J Clin Invest 96:1698-705. 1995
    ..These results may explain a range of pharmacological interactions observed between various drugs in patients...
  46. ncbi request reprint Sequence of mdr3 cDNA encoding a human P-glycoprotein
    A M van der Bliek
    The Netherlands Cancer Institute, Department of Molecular Biology, Amsterdam
    Gene 71:401-11. 1988
    ..80% of the amino acids are conserved between the products of mdr1 and mdr3. Although the function of mdr3 is not yet known, its high homology with mdr1 suggests that it also encodes an efflux pump with broad specificity...
  47. ncbi request reprint From cancer cells to trypanosomes and back again
    P Borst
    Division of Molecular Biology and Center for Biomedical Genetics, The Netherlands Cancer Institute, Amsterdam
    Cell Mol Life Sci 63:745-54. 2006
  48. ncbi request reprint Increased sensitivity to anticancer drugs and decreased inflammatory response in mice lacking the multidrug resistance-associated protein
    J Wijnholds
    Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam
    Nat Med 3:1275-9. 1997
    ..Our results suggest that this ubiquitous GS-X pump is dispensable in mice, making treatment of MDR with MRP-specific reversal agents potentially feasible...
  49. ncbi request reprint MDR1 P-glycoprotein is a lipid translocase of broad specificity, while MDR3 P-glycoprotein specifically translocates phosphatidylcholine
    A van Helvoort
    Department of Cell Biology, Faculty of Medicine and Institute of Biomembranes, Universiteit Utrecht, The Netherlands
    Cell 87:507-17. 1996
    ..Since no vesicular secretion occurs at 15 degrees C, the short-chain lipids must have been translocated by the Pgps across the plasma membrane before extraction into the medium by the lipid-acceptor albumin...
  50. ncbi request reprint What have we learnt thus far from mice with disrupted P-glycoprotein genes?
    P Borst
    Division of Molecular Biology, Netherlands Cancer Institute
    Eur J Cancer 32:985-90. 1996
  51. pmc The human multidrug resistance-associated protein functionally complements the yeast cadmium resistance factor 1
    R Tommasini
    The Institute of Plant Science, Swiss Federal Institute of Technology, Zurich, Switzerland
    Proc Natl Acad Sci U S A 93:6743-8. 1996
    ..Our results indicate that yeast YCF1 is a glutathione S-conjugate pump, like MRP, and they raise the possibility that the cadmium resistance in yeast involves cotransport of cadmium with glutathione derivatives...
  52. pmc The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver
    A M van der Bliek
    Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam
    EMBO J 6:3325-31. 1987
    ....
  53. ncbi request reprint Genes amplified and overexpressed in human multidrug-resistant cell lines
    A M van der Bliek
    Division of Molecular Biology, Netherlands Cancer Institute, Amsterdam
    Cancer Res 48:5927-32. 1988
    ..Our results confirm the central role of the mdr1 (pgp1) gene in MDR and suggest that different cross-resistance patterns are not due to differential expression of different P-glycoprotein genes...