Research Topics
Species | Berthe M P AlemanSummaryAffiliation: The Netherlands Cancer Institute Country: The Netherlands Publications
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Publications
Involved-field radiotherapy for advanced Hodgkin's lymphomaBerthe M P Aleman
Netherlands Cancer Institute, Amsterdam, The Netherlands
N Engl J Med 348:2396-406. 2003..The use of involved-field radiotherapy after chemotherapy for advanced Hodgkin's lymphoma is controversial...
Quality control of involved-field radiotherapy in patients with advanced Hodgkin's lymphoma (EORTC 20884)Berthe M P Aleman
Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Int J Radiat Oncol Biol Phys 63:1184-90. 2005....
Role of radiotherapy in the treatment of lymphomas of the gastrointestinal tractBerthe M P Aleman
Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Best Pract Res Clin Gastroenterol 24:27-34. 2010..In patients with gastric DLBCL conservative treatment with anthracycline-based chemotherapy alone or in combination with involved-field radiotherapy has become the therapy of choice...
Involved-field radiotherapy for patients in partial remission after chemotherapy for advanced Hodgkin's lymphomaBerthe M P Aleman
Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam
Int J Radiat Oncol Biol Phys 67:19-30. 2007..The purpose of this study was to describe the role of radiotherapy in patients with advanced HL who were in partial remission (PR) after chemotherapy...
Are we improving the long-term burden of Hodgkin's lymphoma patients with modern treatment?Berthe M P Aleman
Department of Radiotherapy, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
Hematol Oncol Clin North Am 21:961-75. 2007..Because treatment always has side effects to some extent, awareness of possible late effects after treatment remains important for patients and treating physicians...
Roles of radiation dose and chemotherapy in the etiology of stomach cancer as a second malignancyAlexandra W van den Belt-Dusebout
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Int J Radiat Oncol Biol Phys 75:1420-9. 2009..To evaluate the roles of radiation dose, chemotherapy, and other factors in the etiology of stomach cancer in long-term survivors of testicular cancer or Hodgkin lymphoma...
Increased risk of stroke and transient ischemic attack in 5-year survivors of Hodgkin lymphomaMarie L De Bruin
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
J Natl Cancer Inst 101:928-37. 2009..We quantified the long-term risk of cerebrovascular disease associated with the use of radiotherapy and chemotherapy in survivors of Hodgkin lymphoma and explored potential pathogenic mechanisms...
Treatment-specific risks of second malignancies and cardiovascular disease in 5-year survivors of testicular cancerAlexandra W van den Belt Dusebout
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
J Clin Oncol 25:4370-8. 2007..To compare radiotherapy and chemotherapy effects on long-term risks of second malignant neoplasms (SMNs) and cardiovascular diseases (CVDs) in testicular cancer (TC) survivors...
Breast cancer risk in female survivors of Hodgkin's lymphoma: lower risk after smaller radiation volumesMarie L De Bruin
Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Clin Oncol 27:4239-46. 2009..We assessed the long-term risk of breast cancer (BC) after treatment for Hodgkin's lymphoma (HL). We focused on the volume of breast tissue exposed to radiation and the influence of gonadotoxic chemotherapy (CT)...
Treatment-related risk factors for premature menopause following Hodgkin lymphomaMarie L De Bruin
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam
Blood 111:101-8. 2008..As long as alkylating agents will be used for curing HL, premature menopause will remain a frequent adverse treatment effect, with various clinical implications...
Chemoradiation for esophageal cancer: institutional experience with three different regimensEwout F W Courrech Staal
Department of Surgical Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Am J Clin Oncol 34:343-9. 2011..The aim of this study was to retrospectively evaluate toxicity and efficacy of 3 chemoradiation regimens...
Combined-modality therapy for clinical stage I or II Hodgkin's lymphoma: long-term results of the European Organisation for Research and Treatment of Cancer H7 randomized controlled trialsEvert M Noordijk
Department of Radiotherapy, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands
J Clin Oncol 24:3128-35. 2006..The aim of this study was to reduce this toxicity using a combination of low-intensity chemotherapy and involved-field radiotherapy (IF-RT) without jeopardizing disease control...
Roles of radiotherapy and chemotherapy in the development of contralateral breast cancerMaartje J Hooning
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
J Clin Oncol 26:5561-8. 2008..Few studies have examined whether modern radiotherapy and chemotherapy affect the risk of contralateral breast cancer (CBC), and results are inconclusive...
Long-term risk of cardiovascular disease in 10-year survivors of breast cancerMaartje J Hooning
Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Natl Cancer Inst 99:365-75. 2007..Few data on long-term cardiovascular disease risk according to specific radiation fields are available, and interaction with known cardiovascular risk factors has not been examined...
Decreased risk of stroke among 10-year survivors of breast cancerMaartje J Hooning
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
J Clin Oncol 24:5388-94. 2006..HT is associated with an increased risk of stroke. Radiation fields including the carotid artery do not seem to increase the risk of stroke compared with other fields...
Malignant mesothelioma after radiation treatment for Hodgkin lymphomaMarie L De Bruin
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam
Blood 113:3679-81. 2009..The evidence for radiotherapy as cause for mesothelioma independent of exposure to asbestos is expanding, and the diagnosis of mesothelioma should be kept in mind whenever related symptoms arise in patients who had previous irradiation...
Cause-specific mortality in long-term survivors of breast cancer: A 25-year follow-up studyMaartje J Hooning
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Int J Radiat Oncol Biol Phys 64:1081-91. 2006..Patients irradiated after 1979 experience low (postmastectomy RT) or no (postlumpectomy RT) excess mortality from CVD...
[Long-term complications following treatment of testicular cancer and Hodgkin lymphoma]A W Sandra van den Belt-Dusebout
Het Nederlands Kanker Instituut Antoni van Leeuwenhoek Ziekenhuis, afd Epidemiologie, Amsterdam, The Netherlands
Ned Tijdschr Geneeskd 154:A2229. 2010..Because of the relatively high risks of late treatment complications, recommendations for follow-up for survivors of testicular cancer and Hodgkin lymphoma are necessary...
Long-term risk of cardiovascular disease in 5-year survivors of testicular cancerAlexandra W van den Belt-Dusebout
Department of Epidemiology, The Netherlands Cancer Institute, Amsterdam, The Netherlands
J Clin Oncol 24:467-75. 2006..Intervention in modifiable cardiovascular risk factors is especially important in TC survivors. Whether BEP treatment increases CVD risk should be evaluated after more prolonged follow-up...
Long-term results of stomach-conserving therapy in gastric MALT lymphomaConny Vrieling
Department of Radiation Oncology, Netherlands Cancer Institute Antoni van Leeuwenhoek ziekenhuis, Amsterdam, The Netherlands
Radiother Oncol 87:405-11. 2008..To evaluate long-term results of stomach-conserving therapy and to assess the value of histological probable minimal residual disease (pMRD) in predicting outcome in patients with gastric MALT lymphoma...
Long-term cause-specific mortality of patients treated for Hodgkin's diseaseBerthe M P Aleman
Department of Epidemiology, The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands
J Clin Oncol 21:3431-9. 2003..Increased risk of death from SCs and CVDs was found especially in patients treated before age 21, but these risks seemed to abate with age...
Late cardiotoxicity after treatment for Hodgkin lymphomaBerthe M P Aleman
Department of Radiotherapy, The Netherlands Cancer Institute, Amsterdam, The Netherlands
Blood 109:1878-86. 2007..Anthracyclines further increase the elevated risks of CHF and valvular disorders from mediastinal radiotherapy...
Treatment of extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue with fludarabine: effect on tumor microenvironmentJan Paul de Boer
Department of Medical Oncology, Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Leuk Lymphoma 52:2262-9. 2011..In addition an increase in density of FOXP3 + cells (i.e. Tregs) was seen (p = 0.047). These alterations in different T-cell subsets were not observed in gastric biopsy samples of patients treated with HP-eradication only...
Low-dose involved-field radiotherapy as alternative treatment of nodular lymphocyte predominance Hodgkin's lymphomaRick L M Haas
Department of Radiotherapy, The Netherlands Cancer Institute Amsterdam, Amsterdam, The Netherlands
Int J Radiat Oncol Biol Phys 74:1199-202. 2009..Considerable discussion is ongoing on the treatment of primary and relapsed disease...
Genetic variants in TGFβ-1 and PAI-1 as possible risk factors for cardiovascular disease after radiotherapy for breast cancerFlorentine S M Hilbers
Division of Psychosocial Research and Epidemiology, Netherlands Cancer Institute, Amsterdam, Netherlands
Radiother Oncol 102:115-21. 2012..We examined the effects of two polymorphisms, TGFβ1 29C>T and PAI-1 5G>4G, on CVD incidence...
Recurrences after peritoneal carcinomatosis of colorectal origin treated by cytoreduction and hyperthermic intraperitoneal chemotherapy: location, treatment, and outcomeVic J Verwaal
Department of Surgery, The Netherlands Cancer Institute and Antoni van Leeuwenhoeck Hospital, Amsterdam, The Netherlands
Ann Surg Oncol 11:375-9. 2004..This study evaluates the outcome of such recurrences after initial treatment by cytoreduction and HIPEC...
Roles of radiation dose, chemotherapy, and hormonal factors in breast cancer following Hodgkin's diseaseFlora E van Leeuwen
Department of Epidemiology, Netherlands Cancer Institute, Amsterdam, The Netherlands
J Natl Cancer Inst 95:971-80. 2003..Female survivors of Hodgkin's disease (HD) have a strongly elevated risk of breast cancer, but factors responsible for the increased risk are not well known...
Outcome of low-volume surgery for esophageal cancer in a high-volume referral centerEwout F W Courrech Staal
Department of Surgical Oncology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
Ann Surg Oncol 16:3219-26. 2009..The objective of our study was to evaluate the results of esophageal cancer surgery in our institute and to compare these results with published data from high-surgical-volume institutions...
Impact of involved field radiotherapy in partial response after doxorubicin-based chemotherapy for advanced aggressive non-Hodgkin's lymphomaElizabeth C Moser
European Organisation for Research and Treatment of Cancer EORTC Data Center, Brussels, Belgium
Int J Radiat Oncol Biol Phys 66:1168-77. 2006..We evaluated the impact of radiotherapy on outcome in PR patients treated in four successive European Organization for Research and Treatment of Cancer trials for aggressive NHL...
Re: Radiation therapy in the treatment of Hodgkin's disease--do you see what I see?Berthe M P Aleman
J Natl Cancer Inst 96:235-6; author reply 236-7. 2004
Cardiotoxic effects of tangential breast irradiation in early breast cancer patients: the role of irradiated heart volumeJacques H Borger
Maastricht Radiation Oncology Clinic, Maastricht, The Netherlands
Int J Radiat Oncol Biol Phys 69:1131-8. 2007..To assess the risk of cardiovascular disease (CVD) after postlumpectomy irradiation restricted to tangential fields...
Radiotherapy in advanced-stage Hodgkin's lymphomaJohn M M Raemaekers
J Clin Oncol 23:245-6; author reply 246. 2005
Single-dose brachytherapy versus metal stent placement for the palliation of dysphagia from oesophageal cancer: multicentre randomised trialMarjolein Y V Homs
Department of Gastroenterology and Hepatology, Erasmus MC/University Medical Centre Rotterdam, Rotterdam, Netherlands
Lancet 364:1497-504. 2004..Since brachytherapy was also associated with fewer complications than stent placement, we recommend it as the primary treatment for palliation of dysphagia from oesophageal cancer...
