Bjorn Lars Herpers

Summary

Affiliation: St. Antonius Hospital
Country: The Netherlands

Publications

  1. ncbi [A patient with Legionella pneumophila serogroup-3 pneumonia, detected by PCR]
    B L Herpers
    St Antonius Ziekenhuis, afd Medische Microbiologie en Immunologie, Nieuwegein
    Ned Tijdschr Geneeskd 149:2009-12. 2005
  2. pmc Mannose binding lectin plays a crucial role in innate immunity against yeast by enhanced complement activation and enhanced uptake of polymorphonuclear cells
    Eveline C van Asbeck
    Eijkman Winkler Institute for Medical and Clinical Microbiology, Utrecht University Hospital, Utrecht, The Netherlands
    BMC Microbiol 8:229. 2008
  3. pmc Real-time PCR assay targets the 23S-5S spacer for direct detection and differentiation of Legionella spp. and Legionella pneumophila
    Bjorn L Herpers
    Department of Medical Microbiology and Immunology, St Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands
    J Clin Microbiol 41:4815-6. 2003
  4. ncbi Coding and non-coding polymorphisms in the lectin pathway activator L-ficolin gene in 188 Dutch blood bank donors
    Bjorn Lars Herpers
    St Antonius Hospital Nieuwegein, Department of Medical Microbiology and Immunology, P O Box 2500, 3430 EM Nieuwegein, Netherlands
    Mol Immunol 43:851-5. 2006
  5. doi Deficient mannose-binding lectin-mediated complement activation despite mannose-binding lectin-sufficient genotypes in an outbreak of Legionella pneumophila pneumonia
    Bjorn L Herpers
    Department of Medical Microbiology and Immunology, St Antonius Hospital, Nieuwegein, The Netherlands
    Hum Immunol 70:125-9. 2009
  6. doi Hemolytic assay for the measurement of functional human mannose-binding lectin: a modification to avoid interference from classical pathway activation
    Bjorn L Herpers
    Department of Medical Microbiology and Immunology, St Antonius Hospital, Nieuwegein, The Netherlands
    J Immunol Methods 343:61-3. 2009
  7. doi Intravenous tigecycline as adjunctive or alternative therapy for severe refractory Clostridium difficile infection
    Bjorn L Herpers
    Department of Medical Microbiology and Immunology, St Antonius Hospital, PO Box 2500, Nieuwegein 3430 EM, The Netherlands
    Clin Infect Dis 48:1732-5. 2009
  8. pmc Acute-phase responsiveness of mannose-binding lectin in community-acquired pneumonia is highly dependent upon MBL2 genotypes
    B L Herpers
    Department of Medical Microbiology and Immunology, Antonius Hospital, Nieuwgein, The Netherlands
    Clin Exp Immunol 156:488-94. 2009

Collaborators

Detail Information

Publications8

  1. ncbi [A patient with Legionella pneumophila serogroup-3 pneumonia, detected by PCR]
    B L Herpers
    St Antonius Ziekenhuis, afd Medische Microbiologie en Immunologie, Nieuwegein
    Ned Tijdschr Geneeskd 149:2009-12. 2005
    ..It is therefore advocated to expand the diagnostics to a Legionella PCR on respiratory material of patients with clinical signs of Legionella pneumonia in whom the urinary antigen test is negative...
  2. pmc Mannose binding lectin plays a crucial role in innate immunity against yeast by enhanced complement activation and enhanced uptake of polymorphonuclear cells
    Eveline C van Asbeck
    Eijkman Winkler Institute for Medical and Clinical Microbiology, Utrecht University Hospital, Utrecht, The Netherlands
    BMC Microbiol 8:229. 2008
    ..We investigated the contribution of MBL to antifungal innate immunity towards C. parapsilosis in vitro...
  3. pmc Real-time PCR assay targets the 23S-5S spacer for direct detection and differentiation of Legionella spp. and Legionella pneumophila
    Bjorn L Herpers
    Department of Medical Microbiology and Immunology, St Antonius Hospital, Koekoekslaan 1, 3435 CM Nieuwegein, The Netherlands
    J Clin Microbiol 41:4815-6. 2003
    ..In sputum samples from 23 controls and 17 patients with legionellosis, defined by positive culture, urinary antigen testing, or seroconversion, 94% sensitivity and 100% specificity were observed...
  4. ncbi Coding and non-coding polymorphisms in the lectin pathway activator L-ficolin gene in 188 Dutch blood bank donors
    Bjorn Lars Herpers
    St Antonius Hospital Nieuwegein, Department of Medical Microbiology and Immunology, P O Box 2500, 3430 EM Nieuwegein, Netherlands
    Mol Immunol 43:851-5. 2006
    ..As this domain is responsible for binding of L-ficolin, these newly found coding polymorphisms could alter the affinity of the protein for its substrates and possibly alter the ability of L-ficolin to recognize invading microorganisms...
  5. doi Deficient mannose-binding lectin-mediated complement activation despite mannose-binding lectin-sufficient genotypes in an outbreak of Legionella pneumophila pneumonia
    Bjorn L Herpers
    Department of Medical Microbiology and Immunology, St Antonius Hospital, Nieuwegein, The Netherlands
    Hum Immunol 70:125-9. 2009
    ..Together, these genotypical and functional data suggest that the observed deficiency of lectin pathway activation is an effect of legionellosis rather than a risk factor for acquiring it...
  6. doi Hemolytic assay for the measurement of functional human mannose-binding lectin: a modification to avoid interference from classical pathway activation
    Bjorn L Herpers
    Department of Medical Microbiology and Immunology, St Antonius Hospital, Nieuwegein, The Netherlands
    J Immunol Methods 343:61-3. 2009
    ..Classical pathway interference in functional MBL assays can and should be inhibited to prevent that MBL deficiency is overlooked and patients are misdiagnosed...
  7. doi Intravenous tigecycline as adjunctive or alternative therapy for severe refractory Clostridium difficile infection
    Bjorn L Herpers
    Department of Medical Microbiology and Immunology, St Antonius Hospital, PO Box 2500, Nieuwegein 3430 EM, The Netherlands
    Clin Infect Dis 48:1732-5. 2009
    ..Symptoms improved within 1 week. No relapses were observed. This favorable outcome suggests that tigecycline might be a useful alternative for treating severe refractory CDI...
  8. pmc Acute-phase responsiveness of mannose-binding lectin in community-acquired pneumonia is highly dependent upon MBL2 genotypes
    B L Herpers
    Department of Medical Microbiology and Immunology, Antonius Hospital, Nieuwgein, The Netherlands
    Clin Exp Immunol 156:488-94. 2009
    ..These data suggest that heterogeneity in protein responses in the acute phase of disease should always be viewed in the light of possible influences of genetic differences in both structural and regulatory parts of the gene...