Joost Smolders

Summary

Country: The Netherlands

Publications

  1. doi Fok-I vitamin D receptor gene polymorphism (rs10735810) and vitamin D metabolism in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neuroimmunol 207:117-21. 2009
  2. pmc Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    PLoS ONE 4:e6635. 2009
  3. doi Vitamin D as an immune modulator in multiple sclerosis, a review
    Joost Smolders
    Department of Neurology, University Hospital Maastricht, Maastricht, The Netherlands
    J Neuroimmunol 194:7-17. 2008
  4. doi Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis
    J Smolders
    School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Mult Scler 14:1220-4. 2008
  5. doi The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Autoimmun Rev 8:621-6. 2009
  6. pmc Vitamin d and multiple sclerosis: correlation, causality, and controversy
    Joost Smolders
    Division of Clinical and Experimental Immunology, Department of Internal Medicine and School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, P O Box 616, 6200 MD Maastricht, The Netherlands
    Autoimmune Dis 2011:629538. 2011
  7. pmc Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    PLoS ONE 5:e15235. 2010
  8. doi Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Ann N Y Acad Sci 1173:515-20. 2009
  9. doi Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200MD Maastricht, The Netherlands
    J Steroid Biochem Mol Biol 121:243-6. 2010
  10. doi Effect of vitamin D(3) supplementation on peripheral B cell differentiation and isotype switching in patients with multiple sclerosis
    Stephanie Knippenberg
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Mult Scler 17:1418-23. 2011

Collaborators

Detail Information

Publications18

  1. doi Fok-I vitamin D receptor gene polymorphism (rs10735810) and vitamin D metabolism in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neuroimmunol 207:117-21. 2009
    ..In conclusion, we demonstrated the importance of the Fok-I VDRG polymorphism for vitamin D metabolism. This should be taken into account in association and ultimately intervention studies on vitamin D and MS...
  2. pmc Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    PLoS ONE 4:e6635. 2009
    ..A poor vitamin D status has been linked with MS incidence and MS disease activity. In the present study, we assess a potential in vivo correlation between vitamin D status and Treg function in relapsing remitting MS (RRMS) patients...
  3. doi Vitamin D as an immune modulator in multiple sclerosis, a review
    Joost Smolders
    Department of Neurology, University Hospital Maastricht, Maastricht, The Netherlands
    J Neuroimmunol 194:7-17. 2008
    ....
  4. doi Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis
    J Smolders
    School for Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands
    Mult Scler 14:1220-4. 2008
    ..We investigated the association between serum levels of 25(OH)D and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active metabolite, and clinical MS severity as expressed by EDSS-score and relapse rate...
  5. doi The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Autoimmun Rev 8:621-6. 2009
    ..We conclude that polymorphisms of the VDR have major effects on vitamin D function and metabolism, and should therefore be assessed in studies on vitamin D and MS...
  6. pmc Vitamin d and multiple sclerosis: correlation, causality, and controversy
    Joost Smolders
    Division of Clinical and Experimental Immunology, Department of Internal Medicine and School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, P O Box 616, 6200 MD Maastricht, The Netherlands
    Autoimmune Dis 2011:629538. 2011
    ..This review discusses studies on vitamin D status, Expanded Disability Status Scale (EDSS) score, and relapse activity of MS. Furthermore, several considerations for intervention studies on vitamin D supplementation in MS are provided...
  7. pmc Safety and T cell modulating effects of high dose vitamin D3 supplementation in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    PLoS ONE 5:e15235. 2010
    ..In the present study, we studied the effects of high dose vitamin D3 supplementation on safety and T cell related outcome measures...
  8. doi Association study on two vitamin D receptor gene polymorphisms and vitamin D metabolites in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Ann N Y Acad Sci 1173:515-20. 2009
    ..Another SNP of the VDR gene, Fokl (rs10735810), has been associated with serum levels of 25-hydroxyvitamin D [25(OH)D]...
  9. doi Regulatory T cell function correlates with serum 25-hydroxyvitamin D, but not with 1,25-dihydroxyvitamin D, parathyroid hormone and calcium levels in patients with relapsing remitting multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200MD Maastricht, The Netherlands
    J Steroid Biochem Mol Biol 121:243-6. 2010
    ..These results suggest that the serum levels of 1,25(OH)2D, PTH, and total calcium are not critically involved in the correlation between vitamin D status and T cell regulation...
  10. doi Effect of vitamin D(3) supplementation on peripheral B cell differentiation and isotype switching in patients with multiple sclerosis
    Stephanie Knippenberg
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Mult Scler 17:1418-23. 2011
    ..Since there is an increasing interest in the role of B cells in the pathophysiology of MS, we studied the role of vitamin D on B cells in vivo in patients with MS...
  11. doi Th17 expansion in MS patients is counterbalanced by an expanded CD39+ regulatory T cell population during remission but not during relapse
    Evelyn Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neuroimmunol 240:97-103. 2011
    ..A clear role for vitamin D in this regulation could not be established...
  12. doi Vitamin D-related gene expression profiles in immune cells of patients with relapsing remitting multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, PO Box 616, 6200 MD Maastricht, The Netherlands
    J Neuroimmunol 235:91-7. 2011
    ..Our results suggest that vit-D processing by immune cells is not impaired in RRMS, and is potentially relevant for the composition of the peripheral CD4+ T-cell compartment...
  13. doi Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naïve/memory Breg ratio during a relapse but not in remission
    Stephanie Knippenberg
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Universiteitssingel 50, Maastricht, The Netherlands
    J Neuroimmunol 239:80-6. 2011
    ..We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers...
  14. doi Intracellular IL-10 detection in T cells by flowcytometry: the use of protein transport inhibitors revisited
    Anne Hilde Muris
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Immunol Methods 381:59-65. 2012
    ..It is important to consider this for future research or when interpreting historical IL-10 data...
  15. doi Effects of vitamin D on the peripheral adaptive immune system: a review
    Evelyn Peelen
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Autoimmun Rev 10:733-43. 2011
    ..Upcoming vitamin D supplementation trials will further elucidate the in vivo effects of vitamin D on the immune system and its potency to serve as an immune regulating agent in autoimmune diseases...
  16. doi Vitamin D in the healthy and inflamed central nervous system: access and function
    Joost Smolders
    Department of Internal Medicine, Division of Clinical and Experimental Immunology, and School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    J Neurol Sci 311:37-43. 2011
    ..We conclude that a local role of vitamin D in the inflamed CNS is likely and potentially relevant to MS. Future studies should further characterize the impact of vitamin D on the local disease process of MS in the CNS...
  17. doi Efficacy of vitamin D3 as add-on therapy in patients with relapsing-remitting multiple sclerosis receiving subcutaneous interferon β-1a: a Phase II, multicenter, double-blind, randomized, placebo-controlled trial
    Joost Smolders
    Maastricht University Medical Centre, Maastricht, The Netherlands
    J Neurol Sci 311:44-9. 2011
    ..Recruitment began in February 2011 and is aimed to take place over 1 calendar year due to the potential influence of seasonal differences in 25(OH)D levels...
  18. doi Vitamin D as a T-cell modulator in multiple sclerosis
    Joost Smolders
    School for Mental Health and Neuroscience, Maastricht University Medical Center, Maastricht, The Netherlands
    Vitam Horm 86:401-28. 2011
    ....