Rob ter Heine

Summary

Affiliation: Slotervaart Hospital
Country: The Netherlands

Publications

  1. doi request reprint Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liquid chromatography coupled with tandem mass spectrometry
    R Ter Heine
    Slotervaart Hospital, Department of Pharmacy and Pharmacology, Louwesweg 6, 1066EC Amsterdam, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 877:575-80. 2009
  2. doi request reprint Quantification of the HIV-integrase inhibitor raltegravir and detection of its main metabolite in human plasma, dried blood spots and peripheral blood mononuclear cell lysate by means of high-performance liquid chromatography tandem mass spectrometry
    R Ter Heine
    Slotervaart Hospital, Department of Pharmacy and Pharmacology, Louwesweg 6, 1066EC Amsterdam, Netherlands
    J Pharm Biomed Anal 49:451-8. 2009
  3. doi request reprint Quantification of protease inhibitors and non-nucleoside reverse transcriptase inhibitors in dried blood spots by liquid chromatography-triple quadrupole mass spectrometry
    R Ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066EC, Amsterdam, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 867:205-12. 2008
  4. ncbi request reprint A pharmacokinetic and pharmacogenetic study of efavirenz in children: dosing guidelines can result in subtherapeutic concentrations
    Rob ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    Antivir Ther 13:779-87. 2008
  5. doi request reprint Quantification of etravirine (TMC125) in plasma, dried blood spots and peripheral blood mononuclear cell lysate by liquid chromatography tandem mass spectrometry
    R Ter Heine
    Department of Pharmacy and Pharmacology, Louwesweg 6, 1066EC Amsterdam, The Netherlands
    J Pharm Biomed Anal 49:393-400. 2009
  6. doi request reprint Clinical evaluation of the determination of plasma concentrations of darunavir, etravirine, raltegravir and ritonavir in dried blood spot samples
    Rob ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Louwesweg, Amsterdam, The Netherlands
    Bioanalysis 3:1093-7. 2011
  7. ncbi request reprint Case series of acute hepatitis in a non-selected group of HIV-infected patients on nevirapine-containing antiretroviral treatment
    Monique M de Maat
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    AIDS 17:2209-14. 2003
  8. ncbi request reprint Prolonged exposure to tenofovir monotherapy 1 month after treatment discontinuation because of tenofovir-related renal failure
    Rob ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    Antivir Ther 14:299-301. 2009
  9. doi request reprint Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry
    Robert S Jansen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 878:621-7. 2010
  10. pmc Intracellular and plasma steady-state pharmacokinetics of raltegravir, darunavir, etravirine and ritonavir in heavily pre-treated HIV-infected patients
    Rob ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    Br J Clin Pharmacol 69:475-83. 2010

Collaborators

Detail Information

Publications15

  1. doi request reprint Quantification of HIV protease inhibitors and non-nucleoside reverse transcriptase inhibitors in peripheral blood mononuclear cell lysate using liquid chromatography coupled with tandem mass spectrometry
    R Ter Heine
    Slotervaart Hospital, Department of Pharmacy and Pharmacology, Louwesweg 6, 1066EC Amsterdam, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 877:575-80. 2009
    ..Using the developed assay and a previously developed assay for these analytes in plasma, the relationship between plasma and intracellular pharmacokinetics and their relationship with therapy outcome can now be determined...
  2. doi request reprint Quantification of the HIV-integrase inhibitor raltegravir and detection of its main metabolite in human plasma, dried blood spots and peripheral blood mononuclear cell lysate by means of high-performance liquid chromatography tandem mass spectrometry
    R Ter Heine
    Slotervaart Hospital, Department of Pharmacy and Pharmacology, Louwesweg 6, 1066EC Amsterdam, Netherlands
    J Pharm Biomed Anal 49:451-8. 2009
    ..The method is now applied for therapeutic drug monitoring and pharmacological research in HIV-infected patients treated with raltegravir...
  3. doi request reprint Quantification of protease inhibitors and non-nucleoside reverse transcriptase inhibitors in dried blood spots by liquid chromatography-triple quadrupole mass spectrometry
    R Ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066EC, Amsterdam, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 867:205-12. 2008
    ..The method enabled patient-friendly sample collection, easy and cheap sample shipment and non-hospital based sampling for therapeutic drug monitoring and pharmacokinetic studies...
  4. ncbi request reprint A pharmacokinetic and pharmacogenetic study of efavirenz in children: dosing guidelines can result in subtherapeutic concentrations
    Rob ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    Antivir Ther 13:779-87. 2008
    ..Our main objectives were to study the population pharmacokinetics of efavirenz and to explore the adequacy of dosing guidelines...
  5. doi request reprint Quantification of etravirine (TMC125) in plasma, dried blood spots and peripheral blood mononuclear cell lysate by liquid chromatography tandem mass spectrometry
    R Ter Heine
    Department of Pharmacy and Pharmacology, Louwesweg 6, 1066EC Amsterdam, The Netherlands
    J Pharm Biomed Anal 49:393-400. 2009
    ....
  6. doi request reprint Clinical evaluation of the determination of plasma concentrations of darunavir, etravirine, raltegravir and ritonavir in dried blood spot samples
    Rob ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Louwesweg, Amsterdam, The Netherlands
    Bioanalysis 3:1093-7. 2011
    ..Our purpose was to clinically evaluate DBS sampling for the determination of plasma concentrations for the novel antiretroviral drugs etravirine, darunavir/ritonavir and raltegravir...
  7. ncbi request reprint Case series of acute hepatitis in a non-selected group of HIV-infected patients on nevirapine-containing antiretroviral treatment
    Monique M de Maat
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    AIDS 17:2209-14. 2003
    ..To evaluate the characteristics of patients who developed acute clinical hepatitis in an unselected outpatient population...
  8. ncbi request reprint Prolonged exposure to tenofovir monotherapy 1 month after treatment discontinuation because of tenofovir-related renal failure
    Rob ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    Antivir Ther 14:299-301. 2009
    ..We considered this case report important because exposure to tenofovir monotherapy might have consequences for future discontinuation strategies in cases of renal failure...
  9. doi request reprint Simultaneous quantification of emtricitabine and tenofovir nucleotides in peripheral blood mononuclear cells using weak anion-exchange liquid chromatography coupled with tandem mass spectrometry
    Robert S Jansen
    Department of Pharmacy and Pharmacology, Slotervaart Hospital The Netherlands Cancer Institute, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 878:621-7. 2010
    ..3 and 9.81% deviation and the coefficients of variation lower than 14.7%. The stability of the compounds was assessed under various analytically relevant conditions. The method was successfully applied to clinical samples...
  10. pmc Intracellular and plasma steady-state pharmacokinetics of raltegravir, darunavir, etravirine and ritonavir in heavily pre-treated HIV-infected patients
    Rob ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    Br J Clin Pharmacol 69:475-83. 2010
    ..To study the steady-state plasma and intracellular pharmacokinetics of raltegravir, etravirine, darunavir and ritonavir in heavily pre-treated patients...
  11. ncbi request reprint Fast and simultaneous determination of darunavir and eleven other antiretroviral drugs for therapeutic drug monitoring: method development and validation for the determination of all currently approved HIV protease inhibitors and non-nucleoside reverse tr
    Rob ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Rapid Commun Mass Spectrom 21:2505-14. 2007
    ..The method is now successfully applied for routine therapeutic drug monitoring and pharmacokinetic studies in HIV-infected patients...
  12. doi request reprint A less sensitive detector does not necessarily result in a less sensitive method: fast quantification of 13 antiretroviral analytes in plasma with liquid chromatography coupled with tandem mass spectrometry
    Rob ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    Clin Chem Lab Med 48:1153-5. 2010
    ..We report the transfer of this method from the API3000 to a supposedly less sensitive Sciex API365 mass spectrometer...
  13. doi request reprint An integrated pharmacokinetic model for the influence of CYP3A4 expression on the in vivo disposition of lopinavir and its modulation by ritonavir
    Rob ter Heine
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Amsterdam, The Netherlands
    J Pharm Sci 100:2508-15. 2011
    ..Hepatic CYP3A4 related systemic clearance was inversely related to ritonavir exposure and not only hepatic but also intestinal CYP3A4 expression contributed to systemic clearance of lopinavir...
  14. ncbi request reprint Incidence and risk factors for nevirapine-associated rash
    Monique M R de Maat
    Department of Pharmacy and Pharmacology, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Eur J Clin Pharmacol 59:457-62. 2003
    ..Possible risk factors including plasma concentrations of nevirapine were evaluated for their relationship with the occurrence of a rash...
  15. doi request reprint Coadministration of ritonavir strongly enhances the apparent oral bioavailability of docetaxel in patients with solid tumors
    Roos L Oostendorp
    Department of Medical Oncology, Division of Clinical Pharmacology, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Clin Cancer Res 15:4228-33. 2009
    ..To enhance the systemic exposure to oral docetaxel by coadministration of ritonavir, an efficacious inhibitor of CYP 3A4 with minor P-glycoprotein inhibiting effects, in patients with cancer...