Alfons A den Broeder

Summary

Affiliation: Sint Maartenskliniek
Country: The Netherlands

Publications

  1. pmc Dose REduction strategy of subcutaneous TNF inhibitors in rheumatoid arthritis: design of a pragmatic randomised non inferiority trial, the DRESS study
    Alfons A den Broeder
    Department of Rheumatology, Sint Maartenskliniek, PO Box 9011, Nijmegen 6500 GM, The Netherlands
    BMC Musculoskelet Disord 14:299. 2013
  2. ncbi request reprint Risk factors for surgical site infections and other complications in elective surgery in patients with rheumatoid arthritis with special attention for anti-tumor necrosis factor: a large retrospective study
    Alfons A den Broeder
    Department of Rheumatology and Orthopaedic Surgery, Sint Maartenskliniek, The Netherlands
    J Rheumatol 34:689-95. 2007
  3. pmc Non-pharmacological care for patients with generalized osteoarthritis: design of a randomized clinical trial
    Thomas J Hoogeboom
    Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands
    BMC Musculoskelet Disord 11:142. 2010
  4. ncbi request reprint Treatment outcomes of a Numeric Rating Scale (NRS)-guided pharmacological pain management strategy in symptomatic knee and hip osteoarthritis in daily clinical practice
    Gijs F Snijders
    Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands
    Clin Exp Rheumatol 30:164-70. 2012
  5. doi request reprint A tight control treatment strategy aiming for remission in early rheumatoid arthritis is more effective than usual care treatment in daily clinical practice: a study of two cohorts in the Dutch Rheumatoid Arthritis Monitoring registry
    Lydia G Schipper
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 71:845-50. 2012
  6. doi request reprint Fatigue in knee and hip osteoarthritis: the role of pain and physical function
    Gijs F Snijders
    Department of Rheumatology, Sint Maartenskliniek, P O Box 9011, 6500 GM Nijmegen, The Netherlands
    Rheumatology (Oxford) 50:1894-900. 2011
  7. pmc The combined use of disease activity and infliximab serum trough concentrations for early prediction of (non-)response to infliximab in rheumatoid arthritis
    Bart J F van den Bemt
    Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands
    Br J Clin Pharmacol 76:939-45. 2013
  8. ncbi request reprint The reason for discontinuation of the first tumor necrosis factor (TNF) blocking agent does not influence the effect of a second TNF blocking agent in patients with rheumatoid arthritis
    Marlies Blom
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, H 470, 6500 HB Nijmegen, The Netherlands
    J Rheumatol 36:2171-7. 2009
  9. doi request reprint Difference in the risk of serious infections in patients with rheumatoid arthritis treated with adalimumab, infliximab and etanercept: results from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry
    Sanne A A van Dartel
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 72:895-900. 2013
  10. doi request reprint Down-titration and discontinuation of infliximab in rheumatoid arthritis patients with stable low disease activity and stable treatment: an observational cohort study
    Aatke van der Maas
    Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, Postbus 9011, Nijmegen 6500 GM, The Netherlands
    Ann Rheum Dis 71:1849-54. 2012

Collaborators

Detail Information

Publications25

  1. pmc Dose REduction strategy of subcutaneous TNF inhibitors in rheumatoid arthritis: design of a pragmatic randomised non inferiority trial, the DRESS study
    Alfons A den Broeder
    Department of Rheumatology, Sint Maartenskliniek, PO Box 9011, Nijmegen 6500 GM, The Netherlands
    BMC Musculoskelet Disord 14:299. 2013
    ..However, long term safety, cost effectiveness and feasibility in clinical practice remain uncertain...
  2. ncbi request reprint Risk factors for surgical site infections and other complications in elective surgery in patients with rheumatoid arthritis with special attention for anti-tumor necrosis factor: a large retrospective study
    Alfons A den Broeder
    Department of Rheumatology and Orthopaedic Surgery, Sint Maartenskliniek, The Netherlands
    J Rheumatol 34:689-95. 2007
    ..To identify risk factors for surgical site infection (SSI) in patients with rheumatoid arthritis (RA) with special attention for anti-tumor necrosis factor (anti-TNF) treatment...
  3. pmc Non-pharmacological care for patients with generalized osteoarthritis: design of a randomized clinical trial
    Thomas J Hoogeboom
    Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands
    BMC Musculoskelet Disord 11:142. 2010
    ..The secondary objective is to compare the cost-effectiveness of both interventions...
  4. ncbi request reprint Treatment outcomes of a Numeric Rating Scale (NRS)-guided pharmacological pain management strategy in symptomatic knee and hip osteoarthritis in daily clinical practice
    Gijs F Snijders
    Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands
    Clin Exp Rheumatol 30:164-70. 2012
    ..To describe the results of a Numeric Rating Scale (NRS)-guided pharmacological pain management strategy in symptomatic knee and hip osteoarthritis (OA) in daily clinical practice...
  5. doi request reprint A tight control treatment strategy aiming for remission in early rheumatoid arthritis is more effective than usual care treatment in daily clinical practice: a study of two cohorts in the Dutch Rheumatoid Arthritis Monitoring registry
    Lydia G Schipper
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 71:845-50. 2012
    ..However, the question is whether these results can be translated into daily clinical practice and clinical remission is a reachable target indeed...
  6. doi request reprint Fatigue in knee and hip osteoarthritis: the role of pain and physical function
    Gijs F Snijders
    Department of Rheumatology, Sint Maartenskliniek, P O Box 9011, 6500 GM Nijmegen, The Netherlands
    Rheumatology (Oxford) 50:1894-900. 2011
    ....
  7. pmc The combined use of disease activity and infliximab serum trough concentrations for early prediction of (non-)response to infliximab in rheumatoid arthritis
    Bart J F van den Bemt
    Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands
    Br J Clin Pharmacol 76:939-45. 2013
    ....
  8. ncbi request reprint The reason for discontinuation of the first tumor necrosis factor (TNF) blocking agent does not influence the effect of a second TNF blocking agent in patients with rheumatoid arthritis
    Marlies Blom
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, H 470, 6500 HB Nijmegen, The Netherlands
    J Rheumatol 36:2171-7. 2009
    ..To investigate whether the reason for discontinuation of the first tumor necrosis factor (TNF) blocking agent influences the effect of a second TNF blocking agent...
  9. doi request reprint Difference in the risk of serious infections in patients with rheumatoid arthritis treated with adalimumab, infliximab and etanercept: results from the Dutch Rheumatoid Arthritis Monitoring (DREAM) registry
    Sanne A A van Dartel
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Rheum Dis 72:895-900. 2013
    ..Tumour necrosis factor (TNF)-inhibiting therapy increases the risk of serious infections in rheumatoid arthritis (RA). However, it is not clear whether this risk differs between TNF inhibitors...
  10. doi request reprint Down-titration and discontinuation of infliximab in rheumatoid arthritis patients with stable low disease activity and stable treatment: an observational cohort study
    Aatke van der Maas
    Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, Postbus 9011, Nijmegen 6500 GM, The Netherlands
    Ann Rheum Dis 71:1849-54. 2012
    ..Therefore, our local treatment protocol includes tapering infliximab dose. This observational study describes the prevalence of successful down-titration in daily clinical practice and its effect on costs and quality of life (QoL)...
  11. pmc Longitudinal impact of joint pain comorbidity on quality of life and activity levels in knee osteoarthritis: data from the Osteoarthritis Initiative
    Thomas J Hoogeboom
    Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands
    Rheumatology (Oxford) 52:543-6. 2013
    ..Joint pain comorbidity (JPC) is common in individuals with knee OA. This study investigates the longitudinal association between JPC and health-related quality of life (HRQoL) and physical activity levels in individuals with knee OA...
  12. doi request reprint Treatment strategies aiming at remission in early rheumatoid arthritis patients: starting with methotrexate monotherapy is cost-effective
    Lydia G Schipper
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Sint Maartenskliniek Nijmegen, Nijmegen, The Netherlands
    Rheumatology (Oxford) 50:1320-30. 2011
    ....
  13. pmc The Dutch Lower Extremity Functional Scale was highly reliable, valid and responsive in individuals with hip/knee osteoarthritis: a validation study
    Thomas J Hoogeboom
    Department of Rheumatology, Sint Maartenskliniek, PO Box 9011, Nijmegen, 6500 GM, The Netherlands
    BMC Musculoskelet Disord 13:117. 2012
    ..Therefore, we translated the LEFS to Dutch and studied its psychometric properties (i.e. validity, reliability and responsiveness). In addition, we assessed the discriminate validity of the LEFS, HOOS and KOOS...
  14. doi request reprint Effectiveness of a third tumor necrosis factor-α-blocking agent compared with rituximab after failure of 2 TNF-blocking agents in rheumatoid arthritis
    Marlies Blom
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, HB Nijmegen, The Netherlands
    J Rheumatol 38:2355-61. 2011
    ..To compare the effectiveness of a third tumor necrosis factor-α (TNF-α)-blocking agent with rituximab after failure of 2 TNF-blocking agents in patients with rheumatoid arthritis (RA) in daily clinical practice...
  15. pmc Low infliximab serum trough levels and anti-infliximab antibodies are prevalent in rheumatoid arthritis patients treated with infliximab in daily clinical practice: results of an observational cohort study
    Aatke van der Maas
    Department of Rheumatology, Sint Maartenskliniek, Hengstdal 3, 6522 JV, Nijmegen, The Netherlands
    BMC Musculoskelet Disord 13:184. 2012
    ..To get insight in the prevalence of high, or low/no serum infliximab trough levels in patients with low disease activity and if serum trough levels are stable and reliable longitudinally we conducted a prospective cohort study..
  16. ncbi request reprint Should we redefine treatment targets in rheumatoid arthritis? Low disease activity is sufficiently strict for patients who are anticitrullinated protein antibody-negative
    Yvonne M R de Punder
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Rheumatol 40:1268-74. 2013
    ..Our objective was to show the difference in prognosis at similar disease activity levels, and to illustrate how this could be translated to differentiation of treatment targets...
  17. pmc Anti-infliximab antibodies are already detectable in most patients with rheumatoid arthritis halfway through an infusion cycle: an open-label pharmacokinetic cohort study
    Bart J F van den Bemt
    Department of Pharmacy, Sint Maartenskliniek, Nijmegen, The Netherlands
    BMC Musculoskelet Disord 12:12. 2011
    ....
  18. doi request reprint Methotrexate therapy in rheumatoid arthritis after failure to sulphasalazine: to switch or to add?
    Lydia G Schipper
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, NL 6500 HB, Nijmegen, The Netherlands
    Rheumatology (Oxford) 48:1247-53. 2009
    ..In this study, we compared the efficacy of a switch to MTX monotherapy with that of the addition of MTX to SSZ in the daily clinical practice of RA patients who had failed SSZ monotherapy in the Nijmegen RA Inception Cohort...
  19. pmc Time to achieve remission determines time to be in remission
    Lydia G Schipper
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen, 6500 HB, The Netherlands
    Arthritis Res Ther 12:R97. 2010
    ..The aim was to study the association between time-to-remission and sustainability of remission in a cohort of early RA patients treated according to daily practice...
  20. ncbi request reprint Dose reduction of tocilizumab in rheumatoid arthritis patients with low disease activity
    N van Herwaarden
    Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands
    Clin Exp Rheumatol 32:390-4. 2014
    ..We investigated the feasibility of dose reduction to 4 mg/kg in patients who reached low disease activity at the registered dose of 8 mg/kg...
  21. ncbi request reprint Construct and criterion validity of several proposed DAS28-based rheumatoid arthritis flare criteria: an OMERACT cohort validation study
    Aatke van der Maas
    Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands
    Ann Rheum Dis 72:1800-5. 2013
    ..To describe rheumatoid arthritis (RA) worsening that leads to change or re-initiation of treatment, several Disease Activity Score 28 (DAS28)-based flare criteria have been described, but none validated...
  22. doi request reprint Joint-pain comorbidity, health status, and medication use in hip and knee osteoarthritis: a cross-sectional study
    Thomas J Hoogeboom
    Sint Maartenskliniek, Nijmegen, The Netherlands
    Arthritis Care Res (Hoboken) 64:54-8. 2012
    ..To determine the prevalence of joint-pain comorbidities in individuals with hip or knee osteoarthritis (OA) and to assess the differences in the characteristics of people with and without joint-pain comorbidities...
  23. doi request reprint The effects of doxycycline on reducing symptoms in knee osteoarthritis: results from a triple-blinded randomised controlled trial
    Gijs F Snijders
    Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands
    Ann Rheum Dis 70:1191-6. 2011
    ..The objective of this study was to investigate the effectiveness of doxycycline on pain and daily functioning in symptomatic knee osteoarthritis...
  24. ncbi request reprint Ultrasonographic analysis in knee osteoarthritis: evaluation of inter-observer reliability
    Karen Bevers
    Department of Rheumatology, Sint Maartenskliniek, Nijmegen, The Netherlands
    Clin Exp Rheumatol 30:673-8. 2012
    ..The objective of this study was to assess inter-observer reliability of ultrasonography (US) in the evaluation of specifically defined features in osteoarthritis (OA) of the knee...
  25. ncbi request reprint Neutrophil migration and production of reactive oxygen species during treatment with a fully human anti-tumor necrosis factor-alpha monoclonal antibody in patients with rheumatoid arthritis
    Alfons A den Broeder
    Department of Rheumatology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Rheumatol 30:232-7. 2003
    ....