Margje Sinnema

Summary

Country: The Netherlands

Publications

  1. doi request reprint Dementia in a woman with Prader-Willi syndrome
    Margje Sinnema
    Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
    Eur J Med Genet 53:145-8. 2010
  2. doi request reprint The use of medical care and the prevalence of serious illness in an adult Prader-Willi syndrome cohort
    Margje Sinnema
    Department of Clinical Genetics, Maastricht UMC, The Netherlands
    Eur J Med Genet 56:397-403. 2013
  3. doi request reprint Aging in Prader-Willi syndrome: twelve persons over the age of 50 years
    Margje Sinnema
    Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
    Am J Med Genet A 158:1326-36. 2012
  4. doi request reprint Behavioral phenotype in adults with Prader-Willi syndrome
    Margje Sinnema
    Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
    Res Dev Disabil 32:604-12. 2011
  5. doi request reprint Psychiatric illness in a cohort of adults with Prader-Willi syndrome
    Margje Sinnema
    Department of Clinical Genetics, Maastricht University Medical Centre, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Res Dev Disabil 32:1729-35. 2011
  6. doi request reprint Physical health problems in adults with Prader-Willi syndrome
    Margje Sinnema
    Department of Clinical Genetics, Maastricht UMC, Maastricht University, Maastricht, The Netherlands
    Am J Med Genet A 155:2112-24. 2011
  7. pmc Different distribution of the genetic subtypes of the Prader-Willi syndrome in the elderly
    Margje Sinnema
    Department of Clinical Genetics, Maastricht UMC, Maastricht, The Netherlands
    Eur J Hum Genet 18:993-8. 2010
  8. ncbi request reprint Healthcare transition in persons with intellectual disabilities: general issues, the Maastricht model, and Prader-Willi syndrome
    Constance T R M Schrander-Stumpel
    Department of Clinical Genetics, Academic Hospital Maastricht and Research Institute Growth and Development GROW, Maastricht Univesity, The Netherlands
    Am J Med Genet C Semin Med Genet 145:241-7. 2007
  9. doi request reprint Lymphedema in Prader-Willi syndrome
    Martijn V Heitink
    Department of Dermatology, Maastricht University Center for Molecular Dermatology, GROW School for Oncology and Developmental Biology, and Governor Kremers Center, University Medical Center Maastricht, The Netherlands
    Int J Dermatol 47:42-4. 2008

Collaborators

  • Stewart L Einfeld
  • Martijn V Heitink
  • Constance T R M Schrander-Stumpel
  • Lieke van den Hout
  • Henny M J van Schrojenstein Lantman-de Valk
  • Jaap J P Schrander
  • Leopold M G Curfs
  • Annemieke Wagemans
  • Marian A Maaskant

Detail Information

Publications9

  1. doi request reprint Dementia in a woman with Prader-Willi syndrome
    Margje Sinnema
    Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
    Eur J Med Genet 53:145-8. 2010
    ..Dementia might be associated with PWS. In the case of dementia, more clinical studies are warranted to observe whether premature Alzheimer changes or indications of other dementia forms indeed occur more prevalent in people with PWS...
  2. doi request reprint The use of medical care and the prevalence of serious illness in an adult Prader-Willi syndrome cohort
    Margje Sinnema
    Department of Clinical Genetics, Maastricht UMC, The Netherlands
    Eur J Med Genet 56:397-403. 2013
    ..We report on the consequences of high morbidity rates such as prevalence rate of hospital admissions, medication use and surgery in a Dutch cohort of adults with PWS. Special attention is paid to causes and symptoms of serious illness...
  3. doi request reprint Aging in Prader-Willi syndrome: twelve persons over the age of 50 years
    Margje Sinnema
    Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
    Am J Med Genet A 158:1326-36. 2012
    ..Special medical surveillance of people with PWS from 40 years onwards would ensure that intervention and support is offered with respect to specific areas of decline at the earliest possible time...
  4. doi request reprint Behavioral phenotype in adults with Prader-Willi syndrome
    Margje Sinnema
    Department of Clinical Genetics, Maastricht University Medical Centre, Maastricht, The Netherlands
    Res Dev Disabil 32:604-12. 2011
    ..Longitudinal studies are warranted to gain more insight into the natural history and course of behavioral problems in adults and older people with PWS over the long term and possible risk and preventive factors...
  5. doi request reprint Psychiatric illness in a cohort of adults with Prader-Willi syndrome
    Margje Sinnema
    Department of Clinical Genetics, Maastricht University Medical Centre, GROW School for Oncology and Developmental Biology, Maastricht University, Maastricht, The Netherlands
    Res Dev Disabil 32:1729-35. 2011
    ..More attention should be paid to the presence of precursor symptoms, indicating a developing psychiatric episode. Longitudinal studies are needed to gain more insight into the natural history of psychiatric illness in adults with PWS...
  6. doi request reprint Physical health problems in adults with Prader-Willi syndrome
    Margje Sinnema
    Department of Clinical Genetics, Maastricht UMC, Maastricht University, Maastricht, The Netherlands
    Am J Med Genet A 155:2112-24. 2011
    ..This underscores the importance of developing monitoring programs which would help to recognize physical health problems at an early stage...
  7. pmc Different distribution of the genetic subtypes of the Prader-Willi syndrome in the elderly
    Margje Sinnema
    Department of Clinical Genetics, Maastricht UMC, Maastricht, The Netherlands
    Eur J Hum Genet 18:993-8. 2010
    ..The results underline both the need for correct genetic diagnosis in all persons with PWS and adjustment of the guidelines for preventive management in adulthood...
  8. ncbi request reprint Healthcare transition in persons with intellectual disabilities: general issues, the Maastricht model, and Prader-Willi syndrome
    Constance T R M Schrander-Stumpel
    Department of Clinical Genetics, Academic Hospital Maastricht and Research Institute Growth and Development GROW, Maastricht Univesity, The Netherlands
    Am J Med Genet C Semin Med Genet 145:241-7. 2007
    ..Osteoporosis and sleep apnoea seem to be underestimated. Further longitudinal research is necessary for a better understanding of the aging process in PWS...
  9. doi request reprint Lymphedema in Prader-Willi syndrome
    Martijn V Heitink
    Department of Dermatology, Maastricht University Center for Molecular Dermatology, GROW School for Oncology and Developmental Biology, and Governor Kremers Center, University Medical Center Maastricht, The Netherlands
    Int J Dermatol 47:42-4. 2008
    ..After edema reduction, elastic compressive stockings were fit. To the best of our knowledge, this is the first report on primary lymphedema in a patient with Prader-Willi syndrome, an association that is probably often missed...