Peter A G M De Smet

..At present, such studies are particularly important for Germany, but in the future they may also become relevant for other countries, inside as well as outside Europe...

..The objective of our study was to measure the frequency, nature and management of drug-drug interaction alerts as these occur in daily practice of Dutch community pharmacies...

..Further pharmacokinetic studies to unveil potential Western and especially African herb-antiretroviral drug interactions are urgently required, and the clinical significance of these interactions should be assessed...

..These results strongly suggest that the rationale for therapeutic drug monitoring and CYP genotyping when prescribing antidepressants in secondary care also applies to the primary care setting...

..This paper reviews which steps should be explored or taken in these domains to improve the clinical risk management of adverse herb-drug interactions...

..A broad selection of specific examples and references that can be used as a basis for explicit screening of medication patterns in outpatients is also offered...

..It argues that specific components of clinical risk management need to be evaluated, before adoption, and then actively implemented if proven valuable...

..In addition, specific studies are needed to establish whether undesirable effects occur at the patient level...

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..This article describes the architecture, implementation and current status of the CMR in The Netherlands and compare it with similar systems in other countries...

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..An informative discontinuation letter for patients has been shown to reduce long-term benzodiazepine use in general practice. However, little is known about its wide scale implementation in primary care...

..We aimed to assess which method serves best to identify all patients with ACD in Dutch primary care: morbidity records, antiplatelet prescribing records or a combination of these...

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..It is up to the healthcare workers whether or not to implement the recommendations in clinical practice, which may lead to variations in degrees of uptake of the recommendations...

..These studies prompted the initiation of a Dutch multidisciplinary task force, which was assigned to reduce the number of prescriber-related hospital admissions related to medications (HARMs) in a quick-win way...

..The objective of the study was to assess the association between the quality of drug prescribing based on three indicator types derived from the DU90% method and different levels of functioning in pharmacotherapy audit meetings (PTAMs)...

..The aim of the study was to compare the effectiveness of intensive support for implementation of this tool in community pharmacies with minimal implementation support...

..Older people are prone to problems related to use of medicines. As they tend to use many different medicines, monitoring pharmacotherapy for older people in primary care is important...

..Research into the effective and efficient implementation of current guidelines on secondary prevention is therefore needed...

..Future studies should also assess whether results are sustained, the optimal time interval between reviews of repeat prescriptions, and the possibilities offered by new computerised support technologies...

..This case report describes the actual course of treatment, the reasons why it went wrong, and possible preventive measures...

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..In addition, serum creatinine monitoring was significantly less often performed in high-risk patients compared with low-risk patients...

..Improving the functioning of score lines may be a more practical approach than banning this dosage form...

..Our objective was to examine the clinical value of pharmacists' interventions to correct prescription errors...

..Therefore, it is important to review pharmacotherapy concerning older patients in primary care in a reliable way...

..Little is known about compliance with pharmacy practice guidelines for the management of drug-drug interaction alerts...

..Adequate dosing of medication in renal impairment to prevent hospitalizations and adverse reactions is a growing concern in the aging society. There are several dosing guidelines available, but structural use is uncommon...

..Awareness of these drug interactions and more frequent monitoring of INR values during the initial stages of antibacterial drug therapy are warranted to minimize the risk of bleeding complications...

..We investigated whether NSAIDs were associated with overanticoagulation during therapy with coumarins and evaluated the effect of the CYP2C9 polymorphisms on this potential interaction...

..This raised the question, how often Dutch community pharmacists have personal consultations with their patients in daily practice, on which factors this depends, and what kind of topics are discussed during these meetings...

..4, 95% confidence interval 2.2, 5.3). In view of the widespread use of lactulose, especially among the elderly, awareness of this potential drug interaction is required...

..Phenprocoumon appears to be a clinically useful alternative in patients carrying the CYP2C9*2 and *3 alleles...

..Documentation of diseases and intolerabilities in electronic patient records (EPRs) in pharmacies is needed to produce an alert in case a contraindicated medicine is prescribed. Limited research is available concerning EPRs in pharmacies...