Research Topics
| John John B SchnogSummaryCountry: The Netherlands Publications
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Publications
Plasma concentrations of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell patients but do not increase further during painful crisisPrecious P Landburg
Immunology Laboratory Department, Red Cross Blood Bank Foundation Curaçao, Curacao, Netherlands Antilles
Am J Hematol 83:577-9. 2008..54 micromol/L, HbAA 0.39 micromol/L) (P < 0.001). Yet plasma ADMA concentrations did not increase further at presentation with a painful crisis implicating no role of primary importance during vaso-occlusive crises...
Evidence for a metabolic shift of arginine metabolism in sickle cell diseaseJohn John B Schnog
Department of Internal Medicine 9B, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
Ann Hematol 83:371-5. 2004....- Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell diseaseJ B Schnog
Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
Ann Hematol 84:282-6. 2005..These results suggest an important role of ADMA in limiting NO availability in SCD, and its role in the pathophysiology of SCD should be further investigated... - Sickle cell disease; a general overviewJ B Schnog
Department of Internal Medicine, St Elisabeth Hospital, Curacao, The Netherlands Antilles
Neth J Med 62:364-74. 2004..With the increasing prevalence of SCD in the Netherlands, a fundamental understanding of its pathophysiology and clinical syndromes is of importance for local medical practitioners... 
N-acetylcysteine reduces oxidative stress in sickle cell patientsErfan Nur
Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
Ann Hematol 91:1097-105. 2012..These data indicate that N-acetylcysteine treatment of sickle cell patients may reduce SCD related oxidative stress...- Urinary markers of bone resorption, pyridinoline and deoxypyridinoline, are increased in sickle cell patients with further increments during painful crisisErfan Nur
Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, Amsterdam, The Netherlands
Am J Hematol 85:902-4. 2010..Urinary PYD and DPD concentrations are potentially diagnostic and prognostic tools in SCD... - Plasma levels of advanced glycation end products are associated with haemolysis-related organ complications in sickle cell patientsErfan Nur
Department of Internal Medicine, Slotervaart Hospital Department of Haematology Academic Medical Centre, Amsterdam, The Netherlands
Br J Haematol 151:62-9. 2010..Measurement of AGEs might be useful in predicting organ complications in SCD... - ADAMTS13 activity in sickle cell diseaseJohn John B Schnog
Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
Am J Hematol 81:492-8. 2006..67, P = 0.002). Although SCD is characterized by elevated VWF:Ag levels, no severe ADAMTS13 deficiency was detected in our patients... - Large and medium-sized pulmonary artery obstruction does not play a role of primary importance in the etiology of sickle-cell disease-associated pulmonary hypertensionEduard J van Beers
Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
Chest 133:646-52. 2008..The potential role of pulmonary artery obstruction, whether due to emboli or in situ thrombosis, in the etiology of SCD-related PHT is unknown... - Plasma levels of pentraxin-3, an acute phase protein, are increased during sickle cell painful crisisErfan Nur
Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
Blood Cells Mol Dis 46:189-94. 2011..The increase of PTX3 levels during painful crisis and their relation to the duration of subsequent hospital stay suggest that PTX3 might serve both as a diagnostic and severity marker of the painful sickle cell crisis... - Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytesErfan Nur
Dept of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
Biochim Biophys Acta 1812:1412-7. 2011..GSSG efflux, mediated by multidrug resistance-associated protein-1, is increased in sickle erythrocytes, resulting in net loss of intracellular glutathione and possibly higher susceptibility to oxidative stress... - Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease managementErfan Nur
Department of Internal Medicine, Slotervaart Hospital Amsterdam, The Netherlands
Am J Hematol 86:484-9. 2011..This review will summarize the role of ROS in SCD and their potential implication for SCD management... - Cardiopulmonary imaging, functional and laboratory studies in sickle cell disease associated pulmonary hypertensionEduard J van Beers
Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
Am J Hematol 83:850-4. 2008..The performed imaging and functional studies do not seem to be of value in identifying etiological conditions (such as airflow obstruction or parenchymal lung disease) nor do they offer clues to the presence of mild PHT in SCD... - Elevated endothelial progenitor cells during painful sickle cell crisisRachel T van Beem
Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands
Exp Hematol 37:1054-9. 2009..Circulating endothelial progenitor cells (EPCs) counts were determined in patients with sickle cell disease (SCD) to elucidate their role in SCD-related ischemia-induced angiogenesis and reendothelialization... - Serum levels of angiogenic factors indicate a pro-angiogenic state in adults with sickle cell diseaseAshley J Duits
Immunology Laboratory Department, Red Cross Blood Bank Foundation, Curacao, Netherlands Antilles
Br J Haematol 134:116-9. 2006..During painful crises, increased Ang-2 (P < 0.001) and PlGF (P = 0.04) occurred in HbSS and Ang-2 (P = 0.05) in HbSC patients. These results indicate a pro-angiogenic state in SCD, mainly because of elevated Ang-2 levels... - Sickle cell disease-related organ damage occurs irrespective of pain rate: implications for clinical practiceEduard J van Beers
Department of Haematology, F4 224, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
Haematologica 93:757-60. 2008.... - Sickle cell patients are characterized by a reduced glycocalyx volumeEduard J van Beers
Haematologica 93:307-8. 2008..47L, IQR 0.27-0.66, HbSC/HbSbeta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1 x 10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease... - Optimization of folic acid, vitamin B(12), and vitamin B(6) supplements in pediatric patients with sickle cell diseaseFey P L van der Dijs
Analytic Diagnostic Center, , The Netherlands Antilles
Am J Hematol 69:239-46. 2002..5-5 U.S. 1998 RDA), and 6 mg vitamin B(6) (4.6-10 U.S. 1998 RDA). This combination may by simple and relatively inexpensive means reduce these patients' inherently high risk of endothelial damage...