John John B Schnog

Summary

Country: The Netherlands

Publications

  1. doi request reprint Plasma concentrations of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell patients but do not increase further during painful crisis
    Precious P Landburg
    Immunology Laboratory Department, Red Cross Blood Bank Foundation Curaçao, Curacao, Netherlands Antilles
    Am J Hematol 83:577-9. 2008
  2. ncbi request reprint Evidence for a metabolic shift of arginine metabolism in sickle cell disease
    John John B Schnog
    Department of Internal Medicine 9B, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Ann Hematol 83:371-5. 2004
  3. ncbi request reprint Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell disease
    J B Schnog
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    Ann Hematol 84:282-6. 2005
  4. ncbi request reprint Sickle cell disease; a general overview
    J B Schnog
    Department of Internal Medicine, St Elisabeth Hospital, Curacao, The Netherlands Antilles
    Neth J Med 62:364-74. 2004
  5. pmc N-acetylcysteine reduces oxidative stress in sickle cell patients
    Erfan Nur
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    Ann Hematol 91:1097-105. 2012
  6. doi request reprint Urinary markers of bone resorption, pyridinoline and deoxypyridinoline, are increased in sickle cell patients with further increments during painful crisis
    Erfan Nur
    Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, Amsterdam, The Netherlands
    Am J Hematol 85:902-4. 2010
  7. doi request reprint Plasma levels of advanced glycation end products are associated with haemolysis-related organ complications in sickle cell patients
    Erfan Nur
    Department of Internal Medicine, Slotervaart Hospital Department of Haematology Academic Medical Centre, Amsterdam, The Netherlands
    Br J Haematol 151:62-9. 2010
  8. doi request reprint Large and medium-sized pulmonary artery obstruction does not play a role of primary importance in the etiology of sickle-cell disease-associated pulmonary hypertension
    Eduard J van Beers
    Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    Chest 133:646-52. 2008
  9. ncbi request reprint Optimization of folic acid, vitamin B(12), and vitamin B(6) supplements in pediatric patients with sickle cell disease
    Fey P L van der Dijs
    Analytic Diagnostic Center, Curacao, The Netherlands Antilles
    Am J Hematol 69:239-46. 2002
  10. ncbi request reprint ADAMTS13 activity in sickle cell disease
    John John B Schnog
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    Am J Hematol 81:492-8. 2006

Collaborators

Detail Information

Publications18

  1. doi request reprint Plasma concentrations of asymmetric dimethylarginine, an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell patients but do not increase further during painful crisis
    Precious P Landburg
    Immunology Laboratory Department, Red Cross Blood Bank Foundation Curaçao, Curacao, Netherlands Antilles
    Am J Hematol 83:577-9. 2008
    ..54 micromol/L, HbAA 0.39 micromol/L) (P < 0.001). Yet plasma ADMA concentrations did not increase further at presentation with a painful crisis implicating no role of primary importance during vaso-occlusive crises...
  2. ncbi request reprint Evidence for a metabolic shift of arginine metabolism in sickle cell disease
    John John B Schnog
    Department of Internal Medicine 9B, Slotervaart Hospital, Louwesweg 6, 1066 EC Amsterdam, The Netherlands
    Ann Hematol 83:371-5. 2004
    ....
  3. ncbi request reprint Plasma levels of asymmetric dimethylarginine (ADMA), an endogenous nitric oxide synthase inhibitor, are elevated in sickle cell disease
    J B Schnog
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    Ann Hematol 84:282-6. 2005
    ..These results suggest an important role of ADMA in limiting NO availability in SCD, and its role in the pathophysiology of SCD should be further investigated...
  4. ncbi request reprint Sickle cell disease; a general overview
    J B Schnog
    Department of Internal Medicine, St Elisabeth Hospital, Curacao, The Netherlands Antilles
    Neth J Med 62:364-74. 2004
    ..With the increasing prevalence of SCD in the Netherlands, a fundamental understanding of its pathophysiology and clinical syndromes is of importance for local medical practitioners...
  5. pmc N-acetylcysteine reduces oxidative stress in sickle cell patients
    Erfan Nur
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    Ann Hematol 91:1097-105. 2012
    ..These data indicate that N-acetylcysteine treatment of sickle cell patients may reduce SCD related oxidative stress...
  6. doi request reprint Urinary markers of bone resorption, pyridinoline and deoxypyridinoline, are increased in sickle cell patients with further increments during painful crisis
    Erfan Nur
    Department of Internal Medicine, Slotervaart Hospital, Louwesweg 6, Amsterdam, The Netherlands
    Am J Hematol 85:902-4. 2010
    ..Urinary PYD and DPD concentrations are potentially diagnostic and prognostic tools in SCD...
  7. doi request reprint Plasma levels of advanced glycation end products are associated with haemolysis-related organ complications in sickle cell patients
    Erfan Nur
    Department of Internal Medicine, Slotervaart Hospital Department of Haematology Academic Medical Centre, Amsterdam, The Netherlands
    Br J Haematol 151:62-9. 2010
    ..Measurement of AGEs might be useful in predicting organ complications in SCD...
  8. doi request reprint Large and medium-sized pulmonary artery obstruction does not play a role of primary importance in the etiology of sickle-cell disease-associated pulmonary hypertension
    Eduard J van Beers
    Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    Chest 133:646-52. 2008
    ..The potential role of pulmonary artery obstruction, whether due to emboli or in situ thrombosis, in the etiology of SCD-related PHT is unknown...
  9. ncbi request reprint Optimization of folic acid, vitamin B(12), and vitamin B(6) supplements in pediatric patients with sickle cell disease
    Fey P L van der Dijs
    Analytic Diagnostic Center, Curacao, The Netherlands Antilles
    Am J Hematol 69:239-46. 2002
    ..5-5 U.S. 1998 RDA), and 6 mg vitamin B(6) (4.6-10 U.S. 1998 RDA). This combination may by simple and relatively inexpensive means reduce these patients' inherently high risk of endothelial damage...
  10. ncbi request reprint ADAMTS13 activity in sickle cell disease
    John John B Schnog
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    Am J Hematol 81:492-8. 2006
    ..67, P = 0.002). Although SCD is characterized by elevated VWF:Ag levels, no severe ADAMTS13 deficiency was detected in our patients...
  11. doi request reprint Plasma levels of pentraxin-3, an acute phase protein, are increased during sickle cell painful crisis
    Erfan Nur
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    Blood Cells Mol Dis 46:189-94. 2011
    ..The increase of PTX3 levels during painful crisis and their relation to the duration of subsequent hospital stay suggest that PTX3 might serve both as a diagnostic and severity marker of the painful sickle cell crisis...
  12. doi request reprint Increased efflux of oxidized glutathione (GSSG) causes glutathione depletion and potentially diminishes antioxidant defense in sickle erythrocytes
    Erfan Nur
    Dept of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    Biochim Biophys Acta 1812:1412-7. 2011
    ..GSSG efflux, mediated by multidrug resistance-associated protein-1, is increased in sickle erythrocytes, resulting in net loss of intracellular glutathione and possibly higher susceptibility to oxidative stress...
  13. doi request reprint Oxidative stress in sickle cell disease; pathophysiology and potential implications for disease management
    Erfan Nur
    Department of Internal Medicine, Slotervaart Hospital Amsterdam, The Netherlands
    Am J Hematol 86:484-9. 2011
    ..This review will summarize the role of ROS in SCD and their potential implication for SCD management...
  14. doi request reprint Cardiopulmonary imaging, functional and laboratory studies in sickle cell disease associated pulmonary hypertension
    Eduard J van Beers
    Department of Hematology, Academic Medical Center, Amsterdam, The Netherlands
    Am J Hematol 83:850-4. 2008
    ..The performed imaging and functional studies do not seem to be of value in identifying etiological conditions (such as airflow obstruction or parenchymal lung disease) nor do they offer clues to the presence of mild PHT in SCD...
  15. doi request reprint Elevated endothelial progenitor cells during painful sickle cell crisis
    Rachel T van Beem
    Department of Experimental Immunohematology, Sanquin Research and Landsteiner Laboratory, Amsterdam, The Netherlands
    Exp Hematol 37:1054-9. 2009
    ..Circulating endothelial progenitor cells (EPCs) counts were determined in patients with sickle cell disease (SCD) to elucidate their role in SCD-related ischemia-induced angiogenesis and reendothelialization...
  16. ncbi request reprint Serum levels of angiogenic factors indicate a pro-angiogenic state in adults with sickle cell disease
    Ashley J Duits
    Immunology Laboratory Department, Red Cross Blood Bank Foundation, Curacao, Netherlands Antilles
    Br J Haematol 134:116-9. 2006
    ..During painful crises, increased Ang-2 (P < 0.001) and PlGF (P = 0.04) occurred in HbSS and Ang-2 (P = 0.05) in HbSC patients. These results indicate a pro-angiogenic state in SCD, mainly because of elevated Ang-2 levels...
  17. doi request reprint Sickle cell patients are characterized by a reduced glycocalyx volume
    Eduard J van Beers
    Haematologica 93:307-8. 2008
    ..47L, IQR 0.27-0.66, HbSC/HbSbeta(+)-thalassemia 0.23L, 0.0-0.58) compared with controls (1 x 10(9)L, 0.52-1.77) (p=0.03). Reduced glycocalyx may be a new factor in the pathophysiology of sickle cell disease...
  18. doi request reprint Sickle cell disease-related organ damage occurs irrespective of pain rate: implications for clinical practice
    Eduard J van Beers
    Department of Haematology, F4 224, Academic Medical Center, PO Box 22660, 1100 DD Amsterdam, The Netherlands
    Haematologica 93:757-60. 2008
    ....