- Nab2 regulates secondary CD8+ T-cell responses through control of TRAIL expressionMonika C Wolkers
Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology, CA, USA
Blood 119:798-804. 2012..These findings identify Nab2 as a mediator of Th-dependent CD8(+) T-cell memory responses through the regulation of TRAIL and the promotion of secondary expansion, and suggest a mechanism through which this operates...
- Interleukin-2 rescues helpless effector CD8+ T cells by diminishing the susceptibility to TRAIL mediated deathMonika C Wolkers
Department of Cellular Immunology, La Jolla Institute for Allergy and Immunology, 9420 Athena Circle, La Jolla, CA 92037, USA
Immunol Lett 139:25-32. 2011..Collectively, these data demonstrate that the helpless phenotype is not fixed, and that IL-2R signaling at the time of reactivation can play an important role in restoring CD8(+) T cell function...