P F van der Meer

..8 and that will give sufficient platelet increments after transfusion: a 1-hour CCI of >7.5 and a 20-hour CCI of >2.5...

..It was therefore our aim to study the effects of interruption of agitation on the in vitro parameters of PCs stored in platelet additive solutions...

..Welds were made with Terumo SCD (T-SCD) or CompoDock S2, and unwelded tubing served as reference...

..The rates at which the deleterious effects occur, however, are unknown. Therefore, in vitro parameters of PCs in additive solution (AS) during various periods without agitation have been investigated...

..This study compared cooling efficiency and in vitro quality of plasma and of stored white cell (WBC)-reduced red cells (RBCs) from overnight-stored WB, cooled with either of the systems...

..Apheresis donation procedures have fewer adverse events. All these factors need to be considered and weighed when selecting a method of platelet collection for a blood center...

..We evaluated the maximal storage time of the volume-reduced PCs in gas-permeable containers...

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..For hygienic purposes, plastic overwraps can be used for storage of leucoreduced red cell concentrates (LR-RCC). However, the effect of the use of such overwrapping on in vitro parameters during 42 days of storage was unknown...

..Thus, PASs seem to be an excellent replacement for (part of) the plasma when producing PCs, and allow extended storage with maintenance of quality, but more clinical studies are needed to substantiate in vitro results...

..It was our aim to compare currently used hematology analyzers for counting PLTs in PLT concentrates using fixed human PLTs...

..To increase blood donation speed, the connection between the needle and the tubing was modified. The aim was to evaluate the effect of this modification on various donation parameters...

..The study was performed in four blood centres where each tested four conditions. Study..

..This paper reviews alternative, non-radioactive methods, which includes biotinylation of platelets, and discrimination of transfused platelets based on HLA discrepancy. The benefits and disadvantages of these methods will be discussed...

..Until now, no paired comparison had been performed, and it was our aim to compare the effect of active versus no active cooling on the in vitro quality of WB and subsequently prepared blood components...

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..It is logistically preferable to hold WB overnight at room temperature for next-day processing. We compared in vitro quality of PLT-rich plasma (PRP)-derived PLT concentrates (PCs) from fresh versus overnight-held WB...

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..We investigated the mixing capacity of two whole blood (WB) collection mixers...

..The effect of storage time on the composition of WB and subsequently prepared WBC-reduced RBCs was studied...

..Extension of storage of leucocyte-reduced platelet concentrates (LR-PCs) to 7 days has recently been introduced, but the effect of gamma irradiation on in vitro parameters was unknown...

..The aim was to investigate PCs, WBC reduced and bacterially screened, from single-donor apheresis procedures, divided in 3 or 4 pediatric units and stored up to 5 days...

..The aim of this study was to examine in-vitro storage characteristics of PCs in various storage solutions: plasma only, or mixtures of plasma with PAS-II, PAS-III, PAS-IIIM, and Composol...

..8 and 7.4 and presence of the swirling effect. Our aim was to develop a standardized, semiautomated method for the production of LD-PC, by pooling of buffy coats (BC), and prestorage leukoreduction by filtration...

..We investigated the occurrence and production of WBC fragments in platelet concentrates (PCs) and plasma units, during storage and filtration, by using real-time polymerase chain reaction (PCR) and flow cytometry...

..For this, we varied the composition of the cryopreservation medium and studied various parameters of cryopreserved LR-PCs for up to 24 h after thawing at room temperature...

..Composol-PS has a slightly better buffering capacity, reflected as a more constant pH throughout the storage period...

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..Validation of blood gas analysers for pH measurement of these solutions is therefore mandatory...

..This filter has a 'limited' leukoreducing capacity, hence the filter is called a 'polishing' filter...

..However, the use of the mitochondrial inhibitor antimycin A is incompatible with platelet transfusion...

..The effect of these parameters of the initial cooling of leucoreduced red cell concentrates (LR-RCC) on in vitro quality is not known...

..The aim of this study was to investigate the influence of the filtration temperature, the wettability of the filter material, and the timing of the filtration after collection...

..In this study, three flow cytometric, low-level WBC counting methods were cross compared using two flow cytometers...

..The reproducibility of RBC ATP, DPG and haemolysis measurements between centres was investigated...

..To confirm the preliminary results and to evaluate the effects of different preparation protocols, an international multicentre study, which included 11 different sites, was conducted...