Ineke G A Bos

Summary

Affiliation: Sanquin Research
Country: The Netherlands

Publications

  1. ncbi request reprint Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor
    Ineke G A Bos
    Dept of Immunopathology, Sanquin Research at CLB, and Landsteiner Laboratory, Academical Medical Centre, University of Amsterdam, The Netherlands
    Biochim Biophys Acta 1648:75-83. 2003
  2. ncbi request reprint The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant
    Ineke G A Bos
    Department of Immunopathology, Sanquin Research at CLB, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 278:29463-70. 2003
  3. ncbi request reprint Effect of reactive site loop elongation on the inhibitory activity of C1-inhibitor
    Ineke G A Bos
    Department of Immunopathology, Sanquin Research at CLB, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Biochim Biophys Acta 1699:139-44. 2004
  4. ncbi request reprint Structure and function of C1-inhibitor
    Ineke G A Wagenaar-Bos
    Department of Immunopathology, Sanquin Research at CLB and Landsteiner Laboratory, Academical Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Immunol Allergy Clin North Am 26:615-32. 2006
  5. doi request reprint Functional C1-inhibitor diagnostics in hereditary angioedema: assay evaluation and recommendations
    Ineke G A Wagenaar-Bos
    Department of Immunopathology, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol Methods 338:14-20. 2008
  6. ncbi request reprint Pharmaceutical proteins from methylotrophic yeasts
    Eric C de Bruin
    Department of Immunopathology, Sanquin Research at CLB, Amsterdam, The Netherlands
    Methods Mol Biol 308:65-76. 2005
  7. ncbi request reprint Structural and functional aspects of C1-inhibitor
    Ineke G A Bos
    Dept Immunopathology, Academical Medical Centre, University of Amsterdam, The Netherlands
    Immunobiology 205:518-33. 2002

Collaborators

  • C Erik Hack
  • Hilary Longhurst
  • E W Nielsen
  • K Bork
  • M Cicardi
  • Ineke G A Wagenaar-Bos
  • Eric C de Bruin
  • George Fust
  • Margarita Lopez-Trascasa
  • Emel Aygören-Pürsün
  • Lilian Varga
  • Anette Bygum
  • Ed Nieuwenhuys
  • Jerzy Naskalski
  • Helen I Joller-Jemelka
  • Denise Ponard
  • S Marieke Van Ham
  • Hanna Gregorek
  • Christian Drouet
  • Christoph Bucher
  • Eric Wagner
  • Wolfhart Kreuz
  • Alaco Hickey
  • Maria Kapusta
  • Lennart Truedsson
  • Henriette Farkas
  • Kazimierz Madalinski
  • Lorenza Zingale
  • Erwin H Duitman
  • Marten Veenhuis
  • Arjo L de Boer

Detail Information

Publications7

  1. ncbi request reprint Recombinant human C1-inhibitor produced in Pichia pastoris has the same inhibitory capacity as plasma C1-inhibitor
    Ineke G A Bos
    Dept of Immunopathology, Sanquin Research at CLB, and Landsteiner Laboratory, Academical Medical Centre, University of Amsterdam, The Netherlands
    Biochim Biophys Acta 1648:75-83. 2003
    ..We conclude that the P. pastoris system is capable of high-level production of functionally and structurally intact human C1 inhibitor...
  2. ncbi request reprint The functional integrity of the serpin domain of C1-inhibitor depends on the unique N-terminal domain, as revealed by a pathological mutant
    Ineke G A Bos
    Department of Immunopathology, Sanquin Research at CLB, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
    J Biol Chem 278:29463-70. 2003
    ....
  3. ncbi request reprint Effect of reactive site loop elongation on the inhibitory activity of C1-inhibitor
    Ineke G A Bos
    Department of Immunopathology, Sanquin Research at CLB, and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Biochim Biophys Acta 1699:139-44. 2004
    ..These data suggest that the relatively weak inhibitory activity of C1-Inh is not the result of its short RSL. The short RSL of C1-Inh has, surprisingly, the optimal length for inhibition...
  4. ncbi request reprint Structure and function of C1-inhibitor
    Ineke G A Wagenaar-Bos
    Department of Immunopathology, Sanquin Research at CLB and Landsteiner Laboratory, Academical Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Immunol Allergy Clin North Am 26:615-32. 2006
    ..Recent studies suggest some anti-inflammatory functions for this N-terminal part, possibly explaining the effects of C1-INH in diseases other than HAE...
  5. doi request reprint Functional C1-inhibitor diagnostics in hereditary angioedema: assay evaluation and recommendations
    Ineke G A Wagenaar-Bos
    Department of Immunopathology, University of Amsterdam, Amsterdam, The Netherlands
    J Immunol Methods 338:14-20. 2008
    ..It can be concluded that the diagnosis of fC1-Inh deficiency was made correctly in most cases in this survey. We can recommend the chromogenic assay for the determination of fC1-Inh, while the complex ELISA needs further investigation...
  6. ncbi request reprint Pharmaceutical proteins from methylotrophic yeasts
    Eric C de Bruin
    Department of Immunopathology, Sanquin Research at CLB, Amsterdam, The Netherlands
    Methods Mol Biol 308:65-76. 2005
  7. ncbi request reprint Structural and functional aspects of C1-inhibitor
    Ineke G A Bos
    Dept Immunopathology, Academical Medical Centre, University of Amsterdam, The Netherlands
    Immunobiology 205:518-33. 2002
    ..This model gives insight into a possible potentiation mechanism of C1-Inh and based on this model the essential residues for efficient inhibition by C1-Inh are discussed...