R C Aalberse

Summary

Affiliation: Sanquin Research
Country: The Netherlands

Publications

  1. pmc IgG4 breaking the rules
    Rob C Aalberse
    Department of Immunopathology, CLB, Amsterdam, The Netherlands
    Immunology 105:9-19. 2002
  2. ncbi request reprint Coughing in pre-school children in general practice: when are RAST's for inhalation allergy indicated?
    Petra E D Eysink
    Department of General Practice, Division Clinical Methods and Public Health, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Pediatr Allergy Immunol 15:394-400. 2004
  3. pmc Assessment of allergen cross-reactivity
    Rob C Aalberse
    Sanquin Research and Karl Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Mol Allergy 5:2. 2007
  4. ncbi request reprint Assessment of sequence homology and cross-reactivity
    Rob C Aalberse
    Department of Immunopathology, Sanquin Research at CLB, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Toxicol Appl Pharmacol 207:149-51. 2005
  5. doi request reprint The role of IgG antibodies in allergy and immunotherapy
    R Aalberse
    Sanquin Research and Academic Medical Centre, Amsterdam, The Netherlands
    Allergy 66:28-30. 2011
  6. doi request reprint Differentiating the cellular and humoral components of neuromuscular blocking agent-induced anaphylactic reactions in patients undergoing anaesthesia
    R C Aalberse
    Department of Immunopathology, Sanquin Research, Plesmanlaan 125, 1066CX Amsterdam, The Netherlands
    Br J Anaesth 106:665-74. 2011
  7. ncbi request reprint In silico predictability of allergenicity: from amino acid sequence via 3-D structure to allergenicity
    Rob C Aalberse
    Sanquin Research at CLB, Landsteiner Laboratory, Academic Medical Centre, Department of Immunopathology, Amsterdam, The Netherlands
    Mol Nutr Food Res 50:625-7. 2006
  8. doi request reprint Immunoglobulin G4: an odd antibody
    R C Aalberse
    Sanquin and Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Allergy 39:469-77. 2009
  9. ncbi request reprint Structural features of allergenic molecules
    Rob C Aalberse
    Sanquin Research at CLB and Karl Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Chem Immunol Allergy 91:134-46. 2006
  10. doi request reprint IgE-binding epitopes: a reappraisal
    R C Aalberse
    Department of Immunopathology, Sanquin Research and Academic Medical Centre, Amsterdam, The Netherlands
    Allergy 66:1261-74. 2011

Collaborators

Detail Information

Publications61

  1. pmc IgG4 breaking the rules
    Rob C Aalberse
    Department of Immunopathology, CLB, Amsterdam, The Netherlands
    Immunology 105:9-19. 2002
    ..The main function of IgG4, however, is presumably to interfere with immune inflammation induced by complement-fixing antibodies, or, in the case of helminth infection or allergy, by IgE antibodies...
  2. ncbi request reprint Coughing in pre-school children in general practice: when are RAST's for inhalation allergy indicated?
    Petra E D Eysink
    Department of General Practice, Division Clinical Methods and Public Health, Academic Medical Center University of Amsterdam, Amsterdam, The Netherlands
    Pediatr Allergy Immunol 15:394-400. 2004
    ..The scoring formula may help GPs to identify children with a low probability of being sensitized. This may form the basis for watchful waiting. In others, allergy testing may be useful to gain more diagnostic certainty...
  3. pmc Assessment of allergen cross-reactivity
    Rob C Aalberse
    Sanquin Research and Karl Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Mol Allergy 5:2. 2007
    ..The need to define the affinity threshold of the assay and a caveat on the use of serum pools are also discussed...
  4. ncbi request reprint Assessment of sequence homology and cross-reactivity
    Rob C Aalberse
    Department of Immunopathology, Sanquin Research at CLB, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Toxicol Appl Pharmacol 207:149-51. 2005
    ..Yet, pre-existing cross-reactive T cell activity is likely to influence the outcome not only of the immune response, but also of the effector phase of the allergic reaction...
  5. doi request reprint The role of IgG antibodies in allergy and immunotherapy
    R Aalberse
    Sanquin Research and Academic Medical Centre, Amsterdam, The Netherlands
    Allergy 66:28-30. 2011
    ..IgG(4) can undergo in vitro switching to create bispecific antibodies that recognize more than one antigen, which has important consequences for reducing IgE-allergen complexes in immunotherapy...
  6. doi request reprint Differentiating the cellular and humoral components of neuromuscular blocking agent-induced anaphylactic reactions in patients undergoing anaesthesia
    R C Aalberse
    Department of Immunopathology, Sanquin Research, Plesmanlaan 125, 1066CX Amsterdam, The Netherlands
    Br J Anaesth 106:665-74. 2011
    ..The significance of IgE antibodies to neuromuscular blocking agent (NMBA)-induced anaphylactic reactions during anaesthesia is unclear. We investigated the relevance of IgE to rocuronium using an in vitro technique...
  7. ncbi request reprint In silico predictability of allergenicity: from amino acid sequence via 3-D structure to allergenicity
    Rob C Aalberse
    Sanquin Research at CLB, Landsteiner Laboratory, Academic Medical Centre, Department of Immunopathology, Amsterdam, The Netherlands
    Mol Nutr Food Res 50:625-7. 2006
    ..The question of whether any antigen can be allergenic is still a matter of debate...
  8. doi request reprint Immunoglobulin G4: an odd antibody
    R C Aalberse
    Sanquin and Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Clin Exp Allergy 39:469-77. 2009
    ..The existence of the IgG4 subclass, its up-regulation by anti-inflammatory factors and its own anti-inflammatory characteristics may help the immune system to dampen inappropriate inflammatory reactions...
  9. ncbi request reprint Structural features of allergenic molecules
    Rob C Aalberse
    Sanquin Research at CLB and Karl Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Chem Immunol Allergy 91:134-46. 2006
    ..According to this working hypothesis, the choice between these two routes is determined at the level of the germinal center activity...
  10. doi request reprint IgE-binding epitopes: a reappraisal
    R C Aalberse
    Department of Immunopathology, Sanquin Research and Academic Medical Centre, Amsterdam, The Netherlands
    Allergy 66:1261-74. 2011
    ....
  11. ncbi request reprint Der p 1 and Der p 2 induce less severe late asthmatic responses than native Dermatophagoides pteronyssinus extract after a similar early asthmatic response
    M J Van Der Veen
    Department of Pulmonology, Academic Medical Centre, University of Amsterdam, 1100 DE Amsterdam, The Netherlands
    Clin Exp Allergy 31:705-14. 2001
    ....
  12. ncbi request reprint The stripped basophil histamine release bioassay as a tool for the detection of allergen-specific IgE in serum
    I Kleine Budde
    Department of Immunopathology, CLB, Academic Medical Centre, University of Amsterdam, The Netherlands
    Int Arch Allergy Immunol 126:277-85. 2001
    ..Especially with sera containing IgE against minor components, this assay is more suitable than the RAST. Furthermore, in this assay, the dependency of IgE and of allergen-specific IgE in reactions can be studied in more detail...
  13. doi request reprint IgG4 antibodies against rodents in laboratory animal workers do not protect against allergic sensitization
    E J M Krop
    Department of Pulmonology, Academic Medical Center, University of Amsterdam, The Netherlands
    Allergy 66:517-22. 2011
    ..However, studies suggesting this protective effect all had a cross-sectional design, making it impossible to study the development of both responses...
  14. ncbi request reprint Immune reactivity to mite allergens in nonatopic subjects: immune deviation or immune ignorance
    R C Aalberse
    CLB and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int Arch Allergy Immunol 124:208-9. 2001
    ..We conclude that the pattern of IgG antibody in subjects without IgE to mites does not support the notion of immune deviation, but rather indicates a lack of a mite-induced high-affinity immune response...
  15. ncbi request reprint Inadvertent BSA-induced elution of IgE in the BSA-RAST
    I Kleine Budde
    Department of Immunopathology, CLB and Laboratory of Experimental and Clinical Immunology, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 56:1055-60. 2001
    ..CONCLUSIONS: Dissociation of IgE from immobilized protein in the presence of soluble protein should be taken into account, particularly when IgE to mammalian serum albumin is involved (milk, meat, or animal dander)...
  16. ncbi request reprint Recombinant major urinary proteins of the mouse in specific IgE and IgG testing
    Esmeralda J M Krop
    Department of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int Arch Allergy Immunol 144:296-304. 2007
    ..We tested the use of recombinant variants of the major mouse allergen Mus m 1 in detection of mouse-specific antibodies in sera of laboratory animal workers and children...
  17. ncbi request reprint Histamine-releasing factors, a heterogeneous group of different activities
    I Kleine Budde
    Department of Immunopathology, Sanquin Research at CLB, Amsterdam, The Netherlands
    Clin Exp Allergy 33:1175-82. 2003
    ..It might be better to avoid this terminology on and just describe the activity of the factors. Autoallergenic activity is likely to explain most, if not all, IgE-dependent activity...
  18. ncbi request reprint Cross-reactivity of IgE antibodies to allergens
    R C Aalberse
    CLB and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 56:478-90. 2001
    ..It is expected that similarity in short stretches of the linear amino-acid sequence is unlikely to result in relevant cross-reactivity between two proteins unless there is similarity in the protein fold...
  19. ncbi request reprint Structural aspects of cross-reactivity and its relation to antibody affinity
    R C Aalberse
    CLB and the Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam
    Allergy 56:27-9. 2001
    ..The implication is that a mast cell can be triggered by a single high-affinity antibody in combination with one or more low-affinity antibodies...
  20. ncbi request reprint Immunochemical characterization of two Pichia pastoris-derived recombinant group 5 Dactylis glomerata isoallergens
    E van Oort
    CLB Department of Immunopathology, Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Int Arch Allergy Immunol 126:196-205. 2001
    ..CONCLUSIONS: Dac g 5 was successfully cloned and expressed in P. pastoris. Minor differences in primary structure between isoforms influence their immune reactivity...
  21. ncbi request reprint Substitution of Pichia pastoris-derived recombinant proteins with mannose containing O- and N-linked glycans decreases specificity of diagnostic tests
    Erica van Oort
    Sanquin, Department of Immunopathology and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int Arch Allergy Immunol 135:187-95. 2004
    ..Recombinant proteins from Pichia pastoris need to be fully evaluated before used as diagnostic tools...
  22. ncbi request reprint IgE testing in capillary blood
    Steven O Stapel
    Sanquin CLB, Department of Allergy, Amsterdam, The Netherlands
    Pediatr Allergy Immunol 15:230-3. 2004
    ....
  23. doi request reprint Human IgG4 binds to IgG4 and conformationally altered IgG1 via Fc-Fc interactions
    Theo Rispens
    Sanquin Research, Amsterdam, The Netherlands
    J Immunol 182:4275-81. 2009
    ..By contrast, IgG4 Fc recognizes IgG1 only after a conformational change that renders CH3(IgG1) accessible to an interaction with the CH3(IgG4). Such Fc interactions may enhance Ag binding of IgG4 in vivo...
  24. doi request reprint Measurement of serum levels of natalizumab, an immunoglobulin G4 therapeutic monoclonal antibody
    Theo Rispens
    Sanquin Research, 1066 CX Amsterdam, The Netherlands
    Anal Biochem 411:271-6. 2011
    ..We demonstrate how these features can interfere with measurement of specific IgG4 and describe how we addressed these issues, resulting in an assay that is not sensitive to Fab arm exchange by natalizumab or to IgG4 Fc interactions...
  25. doi request reprint Hybrid IgG4/IgG4 Fc antibodies form upon 'Fab-arm' exchange as demonstrated by SDS-PAGE or size-exclusion chromatography
    Theo Rispens
    Sanquin Research, Amsterdam, The Netherlands
    Mol Immunol 47:1592-4. 2010
    ....
  26. doi request reprint Traces of pFc' in IVIG interact with human IgG Fc domains and counteract aggregation
    Theo Rispens
    Sanquin Research, Amsterdam, The Netherlands
    Eur J Pharm Sci 40:62-8. 2010
    ..Thus, pFc' can modulate Fc interactions and may therefore reduce adverse effects of IVIG, in particular by preventing oligomerization...
  27. ncbi request reprint The apparent monovalency of human IgG4 is due to bispecificity
    R C Aalberse
    CLB, Sanquin, and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands
    Int Arch Allergy Immunol 118:187-9. 1999
    ..The postulated bispecific IgG4 antibodies can indeed be found in selected human sera following repeated immunization with two non-crossreacting antigens...
  28. doi request reprint Dynamics in cytokine responses during the development of occupational sensitization to rats
    Esmeralda J M Krop
    Department of Pulmonology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Allergy 65:1227-33. 2010
    ..In a cohort of starting laboratory animal workers, we previously found 20% sensitization to animal allergens within 2 years...
  29. ncbi request reprint Do levels of immunoglobulin G antibodies to foods predict the development of immunoglobulin E antibodies to cat, dog and/or mite?
    P E D Eysink
    Department of General Practice, Division of Public Health, Academic Medical Center, University of Amsterdam, The Netherlands
    Clin Exp Allergy 32:556-62. 2002
    ..In children at high risk of inhalation allergy, food sensitization is associated with an increased risk for sensitization to inhalant allergens. Furthermore, this association was also found in a cross-sectional study...
  30. ncbi request reprint Allergens from mites: implications of cross-reactivity between invertebrate antigens
    R C Aalberse
    Central Laboratory of the Blood Transfusion Service and Academic Medical Centre, University of Amsterdam, The Netherlands
    Allergy 53:47-8. 1998
    ..Purified (recombinant) allergens, selected for low cross-reactivity, are urgently needed...
  31. ncbi request reprint How do we avoid developing allergy: modifications of the TH2 response from a B-cell perspective
    Rob C Aalberse
    Sanquin Research at CLB and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Postbox 9190, 1006 AD Amsterdam, The Netherlands
    J Allergy Clin Immunol 113:983-6. 2004
    ..These IgG4-switched B memory cells might occasionally undergo a secondary switch to IgE...
  32. ncbi request reprint IgE binding to pepsin-digested food extracts
    Jaap H Akkerdaas
    Sanquin Research, Department of Immunopathology and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, Amsterdam, The Netherlands
    Int Arch Allergy Immunol 138:203-8. 2005
    ..However, for many foods, purified allergens are not (yet) available...
  33. pmc The analysis and quantification of a clonal B cell response in a hyperimmunized anti-D donor
    S E Dohmen
    Sanquin Research, Amsterdam and Landsteiner Laboratory, Academic Medical Center, University of Amsterdam, Plesmanlaan 125, 10066 CX Amsterdam, The Netherlands
    Clin Exp Immunol 144:223-32. 2006
    ..Furthermore, we found a high frequency of clonal B cells. These results contribute to the understanding of the immune response against RhD in hyperimmunized anti-D donors...
  34. ncbi request reprint Structural biology of allergens
    R C Aalberse
    Department of Allergy, CLB and the Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    J Allergy Clin Immunol 106:228-38. 2000
    ..Within this constraint, any antigen may be allergenic, particularly if it avoids activation of T(H)2-suppressive mechanisms (CD8 cells and T(H)1 cells)...
  35. ncbi request reprint Allergen-induced bronchial inflammation in house dust mite-allergic patients with or without asthma
    C E Lopuhaä
    Department of Pulmonology, Academic Medical Center, Amsterdam, The Netherlands
    Clin Exp Allergy 32:1720-7. 2002
    ..The level of allergen-specific IgE antibodies does not seem to be decisive for asthmatic symptoms. Moreover, levels of exposure to mite allergens do not seem to differ significantly between asthmatic and non-asthmatics individuals...
  36. ncbi request reprint The inter-heavy chain disulfide bonds of IgG4 are in equilibrium with intra-chain disulfide bonds
    J Schuurman
    Laboratory for Experimental and Clinical Immunology, Department of Immunopathology of the CLB, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Mol Immunol 38:1-8. 2001
    ....
  37. ncbi request reprint Anti-inflammatory activity of human IgG4 antibodies by dynamic Fab arm exchange
    Marijn van der Neut Kolfschoten
    Sanquin Research AMC Landsteiner Laboratory, Department of Immunopathology, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    Science 317:1554-7. 2007
    ..IgG4 Fab arm exchange is suggested to be an important biological mechanism that provides the basis for the anti-inflammatory activity attributed to IgG4 antibodies...
  38. ncbi request reprint Lack of correlation between bronchial late allergic reaction to Dermatophagoides pteronyssinus and in vitro immunoglobulin E reactivity to histamine-releasing factor derived from mononuclear cells
    Ilona Kleine Budde
    Department of Immunopathology, Sanquin Research at CLB, Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, The Netherlands
    Ann Allergy Asthma Immunol 89:606-12. 2002
    ..Sera capable of passively sensitizing basophils to release histamine to HRF were designated IgE+ sera. IgE+ and HRF have been suggested to play a role in late allergic reaction (LAR)...
  39. doi request reprint Detection of conformational changes in immunoglobulin G using isothermal titration calorimetry with low-molecular-weight probes
    Theo Rispens
    Sanquin Research, 1066 CX Amsterdam, The Netherlands
    Anal Biochem 380:303-9. 2008
    ..The data illustrate that ITC with low-molecular-weight probes is a versatile tool to monitor conformational changes in proteins with a wider application potential than fluorescence measurements...
  40. ncbi request reprint Maturation of Pichia pastoris-derived recombinant pro-Der p 1 induced by deglycosylation and by the natural cysteine protease Der p 1 from house dust mite
    Erica van Oort
    CLB Department of Immunopathology and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, The Netherlands
    Eur J Biochem 269:671-9. 2002
    ..In conclusion, high-level expression of rpro-Der p 1 in P. pastoris results in a stable hypoallergenic proenzyme with potential for use in allergen-specific immunotherapy...
  41. ncbi request reprint Characterization of immunoglobulin G fragments in liquid intravenous immunoglobulin products
    Robert V Diemel
    Department of Immunopathology, Section of Immunoglobulin Research, Sanquin Research at CLB, Amsterdam, The Netherlands
    Transfusion 45:1601-9. 2005
    ..Preferably, such liquid products should not alter after storage outside the refrigerator. Therefore, a thorough characterization of immunoglobulin G (IgG) fragmentation at various storage temperatures is required...
  42. ncbi request reprint Characterization of natural Dac g 1 variants: an alternative to recombinant group 1 allergens
    Erica van Oort
    Department of Immunopathology, Sanquin Research, Plesmanlaan 125, 1066 CX Amsterdam, The Netherlands
    J Allergy Clin Immunol 114:1124-30. 2004
    ..Production of soluble correctly folded recombinant group 1 allergens has proven to be difficult. Purified natural group 1 allergens could be an alternative for application in immunotherapy...
  43. pmc Spreading of occupational allergens: laboratory animal allergens on hair-covering caps and in mattress dust of laboratory animal workers
    Esmeralda J M Krop
    Department of Pulmonology, Academic Medical Center, Amsterdam, The Netherlands
    Occup Environ Med 64:267-72. 2007
    ..Family members of laboratory animal workers are at risk of developing allergy to laboratory animals. Little is known about the spreading of laboratory animal allergens outside the animal facilities...
  44. pmc Accuracy of specific IgE in the prediction of asthma: development of a scoring formula for general practice
    Petra E D Eysink
    Department of General Practice, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Br J Gen Pract 55:125-31. 2005
    ..The additional diagnostic value of specific immunoglobulin E (IgE) to inhalent allergens remains unclear...
  45. ncbi request reprint A novel approach for the detection of potentially hazardous pepsin stable hazelnut proteins as contaminants in chocolate-based food
    Jaap H Akkerdaas
    Sanquin Research, Department of Immunopathology and Laboratory for Experimental and Clinical Immunology, Academic Medical Centre, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
    J Agric Food Chem 52:7726-31. 2004
    ..It can be concluded that the application of antibodies directed to pepsin-digested food extracts in ELISA can facilitate specific detection of stable proteins that have the highest potential of inducing severe food anaphylaxis...
  46. doi request reprint Associations between pre-employment immunologic and airway mucosal factors and the development of occupational allergy
    Esmeralda J M Krop
    Department of Pulmonology, Academic Medical Center, University of Amsterdam, The Netherlands
    J Allergy Clin Immunol 123:694-700, 700.e1-3. 2009
    ..Atopy is a major risk factor for sensitization, but it is considered insufficient to advise against working with animals...
  47. ncbi request reprint How accurate and safe is the diagnosis of hazelnut allergy by means of commercial skin prick test reagents?
    Jaap H Akkerdaas
    Department of Immunopathology, Sanquin Research at CLB, Amsterdam, The Netherlands
    Int Arch Allergy Immunol 132:132-40. 2003
    ..Tree nut allergy is frequently associated with severe reactions. Diagnosis partially relies on in vivo testing by means of a skin prick test (SPT) using commercially available SPT reagents...
  48. pmc Studies on the association between immunoglobulin E autoreactivity and immunoglobulin E-dependent histamine-releasing factors
    Ilona Kleine Budde
    Department of Immunopathology, Sanquin Research at CLB, Landsteiner Laboratory, Academic Medical Centre, University of Amsterdam, Plesmanlaan 125, Amsterdam, The Netherlands
    Immunology 107:243-51. 2002
    ..A 20 000 MW IgE-defined autoantigen cross-reacted with a shrimp allergen. Our results indicate that IgE-reactivity to immunoblotted human protein and IgE-dependent HRF activity are distinct entities that may co-occur in atopic patients...
  49. doi request reprint IgG subclasses of anti-FVIII antibodies during immune tolerance induction in patients with hemophilia A
    Pauline M W van Helden
    Department of Plasma Proteins, Van Creveld Laboratorium and Landsteiner Laboratorium of the AMC at Sanquin Research, Amsterdam, The Netherlands
    Br J Haematol 142:644-52. 2008
    ..Future studies will need to address whether monitoring the relative contribution of anti-FVIII subclasses IgG1 and IgG4 may be useful for the identification of patients who are at risk of failing ITI...
  50. ncbi request reprint Comparison of allergen-induced late inflammatory reactions in the nose and in the skin in house dust mite-allergic patients with or without asthma
    Christa E Lopuhaa
    Department of Pulmonology, Academic Medical Center, Amsterdam, The Netherlands
    Int Arch Allergy Immunol 130:266-74. 2003
    ..We hypothesized that differences in the late allergic inflammatory reaction to allergen between asthmatic and non-asthmatic house dust mite-allergic individuals might contribute to the difference in the clinical presentation of allergy...
  51. ncbi request reprint The major grass pollen group 5 allergen from Dactylis glomerata and its C-terminal split product both behave as dimers: implications for allergen standardization
    Erica van Oort
    Sanquin, Department of Immunopathology and Laboratory for Experimental and Clinical Immunology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Int Arch Allergy Immunol 136:113-22. 2005
    ..The aim of this study was to investigate these group 5 molecular entities and to compare their allergenicity and behavior in quantitative immunoassays...
  52. ncbi request reprint Cloning of oleosin, a putative new hazelnut allergen, using a hazelnut cDNA library
    Jaap H Akkerdaas
    Academical Medical Center, Department of Experimental Immunology, University of Amsterdam, Amsterdam, The Netherlands
    Mol Nutr Food Res 50:18-23. 2006
    ..Hazelnut contains multiple isoforms of oleosin. IgE binding of a hazelnut-allergic patient to a recombinant version suggest that hazelnut oleosin is an allergen, as has been described for peanut and sesame...
  53. ncbi request reprint IgE to Bet v 1 and profilin: cross-reactivity patterns and clinical relevance
    Marjolein Wensing
    Department of Dermatology Allergology, University Medical Centre Utrecht, The Netherlands
    J Allergy Clin Immunol 110:435-42. 2002
    ..Individuals with pollen allergy often have IgE against plant-derived foods. This can be due to cross-reactive IgE against Bet v 1 and homologues, profilins, and/or cross-reactive carbohydrate determinants...
  54. ncbi request reprint Mouse allergen exposure and immunologic responses: IgE-mediated mouse sensitization and mouse specific IgG and IgG4 levels
    Elizabeth C Matsui
    Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Ann Allergy Asthma Immunol 93:171-8. 2004
    ..Although there is evidence that contact with mice is associated with IgE-mediated mouse sensitization and mouse specific antibody responses, the exposure-response relationships remain unclear...
  55. ncbi request reprint Elevated levels of IgG and IgG4 to Malassezia allergens in atopic eczema patients with IgE reactivity to Malassezia
    Catharina Johansson
    Department of Medicine, Unit of Clinical Allergy Research, Karolinska Institute and Hospital, Stockholm, Sweden
    Int Arch Allergy Immunol 135:93-100. 2004
    ..Elevated serum IgE levels, T-cell proliferation and positive skin prick test (SPT) and atopy patch test (APT) reactions to Malassezia are found among AE patients...
  56. ncbi request reprint Effect of mattress encasings on atopic dermatitis outcome measures in a double-blind, placebo-controlled study: the Dutch mite avoidance study
    Albert Jan Oosting
    Department of Dermatology and Allergology, University Medical Centre Utrecht, The Netherlands
    J Allergy Clin Immunol 110:500-6. 2002
    ..House dust mite (HDM) allergen might induce and maintain atopic dermatitis (AD). Reduction of allergen load by applying encasings might improve the clinical symptoms of AD...
  57. pmc Mite and pet allergen levels in homes of children born to allergic and nonallergic parents: the PIAMA study
    Rob T van Strien
    Department of Environmental and Occupational Health, Institute for Risk Assessment Sciences, Utrecht University, Utrecht, The Netherlands
    Environ Health Perspect 110:A693-8. 2002
    ..Parental mattresses in homes of allergic mothers had lower cat and mite (but not dog) allergen loadings than mattresses in homes of nonallergic parents. Paternal (as opposed to maternal) allergy seemed to have little influence...
  58. doi request reprint Cross-reactive IgE antibody responses to tropomyosins from Ascaris lumbricoides and cockroach
    Ana Beatriz R Santos
    Department of Internal Medicine, School of Medicine of Ribeirao Preto, University of Sao Paulo, Ribeirao Preto, Brazil
    J Allergy Clin Immunol 121:1040-6.e1. 2008
    ..Evidence indicates that infection with Ascaris lumbricoides may promote development of allergy and asthma...
  59. ncbi request reprint Evaluation of impermeable covers for bedding in patients with allergic rhinitis
    Ingrid Terreehorst
    Department of Allergology, Erasmus Medical Center, Rotterdam, Netherlands
    N Engl J Med 349:237-46. 2003
    ....
  60. ncbi request reprint Allergen exposure in infancy and the development of sensitization, wheeze, and asthma at 4 years
    Jessica E Brussee
    Center for Prevention and Health Services Research, National Institute for Public Health and Environment, Bilthoven, The Netherlands
    J Allergy Clin Immunol 115:946-52. 2005
    ..The relationship between mite and pet allergen exposure in infancy and the subsequent development of sensitization and asthma is complex...
  61. ncbi request reprint The effect of prenatal exposure on total IgE at birth and sensitization at twelve months and four years of age: The PIAMA study
    Marjan Kerkhof
    Department of Epidemiology, University of Groningen, Groningen, The Netherlands
    Pediatr Allergy Immunol 16:10-8. 2005
    ..Our results suggest a short-lasting protective effect of prenatal exposure to pets on total IgE at birth and early sensitization...