M Samsom

Summary

Country: The Netherlands

Publications

  1. ncbi Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients
    M Samsom
    Gastrointestinal Motility Unit, University Hospital Utrecht, Utrecht, The Netherlands
    Gastroenterology 116:515-20. 1999
  2. ncbi Effect of inhibition of gastric acid secretion on antropyloroduodenal motor activity and duodenal acid hypersensitivity in functional dyspepsia
    M P Schwartz
    Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Center, Utrecht, The Netherlands
    Aliment Pharmacol Ther 15:1921-8. 2001
  3. doi Effect of proximal gastric volume on hiatal hernia
    R C H Scheffer
    Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Neurogastroenterol Motil 22:552-6, e120. 2010
  4. doi Gastroesophageal reflux disease is associated with the C825T polymorphism in the G-protein beta3 subunit gene (GNB3)
    D R de Vries
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Gastroenterol 104:281-5. 2009
  5. ncbi Effect of coffee on gastro-oesophageal reflux in patients with reflux disease and healthy controls
    P J Boekema
    Department of Gastroenterology, University Medical Center, Utrecht, The Netherlands
    Eur J Gastroenterol Hepatol 11:1271-6. 1999
  6. ncbi Air swallowing, belching, acid and non-acid reflux in patients with functional dyspepsia
    J M Conchillo
    Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Aliment Pharmacol Ther 25:965-71. 2007
  7. ncbi Chemospecific alterations in duodenal perception and motor response in functional dyspepsia
    M P Schwartz
    Department of Gastroenterology and Surgery, University Medical Center, Utrecht, The Netherlands
    Am J Gastroenterol 96:2596-602. 2001
  8. ncbi Role of intra-oesophageal impedance monitoring in the evaluation of endoscopic gastroplication for gastro-oesophageal reflux disease
    J M Conchillo
    Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Aliment Pharmacol Ther 26:61-8. 2007
  9. ncbi The gastro-oesophageal common cavity revisited
    M C Aanen
    Gastrointestinal Research Unit, University Medical Center, Utrecht, The Netherlands
    Neurogastroenterol Motil 18:1056-61. 2006
  10. doi Validation of a disease-specific quality-of-life questionnaire in a large sample of Dutch achalasia patients
    R Frankhuisen
    Department of Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands
    Dis Esophagus 21:544-50. 2008

Collaborators

Detail Information

Publications32

  1. ncbi Abnormal clearance of exogenous acid and increased acid sensitivity of the proximal duodenum in dyspeptic patients
    M Samsom
    Gastrointestinal Motility Unit, University Hospital Utrecht, Utrecht, The Netherlands
    Gastroenterology 116:515-20. 1999
    ..The aim of this study was to investigate clearance of acid from the duodenum and its relationship with symptoms in patients with functional dyspepsia...
  2. ncbi Effect of inhibition of gastric acid secretion on antropyloroduodenal motor activity and duodenal acid hypersensitivity in functional dyspepsia
    M P Schwartz
    Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Center, Utrecht, The Netherlands
    Aliment Pharmacol Ther 15:1921-8. 2001
    ..Heightened visceroperception and a decreased duodenal motor response to intraduodenal acid infusion have been reported in functional dyspepsia...
  3. doi Effect of proximal gastric volume on hiatal hernia
    R C H Scheffer
    Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Neurogastroenterol Motil 22:552-6, e120. 2010
    ..Therefore, the aim of this study was to investigate the relationship between proximal gastric volume, the presence of a hiatal hernia profile and acid reflux...
  4. doi Gastroesophageal reflux disease is associated with the C825T polymorphism in the G-protein beta3 subunit gene (GNB3)
    D R de Vries
    Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Gastroenterol 104:281-5. 2009
    ....
  5. ncbi Effect of coffee on gastro-oesophageal reflux in patients with reflux disease and healthy controls
    P J Boekema
    Department of Gastroenterology, University Medical Center, Utrecht, The Netherlands
    Eur J Gastroenterol Hepatol 11:1271-6. 1999
    ..Many patients with gastro-oesophageal reflux disease (GORD) report that coffee aggravates their symptoms and doctors tend to discourage its use in GORD...
  6. ncbi Air swallowing, belching, acid and non-acid reflux in patients with functional dyspepsia
    J M Conchillo
    Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Aliment Pharmacol Ther 25:965-71. 2007
    ..We hypothesized that patients with functional dyspepsia possibly have a higher frequency of belching than healthy subjects secondary to frequent air swallowing...
  7. ncbi Chemospecific alterations in duodenal perception and motor response in functional dyspepsia
    M P Schwartz
    Department of Gastroenterology and Surgery, University Medical Center, Utrecht, The Netherlands
    Am J Gastroenterol 96:2596-602. 2001
    ....
  8. ncbi Role of intra-oesophageal impedance monitoring in the evaluation of endoscopic gastroplication for gastro-oesophageal reflux disease
    J M Conchillo
    Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Aliment Pharmacol Ther 26:61-8. 2007
    ..In the evaluation of several endoscopic antireflux procedures, a discrepancy in the degree of improvement between symptoms and objective reflux parameters as measured by pH-metry has been reported...
  9. ncbi The gastro-oesophageal common cavity revisited
    M C Aanen
    Gastrointestinal Research Unit, University Medical Center, Utrecht, The Netherlands
    Neurogastroenterol Motil 18:1056-61. 2006
    ..The common cavity is a specific but not a sensitive marker of gastro-oesophageal reflux. Furthermore, common cavities are not specific for a particular type of reflux...
  10. doi Validation of a disease-specific quality-of-life questionnaire in a large sample of Dutch achalasia patients
    R Frankhuisen
    Department of Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands
    Dis Esophagus 21:544-50. 2008
    ..The questionnaire was easy in use. The translated version of the achalasia-DSQoL is a valid and reliable instrument to compare groups of achalasia patients although the question concerning heartburn should be excluded...
  11. ncbi Impaired bolus transit across the esophagogastric junction in postfundoplication dysphagia
    R C H Scheffer
    Gastrointestinal Research Unit, Departments of Surgery and Gastroenterology, University Medical Center, Utrecht, The Netherlands
    Am J Gastroenterol 100:1677-84. 2005
    ..This study assessed the effect of fundoplication on liquid and solid bolus transit across the esophagogastric junction (EGJ) in relation to EGJ dynamics and dysphagia...
  12. ncbi Clinical relevance of antroduodenal manometry
    M A Verhagen
    Gastrointestinal Motility Unit, University Hospital, Utrecht, The Netherlands
    Eur J Gastroenterol Hepatol 11:523-8. 1999
    ..To evaluate the outcome of antroduodenal manometry studies and their effect on the clinical treatment of patients...
  13. ncbi Interdigestive gallbladder emptying, antroduodenal motility, and motilin release patterns are altered in cholesterol gallstone patients
    M F Stolk
    Department of Gastroenterology, University Hospital, Utrecht, The Netherlands
    Dig Dis Sci 46:1328-34. 2001
    ..In conclusion, cholesterol gallstone patients have an abnormal MMC and motilin release pattern. Their interdigestive gallbladder emptying is reduced and dissociated from the MMC. These disturbances may contribute to gallstone formation...
  14. ncbi Prevalence of delayed gastric emptying in diabetic patients and relationship to dyspeptic symptoms: a prospective study in unselected diabetic patients
    M Samsom
    Gastrointestinal Research Unit, University Medical Center, Utrecht, The Netherlands
    Diabetes Care 26:3116-22. 2003
    ....
  15. ncbi Manometric artefacts suggesting compression of the duodenum by the superior mesenteric artery in healthy humans
    M P Schwartz
    Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Center, Utrecht, The Netherlands
    Neurogastroenterol Motil 13:143-9. 2001
    ..In addition, a 'silent' region was present just distal to this site, the origin of which is uncertain...
  16. doi Candidate genotypes associated with functional dyspepsia
    N van Lelyveld
    Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neurogastroenterol Motil 20:767-73. 2008
    ..Tertiary referral FD is associated with the 825T allele of the GNB3 gene. The increased signal transduction associated with this allele may contribute to the abnormalities in gastroduodenal sensory and motor function observed in FD...
  17. doi In GERD patients, mucosal repair associated genes are upregulated in non-inflamed oesophageal epithelium
    D R de Vries
    Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    J Cell Mol Med 13:936-47. 2009
    ..Possibly this process helps maintaining barrier function...
  18. pmc Impact of delayed gastric emptying on the outcome of antireflux surgery
    J E Bais
    Gastrointestinal Research Unit, University Medical Centre Utrecht University, Utrecht, The Netherlands
    Ann Surg 234:139-46. 2001
    ..Delayed gastric emptying is not a contraindication for antireflux surgery...
  19. ncbi Human duodenal motor activity in response to acid and different nutrients
    M P Schwartz
    Department of Gastroenterology, University Medical Center, Utrecht, The Netherlands
    Dig Dis Sci 46:1472-81. 2001
    ..The findings suggest that chemoreceptors in the duodenal wall provide input to local or regional control mechanisms involved in the regulation of duodenal motility...
  20. doi Serotonergic signalling in the stomach and duodenum of patients with gastroparesis
    N van Lelyveld
    Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neurogastroenterol Motil 20:448-55. 2008
    ..015). This study suggests that the delayed gastric emptying and upper abdominal symptoms in idiopathic gastroparesis do not result from altered mucosal 5-HT biosynthetic and uptake capacity...
  21. ncbi Regional differences in expression of TPH-1, SERT, 5-HT(3) and 5-HT(4) receptors in the human stomach and duodenum
    N van Lelyveld
    Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neurogastroenterol Motil 19:342-8. 2007
    ....
  22. doi Trypsinogen IV, serotonin transporter transcript levels and serotonin content are increased in small intestine of irritable bowel syndrome patients
    A P M Kerckhoffs
    Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Neurogastroenterol Motil 20:900-7. 2008
    ..Increased SERT expression and mucosal 5-HT content in IBS suggest higher 5-HT availability. Both may contribute to small intestinal visceral hypersensitivity in IBS patients...
  23. ncbi The effect of coffee on gastric emptying and oro-caecal transit time
    P J Boekema
    University Medical Center Utrecht, Utrecht, The Netherlands
    Eur J Clin Invest 30:129-34. 2000
    ..The consumption of coffee allegedly induces or aggravates gastrointestinal symptoms. In order to investigate the effect of coffee on gastrointestinal motility we studied the effect of coffee on gastric emptying and oro-caecal transit time...
  24. ncbi Small intestinal glucose absorption and duodenal motility in type 1 diabetes mellitus
    C K Rayner
    Gastrointestinal Research Unit, Department of Gastroenterolog University Medical Center, Utrecht, The Netherlands
    Am J Gastroenterol 97:3123-30. 2002
    ..Our aim was to evaluate small intestinal glucose absorption and duodenal motor responses to intraduodenal nutrients, in patients with type 1 diabetes and controls...
  25. doi High prevalence of esophageal involvement in lichen planus: a study using magnification chromoendoscopy
    R Quispel
    Department of Gastroenterology, University Medical Center Utrecht, Utrecht, The Netherlands
    Endoscopy 41:187-93. 2009
    ..We performed a study to establish the prevalence of endoscopic and histopathologic abnormalities consistent with lichen planus and (pre-) malignancy in a cohort of patients with lichen planus...
  26. ncbi The 5-HT4 antagonist R216073 does not affect gastric motor and sensory function in patients with functional dyspepsia
    N van Lelyveld
    Department of Gastroenterology, Gastrointestinal Research Unit, University Medical Centre Utrecht, Utrecht, The Netherlands
    Aliment Pharmacol Ther 24:669-77. 2006
    ..While 5-HT4 agonists are known for their prokinetics properties, the effect of 5-HT4 antagonists on upper gastrointestinal functions is largely unknown...
  27. ncbi Long-term effect of fundoplication on motility of the oesophagus and oesophagogastric junction
    R C H Scheffer
    Gastrointestinal Research Unit, Departments of Surgery and Gastroenterology, University Medical Centre Utrecht, Utrecht, The Netherlands
    Br J Surg 91:1466-72. 2004
    ..This study assessed the long-term effect of Nissen fundoplication on oesophageal and oesophagogastric junction (OGJ) motility...
  28. ncbi Relationships between gastric accommodation and gastrointestinal sensations in healthy volunteers. A study using the barostat technique and two- and three-dimensional ultrasonography
    M W Mundt
    Gastrointestinal Research Unit, Department of Gastroenterology, University Medical Center, Utrecht, The Netherlands
    Dig Dis Sci 50:1654-60. 2005
    ..001). Proximal volume was not correlated with fullness (r = 0.10, P = NS). We conclude that fullness is related to antral volume and area rather than proximal volume. The gastric antrum may play a key role in normal appetite regulation...
  29. ncbi Assessment of oesophageal emptying in achalasia patients by intraluminal impedance monitoring
    J M Conchillo
    Department of Gastroenterology and Hepatology, University Medical Center, Utrecht, The Netherlands
    Neurogastroenterol Motil 18:971-7. 2006
    ..44 (P = 0.01) at 15 min. We conclude that in achalasia patients, low baseline impedance levels and air entrapment in the proximal oesophagus limit the value of intraluminal impedance monitoring as a test of oesophageal emptying...
  30. ncbi Association between pain episodes and high amplitude propagated pressure waves in patients with irritable bowel syndrome
    C H M Clemens
    Gastrointestinal Research Unit, University Medical Center Utrecht, Utrecht, The Netherlands
    Am J Gastroenterol 98:1838-43. 2003
    ..The aim of this study was to quantify the temporal relationship between pain episodes and the occurrence of high amplitude propagated pressure waves (HAPPWs)...
  31. doi Psychopathology is associated with dyspeptic symptom severity in primary care patients with a new episode of dyspepsia
    S Mujakovic
    University Medical Centre Utrecht, Julius Centre for Health Sciences and Primary Care, Utrecht, The Netherlands
    Aliment Pharmacol Ther 29:580-8. 2009
    ..Personality and psychiatric disorders are reported to be more common in dyspeptic patients with severe complaints, but it remains unclear whether this association exists for patients with mild and moderate dyspepsia...
  32. pmc Intraduodenal conjugated bile salts exert negative feedback control on gall bladder emptying in the fasting state without affecting cholecystokinin release or antroduodenal motility
    N A M Van Ooteghem
    Gastrointestinal Research Unit, Departments of Gastroenterology and Surgery, University Hospital Utrecht, The Netherlands
    Gut 50:669-74. 2002
    ..Intraduodenal bile salts exert negative feedback control on postprandial gall bladder emptying. Aims: We wished to examine whether a similar control mechanism occurs in the fasting state...