R A Hartskeerl

Summary

Affiliation: Royal Tropical Institute
Country: The Netherlands

Publications

  1. ncbi request reprint Classification of leptospira from the eyes of horses suffering from recurrent uveitis
    R A Hartskeerl
    Department of Biomedical Research, Leptospirosis Reference Centre WHO FAO OIE RIVM, Royal Tropical Institute, Amsterdam, The Netherlands
    J Vet Med B Infect Dis Vet Public Health 51:110-5. 2004
  2. pmc Conservation of the S10-spc-alpha locus within otherwise highly plastic genomes provides phylogenetic insight into the genus Leptospira
    Berta Victoria
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Santiago de Compostela, Galicia, Spain
    PLoS ONE 3:e2752. 2008
  3. pmc Development and validation of a real-time PCR for detection of pathogenic leptospira species in clinical materials
    Ahmed Ahmed
    WHO FAO OIE and National Collaborating Centre for Reference and Research on Leptospirosis and Section of Epidemiology, Department of Biomedical Research, Royal Tropical Institute KIT, Amsterdam, The Netherlands
    PLoS ONE 4:e7093. 2009
  4. ncbi request reprint International Leptospirosis Society: objectives and achievements
    Rudy A Hartskeerl
    WHO FAO OIE Leptospirosis Reference Center, KIT Koninklijk Instituut voor de Tropen Royal Tropical Institute
    Rev Cubana Med Trop 57:7-10. 2005
  5. pmc Multilocus sequence typing method for identification and genotypic classification of pathogenic Leptospira species
    Niyaz Ahmed
    Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500076, India
    Ann Clin Microbiol Antimicrob 5:28. 2006
  6. ncbi request reprint International multi-centre evaluation of a dipstick assay for human leptospirosis
    H L Smits
    Department of Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands
    Trop Med Int Health 5:124-8. 2000
  7. pmc Simple latex agglutination assay for rapid serodiagnosis of human leptospirosis
    H L Smits
    Department of Biomedical Research, Royal Tropical Institute, 1105 AZ Amsterdam, The Netherlands
    J Clin Microbiol 38:1272-5. 2000
  8. pmc International multicenter evaluation of the clinical utility of a dipstick assay for detection of Leptospira-specific immunoglobulin M antibodies in human serum specimens
    H L Smits
    Department for Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands
    J Clin Microbiol 37:2904-9. 1999
  9. ncbi request reprint Detection of seven species of pathogenic leptospires by PCR using two sets of primers
    C Gravekamp
    NH Swellengrebel Laboratory for Tropical Hygiene, Royal Tropical Institute, WHO FAO Collaborating Centre for Reference and Research on Leptospirosis, Amsterdam, The Netherlands
    J Gen Microbiol 139:1691-700. 1993
  10. ncbi request reprint Leptospirosis: current status and future trends
    R A Hartskeerl
    Department of Biomedical Research, Royal Tropical Institute KIT, Meibergdreef 39, 1105 AZ Amsterdam, Netherlands
    Indian J Med Microbiol 24:309. 2006

Collaborators

Detail Information

Publications21

  1. ncbi request reprint Classification of leptospira from the eyes of horses suffering from recurrent uveitis
    R A Hartskeerl
    Department of Biomedical Research, Leptospirosis Reference Centre WHO FAO OIE RIVM, Royal Tropical Institute, Amsterdam, The Netherlands
    J Vet Med B Infect Dis Vet Public Health 51:110-5. 2004
  2. pmc Conservation of the S10-spc-alpha locus within otherwise highly plastic genomes provides phylogenetic insight into the genus Leptospira
    Berta Victoria
    Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Santiago de Compostela, Galicia, Spain
    PLoS ONE 3:e2752. 2008
    ..These findings demonstrate that the S10-spc-alpha locus is highly conserved throughout the genus and may be more useful in comparing evolution of the genus than loci studied previously...
  3. pmc Development and validation of a real-time PCR for detection of pathogenic leptospira species in clinical materials
    Ahmed Ahmed
    WHO FAO OIE and National Collaborating Centre for Reference and Research on Leptospirosis and Section of Epidemiology, Department of Biomedical Research, Royal Tropical Institute KIT, Amsterdam, The Netherlands
    PLoS ONE 4:e7093. 2009
    ....
  4. ncbi request reprint International Leptospirosis Society: objectives and achievements
    Rudy A Hartskeerl
    WHO FAO OIE Leptospirosis Reference Center, KIT Koninklijk Instituut voor de Tropen Royal Tropical Institute
    Rev Cubana Med Trop 57:7-10. 2005
  5. pmc Multilocus sequence typing method for identification and genotypic classification of pathogenic Leptospira species
    Niyaz Ahmed
    Pathogen Evolution Group, Centre for DNA Fingerprinting and Diagnostics, Hyderabad 500076, India
    Ann Clin Microbiol Antimicrob 5:28. 2006
    ..Only a few resources exist for microbial genotypic data based on individual techniques such as Multiple Locus Sequence Typing (MLST), but unfortunately no such databases are existent for leptospires...
  6. ncbi request reprint International multi-centre evaluation of a dipstick assay for human leptospirosis
    H L Smits
    Department of Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands
    Trop Med Int Health 5:124-8. 2000
    ..It is also easy to use and does not require special equipment or refrigeration. Therefore the assay is ideal for use in developing countries and rural settings...
  7. pmc Simple latex agglutination assay for rapid serodiagnosis of human leptospirosis
    H L Smits
    Department of Biomedical Research, Royal Tropical Institute, 1105 AZ Amsterdam, The Netherlands
    J Clin Microbiol 38:1272-5. 2000
    ..The reagents have a long shelf life, even at tropical temperatures. Together, these factors make the assay suitable for use even at the peripheral level of a health care system as a rapid screening test for leptospirosis...
  8. pmc International multicenter evaluation of the clinical utility of a dipstick assay for detection of Leptospira-specific immunoglobulin M antibodies in human serum specimens
    H L Smits
    Department for Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands
    J Clin Microbiol 37:2904-9. 1999
    ....
  9. ncbi request reprint Detection of seven species of pathogenic leptospires by PCR using two sets of primers
    C Gravekamp
    NH Swellengrebel Laboratory for Tropical Hygiene, Royal Tropical Institute, WHO FAO Collaborating Centre for Reference and Research on Leptospirosis, Amsterdam, The Netherlands
    J Gen Microbiol 139:1691-700. 1993
    ....
  10. ncbi request reprint Leptospirosis: current status and future trends
    R A Hartskeerl
    Department of Biomedical Research, Royal Tropical Institute KIT, Meibergdreef 39, 1105 AZ Amsterdam, Netherlands
    Indian J Med Microbiol 24:309. 2006
  11. doi request reprint Coagulation disorders in patients with severe leptospirosis are associated with severe bleeding and mortality
    J F P Wagenaar
    Department of Internal Medicine, Slotervaart Hospital, Amsterdam, The Netherlands
    Trop Med Int Health 15:152-9. 2010
    ..To determine the involvement of coagulation in bleeding and poor outcome in patients with severe leptospirosis...
  12. doi request reprint Emergence, control and re-emerging leptospirosis: dynamics of infection in the changing world
    R A Hartskeerl
    WHO FAO OIE and National Leptospirosis Reference Centre, KIT Biomedical Research, Amsterdam, The Netherlands
    Clin Microbiol Infect 17:494-501. 2011
    ....
  13. ncbi request reprint Genetic and immunological characterization of the microsporidian Septata intestinalis Cali, Kotler and Orenstein, 1993: reclassification to Encephalitozoon intestinalis
    R A Hartskeerl
    Department of Biomedical Research, Royal Tropical Institute KIT, Amsterdam, The Netherlands
    Parasitology 110:277-85. 1995
    ..intestinalis should be regarded as a species of the genus Encephalitozoon.(ABSTRACT TRUNCATED AT 250 WORDS)..
  14. ncbi request reprint Latex based, rapid and easy assay for human leptospirosis in a single test format
    H L Smits
    Department of Biomedical Research, Royal Tropical Institute, Amsterdam, The Netherlands
    Trop Med Int Health 6:114-8. 2001
    ..2% for samples collected at a later stage. The specificity was 93.9% and 89.8%, respectively. These characteristics make the test ideal for use in areas where the disease is common and where laboratory support is not routinely available...
  15. ncbi request reprint Leptospirosis with pulmonary hemorrhage, caused by a new strain of serovar Lai: Langkawi
    Jiri F P Wagenaar
    Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam, The Netherlands
    J Travel Med 11:379-81. 2004
  16. doi request reprint Seroepidemiology and serological follow-up of anti-leptospiral IgG in children in Southern Vietnam
    Khoa T D Thai
    Division of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, Amsterdam, The Netherlands
    Acta Trop 106:128-31. 2008
    ..This also indicates background reactivity for serological testing and thus serological result of a single serum sample must be carefully interpreted...
  17. doi request reprint Arenal, a new Leptospira serovar of serogroup Javanica, isolated from a patient in Costa Rica
    Ma de los A Valverde
    Centro Nacional de Referencia Leptospirosis, INCIENSA Instituto Costarricense de Investigación y Enseñanza en Nutrición y Salud, Costa Rica
    Infect Genet Evol 8:529-33. 2008
    ..We have identified a novel highly virulent serovar from a patient in Costa Rica that is common in this area, thus posing a threat for the local public and veterinary health...
  18. ncbi request reprint Buenos Aires, a new Leptospira serovar of serogroup Djasiman, isolated from an aborted dog fetus in Argentina
    Carlos A Rossetti
    Instituto de Patobiologia, CNIA, INTA, CC25, 1712 Castelar, Prov Buenos Aires, Argentina
    Vet Microbiol 107:241-8. 2005
    ..However, the isolate could not be identified as any of the known serovars within this serogroup. These results allow us to conclude that the strain Baires represents a new serovar (Buenos Aires) of Djasiman serogroup...
  19. pmc Evaluation of four whole-cell Leptospira-based serological tests for diagnosis of urban leptospirosis
    Alan J A McBride
    Gonçalo Moniz Research Center, Oswaldo Cruz Foundation, Brazilian Ministry of Health, Salvador, Bahia, Brazil
    Clin Vaccine Immunol 14:1245-8. 2007
    ..Testing a second sample will be required in cases with an initial negative result, since sensitivity was low (46 to 68%) during the first week of illness...
  20. pmc Interleukin 12 in part regulates gamma interferon release in human whole blood stimulated with Leptospira interrogans
    Maaike de Fost
    Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Clin Diagn Lab Immunol 10:332-5. 2003
    ..The production of IFN-gamma was largely dependent on IL-12. These data establish that pathogenic leptospires can stimulate the production of type I cytokines involved in cellular immunity...
  21. pmc Leptospirosis, water sports, and chemoprophylaxis
    David A Haake
    Veterans Affairs Greater Los Angeles Healthcare System, and Department of Medicine, University of California Los Angeles School of Medicine, Los Angeles, CA 90073, USA
    Clin Infect Dis 34:e40-3. 2002
    ..Physicians caring for patients who participate in adventure travel involving water sports should be familiar with the risk factors for and diagnosis, prevention, and treatment of leptospirosis...