Wim B van den Berg

Summary

Affiliation: Rheumatology Research Laboratory
Country: The Netherlands

Publications

  1. pmc Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis
    Leo A B Joosten
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 105:9017-22. 2008
  2. ncbi request reprint The role of cytokines and growth factors in cartilage destruction in osteoarthritis and rheumatoid arthritis
    W B van den Berg
    Dept of Rheumatology University Hospital Nijmegen
    Z Rheumatol 58:136-41. 1999
  3. ncbi request reprint TNF alpha and IL-1 beta are separate targets in chronic arthritis
    W B van den Berg
    Department of Rheumatology, University Hospital Nijmegen, The Netherlands
    Clin Exp Rheumatol 17:S105-14. 1999
  4. pmc Arguments for interleukin 1 as a target in chronic arthritis
    W B van den Berg
    Department of Rheumatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Ann Rheum Dis 59:i81-4. 2000
  5. pmc Anti-cytokine therapy in chronic destructive arthritis
    W B van den Berg
    Department of Rheumatology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Arthritis Res 3:18-26. 2001
  6. ncbi request reprint Lessons from animal models of osteoarthritis
    W B van den Berg
    Rheumatology Research and Advanced Therapeutics, University Medical Center, Nijmegen Geert Grooteplein 26 28 6500 HB, Nijmegen, The Netherlands
    Curr Opin Rheumatol 13:452-6. 2001
  7. ncbi request reprint Lessons from animal models of arthritis
    Wim B van den Berg
    Center of Rheumatology Research and Advanced Therapeutics, Nijmegen Center of Molecular Life Sciences, Geert Grooteplein 26 28, 6500 HB Nijmegen, The Netherlands
    Curr Rheumatol Rep 4:232-9. 2002
  8. ncbi request reprint Is there a rationale for combined TNF and IL-1 blocking in arthritis?
    W B van den Berg
    Rheumatology Research and Advanced Therapeutics, University Medical Center Nijmegen, The Netherlands
    Clin Exp Rheumatol 20:S21-5. 2002
  9. ncbi request reprint Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production
    Shahla Abdollahi-Roodsaz
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3753-64. 2008
  10. pmc Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation
    Karin C A M Nabbe
    Department of Experimental Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:R392-401. 2005

Detail Information

Publications103 found, 100 shown here

  1. pmc Differential function of the NACHT-LRR (NLR) members Nod1 and Nod2 in arthritis
    Leo A B Joosten
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 105:9017-22. 2008
    ..Whether a distorted balance between the function of Nod1 and/or Nod2 is involved in the pathogenesis of human autoinflammatory or autoimmune disease, such as rheumatoid arthritis, remains to be elucidated...
  2. ncbi request reprint The role of cytokines and growth factors in cartilage destruction in osteoarthritis and rheumatoid arthritis
    W B van den Berg
    Dept of Rheumatology University Hospital Nijmegen
    Z Rheumatol 58:136-41. 1999
    ..Therapy should be aimed at neutralization of IL-1 and stimulation of safe anabolic growth factors for the articular cartilage, such as IGF-1 and the novel bone and cartilage derived morphogenetic proteins...
  3. ncbi request reprint TNF alpha and IL-1 beta are separate targets in chronic arthritis
    W B van den Berg
    Department of Rheumatology, University Hospital Nijmegen, The Netherlands
    Clin Exp Rheumatol 17:S105-14. 1999
    ..These observations provide evidence for the potential uncoupling of joint inflammation and erosive changes and underline the need for TNF alpha/IL-1 directed combination-therapy approaches...
  4. pmc Arguments for interleukin 1 as a target in chronic arthritis
    W B van den Berg
    Department of Rheumatology, University Medical Centre St Radboud, Nijmegen, The Netherlands
    Ann Rheum Dis 59:i81-4. 2000
    ..IL1b is not necessarily involved in early joint swelling, but is a crucial mediator in chronic arthritis and cartilage erosion in all models studied so far. This makes ILb an attractive target in chronic, destructive arthritis...
  5. pmc Anti-cytokine therapy in chronic destructive arthritis
    W B van den Berg
    Department of Rheumatology, University Medical Center St Radboud, Nijmegen, The Netherlands
    Arthritis Res 3:18-26. 2001
    ..Evidence for this pathway emerged from experimental arthritises in rodents, and is summarized in this review. If elements of the models apply to the arthritic process in RA patients, it is necessary to block IL-1 beta in addition to TNF...
  6. ncbi request reprint Lessons from animal models of osteoarthritis
    W B van den Berg
    Rheumatology Research and Advanced Therapeutics, University Medical Center, Nijmegen Geert Grooteplein 26 28 6500 HB, Nijmegen, The Netherlands
    Curr Opin Rheumatol 13:452-6. 2001
    ..Treatment with a range of disease-modifying drugs showed some efficacy in a number of OA models, but its predictive value for human OA remains obscure...
  7. ncbi request reprint Lessons from animal models of arthritis
    Wim B van den Berg
    Center of Rheumatology Research and Advanced Therapeutics, Nijmegen Center of Molecular Life Sciences, Geert Grooteplein 26 28, 6500 HB Nijmegen, The Netherlands
    Curr Rheumatol Rep 4:232-9. 2002
    ..Gene therapeutic approaches proved efficacious and will provide future ways to control arthritis...
  8. ncbi request reprint Is there a rationale for combined TNF and IL-1 blocking in arthritis?
    W B van den Berg
    Rheumatology Research and Advanced Therapeutics, University Medical Center Nijmegen, The Netherlands
    Clin Exp Rheumatol 20:S21-5. 2002
    ..If elements of the models apply to the arthritic process in RA patients, it is necessary to block IL-1 in addition to TNF...
  9. ncbi request reprint Shift from toll-like receptor 2 (TLR-2) toward TLR-4 dependency in the erosive stage of chronic streptococcal cell wall arthritis coincident with TLR-4-mediated interleukin-17 production
    Shahla Abdollahi-Roodsaz
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3753-64. 2008
    ....
  10. pmc Local IL-13 gene transfer prior to immune-complex arthritis inhibits chondrocyte death and matrix-metalloproteinase-mediated cartilage matrix degradation despite enhanced joint inflammation
    Karin C A M Nabbe
    Department of Experimental Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:R392-401. 2005
    ..This study demonstrates that IL-13 overexpression during ICA diminished both chondrocyte death and MMP-mediated VDIPEN expression, even though joint inflammation was enhanced...
  11. ncbi request reprint Fcgamma receptors directly mediate cartilage, but not bone, destruction in murine antigen-induced arthritis: uncoupling of cartilage damage from bone erosion and joint inflammation
    Peter L van Lent
    Rheumatology Department, Radboud University Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 54:3868-77. 2006
    ..To determine the relationship between synovial inflammation and the concomitant occurrence of cartilage and bone erosion during conditions of variable inflammation using various Fcgamma receptor knockout (FcgammaR(-/-)) mice...
  12. doi request reprint T cell dependence of chronic destructive murine arthritis induced by repeated local activation of Toll-like receptor-driven pathways: crucial role of both interleukin-1beta and interleukin-17
    Leo A B Joosten
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:98-108. 2008
    ..The present study was undertaken to develop a mouse model of chronic destructive arthritis induced by repeated intraarticular (IA) exposure to bacterial cell wall fragments and to investigate the cytokine dependence of this model...
  13. pmc Interleukin-18 promotes joint inflammation and induces interleukin-1-driven cartilage destruction
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Pathol 165:959-67. 2004
    ..These findings implicate that IL-18, in contrast to TNF, contributes through separate pathways to joint inflammation and cartilage destruction...
  14. doi request reprint Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4
    Rik F P Schelbergen
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 64:1477-87. 2012
    ..The purpose of this study was to investigate whether S100A8 and/or S100A9 can interact with chondrocytes from OA patients to increase catabolic mediators...
  15. ncbi request reprint Interleukin-17 receptor deficiency results in impaired synovial expression of interleukin-1 and matrix metalloproteinases 3, 9, and 13 and prevents cartilage destruction during chronic reactivated streptococcal cell wall-induced arthritis
    Marije I Koenders
    University Medical Center St Radboud, Nijmegen, The Netherlands
    Arthritis Rheum 52:3239-47. 2005
    ..To examine the role of interleukin-17 receptor (IL-17R) signaling in cartilage destruction and its interrelationship with synovial IL-1 expression during chronic reactivated streptococcal cell wall (SCW)-induced arthritis...
  16. ncbi request reprint Interleukin-17 acts independently of TNF-alpha under arthritic conditions
    Marije I Koenders
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    J Immunol 176:6262-9. 2006
    ..These data provide further understanding of the cytokine interplay during inflammation and demonstrate that, despite a strong TNF dependency under naive conditions, IL-17 acts independently of TNF under arthritic conditions...
  17. ncbi request reprint Treatment with a neutralizing anti-murine interleukin-17 antibody after the onset of collagen-induced arthritis reduces joint inflammation, cartilage destruction, and bone erosion
    Erik Lubberts
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:650-9. 2004
    ..This T cell cytokine is implicated in the initiation phase of arthritis. However, the role of IL-17 during the effector phase of arthritis has still not been identified; this was the objective of the present study...
  18. pmc The role of T-cell interleukin-17 in conducting destructive arthritis: lessons from animal models
    Erik Lubberts
    Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Res Ther 7:29-37. 2005
    ..Anti-IL-17 cytokine therapy is of interest as an additional new anti-rheumatic strategy for RA, in particular in situations in which elevated IL-17 might attenuate the response to anti-TNF/anti-IL-1 therapy...
  19. doi request reprint TLR2 promotes Th2/Th17 responses via TLR4 and TLR7/8 by abrogating the type I IFN amplification loop
    Mark H Wenink
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Geert Grooteplein 8, 6500 HB Nijmegen, The Netherlands
    J Immunol 183:6960-70. 2009
    ..This shift in T cell responses was inherent to the inability of TLR2-stimulated DCs to produce IL-12p70 and was dependent on the production of IL-1 and IL-6...
  20. pmc Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1beta
    Leo A B Joosten
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 60:3651-62. 2009
    ..This study was undertaken to establish the relative importance of caspase 1 and serine proteases in mouse models of acute and chronic inflammatory arthritis...
  21. ncbi request reprint IL-17 promotes bone erosion in murine collagen-induced arthritis through loss of the receptor activator of NF-kappa B ligand/osteoprotegerin balance
    Erik Lubberts
    Rheumatology and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Immunol 170:2655-62. 2003
    ..These findings suggest T cell IL-17 to be an important inducer of RANKL expression leading to loss of the RANKL/OPG balance, stimulating osteoclastogenesis and bone erosion in arthritis...
  22. doi request reprint IL-32gamma and Streptococcus pyogenes cell wall fragments synergise for IL-1-dependent destructive arthritis via upregulation of TLR-2 and NOD2
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands
    Ann Rheum Dis 69:1866-72. 2010
    ..To investigate the potential synergism between interleukin (IL) 32γ and Streptococcus pyogenes cell wall (SCW) fragments in the development of destructive arthritis...
  23. pmc Blocking of interleukin-17 during reactivation of experimental arthritis prevents joint inflammation and bone erosion by decreasing RANKL and interleukin-1
    Marije I Koenders
    Department of Rheumatology, Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, 189, Geert Grooteplein Zuid 26 28, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Pathol 167:141-9. 2005
    ..These data indicate that IL-17 is an important upstream mediator in joint pathology during flare-up of experimental arthritis...
  24. ncbi request reprint Toll-like receptor 2 pathway drives streptococcal cell wall-induced joint inflammation: critical role of myeloid differentiation factor 88
    Leo A B Joosten
    Rheumatology Research Laboratory and Advanced Therapeutics, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Immunol 171:6145-53. 2003
    ..Since agonists of the Toll-like pathway are abundantly involved in both septic and rheumatoid arthritis, targeting of MyD88 may be a novel therapy in inflammatory joint diseases...
  25. ncbi request reprint Expression of toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-gamma
    Timothy R D J Radstake
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:3856-65. 2004
    ..To study the expression of Toll-like receptor 2 (TLR-2) and TLR-4 and its association with proinflammatory cytokines in synovial tissue from patients with rheumatoid arthritis (RA), osteoarthritis (OA), and healthy individuals...
  26. doi request reprint Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: prominent role of Wnt-induced signaling protein 1
    Arjen B Blom
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 60:501-12. 2009
    ..The present study was undertaken to characterize the expression pattern of Wnt and Fz genes during experimental OA and to determine the function of selected genes in experimental and human OA...
  27. pmc A crucial role for tumor necrosis factor receptor 1 in synovial lining cells and the reticuloendothelial system in mediating experimental arthritis
    Onno J Arntz
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 12:R61. 2010
    ..The objective is to investigate the role of TNFR1 in the synovial lining cells (SLC) and the reticuloendothelial system (RES) during experimental arthritis...
  28. doi request reprint Different amplifying mechanisms of interleukin-17 and interferon-gamma in Fcgamma receptor-mediated cartilage destruction in murine immune complex-mediated arthritis
    Lilyanne C Grevers
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 60:396-407. 2009
    ..This study was undertaken to determine the role of IL-17 in FcgammaR-mediated cartilage destruction in IC-mediated arthritis and to compare its effect with that of IFNgamma...
  29. doi request reprint Intravenously delivered glucocorticoid liposomes inhibit osteoclast activity and bone erosion in murine antigen-induced arthritis
    Wouter Hofkens
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Control Release 152:363-9. 2011
    ..Conclusion: Liposomal glucocorticoid delivery rather than free PLP offers a more efficacious way to inhibit both inflammation and bone erosion in rheumatoid arthritis...
  30. ncbi request reprint Local activation of STAT-1 and STAT-3 in the inflamed synovium during zymosan-induced arthritis: exacerbation of joint inflammation in STAT-1 gene-knockout mice
    Alfons S K de Hooge
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:2014-23. 2004
    ..The present study was undertaken to investigate synovial STAT-1 and STAT-3 activation in an experimental animal model of arthritis...
  31. pmc NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritis
    Peter L E M van Lent
    Department of Rheumatology, University Medical Centre, St Radboud, Nijmegen, The Netherlands
    Arthritis Res Ther 7:R885-95. 2005
    ..Upregulation of FcgammaRI by oxygen radicals may contribute to cartilage destruction...
  32. pmc Deficiency of NADPH oxidase components p47phox and gp91phox caused granulomatous synovitis and increased connective tissue destruction in experimental arthritis models
    Fons A J van de Loo
    Department of Rheumatology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Am J Pathol 163:1525-37. 2003
    ..This showed that the involvement of NADPH oxidase in arthritis is probably far more complex and that oxygen radicals might also be important in controlling disease severity, and reducing joint inflammation and connective tissue damage...
  33. pmc IL-32, a proinflammatory cytokine in rheumatoid arthritis
    Leo A B Joosten
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands
    Proc Natl Acad Sci U S A 103:3298-303. 2006
    ..IL-32, strongly associated with TNFalpha, IL-1beta, and IL-18, appears to play a role in human RA and may be a novel target in autoimmune diseases...
  34. pmc Liposomal targeting of prednisolone phosphate to synovial lining macrophages during experimental arthritis inhibits M1 activation but does not favor M2 differentiation
    Wouter Hofkens
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 8:e54016. 2013
    ..To determine the effects of liposomal targeting of prednisolone phosphate (Lip-PLP) to synovial lining macrophages on M1 and M2 polarization in vitro and during experimental arthritis...
  35. pmc Intravenous delivery of HIV-based lentiviral vectors preferentially transduces F4/80+ and Ly-6C+ cells in spleen, important target cells in autoimmune arthritis
    Ben T van den Brand
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    PLoS ONE 8:e55356. 2013
    ..This approach may provide a valuable tool in targeting splenic APCs, to unravel their role in autoimmune arthritis and to identify and validate APC specific therapeutic targets...
  36. ncbi request reprint Crucial role of macrophages in matrix metalloproteinase-mediated cartilage destruction during experimental osteoarthritis: involvement of matrix metalloproteinase 3
    Arjen B Blom
    Radboud University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 56:147-57. 2007
    ..To explore the involvement of synovial macrophages in early cartilage damage in osteoarthritis (OA), and to identify the role of matrix metalloproteinase 3 (MMP-3) in the pathology of early and late OA...
  37. pmc Inflammation-dependent secretion and splicing of IL-32{gamma} in rheumatoid arthritis
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    Proc Natl Acad Sci U S A 108:4962-7. 2011
    ..Splicing of IL-32γ into IL-32β is a safety switch in controlling the effects of IL-32γ and thereby reduces chronic inflammation...
  38. doi request reprint Interleukin-1 drives pathogenic Th17 cells during spontaneous arthritis in interleukin-1 receptor antagonist-deficient mice
    Marije I Koenders
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 58:3461-70. 2008
    ..In this study, the role of Th17 cells and the effect of neutralization of IL-17, IL-1, and tumor necrosis factor alpha (TNFalpha) were investigated in this IL-1-driven murine arthritis model...
  39. doi request reprint S100A8 causes a shift toward expression of activatory Fcγ receptors on macrophages via toll-like receptor 4 and regulates Fcγ receptor expression in synovium during chronic experimental arthritis
    Peter L van Lent
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 62:3353-64. 2010
    ..This study was undertaken to study the active involvement of S100A8, S100A9, and S100A8/S100A9 in FcγR regulation in murine macrophages and synovium during AIA...
  40. ncbi request reprint The functional variant of the inhibitory Fcgamma receptor IIb (CD32B) is associated with the rate of radiologic joint damage and dendritic cell function in rheumatoid arthritis
    Timothy R D J Radstake
    Department of Rheumatology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 54:3828-37. 2006
    ..The purpose of this study was to unravel the role of the inhibitory FcgammaRIIb in rheumatoid arthritis (RA) by studying the effect of the FCGR2B 695T>C polymorphism on susceptibility to RA, severity of the disease, and DC function...
  41. doi request reprint The molecular signature of oxidative metabolism and the mode of macrophage activation determine the shift from acute to chronic disease in experimental arthritis: critical role of interleukin-12p40
    Nozomi Takahashi
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3471-84. 2008
    ..The objective of this study was to identify genes and pathways that determine disease progression based on gene expression profiling in this model...
  42. ncbi request reprint Splenic suppressor of cytokine signaling 3 transgene expression affects T cell responses and prevents development of collagen-induced arthritis
    Sharon Veenbergen
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 58:3742-52. 2008
    ....
  43. doi request reprint The inhibitory Fc gamma IIb receptor dampens TLR4-mediated immune responses and is selectively up-regulated on dendritic cells from rheumatoid arthritis patients with quiescent disease
    Mark H Wenink
    Department of Rheumatology, Nijmegen Centre of Molecular Life Sciences and Radboud University Nijmegen Medical Centre, Geert Grooteplein 8, Nijmegen 6500 HB, The Netherlands
    J Immunol 183:4509-20. 2009
    ..This TLR4-FcgammaRIIb interaction was shown to dependent on the PI3K and Akt pathway...
  44. pmc Local interleukin-1-driven joint pathology is dependent on toll-like receptor 4 activation
    Shahla Abdollahi-Roodsaz
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Am J Pathol 175:2004-13. 2009
    ..These data emphasize the potential relevance of TLR4 activation in rheumatoid arthritis, particularly with respect to IL-1-mediated joint pathology...
  45. ncbi request reprint Induction of cartilage damage by overexpression of T cell interleukin-17A in experimental arthritis in mice deficient in interleukin-1
    Marije I Koenders
    University Medical Center St Radboud, Nijmegen, The Netherlands
    Arthritis Rheum 52:975-83. 2005
    ..To examine the capacity of T cell interleukin-17A (IL-17A; referred to hereinafter as IL-17) to induce cartilage damage during experimental arthritis in the absence of IL-1...
  46. doi request reprint S100A8 enhances osteoclastic bone resorption in vitro through activation of Toll-like receptor 4: implications for bone destruction in murine antigen-induced arthritis
    Lilyanne C Grevers
    Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 63:1365-75. 2011
    ..The aim of the present study was to investigate the role of S100A8 and S100A9 in osteoclastic bone destruction in murine antigen-induced arthritis (AIA)...
  47. doi request reprint Destructive role of myeloid differentiation factor 88 and protective role of TRIF in interleukin-17-dependent arthritis in mice
    Shahla Abdollahi-Roodsaz
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 64:1838-47. 2012
    ..The objective of this study was to investigate the specific roles of MyD88 and TRIF in chronic experimental arthritis and the accompanying adaptive immune responses...
  48. doi request reprint Increase in ALK1/ALK5 ratio as a cause for elevated MMP-13 expression in osteoarthritis in humans and mice
    Esmeralda N Blaney Davidson
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    J Immunol 182:7937-45. 2009
    ..Our data suggest that dominant ALK1 signaling results in deviant chondrocyte behavior, thereby contributing to age-related cartilage destruction and OA...
  49. pmc FcgammaRI up-regulation induced by local adenoviral-mediated interferon-gamma production aggravates chondrocyte death during immune complex-mediated arthritis
    Karin C Nabbe
    Department of Experimental Rheumatology and Advanced Therapeutics, University Medical Center, Nijmegen, The Netherlands
    Am J Pathol 163:743-52. 2003
    ..These results indicate that IFN-gamma overexpression deteriorates cartilage destruction in the presence of ICs and that FcgammaRI is crucial in the development of chondrocyte death...
  50. pmc Stimulation of TLR2 and TLR4 differentially skews the balance of T cells in a mouse model of arthritis
    Shahla Abdollahi-Roodsaz
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Clin Invest 118:205-16. 2008
    ....
  51. ncbi request reprint The functional variant (Asp299gly) of toll-like receptor 4 (TLR4) influences TLR4-mediated cytokine production in rheumatoid arthritis
    Mieke F Roelofs
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Rheumatol 35:558-61. 2008
    ..To investigate functional consequences of the Toll-like receptor 4 (TLR4) variant (Asp299Gly) in rheumatoid arthritis (RA)...
  52. ncbi request reprint Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging
    Alfons S K de Hooge
    Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Osteoarthritis Cartilage 13:66-73. 2005
    ..Interleukin-6 (IL-6) is expressed in osteoarthritic joints but its function in osteoarthritis (OA) is unknown. To study this, spontaneous and experimental OA were evaluated in IL-6 deficient (IL-6(-/-)) mice...
  53. doi request reprint Role of NOD1 polymorphism in susceptibility and clinical progression of rheumatoid arthritis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, internal postal code 463, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Rheumatology (Oxford) 52:806-14. 2013
    ..In this study, the effect of the insertion/deletion polymorphism in NOD1 on RA susceptibility and severity was assessed...
  54. doi request reprint Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis
    Peter L E M van Lent
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 64:1466-76. 2012
    ..To investigate whether alarmins S100A8 and S100A9 are involved in mediating cartilage destruction during murine and human osteoarthritis (OA)...
  55. pmc Interleukin 32 (IL-32) contains a typical α-helix bundle structure that resembles focal adhesion targeting region of focal adhesion kinase-1
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    J Biol Chem 287:5733-43. 2012
    ..This study demonstrates for the first time that IL-32 binds to the extracellular domain of integrins and to intracellular proteins like paxillin and FAK, suggesting a dual role for IL-32 in integrin signaling...
  56. pmc TGF beta-induced cartilage repair is maintained but fibrosis is blocked in the presence of Smad7
    Esmeralda N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, St, Radboud University Medical Centre Nijmegen, Geert Grooteplein 26 28, 6525 GA Nijmegen, The Netherlands
    Arthritis Res Ther 8:R65. 2006
    ..TGFbeta-induced synovial fibrosis was blocked by locally inhibiting TGFbeta signaling in the synovial lining by simultaneously transfecting it with an adenovirus overexpressing Smad7...
  57. doi request reprint A pivotal role for antigen-presenting cells overexpressing SOCS3 in controlling invariant NKT cell responses during collagen-induced arthritis
    Sharon Veenbergen
    Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, The Netherlands
    Ann Rheum Dis 70:2167-75. 2011
    ..A study was undertaken to investigate the contribution of SOCS3 in regulating invariant natural killer T (iNKT) cell responses during collagen-induced arthritis (CIA)...
  58. pmc IL-17 produced by Paneth cells drives TNF-induced shock
    Nozomi Takahashi
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, Netherlands
    J Exp Med 205:1755-61. 2008
    ..These data indicate that innate immune cytokine responses in the local mucosa may participate in rapidly amplifying responses to systemic inflammatory challenges...
  59. pmc Amplifying elements of arthritis and joint destruction
    Wim B van den Berg
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands
    Ann Rheum Dis 66:iii45-8. 2007
    ..Spontaneous T cell-dependent arthritis in IL1Ra-/- mice is absent under germ-free conditions, and markedly suppressed in TLR4-deficient mice. Moreover, TLR4 blocking with a receptor antagonist suppresses erosive arthritis...
  60. doi request reprint Tumour necrosis factor alpha-driven IL-32 expression in rheumatoid arthritis synovial tissue amplifies an inflammatory cascade
    Bas Heinhuis
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500HB, Nijmegen, The Netherlands
    Ann Rheum Dis 70:660-7. 2011
    ..To investigate the interplay between IL-32 and tumour necrosis factor alpha (TNFα) during the chronic inflammation of rheumatoid arthritis (RA) and to assess whether anti-TNFα treatment of RA patients modulates synovial IL-32 expression...
  61. ncbi request reprint Growth plate damage, a feature of juvenile idiopathic arthritis, can be induced by adenoviral gene transfer of oncostatin M: a comparative study in gene-deficient mice
    Alfons S K de Hooge
    Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Arthritis Rheum 48:1750-61. 2003
    ..To investigate the involvement of proinflammatory and destructive mediators in oncostatin M (OSM)-induced joint pathology, using gene-deficient mice...
  62. ncbi request reprint Synovial lining macrophages mediate osteophyte formation during experimental osteoarthritis
    Arjen B Blom
    Experimental Arthritis and Advanced Therapies, University Medical Center Nijmegen, The Netherlands
    Osteoarthritis Cartilage 12:627-35. 2004
    ..The objective of this study was to investigate whether synovial macrophages are involved in osteophyte formation in experimental OA, and if they are, to study which mechanism may be involved...
  63. ncbi request reprint Reduction of osteophyte formation and synovial thickening by adenoviral overexpression of transforming growth factor beta/bone morphogenetic protein inhibitors during experimental osteoarthritis
    Alwin Scharstuhl
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:3442-51. 2003
    ..The aim of this study was to elucidate the role of endogenous TGFbeta and BMP during papain-induced OA-like changes in mice...
  64. pmc Computational design and application of endogenous promoters for transcriptionally targeted gene therapy for rheumatoid arthritis
    Jeroen Geurts
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Mol Ther 17:1877-87. 2009
    ..These results demonstrate the value of bioinformatics for guiding the selection of endogenous promoters for transcriptionally targeted gene therapy...
  65. doi request reprint Increased expression of interleukin-22 by synovial Th17 cells during late stages of murine experimental arthritis is controlled by interleukin-1 and enhances bone degradation
    Renoud J Marijnissen
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, Rheumatology Research and Advanced Therapeutics, Nijmegen, The Netherlands
    Arthritis Rheum 63:2939-48. 2011
    ....
  66. doi request reprint Tumor necrosis factor-interleukin-17 interplay induces S100A8, interleukin-1β, and matrix metalloproteinases, and drives irreversible cartilage destruction in murine arthritis: rationale for combination treatment during arthritis
    Marije I Koenders
    Radboud University Nijmegen Medical Centre, Department of Rheumatology, Nijmegen, The Netherlands
    Arthritis Rheum 63:2329-39. 2011
    ....
  67. ncbi request reprint Large scale protein production of the extracellular domain of the transforming growth factor-beta type II receptor using the Pichia pastoris expression system
    Alwin Scharstuhl
    Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center Nijmegen, Geert Grooteplein Zuid 26 28, 6525 GA, Nijmegen, The Netherlands
    J Chromatogr B Analyt Technol Biomed Life Sci 786:271-7. 2003
    ..In conclusion, our large-scale protein expression procedure results in high quantities of purified solRII, which is a powerful tool to study the natural role of TGF-beta...
  68. doi request reprint The anti-CD20 antibody rituximab reduces the Th17 cell response
    Frank L van de Veerdonk
    Radboud University Nijmegen Medical Center and Nijmegen Institute for Infection, Inflammation, and Immunity, Nijmegen, The Netherlands
    Arthritis Rheum 63:1507-16. 2011
    ..The present study was undertaken to investigate the mechanism of action of rituximab in RA...
  69. ncbi request reprint Citrullination of synovial proteins in murine models of rheumatoid arthritis
    Erik R Vossenaar
    Department of Biochemistry, University of Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:2489-500. 2003
    ....
  70. doi request reprint A novel Saa3-promoter reporter distinguishes inflammatory subtypes in experimental arthritis and human synovial fibroblasts
    Jeroen Geurts
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Ann Rheum Dis 70:1311-9. 2011
    ....
  71. ncbi request reprint Increased expression of Fcgamma receptors II and III on macrophages of rheumatoid arthritis patients results in higher production of tumor necrosis factor alpha and matrix metalloproteinase
    Arjen B Blom
    University Medical Center, Nijmegen, The Netherlands
    Arthritis Rheum 48:1002-14. 2003
    ..We also sought to determine whether mature macrophages from RA patients express aberrant levels of FcgammaRI, FcgammaRII, and FcgammaRIII, and to determine the production of inflammatory mediators after immune complex (IC) stimulation...
  72. ncbi request reprint Inhibition of Toll-like receptor 4 breaks the inflammatory loop in autoimmune destructive arthritis
    Shahla Abdollahi-Roodsaz
    Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Arthritis Rheum 56:2957-67. 2007
    ..The objective of this study was to investigate the involvement of TLR-4 activation in the development and progression of autoimmune destructive arthritis...
  73. ncbi request reprint Association of interleukin-18 expression with enhanced levels of both interleukin-1beta and tumor necrosis factor alpha in knee synovial tissue of patients with rheumatoid arthritis
    Leo A B Joosten
    Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:339-47. 2003
    ....
  74. ncbi request reprint Expression of the dendritic cell-associated C-type lectin DC-SIGN by inflammatory matrix metalloproteinase-producing macrophages in rheumatoid arthritis synovium and interaction with intercellular adhesion molecule 3-positive T cells
    Peter L E M van Lent
    Department of Rheumatology, University Medical Centre Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 48:360-9. 2003
    ....
  75. ncbi request reprint Gene therapy for rheumatoid arthritis. Lessons from animal models, including studies on interleukin-4, interleukin-10, and interleukin-1 receptor antagonist as potential disease modulators
    Fons A J van de Loo
    Department of Rheumatology, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Rheum Dis Clin North Am 28:127-49. 2002
    ..The feasibility of viral transduction of chondrocytes to obtain a tissue-specific approach to treat articular cartilage damage in arthritis needs further attention...
  76. ncbi request reprint Local interleukin-12 gene transfer promotes conversion of an acute arthritis to a chronic destructive arthritis
    Leo A B Joosten
    Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 46:1379-89. 2002
    ....
  77. ncbi request reprint Cytokine targeting in osteoarthritis
    Arjen B Blom
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Curr Drug Targets 8:283-92. 2007
    ..g. with or without marked synovial activation, treatment may be focused mainly on suppression of catabolism or stimulation of anabolism, but combination therapy seems most warranted...
  78. ncbi request reprint Gene therapy works in animal models of rheumatoid arthritis...so what!
    Fons A J van de Loo
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen Centre for Molecular Life Sciences, Geert Grooteplein 28, 6525 GA Nijmegen, The Netherlands
    Curr Rheumatol Rep 8:386-93. 2006
    ....
  79. ncbi request reprint Elevated CXCL16 expression by synovial macrophages recruits memory T cells into rheumatoid joints
    Robbert van der Voort
    Nijmegen Center for Molecular Life Sciences, University Medical Center St Radboud, Nijmegen, The Netherlands
    Arthritis Rheum 52:1381-91. 2005
    ..This study was undertaken to examine the presence of CXCR6+ T cells and of CXCL16, the only ligand for CXCR6, in the joints of patients with rheumatoid arthritis (RA)...
  80. pmc Functional consequences of DECTIN-1 early stop codon polymorphism Y238X in rheumatoid arthritis
    Theo S Plantinga
    Department of Medicine, Radboud University Nijmegen Medical Centre, P, O, Box 9101, 6500 HB Nijmegen, The Netherlands
    Arthritis Res Ther 12:R26. 2010
    ..In this study, dectin-1 mRNA and protein expression, as well as the recently characterized DECTIN-1 Y238X early stop codon polymorphism, were studied in relation to rheumatoid arthritis (RA) susceptibility and severity...
  81. ncbi request reprint Animal models of arthritis. What have we learned?
    Wim B van den Berg
    Rheumatology Research and Advanced Therapeutics Unit, University Medical Center St Radboud, 6500 HB Nijmegen, The Netherlands
    J Rheumatol Suppl 72:7-9. 2005
    ..Although in general more inflammation drives more destruction, the uncoupling of inflammation and erosion can be seen as well, and different mediators are involved in these processes...
  82. pmc Gene therapy in animal models of rheumatoid arthritis: are we ready for the patients?
    Fons A J van de Loo
    Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, University Medical Center Nijmegen, Nijmegen Center for Molecular Life Sciences, Nijmegen, The Netherlands
    Arthritis Res Ther 6:183-96. 2004
    ..Evidence from animal models convincingly supports the application of gene therapy in RA, and the feasibility of gene therapy was recently demonstrated in phase I clinical trials...
  83. doi request reprint IL-17 as a future therapeutic target for rheumatoid arthritis
    Wim B van den Berg
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Nat Rev Rheumatol 5:549-53. 2009
    ..The emergence of IL-17 blockade as a future therapy in rheumatoid arthritis is highlighted, along with the potential goals and limitations of this therapeutic approach...
  84. ncbi request reprint Lessons from animal models of osteoarthritis
    Wim B van den Berg
    Rheumatology Research and Advanced Therapeutics, Radboud University Nijmegen Medical Center, Geert Grooteplein 26, 6525 GA Nijmegen, The Netherlands
    Curr Rheumatol Rep 10:26-9. 2008
    ..Finally, transgenic mice show that osteoprotegerin is protective in OA, and treatment studies with recombinant osteoprotegerin have identified chondrocyte apoptosis blocking as an underlying mechanism...
  85. doi request reprint Selectively induced death of macrophages in the synovial lining of murine knee joints using 10B-liposomes and boron neutron capture synovectomy
    Peter L E M van Lent
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Int J Radiat Biol 85:860-71. 2009
    ....
  86. doi request reprint The macrophage mannose receptor induces IL-17 in response to Candida albicans
    Frank L van de Veerdonk
    Department of Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Cell Host Microbe 5:329-40. 2009
    ..This study identifies the specific pattern recognition receptors that trigger the Th17 response induced by a human pathogen in the absence of mitogenic stimulation...
  87. ncbi request reprint Differential role of IL-18 and IL-12 in the host defense against disseminated Candida albicans infection
    Mihai G Netea
    Department of Medicine, University Medical Center St Radboud, Nijmegen, Nijmegen, The Netherlands
    Eur J Immunol 33:3409-17. 2003
    ..In conclusion, the anticandidal effects of endogenous IL-18 are mediated late during the infection by assuring a proper IFN-gamma response and promoting the infiltration of the site of infection by monocytes...
  88. ncbi request reprint Role of gene therapy in tissue engineering procedures in rheumatology: the use of animal models
    Peter M van der Kraan
    Experimental Rheumatology and Advanced Therapeutics, Nijmegen Center for Molecular Life Sciences, University Medical Center Nijmegen, Geert Grooteplein 26 28, GA 6525, Nijmegen, The Netherlands
    Biomaterials 25:1497-504. 2004
    ..Development of animal models that can be used for tissue engineering experiments and mimic end stage arthritic diseases is needed...
  89. ncbi request reprint Cytokines and joint erosion in arthritis
    Wim B van den Berg
    Rheumatology Research and Advanced Therapeutics, Radboud University, Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlandsw
    Nat Clin Pract Rheumatol 4:58-9. 2008
  90. ncbi request reprint The Toll-like receptor 4 Asp299Gly functional variant is associated with decreased rheumatoid arthritis disease susceptibility but does not influence disease severity and/or outcome
    Timothy R D J Radstake
    University Medical Center Nijmegen, Nijmegen, The Netherlands
    Arthritis Rheum 50:999-1001. 2004
  91. ncbi request reprint Cytokines in the pathogenesis of rheumatoid arthritis and collagen-induced arthritis
    Erik Lubberts
    Rheumatology Research Laboratory, Department of Rheumatology, University Hospital Nijmegen, The Netherlands
    Adv Exp Med Biol 520:194-202. 2003
  92. ncbi request reprint Identification of small heat shock protein B8 (HSP22) as a novel TLR4 ligand and potential involvement in the pathogenesis of rheumatoid arthritis
    Mieke F Roelofs
    Department of Rheumatology Research and Advanced Therapeutics, Nijmegen Center for Molecular Life Sciences, The Netherlands
    J Immunol 176:7021-7. 2006
    ..These findings suggest a role for HSPB8 during the inflammatory process in autoimmune diseases such as RA...
  93. ncbi request reprint Murine antigen-induced arthritis
    Wim B van den Berg
    Radboud University Nijmegen Medical Centre, The Netherlands
    Methods Mol Med 136:243-53. 2007
    ..Concomitant boosting of the immune response with Bordetella pertussis adds to this. T-cell mediated flares can be induced by local or systemic rechallenge with low dose antigen, and display a strong erosive phenotype...
  94. ncbi request reprint Requirement of IL-17 receptor signaling in radiation-resistant cells in the joint for full progression of destructive synovitis
    Erik Lubberts
    Department of Medicine, Gene Therapy Program, Louisiana State University Health Sciences Center, New Orleans, LA 70112, USA
    J Immunol 175:3360-8. 2005
    ..These data strongly indicate that IL-17R signaling in radiation-resistant cells in the joint is required for turning an acute macrophage-mediated inflammation into a chronic destructive synovitis...
  95. doi request reprint Anticytokine treatment of established type II collagen-induced arthritis in DBA/1 mice: a comparative study using anti-TNFalpha, anti-IL-1alpha/beta and IL-1Ra
    Leo A B Joosten
    University Hospital Nijimegen, Nijimegen, The Netherlands
    Arthritis Rheum 58:S110-22. 2008
    ..To examine the role of tumor necrosis factor alpha (TNF alpha), interleukin-1 alpha (IL-1 alpha), and IL-1 beta in collagen-induced arthritis (CIA), immediately after onset and during the phase of established arthritis...
  96. ncbi request reprint Increased synovial tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis
    Maria J Benito
    St Vincent s University Hospital, Elm Park, Dublin, Ireland
    Arthritis Rheum 50:1781-7. 2004
    ....
  97. ncbi request reprint Uncoupling of inflammation and destruction in rheumatoid arthritis: myth or reality?
    Wim B van den Berg
    Arthritis Rheum 52:995-9. 2005
  98. ncbi request reprint Cross-linked type I and type II collagenous matrices for the repair of full-thickness articular cartilage defects--a study in rabbits
    Pieter Buma
    Orthopedic Research Laboratory, Department of Orthopedics, University Medical Center Nijmegen, P O Box 9101, The Netherlands
    Biomaterials 24:3255-63. 2003
    ..Based on these observations it is suggested that a composite matrix consisting of a deep layer of type I collagen and a more superficial layer of type II collagen may be the matrix of choice for cartilage regeneration...
  99. ncbi request reprint Oral administration of the NADPH-oxidase inhibitor apocynin partially restores diminished cartilage proteoglycan synthesis and reduces inflammation in mice
    Sander Hougee
    Numico Research P O Box 7005, Wageningen, NL 6700 CA Wageningen, The Netherlands
    Eur J Pharmacol 531:264-9. 2006
    ..Therefore, apocynin might be of potential use during the treatment of chronic inflammatory joint diseases like osteoarthritis or rheumatoid arthritis...
  100. ncbi request reprint Decreased pro-inflammatory cytokine production by LPS-stimulated PBMC upon in vitro incubation with the flavonoids apigenin, luteolin or chrysin, due to selective elimination of monocytes/macrophages
    Sander Hougee
    Numico Research, P O Box 7005, Wageningen 6700, The Netherlands
    Biochem Pharmacol 69:241-8. 2005
    ..In conclusion, monocytes were specifically eliminated in PBMC by apigenin, chrysin or luteolin treatment in vitro at low concentrations (around 8 microM), in which apigenin appeared to be the most potent...
  101. pmc Elevated extracellular matrix production and degradation upon bone morphogenetic protein-2 (BMP-2) stimulation point toward a role for BMP-2 in cartilage repair and remodeling
    Esmeralda N Blaney Davidson
    Experimental Rheumatology and Advanced Therapeutics, Radboud University Nijmegen Medical Centre, Geert Grooteplein 26 28, Nijmegen, 6500 HB, The Netherlands
    Arthritis Res Ther 9:R102. 2007
    ..Moreover, BMP contributes to the intrinsic repair capacity of damaged cartilage. Increased matrix turnover might be functional in replacing matrix molecules in the repair of a damaged cartilage matrix...