E Lubberts

Summary

Affiliation: Rheumatology Research Laboratory
Country: The Netherlands

Publications

  1. ncbi Regulatory role of interleukin 10 in joint inflammation and cartilage destruction in murine streptococcal cell wall (SCW) arthritis. More therapeutic benefit with IL-4/IL-10 combination therapy than with IL-10 treatment alone
    E Lubberts
    Department of Rheumatology, University Hospital Nijmegen, The Netherlands
    Cytokine 10:361-9. 1998
  2. ncbi Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction
    E Lubberts
    UMC St Radboud, Rheumatology Research Lab, Nijmegen, The Netherlands
    Inflamm Res 51:102-4. 2002
  3. ncbi IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis
    E Lubberts
    Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 167:1004-13. 2001
  4. ncbi IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion
    E Lubberts
    Rheumatology Research Laboratory, Department of Rheumatology, University Hospital Nijmegen, Nijmegen, The Netherlands
    J Clin Invest 105:1697-710. 2000
  5. ncbi Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw
    E Lubberts
    Rheumatology Research Laboratory, Department of Rheumatology, University Hospital Nijmegen, Nijmegen, The Netherlands
    Clin Exp Immunol 120:375-83. 2000
  6. ncbi Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction
    E Lubberts
    Rheumatology Research Lab, Department of Rheumatology, University Hospital Nijmegen, The Netherlands
    J Immunol 163:4546-56. 1999
  7. ncbi Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis
    L A Joosten
    Department of Rheumatology, University Hospital Nijmegen, Nijmegen, The Netherlands
    Arthritis Res 1:81-91. 1999
  8. ncbi Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production
    J P van Hamburg
    Department of Rheumatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Arthritis Rheum 63:73-83. 2011
  9. ncbi An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis
    L A Joosten
    Rheumatology Research Laboratory and Department of Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 165:6553-8. 2000
  10. ncbi Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis
    C Plater-Zyberk
    Serono Pharmaceutical Research Institute, Geneva, Switzerland. Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Clin Invest 108:1825-32. 2001

Collaborators

Detail Information

Publications16

  1. ncbi Regulatory role of interleukin 10 in joint inflammation and cartilage destruction in murine streptococcal cell wall (SCW) arthritis. More therapeutic benefit with IL-4/IL-10 combination therapy than with IL-10 treatment alone
    E Lubberts
    Department of Rheumatology, University Hospital Nijmegen, The Netherlands
    Cytokine 10:361-9. 1998
    ..In conclusion, the data is consistent with a dominant role of IL-10 in natural suppression of arthritis expression, whereas combined treatment with IL-4 and IL-10 appears to be of potential therapeutic value...
  2. ncbi Overexpression of IL-17 in the knee joint of collagen type II immunized mice promotes collagen arthritis and aggravates joint destruction
    E Lubberts
    UMC St Radboud, Rheumatology Research Lab, Nijmegen, The Netherlands
    Inflamm Res 51:102-4. 2002
  3. ncbi IL-1-independent role of IL-17 in synovial inflammation and joint destruction during collagen-induced arthritis
    E Lubberts
    Rheumatology Research Laboratory, Department of Rheumatology, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 167:1004-13. 2001
    ..These findings suggest IL-17 to be a novel target for the treatment of destructive arthritis and may have implications for tissue destruction in other autoimmune diseases...
  4. ncbi IL-4 gene therapy for collagen arthritis suppresses synovial IL-17 and osteoprotegerin ligand and prevents bone erosion
    E Lubberts
    Rheumatology Research Laboratory, Department of Rheumatology, University Hospital Nijmegen, Nijmegen, The Netherlands
    J Clin Invest 105:1697-710. 2000
    ..IL-4 also enhanced synthesis of type I procollagen, suggesting that it promoted tissue repair. These findings may have significant implications for the prevention of bone erosion in arthritis...
  5. ncbi Intra-articular IL-10 gene transfer regulates the expression of collagen-induced arthritis (CIA) in the knee and ipsilateral paw
    E Lubberts
    Rheumatology Research Laboratory, Department of Rheumatology, University Hospital Nijmegen, Nijmegen, The Netherlands
    Clin Exp Immunol 120:375-83. 2000
    ..These data indicate that local over-expression of IL-10 in the knee joint of mice regulates the expression of collagen arthritis, probably through down-regulation of TNF-alpha...
  6. ncbi Adenoviral vector-mediated overexpression of IL-4 in the knee joint of mice with collagen-induced arthritis prevents cartilage destruction
    E Lubberts
    Rheumatology Research Lab, Department of Rheumatology, University Hospital Nijmegen, The Netherlands
    J Immunol 163:4546-56. 1999
    ..Our data show an impressive cartilage-protective effect of local IL-4 and underline the feasibility of local gene therapy with this cytokine in arthritis...
  7. ncbi Protection against cartilage and bone destruction by systemic interleukin-4 treatment in established murine type II collagen-induced arthritis
    L A Joosten
    Department of Rheumatology, University Hospital Nijmegen, Nijmegen, The Netherlands
    Arthritis Res 1:81-91. 1999
    ..Furthermore, it was demonstrated that exposure to IL-4 during the immunization stage reduced onset and severity of CIA. However, after cessation of IL-4 treatment disease expression increased to control values...
  8. ncbi Th17 cells, but not Th1 cells, from patients with early rheumatoid arthritis are potent inducers of matrix metalloproteinases and proinflammatory cytokines upon synovial fibroblast interaction, including autocrine interleukin-17A production
    J P van Hamburg
    Department of Rheumatology, Erasmus MC, University Medical Center, Rotterdam, The Netherlands
    Arthritis Rheum 63:73-83. 2011
    ..The aim of this study was to identify and characterize the functional role of Th17 cells in early RA...
  9. ncbi An IFN-gamma-independent proinflammatory role of IL-18 in murine streptococcal cell wall arthritis
    L A Joosten
    Rheumatology Research Laboratory and Department of Internal Medicine, University Medical Center St Radboud, Nijmegen, The Netherlands
    J Immunol 165:6553-8. 2000
    ..The present study indicates that IL-18 is a proinflammatory cytokine during the onset of murine SCW arthritis, and this inflammatory role of IL-18 is IFN-gamma independent...
  10. ncbi Therapeutic effect of neutralizing endogenous IL-18 activity in the collagen-induced model of arthritis
    C Plater-Zyberk
    Serono Pharmaceutical Research Institute, Geneva, Switzerland. Rheumatology Research Laboratory, University Medical Center Nijmegen, Nijmegen, The Netherlands
    J Clin Invest 108:1825-32. 2001
    ..IL-18 neutralizing antibody or rhIL-18BP could therefore represent new disease-modifying anti-rheumatic drugs that warrant testing in clinical trials in patients with rheumatoid arthritis...
  11. ncbi Local overexpression of adeno-viral IL-4 protects cartilage from metallo proteinase-induced destruction during immune complex-mediated arthritis by preventing activation of pro-MMPs
    P L E M van Lent
    Department of Rheumatology, University Medical Centre Nijmegen, The Netherlands
    Osteoarthritis Cartilage 10:234-43. 2002
    ..To determine whether IL-4 protects against metalloproteinase-induced cartilage destruction during immune complex mediated arthritis and to elucidate its mechanism...
  12. ncbi Does anti-mutated citrullinated vimentin have additional value as a serological marker in the diagnostic and prognostic investigation of patients with rheumatoid arthritis? A systematic review
    J J Luime
    Department of Rheumatology, Erasmus Medical Center, University Medical Center Rotterdam, The Netherlands
    Ann Rheum Dis 69:337-44. 2010
    ..To review the diagnostic and prognostic value of anti-mutated citrullinated vimentin (MCV) in rheumatoid arthritis, taking into account the already available serology...
  13. ncbi 1,25-dihydroxyvitamin D3 modulates Th17 polarization and interleukin-22 expression by memory T cells from patients with early rheumatoid arthritis
    E M Colin
    Erasmus MC, University Medical Center, Department of Rheumatology, Rotterdam, The Netherlands
    Arthritis Rheum 62:132-42. 2010
    ..To examine the immunologic mechanism by which 1,25-dihydroxyvitamin D(3) (1,25[OH](2)D(3)) may prevent corticosteroid-induced osteoporosis in patients with early rheumatoid arthritis (RA), with a focus on T cell biology...
  14. ncbi IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
    M Chabaud
    INSERM U403, , and Departments of Immunology and Rheumatology, , Lyon, France
    Arthritis Res 3:168-77. 2001
    ..In conclusion, the contribution of IL-17 derived from synovium and bone marrow T cells to joint destruction suggests the control of IL-17 for the treatment of RA...
  15. ncbi Il-4 and IL-13, but not IL-10, protect human synoviocytes from apoptosis
    B Relic
    Division of Rheumatology and Department of Orthopedic Surgery, University Hospital, Geneva, Switzerland
    J Immunol 166:2775-82. 2001
    ..The possibility that IL-4 and IL-13 may enhance synovial expansion in vivo by their antiapoptotic effects is discussed...
  16. ncbi Comparison of E-selectin expression at mRNA and protein levels in murine models of inflammation
    M Everts
    Department of Pharmacokinetics and Drug Delivery, University Centre for Pharmacy, Groningen University Institute for Drug Exploration GUIDE, The Netherlands
    Inflamm Res 52:512-8. 2003
    ..In this study several murine models of inflammation were investigated regarding expression of E-selectin...