Marcel M Verbeek

Summary

Affiliation: Radboud University Nijmegen Medical Centre
Country: The Netherlands

Publications

  1. ncbi request reprint Apolipoprotein E genotype regulates amyloid-beta cytotoxicity
    Micha M M Wilhelmus
    Department of Neurology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    J Neurosci 25:3621-7. 2005
  2. ncbi request reprint [Diagnosis in cerebrospinal fluid: possible applications in neurological practice]
    M M Verbeek
    afd Neurologie, Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 149:1833-8. 2005
  3. ncbi request reprint Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, 830 LKN, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500, Nijmegen, The Netherlands
    Acta Neuropathol 111:139-49. 2006
  4. ncbi request reprint Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, 830 LKN, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Brain Res 1089:67-78. 2006
  5. ncbi request reprint Diagnostic accuracy of ELISA and xMAP technology for analysis of amyloid beta(42) and tau proteins
    Thierry S M Reijn
    Department of Neurology, Alzheimer Centre Nijmegen, Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem 53:859-65. 2007
  6. pmc LRP1 shedding in human brain: roles of ADAM10 and ADAM17
    Qiang Liu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Neurodegener 4:17. 2009
  7. pmc Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, Radboud University Nijmegen Medical Centre, 830 LKN, Nijmegen, 6500 HB, Netherlands
    Mol Neurobiol 35:203-16. 2007
  8. ncbi request reprint Increased cerebrospinal fluid chitotriosidase index in patients with multiple sclerosis
    M M Verbeek
    Department of Neurology, Donders Centre for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Acta Neurol Scand 121:309-14. 2010
  9. doi request reprint Technical and biochemical factors affecting cerebrospinal fluid 5-MTHF, biopterin and neopterin concentrations
    M M Verbeek
    Department of Laboratory of Pediatrics, Radboud University Nijmegen Medical Centre, Donders Centre for Neuroscience, The Netherlands
    Mol Genet Metab 95:127-32. 2008
  10. ncbi request reprint Comparison of methods for the detection of oligoclonal IgG bands in cerebrospinal fluid and serum: results of the Dutch Quality Control survey
    Marcel M Verbeek
    Department of Neurology, University Medical Center, 6500 HB Nijmegen, The Netherlands
    Clin Chem 48:1578-80. 2002

Detail Information

Publications111 found, 100 shown here

  1. ncbi request reprint Apolipoprotein E genotype regulates amyloid-beta cytotoxicity
    Micha M M Wilhelmus
    Department of Neurology, Radboud University Nijmegen Medical Center, 6500 HB Nijmegen, The Netherlands
    J Neurosci 25:3621-7. 2005
    ....
  2. ncbi request reprint [Diagnosis in cerebrospinal fluid: possible applications in neurological practice]
    M M Verbeek
    afd Neurologie, Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 149:1833-8. 2005
    ..Contraindications include intracranial space-occupying abnormalities, compression of the spinal cord, haemorrhagic diathesis and abnormalities around the puncture site...
  3. ncbi request reprint Small heat shock protein HspB8: its distribution in Alzheimer's disease brains and its inhibition of amyloid-beta protein aggregation and cerebrovascular amyloid-beta toxicity
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, 830 LKN, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500, Nijmegen, The Netherlands
    Acta Neuropathol 111:139-49. 2006
    ..We conclude that HspB8 might play an important role in regulating Abeta aggregation and, therefore, the development of classic SPs in AD and CAA in HCHWA-D...
  4. ncbi request reprint Small heat shock proteins inhibit amyloid-beta protein aggregation and cerebrovascular amyloid-beta protein toxicity
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, 830 LKN, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Brain Res 1089:67-78. 2006
    ..In conclusion, sHsps may regulate Abeta aggregation and serve as antagonists of the biological action of Abeta, but the extent of their interaction depends on the type of sHsp and Abeta peptide...
  5. ncbi request reprint Diagnostic accuracy of ELISA and xMAP technology for analysis of amyloid beta(42) and tau proteins
    Thierry S M Reijn
    Department of Neurology, Alzheimer Centre Nijmegen, Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Clin Chem 53:859-65. 2007
    ..Recently, the xMAP technology has been introduced as an alternative to ELISA for measurement of these markers...
  6. pmc LRP1 shedding in human brain: roles of ADAM10 and ADAM17
    Qiang Liu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Neurodegener 4:17. 2009
    ..abstract:..
  7. pmc Heat shock proteins and amateur chaperones in amyloid-Beta accumulation and clearance in Alzheimer's disease
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, Radboud University Nijmegen Medical Centre, 830 LKN, Nijmegen, 6500 HB, Netherlands
    Mol Neurobiol 35:203-16. 2007
    ....
  8. ncbi request reprint Increased cerebrospinal fluid chitotriosidase index in patients with multiple sclerosis
    M M Verbeek
    Department of Neurology, Donders Centre for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Acta Neurol Scand 121:309-14. 2010
    ..To investigate chitotriosidase (CTTS) activity in serum and cerebrospinal fluid (CSF) in multiple sclerosis (MS) patients in relation to disease course and CSF markers for immune activation or inflammation...
  9. doi request reprint Technical and biochemical factors affecting cerebrospinal fluid 5-MTHF, biopterin and neopterin concentrations
    M M Verbeek
    Department of Laboratory of Pediatrics, Radboud University Nijmegen Medical Centre, Donders Centre for Neuroscience, The Netherlands
    Mol Genet Metab 95:127-32. 2008
    ..The aim of this study was to investigate which technical and biochemical factors affect the CSF concentration of 5-MTHF, neopterin and biopterin in a pediatric population...
  10. ncbi request reprint Comparison of methods for the detection of oligoclonal IgG bands in cerebrospinal fluid and serum: results of the Dutch Quality Control survey
    Marcel M Verbeek
    Department of Neurology, University Medical Center, 6500 HB Nijmegen, The Netherlands
    Clin Chem 48:1578-80. 2002
  11. ncbi request reprint Aromatic L-amino acid decarboxylase enzyme activity in deficient patients and heterozygotes
    M M Verbeek
    Department of Neurology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Genet Metab 90:363-9. 2007
    ..Confirmation of the diagnosis AADC deficiency is then required by enzyme activity measurement or genetic analysis...
  12. doi request reprint Two Greek siblings with sepiapterin reductase deficiency
    Marcel M Verbeek
    Department of Neurology, Laboratory of Pediatrics and Neurology, 830 LKN, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Mol Genet Metab 94:403-9. 2008
    ..Sepiapterin reductase (SR) deficiency is a rare inherited disorder of neurotransmitter metabolism; less than 25 cases have been described in the literature so far...
  13. ncbi request reprint Mutations in the cyclic adenosine monophosphate response element of the tyrosine hydroxylase gene
    Marcel M Verbeek
    Department of Neurology and Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Ann Neurol 62:422-6. 2007
    ..Our data suggest that, if no mutations are found in the coding regions of the gene in patients strongly suspected of TH deficiency, the search for pathogenic mutations should be extended to regulatory promotor elements...
  14. pmc Cerebrospinal fluid amyloid beta(40) is decreased in cerebral amyloid angiopathy
    Marcel M Verbeek
    Department of Neurology, Radboud University Nijmegen Medical Center, Donders Center for Brain, Cognition and Behavior, Nijmegen, The Netherlands
    Ann Neurol 66:245-9. 2009
    ....
  15. doi request reprint Apolipoprotein E protects cultured pericytes and astrocytes from D-Abeta(1-40)-mediated cell death
    Ilona B Bruinsma
    Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    Brain Res 1315:169-80. 2010
    ..Furthermore, since apoE production in pericytes is genotype dependent, this may contribute to the apoE genotype-dependent development of CAA in vivo...
  16. ncbi request reprint Insulin inhibits amyloid beta-induced cell death in cultured human brain pericytes
    Annemieke A M Rensink
    Department of Neurology, University Medical Centre Nijmegen, The Netherlands
    Neurobiol Aging 25:93-103. 2004
    ..Our data indicate that the formation of a fibril network is essential for Abeta-induced cell death in HBP. Additionally, insulin may be involved in the regulation of Abeta fibrillization in AD...
  17. ncbi request reprint Cerebrospinal fluid amyloid beta42/phosphorylated tau ratio discriminates between Alzheimer's disease and vascular dementia
    Danielle de Jong
    Department of Neurology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Gerontol A Biol Sci Med Sci 61:755-8. 2006
    ....
  18. ncbi request reprint Cerebral amyloid angiopathy with severe secondary vascular pathology: a histopathological study
    Jack van Horssen
    Department of Pathology, University Medical Center, Nijmegen, The Netherlands
    Dement Geriatr Cogn Disord 20:321-30. 2005
    ..The functional impact of CAA and CAA-related secondary vascular changes on cognitive performance warrants further exploration...
  19. doi request reprint Hourly variability of cerebrospinal fluid biomarkers in Alzheimer's disease subjects and healthy older volunteers
    Diane Slats
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neurobiol Aging 33:831.e1-9. 2012
    ..Furthermore, continuous sampling of CSF proved to be a useful and robust method, which may also be used to investigate AD pathogenesis and to evaluate pharmacotherapeutic interventions...
  20. ncbi request reprint Amyloid beta induces cellular relocalization and production of agrin and glypican-1
    Nienke M Timmer
    Department of Neurology, Laboratory of Pediatrics and Neurology, Donders Centre for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Brain Res 1260:38-46. 2009
    ..We conclude that Abeta can modulate the cellular expression of agrin and glypican-1, which may contribute to the accumulation of these HSPG in AD lesions...
  21. ncbi request reprint Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis
    Michel A Willemsen
    Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Department of Paediatric Neurology 820 IKNC, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Brain 133:1810-22. 2010
    ..707T>C mutations. Carriership of at least one promotor mutation, however, apparently predicts type A tyrosine hydroxylase deficiency. Most patients with tyrosine hydroxylase deficiency can be successfully treated with l-dopa...
  22. ncbi request reprint Child neurology: differential diagnosis of a low CSF glucose in children and young adults
    Wilhelmina G Leen
    From the Department of Neurology W G L, B G E, M M V and Department of Pediatric Neurology M A W, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, the Netherlands Department of Pediatrics C J d W, Genetics E J K, and Laboratory Medicine M M V, R A W, Radboud University Medical Centre, Nijmegen, the Netherlands and Department of Pediatrics and Pediatric Neurology J K, Children s Hospital, Aschaffenburg, Germany
    Neurology 81:e178-81. 2013
    ..We present a practical overview on the differential diagnosis of a low CSF glucose and stress the importance of recognizing a low CSF glucose as the diagnostic marker for GLUT1 deficiency syndrome, a treatable neurometabolic disorder. ..
  23. pmc Lipoprotein receptor-related protein-1 mediates amyloid-beta-mediated cell death of cerebrovascular cells
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Center, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Am J Pathol 171:1989-99. 2007
    ..Although perivascular cells may adapt their A beta internalization capacity to the levels of A beta present, saturated LRP-1/LDLR-mediated uptake of A beta results in degeneration of perivascular cells...
  24. doi request reprint Reciprocal interactions between sleep, circadian rhythms and Alzheimer's disease: focus on the role of hypocretin and melatonin
    Diane Slats
    Radboud University Nijmegen Medical Centre, Department of Geriatric Medicine, The Netherlands
    Ageing Res Rev 12:188-200. 2013
    ....
  25. ncbi request reprint Expression pattern of apoptosis-related markers in Huntington's disease
    Jose C Vis
    Department of Neurology 321, University Medical Centre Nijmegen, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Acta Neuropathol 109:321-8. 2005
    ....
  26. doi request reprint Aggregation and cytotoxic properties towards cultured cerebrovascular cells of Dutch-mutated Abeta40 (DAbeta(1-40)) are modulated by sulfate moieties of heparin
    Nienke M Timmer
    Radboud University Nijmegen Medical Centre, Department of Neurology, Department of Laboratory Medicine, Donders Centre for Brain, Cognition and Behavior, Alzheimer Centre Nijmegen, Nijmegen, The Netherlands
    Neurosci Res 66:380-9. 2010
    ..We conclude that sulfate moieties within GAGs, like heparin and HS, have an important role in Abeta aggregation in CAA and in Abeta-mediated toxicity of cerebrovascular cells...
  27. doi request reprint Sulfation of heparan sulfate associated with amyloid-beta plaques in patients with Alzheimer's disease
    Ilona B Bruinsma
    Department of Neurology and Alzheimer Centre, Donders Institute for Brain, Cognition and Behaviour, Centre for Neuroscience, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Acta Neuropathol 119:211-20. 2010
    ....
  28. doi request reprint Cerebrospinal fluid analysis in the workup of GLUT1 deficiency syndrome: a systematic review
    Wilhelmina G Leen
    Department of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    JAMA Neurol 70:1440-4. 2013
    ..Reports of patients with apparently normal CSF glucose levels, however, have raised the question whether CSF analysis is a reliable screening tool for GLUT1 deficiency syndrome...
  29. ncbi request reprint Expression of the cytokine leukemia inhibitory factor and pro-apoptotic insulin-like growth factor binding protein-3 in Alzheimer's disease
    Annemieke A M Rensink
    Department of Pathology, University Medical Center Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Acta Neuropathol 104:525-33. 2002
    ..IGFBP-3 is known to inhibit cell proliferation and induce apoptosis and may therefore contribute to neuronal degeneration in AD...
  30. ncbi request reprint Association between hypocretin-1 and amyloid-β42 cerebrospinal fluid levels in Alzheimer's disease and healthy controls
    Diane Slats
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, 925, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Curr Alzheimer Res 9:1119-25. 2012
    ....
  31. doi request reprint Inhibition of α-synuclein aggregation by small heat shock proteins
    Ilona B Bruinsma
    Department of Neurology and Alzheimer Centre, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Proteins 79:2956-67. 2011
    ..In conclusion, sHsps may regulate α-syn aggregation and, therefore, optimization of the interaction between sHsps and α-syn may be an interesting target for therapeutic intervention in the pathogenesis of α-synucleinopathies...
  32. doi request reprint CSF tau, Aβ42, and MHPG differentiate dementia with Lewy bodies from Alzheimer's disease
    Marjolein B Aerts
    Radboud University Nijmegen Medical Centre, Department of Neurology and Parkinson Center Nijmegen, Nijmegen, The Netherlands
    J Alzheimers Dis 27:377-84. 2011
    ....
  33. doi request reprint CSF neurofilament proteins levels are elevated in sporadic Creutzfeldt-Jakob disease
    Jeroen J J van Eijk
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, The Netherlands
    J Alzheimers Dis 21:569-76. 2010
    ..Prospective studies are needed to determine whether NFL and NFHp35 may be additional tools in the differential diagnosis of rapidly progressive dementias...
  34. doi request reprint MicroRNAs in Alzheimer's disease: differential expression in hippocampus and cell-free cerebrospinal fluid
    Mareike Muller
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Centre, Nijmegen, The Netherlands Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Centre, Nijmegen, The Netherlands
    Neurobiol Aging 35:152-8. 2014
    ..In conclusion, the abnormal expression of several miRNAs in hippocampus of intermediate- and late-stage AD patients suggests their involvement in AD pathogenesis, and low levels of miR-146a in CSF were associated with AD. ..
  35. ncbi request reprint Addition of MHPG to Alzheimer's disease biomarkers improves differentiation of dementia with Lewy bodies from Alzheimer's disease but not other dementias
    Megan K Herbert
    Department of Neurology, Radboud University Medical Centre, and Donders Institute for Brain, Cognition and Behaviour, Nijmegen, The Netherlands Radboud Alzheimer Centre, Nijmegen, The Netherlands Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    Alzheimers Dement 10:448-455.e2. 2014
    ....
  36. pmc Cerebrospinal fluid glucose and lactate: age-specific reference values and implications for clinical practice
    Wilhelmina G Leen
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, The Netherlands
    PLoS ONE 7:e42745. 2012
    ..Furthermore, hypoglycemia was associated with an increased CSF/plasma glucose ratio, whereas hyperglycemia did not affect the CSF/plasma glucose ratio...
  37. doi request reprint Optimisation of the quantification of glutamine synthetase and myelin basic protein in cerebrospinal fluid by a combined acidification and neutralisation protocol
    Megan K Herbert
    Radboud University Nijmegen Medical Centre, Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Nijmegen, The Netherlands
    J Immunol Methods 381:1-8. 2012
    ..Based on our results, we suggest including the AFBN protocol in the evaluation of new biomarker development protocols to avoid confounders such as CSF pH or epitope-masking of the target protein...
  38. ncbi request reprint Small heat shock proteins induce a cerebral inflammatory reaction
    Ilona B Bruinsma
    Departments of Neurology and Alzheimer Centre, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Neurosci 31:11992-2000. 2011
    ..Our results suggest a central role for sHsps in the neuroinflammatory reaction in AD and CAA and thus in contributing to cognitive decline...
  39. ncbi request reprint Current state and future directions of neurochemical biomarkers for Alzheimer's disease
    Danielle de Jong
    Department of Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Clin Chem Lab Med 45:1421-34. 2007
    ..g., multiplex analysis of biomarkers, proteomics), to the discovery of novel, potential biomarkers (e.g., amyloid beta oligomers, isoprostanes), and to the extension of this research towards identification of biomarkers in plasma...
  40. ncbi request reprint CSF neurofilament light chain and tau differentiate multiple system atrophy from Parkinson's disease
    W Farid Abdo
    Department of Neurology, Radboud University, Nijmegen Medical Centre, The Netherlands
    Neurobiol Aging 28:742-7. 2007
    ..In early disease stages it can be clinically difficult to differentiate idiopathic Parkinson's disease (IPD) from patients with multiple system atrophy predominated by parkinsonism (MSA-P)...
  41. ncbi request reprint Small heat shock proteins associated with cerebral amyloid angiopathy of hereditary cerebral hemorrhage with amyloidosis (Dutch type) induce interleukin-6 secretion
    Micha M M Wilhelmus
    Department of Neurology and Alzheimer Centre, Radboud University Nijmegen Medical Centre, The Netherlands
    Neurobiol Aging 30:229-40. 2009
    ....
  42. doi request reprint A prediction model to calculate probability of Alzheimer's disease using cerebrospinal fluid biomarkers
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Alzheimers Dement 9:262-8. 2013
    ..We aimed to develop a prediction model based on cerebrospinal fluid (CSF) biomarkers, that would yield a single estimate representing the probability that dementia in a memory clinic patient is due to Alzheimer's disease (AD)...
  43. doi request reprint Amyloid-β oligomer detection by ELISA in cerebrospinal fluid and brain tissue
    Kim A Bruggink
    Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud Alzheimer Centre, Radboud University Medical Centre, 6500 HB Nijmegen, The Netherlands
    Anal Biochem 433:112-20. 2013
    ..Our data suggest that levels of small oligomers might not be suitable as biomarkers for AD. In addition, we demonstrate the importance of avoiding HAMA interference in assays to quantify Aβ oligomers in human body fluids...
  44. ncbi request reprint Reviewing reasons for the decreased CSF Abeta42 concentration in Alzheimer disease
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Front Biosci (Landmark Ed) 17:2024-34. 2012
    ..Evidence for other possibilities such as a decreased production of Abeta42, an increased proteolytic breakdown or microglial uptake of Abeta42, or an increased clearance of Abeta42 to the blood, is - at best - scarce or even absent...
  45. ncbi request reprint Collagen XVIII: a novel heparan sulfate proteoglycan associated with vascular amyloid depositions and senile plaques in Alzheimer's disease brains
    Jack van Horssen
    Department of Pathology, University Medical Center, Nijmegen, The Netherlands
    Brain Pathol 12:456-62. 2002
    ....
  46. ncbi request reprint A more efficient enzyme-linked immunosorbent assay for measurement of alpha-synuclein in cerebrospinal fluid
    Wieneke J A van Geel
    Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, The Netherlands
    J Neurosci Methods 168:182-5. 2008
    ....
  47. ncbi request reprint Heparan sulphate proteoglycans in Alzheimer's disease and amyloid-related disorders
    Jack van Horssen
    Department of Pathology, University Medical Center, Nijmegen, Netherlands
    Lancet Neurol 2:482-92. 2003
    ....
  48. ncbi request reprint Brain-specific proteins in cerebrospinal fluid for the diagnosis of neurodegenerative diseases
    M M Verbeek
    Department of Neurology, 319 LKN, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Ann Clin Biochem 40:25-40. 2003
    ..Development of disease-specific CSF biomarkers will undoubtedly add to the process of differential diagnosis early in the course of the disease...
  49. ncbi request reprint Movement disorders in GLUT1 deficiency syndrome respond to the modified Atkins diet
    Wilhelmina G Leen
    Department of Neurology, Radboud University Medical Centre, Donders Institute for Brain, Cognition, and Behaviour, Nijmegen, The Netherlands
    Mov Disord 28:1439-42. 2013
    ..First-choice treatment is a ketogenic diet, but compliance is poor. We have investigated the effect of the modified Atkins diet as an alternative treatment for movement disorders in GLUT1DS...
  50. doi request reprint CSF levels of DJ-1 and tau distinguish MSA patients from PD patients and controls
    Megan K Herbert
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Centre, Nijmegen, The Netherlands Department of Laboratory Medicine, Radboud University Medical Centre, Nijmegen, The Netherlands
    Parkinsonism Relat Disord 20:112-5. 2014
    ..92). Our results highlight the potential benefits of a combination of DJ-1 and total tau as biomarkers for differential diagnosis of MSA and PD...
  51. ncbi request reprint Absence of heparan sulfate proteoglycans in Lewy bodies and Lewy neurites in Parkinson's disease brains
    Jack van Horssen
    Department of Pathology, University Medical Center, Nijmegen, The Netherlands
    J Alzheimers Dis 6:469-74. 2004
    ....
  52. doi request reprint CSF neurofilament protein analysis in the differential diagnosis of ALS
    Thierry S Reijn
    Dept of Neurology, Radboud University Nijmegen Medical Centre, 830 LKN, 9101, 6500 HB, Nijmegen, The Netherlands
    J Neurol 256:615-9. 2009
    ..Cerebrospinal fluid (CSF) biomarkers have been studied to differentiate between patients with ALS and neurological controls, but not in comparison to clinically more relevant disorders mimicking ALS...
  53. doi request reprint CSF studies facilitate DNA diagnosis in familial Alzheimer's disease due to a presenilin-1 mutation
    Susanne T de Bot
    Department of Neurology, Donders Centre for Brain Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Alzheimers Dis 17:53-7. 2009
    ..A causative p.L424R PSEN1 mutation was subsequently identified...
  54. ncbi request reprint Cerebrospinal fluid analysis differentiates multiple system atrophy from Parkinson's disease
    W Farid Abdo
    Department of Neurology, University Medical Center, Nijmegen, The Netherlands
    Mov Disord 19:571-9. 2004
    ..We propose that CSF analysis may become part of the diagnostic work-up of patients with parkinsonian syndromes...
  55. doi request reprint Linkage analysis for plasma amyloid beta levels in persons with hypertension implicates Aβ-40 levels to presenilin 2
    Carla A Ibrahim-Verbaas
    Department of Neurology, Erasmus University Medical Center, P O Box 2040, 3000 CA Rotterdam, The Netherlands
    Hum Genet 131:1869-76. 2012
    ..1 × 10(-3) for rs2514299). This linkage study of plasma concentrations of Aβ40 and Aβ42 yielded two suggestive regions, of which one points toward a known locus for familial AD...
  56. doi request reprint TDP-43 plasma levels are higher in amyotrophic lateral sclerosis
    Esther Verstraete
    Department of Neurology, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Utrecht, The Netherlands
    Amyotroph Lateral Scler 13:446-51. 2012
    ..In conclusion, our data indicate that TDP-43 plasma levels may have potential as a marker for ALS. A genotype-phenotype relationship could not, however, be established in this cohort...
  57. doi request reprint Diagnosis of progressive supranuclear palsy: can measurement of tau forms help?
    H Bea Kuiperij
    Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Neurobiol Aging 33:204.e17-8. 2012
    ..We conclude that more sensitive techniques are needed to measure tau forms in CSF...
  58. doi request reprint CSF α-synuclein concentrations do not fluctuate over hours and are not correlated to amyloid β in humans
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Donders Institute for Brain, Cognition and Behaviour, and Alzheimer Centre, Nijmegen, The Netherlands
    Neurosci Lett 504:336-8. 2011
    ..Furthermore, we did not find evidence for an interaction between amyloid β and α-synuclein concentrations in CSF...
  59. ncbi request reprint Measurement of glial fibrillary acidic protein in blood: an analytical method
    Wieneke J A van Geel
    Laboratory of Pediatrics and Neurology, University Medical Centre Nijmegen, Reinier Postlaan 4, 6525 GC Nijmegen, The Netherlands
    Clin Chim Acta 326:151-4. 2002
    ..In the present study, a new assay for the measurement of glial fibrillary acidic protein (GFAP) in human blood is described. The aim of the study was to present the characteristics of a new GFAP assay for blood analysis...
  60. doi request reprint Do amyloid β-associated factors co-deposit with Aβ in mouse models for Alzheimer's disease?
    Nienke M Timmer
    Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    J Alzheimers Dis 22:345-55. 2010
    ..In this review, the co-deposition of factors known to associate with human Aβ deposits is summarized for several different AD mouse models...
  61. ncbi request reprint Creatine protects against 3-nitropropionic acid-induced cell death in murine corticostriatal slice cultures
    Jose C Vis
    Department of Neurology, University Medical Centre Nijmegen, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Brain Res 1024:16-24. 2004
    ....
  62. ncbi request reprint Pathogenesis of cerebral amyloid angiopathy
    Annemieke A M Rensink
    Department of Neurology, Laboratory of Pediatrics and Neurology, University Medical Center, 319, P O Box 9101, 6500 HB, Nijmegen, The Netherlands
    Brain Res Brain Res Rev 43:207-23. 2003
    ....
  63. ncbi request reprint Glial and neuronal proteins in serum predict outcome after severe traumatic brain injury
    P E Vos
    Department of Neurology, University Medical Centre Nijmegen, The Netherlands
    Neurology 62:1303-10. 2004
    ..To study the ability of glial (glial fibrillary acidic protein [GFAP] and S100b) and neuronal (neuron specific enolase [NSE]) protein levels in peripheral blood to predict outcome after severe traumatic brain injury...
  64. doi request reprint Limited expression of heparan sulphate proteoglycans associated with Aβ deposits in the APPswe/PS1dE9 mouse model for Alzheimer's disease
    N M Timmer
    Radboud University Nijmegen Medical Centre, Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Radboud University, Nijmegen, The Netherlands
    Neuropathol Appl Neurobiol 36:478-86. 2010
    ..We aimed to investigate whether co-deposition of HSPG in AD brains can be replicated in the APPswe/PS1dE9 mouse model for AD and if a temporal association of HSPG with Aβ exists...
  65. ncbi request reprint The cerebrospinal fluid amyloid beta42/40 ratio in the differentiation of Alzheimer's disease from non-Alzheimer's dementia
    P E Spies
    Department of Geriatric Medicine, 925, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Curr Alzheimer Res 7:470-6. 2010
    ..This measure may also improve differential diagnosis between AD and other dementia syndromes, such as vascular dementia (VaD), dementia with Lewy bodies (DLB), and frontotemporal dementia (FTD)...
  66. ncbi request reprint Specific association of small heat shock proteins with the pathological hallmarks of Alzheimer's disease brains
    M M M Wilhelmus
    Department of Pathology, Radbound University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neuropathol Appl Neurobiol 32:119-30. 2006
    ..Furthermore, none of the sHsps were observed in NFTs in AD brains. We conclude that specific sHsp species may be involved in the pathogenesis of either SPs or CAA in AD...
  67. ncbi request reprint Biomarkers in spinal cord injury
    M H Pouw
    Department of Orthopedic Surgery, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Spinal Cord 47:519-25. 2009
    ..Literature review...
  68. ncbi request reprint Increased GFAP and S100beta but not NSE serum levels after subarachnoid haemorrhage are associated with clinical severity
    P E Vos
    Department of Neurology, Radboud University Nijmegen Medical Centre, The Netherlands
    Eur J Neurol 13:632-8. 2006
    ..Increased glial (S100beta and GFAP) but not neuronal (NSE) protein serum concentrations are found after SAH, associated to the clinical severity of the initial injury...
  69. ncbi request reprint CSF biomarker profiles do not differentiate between the cerebellar and parkinsonian phenotypes of multiple system atrophy
    W F Abdo
    Institute of Neurology, Radboud University Nijmegen Medical Centre, The Netherlands
    Parkinsonism Relat Disord 13:480-2. 2007
    ..It is unknown whether the variation in clinical expression is also reflected by a different underlying neurochemical profile...
  70. doi request reprint Urinary dopamine in aromatic L-amino acid decarboxylase deficiency: the unsolved paradox
    T Wassenberg
    Radboud University Nijmegen Medical Centre, Department of Neurology, Neurochemistry Lab, Nijmegen, The Netherlands
    Mol Genet Metab 101:349-56. 2010
    ..Genotype/phenotype correlations or alternative metabolic pathways may explain this remarkable finding, but were never studied systematically...
  71. ncbi request reprint CSF analysis differentiates multiple-system atrophy from idiopathic late-onset cerebellar ataxia
    W F Abdo
    Department of Neurology, Radboud University Nijmegen Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Neurology 67:474-9. 2006
    ..Differentiating idiopathic late-onset cerebellar ataxia (ILOCA) from ataxia due to the cerebellar subtype of multiple-system atrophy (MSA-C) can be difficult in the early stages of the disease..
  72. ncbi request reprint The diagnostic value of CSF amyloid-β(43) in differentiation of dementia syndromes
    Kim A Bruggink
    Department of Neurology, 830 LGEM, Radboud University Medical Centre, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Curr Alzheimer Res 10:1034-40. 2013
    ..In conclusion, quantification of Aβ43 in CSF does not add novel diagnostic information to the differential diagnosis of AD compared to existing biomarkers. ..
  73. doi request reprint Methods for analysis of amyloid-β aggregates
    Kim A Bruggink
    Radboud University Nijmegen Medical Centre, Department of Neurology, Department of Laboratory Medicine, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Nijmegen, The Netherlands
    J Alzheimers Dis 28:735-58. 2012
    ..In this review, we provide an overview and discussion of the most important techniques used for these aims. Often a combination of techniques will be appropriate to obtain the most optimal information...
  74. ncbi request reprint Inhibition of amyloid-beta-induced cell death in human brain pericytes in vitro
    Annemieke A M Rensink
    Department of Neurology, University Medical Centre, PO Box 9101, 6500 HB, Nijmegen, The Netherlands
    Brain Res 952:111-21. 2002
    ..Inhibition of fibril formation at the cell surface could be an important factor in therapy aimed at reducing cerebral amyloid angiopathy...
  75. ncbi request reprint CSF protein profiling using Multiplex Immuno-assay: A potential new diagnostic tool for leptomeningeal metastases
    Dieta Brandsma
    Department of Neurology, G03 228, University Medical Center Utrecht, PO Box 85500, 3584 Utrecht, CX, The Netherlands
    J Neurol 253:1177-84. 2006
    ..More sensitive tools are needed to diagnose LM. We measured a profile of proteins involved in adhesion and inflammation in the CSF of LM and control patients and determined their potential diagnostic value for LM...
  76. doi request reprint Enoxaparin treatment administered at both early and late stages of amyloid β deposition improves cognition of APPswe/PS1dE9 mice with differential effects on brain Aβ levels
    Nienke M Timmer
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Alzheimer Centre Nijmegen, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Neurobiol Dis 40:340-7. 2010
    ..In any case, our study suggests that enoxaparin treatment has potential as a therapeutic agent for Alzheimer's disease...
  77. doi request reprint Glucose transporter-1 deficiency syndrome: the expanding clinical and genetic spectrum of a treatable disorder
    Wilhelmina G Leen
    Department of Neurology, Radboud University Nijmegen Medical Centre, 935 Neurology, PO Box 9101, 6500 HB Nijmegen, The Netherlands
    Brain 133:655-70. 2010
    ..Our study demonstrates that a lumbar puncture provides the diagnostic clue to glucose transporter-1 deficiency syndrome and can thereby dramatically reduce diagnostic delay to allow early start of the ketogenic diet...
  78. doi request reprint Cerebrospinal fluid alpha-synuclein does not discriminate between dementia disorders
    Petra E Spies
    Department of Geriatric Medicine, Radboud University Nijmegen Medical Centre, Donders Centre for Neuroscience, Nijmegen, The Netherlands
    J Alzheimers Dis 16:363-9. 2009
    ..We conclude that in clinically diagnosed patients, alpha-synuclein does not appear to be a useful biomarker for the differentiation between DLB and other types of dementia...
  79. ncbi request reprint CXCL16 is elevated in the cerebrospinal fluid versus serum and in inflammatory conditions with suspected and proved central nervous system involvement
    Linda M P le Blanc
    Department of Rheumatology, Radboud University Nijmegen Medical Centre, The Netherlands
    Neurosci Lett 397:145-8. 2006
    ..CCL18 was only elevated in serum of SLE patients. These data suggest that attraction of activated memory type T cells by CXCL16 might play an important role in the orchestration of immune responses in the central nervous system...
  80. pmc CSF neurofilament proteins in the differential diagnosis of dementia
    D De Jong
    Department of Neurology, Radboud University Nijmegen Medical Centre, 6500 HB, Nijmegen, The Netherlands
    J Neurol Neurosurg Psychiatry 78:936-8. 2007
    ..Neurofilament (NF) proteins are major cytoskeletal constituents of neurons. Increased CSF NF levels may reflect neuronal degeneration...
  81. ncbi request reprint Protein S-100B, neuron-specific enolase (NSE), myelin basic protein (MBP) and glial fibrillary acidic protein (GFAP) in cerebrospinal fluid (CSF) and blood of neurological patients
    K J B Lamers
    Laboratory of Pediatrics and Neurology, University Medical Centre Nijmegen, 6500 HB Nijmegen, The Netherlands
    Brain Res Bull 61:261-4. 2003
    ....
  82. doi request reprint Autoantibodies to cytosolic 5'-nucleotidase 1A in inclusion body myositis
    Helma Pluk
    Department of Biomolecular Chemistry, Institute for Molecules and Materials and Nijmegen Center for Molecular Life Sciences, Radboud University Nijmegen, Nijmegen, The Netherlands
    Ann Neurol 73:397-407. 2013
    ..We used human skeletal muscle extracts as a source of antigens to detect autoantibodies in sIBM and to characterize the corresponding antigen...
  83. pmc The paradox of hyperdopaminuria in aromatic L-amino Acid deficiency explained
    Tessa Wassenberg
    Department of Neurology, Radboud University Nijmegen Medical Centre, Donders Centre for Brain, Cognition and Behaviour, Nijmegen, The Netherlands
    JIMD Rep 4:39-45. 2012
    ....
  84. doi request reprint A de novo p.Asp18Asn mutation in TREX1 in a patient with Aicardi-Goutières syndrome
    Charlotte A Haaxma
    Department of Neurology, Donders Institute for Brain, Cognition and Behaviour, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
    Am J Med Genet A 152:2612-7. 2010
    ..This report serves to enhance awareness of de novo heterozygous mutations underlying Aicardi-Goutières syndrome-with a concomitant low risk of recurrence...
  85. pmc Endotoxemia-induced inflammation and the effect on the human brain
    Mark van den Boogaard
    Department of Intensive Care Medicine, Radboud University Nijmegen Medical Centre, PO Box 9101, Nijmegen 6500HB, The Netherlands
    Crit Care 14:R81. 2010
    ..Effects of systemic inflammation on cerebral function are not clear, as both inflammation-induced encephalopathy as well as stress-hormone mediated alertness have been described...
  86. ncbi request reprint Accumulation of the amyloid-beta precursor protein in multivesicular body-like organelles
    Marcel M Verbeek
    Department of Neurology, University Medical Center Nijmegen, The Netherlands
    J Histochem Cytochem 50:681-90. 2002
    ..Accumulation of the APP in this organelle is reflected by its reduced secretion from the cell...
  87. doi request reprint CSF hypocretin-1 levels are normal in patients with amyotrophic lateral sclerosis
    Frank G van Rooij
    Radboud University Nijmegen, Donders Centre for Neuroscience, Medical Centre, Department of Neurology, Nijmegen, The Netherlands
    Amyotroph Lateral Scler 10:487-9. 2009
    ..We conclude that it is unlikely that the hypocretin system is involved in the degenerative process of ALS...
  88. ncbi request reprint Rituximab and intravenous immunoglobulins for relapsing postinfectious opsoclonus-myoclonus syndrome
    Wilhelmina G Leen
    Department of Pediatric Neurology, Radboud University Nijmegen Medical Center, Nijmegen, The Netherlands
    Pediatr Neurol 39:213-7. 2008
    ..Treatment with rituximab in combination with intravenous immunoglobulin, however, resulted in significant longterm clinical improvement...
  89. ncbi request reprint MALDI-TOF mass spectrometry analysis of cerebrospinal fluid tryptic peptide profiles to diagnose leptomeningeal metastases in patients with breast cancer
    Lennard J Dekker
    Laboratory of Neuro Oncology, Department of Neurology, Dr Molewaterplein 40, 3015 GD, Erasmus MC, Rotterdam, The Netherlands
    Mol Cell Proteomics 4:1341-9. 2005
    ..The same method can be used to develop diagnostic assays for other neurological disorders...
  90. ncbi request reprint Accumulation of heparan sulfate proteoglycans in cerebellar senile plaques
    Jack van Horssen
    Department of Pathology, University Medical Center, Nijmegen, The Netherlands
    Neurobiol Aging 23:537-45. 2002
    ....
  91. ncbi request reprint Prediction of poor outcome within the first 3 days of postanoxic coma
    E G J Zandbergen
    Department of Neurology and Clinical Neurophysiology, Academic Medical Centre, University of Amsterdam, Nijmegen, The Netherlands
    Neurology 66:62-8. 2006
    ....
  92. pmc Ten steps to identify atypical parkinsonism
    W F Abdo
    Department of Neurology, Radboud University Nijmegen Medical Centre, 6500 HB Nijmegen, The Netherlands
    J Neurol Neurosurg Psychiatry 77:1367-9. 2006
    ..Balance impairment is a frequently encountered problem in patients with Parkinson's disease. A profound balance disorder, however, is an atypical feature...
  93. ncbi request reprint Heparan sulfate proteoglycan expression in cerebrovascular amyloid beta deposits in Alzheimer's disease and hereditary cerebral hemorrhage with amyloidosis (Dutch) brains
    J van Horssen
    Department of Pathology, University Medical Center, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Acta Neuropathol 102:604-14. 2001
    ..We conclude that specific HSPG species may be involved in the pathogenesis of CAA in both AD and HCHWA-D, and that the pathogenesis of CAA and SPs may differ with regard to the involvement of HSPG species...
  94. ncbi request reprint Differential gene expression in human brain pericytes induced by amyloid-beta protein
    A A M Rensink
    Department of Neurology, University Medical Centre, Nijmegen, The Netherlands
    Neuropathol Appl Neurobiol 30:279-91. 2004
    ....
  95. ncbi request reprint [The possible suppression of Alzheimer's disease by nonsteroidal anti-inflammatory drugs]
    D De Jong
    afd Neurologie, Universitair Medisch Centrum St Radboud, Postbus 9101, 6500 HB Nijmegen
    Ned Tijdschr Geneeskd 146:2074-8. 2002
    ..Large randomized double-blind placebo-controlled trials are needed to provide definitive evidence that NSAIDs have a therapeutic effect on Alzheimer's disease...
  96. ncbi request reprint An enzyme immunoassay to quantify neurofilament light chain in cerebrospinal fluid
    W J A Van Geel
    Laboratory of Pediatrics and Neurology, University Medical Centre Nijmegen, The Netherlands
    J Immunol Methods 296:179-85. 2005
    ..Strongly increased levels of neurofilament light chain were observed in patients with cerebrovascular accidents, subarachnoid hemorrhage and severe traumatic brain injury, suggesting the occurrence of axonal damage in these conditions...
  97. ncbi request reprint CSF hypocretin-1 levels are normal in multiple-system atrophy
    W F Abdo
    Institute of Neurology, Department of Neurology, Radboud University Nijmegen Medical Centre, 830 LKN, P O Box 9101, 6500 Nijmegan, HB, The Netherlands
    Parkinsonism Relat Disord 14:342-4. 2008
    ..We did not observe any differences from control values...
  98. ncbi request reprint Diagnostic accuracy of the clapping test in Parkinsonian disorders
    W F Abdo
    Parkinson Centre Nijmegen ParC, Institute of Neurology 935, Radboud University Nijmegen Medical Centre, 9101, 6500, HB Nijmegen, The Netherlands
    J Neurol 254:1366-9. 2007
    ....
  99. pmc Agrin is a major heparan sulfate proteoglycan accumulating in Alzheimer's disease brain
    M M Verbeek
    Department of Pathology, University Hospital Nijmegen, Nijmegen, The Netherlands
    Am J Pathol 155:2115-25. 1999
    ....
  100. ncbi request reprint CSF levels of growth factors and plasminogen activators in leptomeningeal metastases
    B van de Langerijt
    Department of Neurology, Laboratory of Pediatrics and Neurology, Radboud University Nijmegen Medical Centre, 830 LKN, P O Box 9101, 6500 HB Nijmegen, The Netherlands
    Neurology 67:114-9. 2006
    ....
  101. ncbi request reprint Interleukin-8 CSF levels predict survival in patients with leptomeningeal metastases
    D Brandsma
    Department of Neurology, University Medical Center Utrecht, Utrecht, The Netherlands
    Neurology 66:243-6. 2006
    ..High interleukin (IL)-8 CSF levels predicted short-term survival independently. The data indicate that IL-8 CSF levels may serve as a prognosticator in patients with LM, but prospective validation is needed...